7,097 results match your criteria promising perspectives


Experiences of living with Juvenile Idiopathic Arthritis: a qualitative systematic review.

JBI Evid Synth 2021 Oct 19. Epub 2021 Oct 19.

Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia University of Adelaide Discipline of Paediatrics, Women's and Children's Hospital, Adelaide, SA, Australia Women's and Children's Hospital Department of Rheumatology, Adelaide, SA, Australia JBI, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.

Objective: The objective of this review was to investigate the available qualitative evidence to enhance understanding of the experiences of children, young adults, and their carers living with Juvenile Idiopathic Arthritis in any setting.

Introduction: Juvenile Idiopathic Arthritis is the most common chronic rheumatic disease in childhood. Despite the availability of effective treatments, persistent pain, growth retardation, physical disability, and psychological problems can occur. Read More

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October 2021

Cholangiocarcinoma: new perspectives for new horizons.

Expert Rev Gastroenterol Hepatol 2021 Oct 20. Epub 2021 Oct 20.

Department of Oncology, IRCCS San Raffaele Scientific Institute Hospital, 20019, Milan, Italy.

Introduction: : Biliary tract cancer represents a heterogeneous group of malignancies characterized by dismal prognosis and scarce therapeutic options.

Area Covered: In the last years a growing interest in BTCs pathology has emerged, thus highlighting a significant heterogeneity of the pathways underlying the carcinogenesis process, from both a molecular and genomic point of view. A better understanding of these differences is mandatory in order to deepen the behavior of this complex disease, as well as to identify new targetable target mutations, with the aim to improve the survival outcomes. Read More

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October 2021

Challenges and Strategies of Low-Cost Aluminum Anodes for High-Performance Al-Based Batteries.

Adv Mater 2021 Oct 19:e2102026. Epub 2021 Oct 19.

School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.

The ever-growing market of electric vehicles and the upcoming grid-scale storage systems have stimulated the fast growth of renewable energy storage technologies. Aluminum-based batteries are considered one of the most promising alternatives to complement or possibly replace the current lithium-ion batteries owing to their high specific capacity, good safety, low cost, light weight, and abundant reserves of Al. However, the anode problems in primary and secondary Al batteries, such as, self-corrosion, passive film, and volume expansion, severely limit the batteries' practical performance, thus hindering their commercialization. Read More

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October 2021

Nanowire-based sensor electronics for chemical and biological applications.

Analyst 2021 Oct 20. Epub 2021 Oct 20.

Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan.

Detection and recognition of chemical and biological species sensor electronics are important not only for various sensing applications but also for fundamental scientific understanding. In the past two decades, sensor devices using one-dimensional (1D) nanowires have emerged as promising and powerful platforms for electrical detection of chemical species and biologically relevant molecules due to their superior sensing performance, long-term stability, and ultra-low power consumption. This paper presents a comprehensive overview of the recent progress and achievements in 1D nanowire synthesis, working principles of nanowire-based sensors, and the applications of nanowire-based sensor electronics in chemical and biological analytes detection and recognition. Read More

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October 2021

Controlled coherent dynamics of [VO(TPP)], a prototype molecular nuclear qudit with an electronic ancilla.

Chem Sci 2021 Sep 5;12(36):12046-12055. Epub 2021 Aug 5.

Università di Parma, Dipartimento di Scienze Matematiche, Fisiche e Informatiche I-43124 Parma Italy

We show that [VO(TPP)] (vanadyl tetraphenylporphyrinate) is a promising system to implement quantum computation algorithms based on encoding information in multi-level (qudit) units. Indeed, it embeds a nuclear spin 7/2 coupled to an electronic spin 1/2 by hyperfine interaction. This qubit-qudit unit can be exploited to implement quantum error correction and quantum simulation algorithms. Read More

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September 2021

Advanced Nanotheranostics of CRISPR/Cas for Viral Hepatitis and Hepatocellular Carcinoma.

Adv Sci (Weinh) 2021 Oct 19:e2102051. Epub 2021 Oct 19.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, P. R. China.

Liver disease, particularly viral hepatitis and hepatocellular carcinoma (HCC), is a global healthcare burden and leads to more than 2 million deaths per year worldwide. Despite some success in diagnosis and vaccine development, there are still unmet needs to improve diagnostics and therapeutics for viral hepatitis and HCC. The emerging clustered regularly interspaced short palindromic repeat/associated proteins (CRISPR/Cas) technology may open up a unique avenue to tackle these two diseases at the genetic level in a precise manner. Read More

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October 2021

Therapeutic Feasibility of the Natural Products in the Heart Complaints: An Overview.

J Med Food 2021 Oct 18. Epub 2021 Oct 18.

Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Brazil.

Heart pain is the most frequent complaint leading patients to seek medical help. Functional heart symptoms, especially chest pain, are prevalent and, according to the International Classification of Diseases (ICD-10), are described as "somatoform autonomous functional disorders of the cardiovascular system." The problem lies in the fact that pain does not always have a somatic background, that is, it may be related to crucial underlying heart disease. Read More

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October 2021

SYNBIP: synthetic binding proteins for research, diagnosis and therapy.

Nucleic Acids Res 2021 Oct 19. Epub 2021 Oct 19.

School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.

The success of protein engineering and design has extensively expanded the protein space, which presents a promising strategy for creating next-generation proteins of diverse functions. Among these proteins, the synthetic binding proteins (SBPs) are smaller, more stable, less immunogenic, and better of tissue penetration than others, which make the SBP-related data attracting extensive interest from worldwide scientists. However, no database has been developed to systematically provide the valuable information of SBPs yet. Read More

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October 2021

Nanosonosensitizers With Ultrasound-Induced Reactive Oxygen Species Generation for Cancer Sonodynamic Immunotherapy.

Front Bioeng Biotechnol 2021 30;9:761218. Epub 2021 Sep 30.

Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.

Immunotherapy is a promising therapeutic strategy for cancer, while it has been demonstrated to encounter the issues of low immune responses and underlying immune-related adverse events. The sonodynamic therapy (SDT) that utilizes sonosensitizers to produce reactive oxygen species (ROS) triggered by ultrasound (US) stimulation can be used to ablate tumors, which also leads to the induction of immunogenic cell death (ICD), thus achieving SDT-induced immunotherapy. Further combination of SDT with immunotherapy is able to afford enhanced antitumor immunity for tumor regression. Read More

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September 2021

The Future of Gene Therapy for Transfusion-Dependent Beta-Thalassemia: The Power of the Lentiviral Vector for Genetically Modified Hematopoietic Stem Cells.

Front Pharmacol 2021 1;12:730873. Epub 2021 Oct 1.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ratchathewi, Thailand.

β-thalassemia, a disease that results from defects in β-globin synthesis, leads to an imbalance of β- and α-globin chains and an excess of α chains. Defective erythroid maturation, ineffective erythropoiesis, and shortened red blood cell survival are commonly observed in most β-thalassemia patients. In severe cases, blood transfusion is considered as a mainstay therapy; however, regular blood transfusions result in chronic iron overload with life-threatening complications, e. Read More

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October 2021

Fluorescence-guided surgery in colorectal cancer; A review on clinical results and future perspectives.

Eur J Surg Oncol 2021 Oct 9. Epub 2021 Oct 9.

Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Doctor Molewaterplein 40, 3015, GD, Rotterdam, the Netherlands; Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands. Electronic address:

Background: Colorectal cancer is the fourth most diagnosed malignancy worldwide and surgery is one of the cornerstones of the treatment strategy. Near-infrared (NIR) fluorescence imaging is a new and upcoming technique, which uses an NIR fluorescent agent combined with a specialised camera that can detect light in the NIR range. It aims for more precise surgery with improved oncological outcomes and a reduction in complications by improving discrimination between different structures. Read More

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October 2021

VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives.

Eur J Med Chem 2021 Oct 9;227:113906. Epub 2021 Oct 9.

School of Life Sciences, Tsinghua University, Beijing, 100084, China. Electronic address:

Proteolysis targeting chimeras (PROTACs), which hijack proteins of interest (POIs) and recruit E3 ligases for target degradation via the ubiquitin-proteasome pathway, are a novel drug discovery paradigm that has been widely used as biological tools and medicinal molecules with the potential of clinical application value. To date, a wide variety of small molecule PROTACs have been developed. Importantly, VHL-based PROTACs have emerged to be a promising approach for proteins, including those non-druggable ones, such as transcriptional factors and scaffold proteins. Read More

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October 2021

Fluorescence imaging in the surgical management of liver cancers: Current status and future perspectives.

Asian J Surg 2021 Oct 13. Epub 2021 Oct 13.

Department of General Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. Electronic address:

Over the last decades, imaging technologies have got significant developments and become indispensable in the surgical management of liver cancers. Real-time navigation afforded by intraoperative images has a significant impact on the success of liver surgeries. Fluorescence imaging in the near-infrared spectrum has shown potential for tumor detection and image-guided surgery in clinics. Read More

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October 2021

The global concern of food security during the COVID-19 pandemic: Impacts and perspectives on food security.

Food Chem 2021 Sep 1;370:130830. Epub 2021 Sep 1.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.

COVID-19 is having a far-reaching negative impact on global economic and social development. One of the challenges arising from the pandemic is ensuring food security, especially with respect to cold chain food. Given the current situation of high contagion and large numbers of infected people, the perspective briefed emergency management measures of cold chain food, compared the development of accurate and rapid detection methods of COVID-19 and hazards in foods. Read More

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September 2021

Efficacy of post-inpatient aftercare treatments for anorexia nervosa: a systematic review of randomized controlled trials.

J Eat Disord 2021 Oct 15;9(1):129. Epub 2021 Oct 15.

Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Eberhard Karls University, Osianderstr. 5, 72076, Tübingen, Germany.

Background: Early relapse after inpatient treatment is a serious problem in the management of anorexia nervosa (AN). Specialized aftercare interventions have the potential to bridge the gap between inpatient and outpatient care, to prevent relapse and to improve the long-term outcome for patients with AN.

Methods: Following the guidelines of the PRISMA statement, we conducted a systematic review, synthesizing the evidence from randomized-controlled trials (RCTs) investigating the efficacy of post-inpatient aftercare treatments for AN. Read More

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October 2021

Advances in pretreatment of lignocellulosic biomass for bioenergy production: Challenges and perspectives.

Bioresour Technol 2021 Oct 12;343:126123. Epub 2021 Oct 12.

State Key Laboratory of Urban Water Resources and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

As a clean and renewable energy, bioenergy is one of the most promising alternatives to fossil fuels. Lignocellulose possesses great potential for bioenergy production, but the recalcitrant and heterogeneous structure limits its application. Pretreatment technology offers an effective solution to fractionate the main components of the lignocellulose and uncover the available cellulose. Read More

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October 2021

In Situ Generation of Heterocyclic Polymers by Triple-Bond Based Polymerizations.

Macromol Rapid Commun 2021 Oct 15:e2100524. Epub 2021 Oct 15.

X. Wang, Dr. J. W. Y. Lam, Prof. B. Z. Tang, Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, and Institute of Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Stemming from unique ring structures, heterocyclic polymers exhibit distinguished electrical, mechanical, and photophysical properties and have been widely used in a variety of important applications. Along with the technological significance are the challenges in their synthesis. Traditional synthetic strategies toward heterocyclic polymers often requires the direct attachment of heterocycles to polymer backbones, which are generally limited by the lack of suitable and low-cost heterocyclic monomers, tedious reaction process, difficulties in incorporation of multiple substitutents, etc. Read More

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October 2021

Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2.

J Am Chem Soc 2021 Oct 15. Epub 2021 Oct 15.

University of Basel, Institute of Molecular Pharmacy, Pharmacenter of the University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

The C-type lectin receptor DC-SIGN is a pattern recognition receptor expressed on macrophages and dendritic cells. It has been identified as a promiscuous entry receptor for many pathogens, including epidemic and pandemic viruses such as SARS-CoV-2, Ebola virus, and HIV-1. In the context of the recent SARS-CoV-2 pandemic, DC-SIGN-mediated virus dissemination and stimulation of innate immune responses has been implicated as a potential factor in the development of severe COVID-19. Read More

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October 2021

Chemotherapeutic drug-induced immunogenic cell death for nanomedicine-based cancer chemo-immunotherapy.

Nanoscale 2021 Oct 13. Epub 2021 Oct 13.

College of Pharmacy, Weifang Medical University, Weifang 261053, China.

Chemotherapy has been a conventional paradigm for cancer treatment, and multifarious chemotherapeutic drugs have been widely employed for decades with significant performances in suppressing tumors. Moreover, some of the antitumor chemotherapeutic agents, such as doxorubicin (DOX), oxaliplatin (OXA), cyclophosphamide (CPA) and paclitaxel (PTX), can also tackle tumors through the induction of immunogenic cell death (ICD) in tumor cells to trigger specific antitumor immune responses of the body and improve chemotherapy efficacy. In recent years, chemo-immunotherapy has attracted increasing attention as one of the most promising combination therapies to struggle with malignant tumors. Read More

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October 2021

The role of pharmacogenetics in the treatment of anxiety disorders and the future potential for targeted therapeutics.

Expert Opin Drug Metab Toxicol 2021 Oct 15:1-12. Epub 2021 Oct 15.

Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.

Introduction: Anxiety disorders (AD) are among the most common mental disorders worldwide. Pharmacotherapy, including benzodiazepines, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants is currently based on 'trial-and-error,' and is effective in a subset of patients or produces partial response only. Recent research proposes that treatment response and tolerability of the drugs are associated with genetic factors. Read More

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October 2021

Autoinflammatory process in the pathogenesis of generalized pustular psoriasis and perspectives of its targeted therapy.

Epidemiol Mikrobiol Imunol 2021 ;70(3):199-207

The dysregulated inflammatory process not only plays an important role in the development of chronic plaque psoriasis but also is a major pathogenetic mechanism behind the generalized pustular psoriasis (GPP) and other rare pustular forms of the disease. The key players in this process are the cytokines interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF), IL-12/23, IL-17A and especially IL-36. Their excessive activity or production in some GPP patients is due to mutations in genes that encode molecules involved in inhibiting the action of IL-36 (IL-36Ra) or in intracellular inflammatory signaling (CARD14, AP1S3). Read More

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October 2021

Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury.

Molecules 2021 Sep 30;26(19). Epub 2021 Sep 30.

Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil.

Data obtained from several intensive care units around the world have provided substantial evidence of the strong association between impairment of the renal function and in-hospital deaths of critically ill COVID-19 patients, especially those with comorbidities and requiring renal replacement therapy (RRT). Acute kidney injury (AKI) is a common renal disorder of various etiologies characterized by a sudden and sustained decrease of renal function. Studies have shown that 5-46% of COVID-19 patients develop AKI during hospital stay, and the mortality of those patients may reach up to 100% depending on various factors, such as organ failures and RRT requirement. Read More

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September 2021

At the Cutting Edge against Cancer: A Perspective on Immunoproteasome and Immune Checkpoints Modulation as a Potential Therapeutic Intervention.

Cancers (Basel) 2021 Sep 28;13(19). Epub 2021 Sep 28.

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Immunoproteasome is a noncanonical form of proteasome with enzymological properties optimized for the generation of antigenic peptides presented in complex with class I MHC molecules. This enzymatic property makes the modulation of its activity a promising area of research. Nevertheless, immunotherapy has emerged as a front-line treatment of advanced/metastatic tumors providing outstanding improvement of life expectancy, even though not all patients achieve a long-lasting clinical benefit. Read More

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September 2021

Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives.

Cancers (Basel) 2021 Sep 22;13(19). Epub 2021 Sep 22.

Department of Gastroenterology and Digestive Oncology, Institut du Cancer Paris Carpem, Assistance Publique des Hôpitaux de Paris, European Georges Pompidou Hospital, 75015 Paris, France.

Gastrointestinal (GI) cancers are major health burdens worldwide and biomarkers are needed to improve the management of these diseases along their evolution. Circulating tumor DNA (ctDNA) is a promising non-invasive blood and other bodily-fluid-based biomarker in cancer management that can help clinicians in various cases for the detection, diagnosis, prognosis, monitoring and personalization of treatment in digestive oncology. In addition to the well-studied prognostic role of ctDNA, the main real-world applications appear to be the assessment of minimal residual disease to further guide adjuvant therapy and predict relapse, but also the monitoring of clonal evolution to tailor treatments in metastatic setting. Read More

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September 2021

Promising perspectives on pregnancy in women with congenital heart disease.

Eur Heart J 2021 Oct 12. Epub 2021 Oct 12.

Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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October 2021

High-value products from ex-situ catalytic pyrolysis of polypropylene waste using iron-based catalysts: the influence of support materials.

Waste Manag 2021 Oct 9;136:47-56. Epub 2021 Oct 9.

State Key Laboratory of Coal Combustion, School of Energy and Power Engineering, Huazhong University of Science and Technology, 430074 Wuhan, PR China. Electronic address:

Catalytic pyrolysis is considered a promising strategy for the utilisation of plastic waste from the economic and environmental perspectives. As such, the supporting materials play a critical role in the properties of the catalyst. This study clarified this influence on the dispersion of the iron (Fe) within an experimental context. Read More

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October 2021

Factors Influencing Procurement of Digital Healthcare: A Case Study in Dutch District Nursing.

Int J Health Policy Manag 2021 Aug 29. Epub 2021 Aug 29.

Health Technology Assessment Unit, Department of Epidemiology, University Medical Centre Groningen, Groningen, The Netherlands.

Background: Digital health is considered a promising solution in keeping health care accessible and affordable. However, implementation is often complex and sustainable funding schemes are lacking. Despite supporting policy, scaling up innovative forms of health care progresses much slower than intended in Dutch national framework agreements. Read More

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Tea and its phytochemicals: Hidden health benefits & modulation of signaling cascade by phytochemicals.

Food Chem 2021 Sep 9;371:131098. Epub 2021 Sep 9.

Laboratory of Microbial Interaction, School of Biotechnology, Presidency University, Kolkata, West Bengal, India. Electronic address:

Tea, one of the most widely consumed beverages, is prepared from the leaves of the Camellia sinensis. The promising health recompenses of tea have been linked to its different phenolic components, which have diverse biological characteristics. Tea also contains several flavonoids, alkaloids, phenolic, theanine, etc. Read More

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September 2021

2D/2D Heterojunction systems for the removal of organic pollutants: A review.

Adv Colloid Interface Sci 2021 Oct 5;297:102540. Epub 2021 Oct 5.

College of Environmental Science and Engineering, Key Laboratory of Environmental Biology and Pollution Control, Ministry of Education, Hunan University, Changsha, PR China.

Photocatalysis is considered to be an effective way to remove organic pollutants, but the key to photocatalysis is finding a high-efficiency and stable photocatalyst. 2D materials-based heterojunction has aroused widespread concerns in photocatalysis because of its merits in more active sites, adjustable band gaps and shorter charge transfer distance. Among various 2D heterojunction systems, 2D/2D heterojunction with a face-to-face contact interface is regarded as a highly promising photocatalyst. Read More

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October 2021

Dual-target inhibitors of bromodomain and extra-terminal proteins in cancer: A review from medicinal chemistry perspectives.

Med Res Rev 2021 Oct 11. Epub 2021 Oct 11.

State Key Laboratory of Biotherapy and Cancer Center, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.

Bromodomain-containing protein 4 (BRD4), as the most studied member of the bromodomain and extra-terminal (BET) family, is a chromatin reader protein interpreting epigenetic codes through binding to acetylated histones and non-histone proteins, thereby regulating diverse cellular processes including cell cycle, cell differentiation, and cell proliferation. As a promising drug target, BRD4 function is closely related to cancer, inflammation, cardiovascular disease, and liver fibrosis. Currently, clinical resistance to BET inhibitors has limited their applications but synergistic antitumor effects have been observed when used in combination with other tumor inhibitors targeting additional cellular components such as PLK1, HDAC, CDK, and PARP1. Read More

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October 2021