158 results match your criteria promise degradable

Biocompatibility and degradation of the open-pored magnesium scaffolds LAE442 and La2.

Biomed Mater 2021 Apr 7. Epub 2021 Apr 7.

Clinic of Small Animal Surgery and Reproduction, Ludwig-Maximilians-Universität München Tierärztliche Fakultät, Veterinärstr. 13, München, Bayern, 80539, GERMANY.

Porous magnesium implants are of particular interest for application as resorbable bone substitutes, due to their mechanical strength and a Young's modulus similar to bone. The objective of the present study was to compare the biocompatibility, bone and tissue ingrowth, and the degradation behaviour of scaffolds made from the magnesium alloys LAE442 (n = 40) and Mg-La2 (n = 40) in vivo. For this purpose, cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined, interconnecting pores were produced by investment casting and coated with MgF2. Read More

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Sequestered cell-secreted extracellular matrix proteins improve murine folliculogenesis and oocyte maturation for fertility preservation.

Acta Biomater 2021 Mar 22. Epub 2021 Mar 22.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, 48109, USA; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, 48109, USA; Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

Synthetic matrices offer a high degree of control and tunability for mimicking extracellular matrix functions of native tissue, allowing the study of disease and development in vitro. In this study, we functionalized degradable poly(ethylene glycol) hydrogels with extracellular matrix (ECM)-sequestering peptides aiming to recapitulate the native ECM composition for culture and maturation of ovarian follicular organoids. We hypothesized that ECM-sequestering peptides would facilitate deposition and retention of cell-secreted ECM molecules, thereby recreating cell-matrix interactions in otherwise bioinert PEG hydrogels. Read More

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Fast Thermoresponsive Poly(oligoethylene glycol methacrylate) (POEGMA)-Based Nanostructured Hydrogels for Reversible Tuning of Cell Interactions.

ACS Biomater Sci Eng 2021 Feb 11. Epub 2021 Feb 11.

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada.

Reactive electrospinning is demonstrated as a viable method to create fast-responsive and degradable macroporous thermoresponsive hydrogels based on poly(oligoethylene glycol methacrylate) (POEGMA). Hydrazide- and aldehyde-functionalized POEGMA precursor polymers were coelectrospun to create hydrazone cross-linked nanostructured hydrogels in a single processing step that avoids the need for porogens, phase separation-driving additives, or scaffold postprocessing. The resulting nanostructured hydrogels can respond reversibly and repeatedly to changes in external temperature within seconds, in contrast to the minutes-to-hours response time observed with bulk hydrogels. Read More

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February 2021

Toward Tailoring the Degradation Rate of Magnesium-Based Biomaterials for Various Medical Applications: Assessing Corrosion, Cytocompatibility and Immunological Effects.

Int J Mol Sci 2021 Jan 19;22(2). Epub 2021 Jan 19.

Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.

Magnesium (Mg)-based biomaterials hold considerable promise for applications in regenerative medicine. However, the degradation of Mg needs to be reduced to control toxicity caused by its rapid natural corrosion. In the process of developing new Mg alloys with various surface modifications, an efficient assessment of the relevant properties is essential. Read More

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January 2021

Biodegradable Poly(Lactic Acid) Nanocomposites for Fused Deposition Modeling 3D Printing.

Nanomaterials (Basel) 2020 Dec 21;10(12). Epub 2020 Dec 21.

Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA.

3D printing by fused deposition modelling (FDM) enables rapid prototyping and fabrication of parts with complex geometries. Unfortunately, most materials suitable for FDM 3D printing are non-degradable, petroleum-based polymers. The current ecological crisis caused by plastic waste has produced great interest in biodegradable materials for many applications, including 3D printing. Read More

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December 2020

Influence of extrusion cooking on physicochemical properties and starch digestion kinetics of Sphenostylis stenocarpa, Cajanus cajan, and Vigna subterranean grains.

PLoS One 2020 1;15(12):e0242697. Epub 2020 Dec 1.

Agricultural Biochemistry and Nutrition Laboratory, Department of Animal Science, University of Ibadan, Ibadan, Nigeria.

Thermal degradation of sugars and amino acids, and depolymerization of macromolecules such as starch, proteins and fibre occasioned by high-temperature short-time extrusion cooking modify the physicochemical and functional properties of raw materials. High-temperature short-time extrusion cooking holds promise for the expanded use of non-conventional ingredients as food/feed due to its practicality, increased productivity and efficiency, and ability to retain thermally degradable nutrients during cooking. However, little is known about the effect of the high-temperature short-time extrusion cooking process on the physicochemical properties and starch digestibility of lesser-known grain legumes such as African yam beans (Sphenostylis stenocarpa), Pigeon pea (Cajanus cajan), and Bambara peanut (Vigna subterranean). Read More

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January 2021

Vaccine implants: current status and recent advancements.

Emerg Top Life Sci 2020 12;4(3):319-330

School of Pharmacy, University of Otago, Dunedin, New Zealand.

Implants have long been used in the field of drug delivery as controlled release vehicles and are now being investigated as single-shot vaccine technologies. Implants have shown great promise, minimizing the need for multiple immunizations while stimulating potent immune responses with reduced doses of vaccine. Synchronous release of vaccine components from implants over an appropriate period of time is important in order to avoid issues including immune tolerance, sequestration or deletion. Read More

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December 2020

On-demand degradable embolic microspheres for immediate restoration of blood flow during image-guided embolization procedures.

Biomaterials 2021 Jan 24;265:120408. Epub 2020 Sep 24.

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA; Department of Biomedical Engineering, McCormick School of Engineering, Evanston, IL, 60208, USA; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA. Electronic address:

Degradable embolic agents that provide transient arterial occlusion during embolization procedures have been of interest for many years. Ideally, embolic agents are visible with standard imaging modalities and offer on-demand degradability, permitting physicians to achieve desired arterial occlusion tailored to patient and procedure indication. Subsequent arterial recanalization potentially enhances the overall safety and efficacy of embolization procedures. Read More

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January 2021

Degradation-Dependent Protein Release from Enzyme Sensitive Injectable Glycol Chitosan Hydrogel.

Tissue Eng Part A 2020 Oct 15. Epub 2020 Oct 15.

Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut, USA.

Glycol chitosan (GC) is a hydrophilic chitosan derivative, known for its aqueous solubility. Previously, we have demonstrated the feasibility of preparing injectable, enzymatically crosslinked hydrogels from HPP [3-(4-Hydroxyphenyl)-propionic acid (98%)]-modified GC. However, HPP-GC gels showed very slow degradation, which presents challenges as an protein delivery vehicle. Read More

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October 2020

Evaluation of a novel biodegradable ureteral stent produced from polyurethane and magnesium alloys.

J Biomed Mater Res B Appl Biomater 2021 May 14;109(5):665-672. Epub 2020 Sep 14.

Department of Urology, The Second Affiliated Hospital of Soochow University, Jiangsu, China.

Indwelling ureteral stents represent a very frequently used procedure in urological clinical practice that ensures the drainage of urine from the upper urinary tract. However, the stents could result in many stent-associated complications, such as encrustation and patient discomfort. We developed a new type of biodegradable ureteral stents produced from degradable polyurethane and magnesium alloys. Read More

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Biodistribution of degradable polyanhydride particles in Aedes aegypti tissues.

PLoS Negl Trop Dis 2020 09 8;14(9):e0008365. Epub 2020 Sep 8.

Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, United States of America.

Insecticide resistance poses a significant threat to the control of arthropods that transmit disease agents. Nanoparticle carriers offer exciting opportunities to expand the armamentarium of insecticides available for public health and other pests. Most chemical insecticides are delivered by contact or feeding, and from there must penetrate various biological membranes to reach target organs and kill the pest organism. Read More

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September 2020

Dual-Location Dual-Acid/Glutathione-Degradable Cationic Micelleplexes through Hydrophobic Modification for Enhanced Gene Silencing.

Mol Pharm 2020 10 10;17(10):3979-3989. Epub 2020 Sep 10.

Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec, Canada H4B 1R6.

Gene therapy holds great promise for the treatment of acquired genetic disorders such as cancer with reduced side effects compared to chemotherapy. For gene therapy to be successful, it is crucial to develop efficient and nontoxic gene carriers to overcome the poor stability and low cellular uptake of nucleic acid-based therapeutic agents. Here, we report a new and versatile approach exploring a combination of hydrophobic modifications and dual-stimuli-responsive degradation (SRD) for controlled gene delivery with amphiphilic block copolymer-based nanocarriers. Read More

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October 2020

Development of a Dual Hydrogel Model System for Vascularization.

Macromol Biosci 2020 10 13;20(10):e2000204. Epub 2020 Aug 13.

Department of Orthopedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.

Numerous hydrogel-based culture systems are used to create in vitro model for prevascularization. Hydrogels used to induce a microenvironment conducive to microvessel formation are typically soft and fast degradable, but often suffer from maintaining a lasting perfusable channel in vitro. Here, a dual hydrogel system that consists of photo-crosslinkable gelatin methacrylate (GelMA) and polyethylene glycol dimethacrylate (PEGDMA) is reported. Read More

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October 2020

Synthesis and characterization of proanthocyanidin-chitosan nanoparticles: An assessment on human colorectal carcinoma HT-29 cells.

J Photochem Photobiol B 2020 Sep 17;210:111966. Epub 2020 Jul 17.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; Entomology Research Institute, Loyola College, Chennai 600034, Tamilnadu, India.

Cancer nanotheranostic materials are helpful in monitoring drug delivery and efficacy against tumor cells. Current chemotherapeutic may have adverse side effects and this necessity to discover the new modern therapeutic nano-drugs. In the present study, we designed the new targeted and degradable polymer of bio-active chitosan nanoparticles with proanthocyanidin (PAC-CSNPs) and evaluated its apoptotic effects against human colorectal carcinoma cells (HT-29). Read More

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September 2020

Long-acting mucoadhesive thermogels for improving topical treatments of dry eye disease.

Mater Sci Eng C Mater Biol Appl 2020 Oct 14;115:111095. Epub 2020 May 14.

Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan, ROC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan, ROC; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan, ROC. Electronic address:

Dry eye disease (DED) is the most common ocular disorder that causes persistent discomfort and blurry vision in patients. Despite pharmacotherapy strategies, the current topical administration of eye drops remains a great challenge owing to their low bioavailability and short residence time. Herein, we demonstrate an effective topical treatment of DED via rational design of a long-acting and mucoadhesive drug delivery system. Read More

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October 2020

Photo-responsive degradable hollow mesoporous organosilica nanoplatforms for drug delivery.

J Nanobiotechnology 2020 Jun 15;18(1):91. Epub 2020 Jun 15.

School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, China.

Background: Stimulus-responsive degradable mesoporous organosilica nanoparticles (MONs) have shown great promise as drug carriers via enhancing the efficiency of drug delivery and accelerating the degradation of nanocarriers. However, it remains a great challenge to develop novel light-enabled spatial and temporal degradable MONs with both superior responsiveness for efficient anti-cancer drug delivery and safe exocytosis.

Results: We report a novel photo-responsive degradable hollow mesoporous organosilica nanoplatform (HMONs@GOQD). Read More

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Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO nanoformulation triggers ferroptosis in target tumor cells.

Sci Adv 2020 May 29;6(18):eaax1346. Epub 2020 Apr 29.

School of Life Science, Chongqing University, Chongqing 400044, P. R. China.

The rapid development of treatment resistance in tumors poses a technological bottleneck in clinical oncology. Ferroptosis is a form of regulated cell death with clinical translational potential, but the efficacy of ferroptosis-inducing agents is susceptible to many endogenous factors when administered alone, for which some cooperating mechanisms are urgently required. Here, we report an amorphous calcium carbonate (ACC)-based nanoassembly for tumor-targeted ferroptosis therapy, in which the totally degradable ACC substrate could synergize with the therapeutic interaction between doxorubicin (DOX) and Fe. Read More

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Fluorescent conjugated polymer nanovector for in vivo tracking and regulating the fate of stem cells for restoring infarcted myocardium.

Acta Biomater 2020 06 12;109:195-207. Epub 2020 Apr 12.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, PR China. Electronic address:

Stem cell therapy holds great promise for cardiac regeneration. However, the lack of ability to control stem cell fate after in vivo transplantation greatly restricts its therapeutic outcomes. MicroRNA delivery has emerged as a powerful tool to control stem cell fate for enhanced cardiac regeneration. Read More

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Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels.

Biomacromolecules 2020 06 16;21(6):2246-2257. Epub 2020 Apr 16.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.

The reactivation of the innate immune system by toll-like receptor (TLR) agonists holds promise for anticancer immunotherapy. Severe side effects caused by unspecific and systemic activation of the immune system upon intravenous injection prevent the use of small-molecule TLR agonists for such purposes. However, a covalent attachment of small-molecule imidazoquinoline (IMDQ) TLR7/8 agonists to pH-degradable polymeric nanogels could be shown to drastically reduce the systemic inflammation but retain the activity to tumoral tissues and their draining lymph nodes. Read More

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The bioeffects of degradable products derived from a biodegradable Mg-based alloy in macrophages via heterophagy.

Acta Biomater 2020 04 8;106:428-438. Epub 2020 Feb 8.

Department of Rheumatology and Immunology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127 China; Division of Immunology, Institute of Pediatric Translational Medicine, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127 China. Electronic address:

Biodegradable magnesium alloys are promising candidates for use in biomedical applications. However, degradable particles (DPs) derived from Mg-based alloys have been observed in tissue in proximity to sites of implantation, which might result in unexpected effects. Although previous in vitro studies have found that macrophages can take up DPs, little is known about the potential phagocytic pathway and the mechanism that processes DPs in cells. Read More

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Design of a new magnesium-based anterior cruciate ligament interference screw using finite element analysis.

J Orthop Translat 2020 Jan 14;20:25-30. Epub 2019 Oct 14.

Department of Chemical, Biological, and Bioengineering, North Carolina A&T State University, Greensboro, NC, USA.

Background/objective: In anterior cruciate ligament ​reconstruction, a tendon graft, anchored by interference screws (IFSs), is frequently used as a replacement for the damaged ligament. Generally, IFSs are classified as being either metallic or polymeric. Metallic screws have sharp threads that lacerate the graft, preventing solid fixation. Read More

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January 2020

Fabrication of High-Strength and Porous Hybrid Scaffolds Based on Nano-Hydroxyapatite and Human-Like Collagen for Bone Tissue Regeneration.

Polymers (Basel) 2020 Jan 1;12(1). Epub 2020 Jan 1.

Shanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, China.

A novel, three-dimensional, porous, human-like collagen (HLC)/nano-hydroxyapatite (n-HA) scaffold cross-linked by 1,2,7,8-diepoxyoctane (DEO) was successfully fabricated, which showed excellent mechanical and superior biological properties for bone tissue regeneration in this study. The physicochemical characterizations of different n-HA/HLC/DEO (nHD) scaffolds were investigated by determining the morphology, compression stress, elastic modulus, Young's modulus and enzymatic hydrolysis behavior in vitro. The results demonstrated that nHD-2 and nHD-3 scaffolds showed superior mechanical properties and resistance to enzymatic hydrolysis compared to nHD-1 scaffolds. Read More

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January 2020

Design of Degradable Polyphosphoester Networks with Tailor-Made Stiffness and Hydrophilicity as Scaffolds for Tissue Engineering.

Biomacromolecules 2020 02 14;21(2):349-355. Epub 2019 Nov 14.

Centre for Education and Research on Macromolecules (CERM), CESAM Research Unit , University of Liege (ULiège) , Building B6a , 4000 Liège , Belgium.

In the recent decades, biodegradable and biocompatible polyphosphoesters (PPEs) have gained wide attention in the biomedical field as relevant substitutes for conventional aliphatic polyesters. These amorphous materials of low glass transition temperature offer promise for the design of soft scaffolds for tissue engineering. Advantageously, the easy variation of the nature of the lateral pendant groups of PPEs allows the insertion of pendent unsaturations valuable for their further cross-linking. Read More

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February 2020

Built-In Active Microneedle Patch with Enhanced Autonomous Drug Delivery.

Adv Mater 2020 Jan 4;32(1):e1905740. Epub 2019 Nov 4.

Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.

The use of microneedles has facilitated the painless localized delivery of drugs across the skin. However, their efficacy has been limited by slow diffusion of molecules and often requires external triggers. Herein, an autonomous and degradable, active microneedle delivery platform is introduced, employing magnesium microparticles loaded within the microneedle patch, as the built-in engine for deeper and faster intradermal payload delivery. Read More

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January 2020

Magnetic Liquid Metal (Fe-EGaIn) Based Multifunctional Electronics for Remote Self-Healing Materials, Degradable Electronics, and Thermal Transfer Printing.

Adv Sci (Weinh) 2019 Oct 22;6(20):1901478. Epub 2019 Aug 22.

Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China.

Flexible materials with the ability to be bent, strained, or twisted play a critical role in soft robots and stretchable electronics. Although tremendous efforts are focused on developing new stretchable materials with excellent stability, inevitable mechanical damage due to long term deformation is still an urgent problem to be tackled. Here, a magnetic healing method based on Fe-doped liquid metal (Fe-GaIn) conductive ink via a noncontact way is proposed. Read More

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October 2019

Characterization and Analysis of Collective Cellular Behaviors in 3D Dextran Hydrogels with Homogenous and Clustered RGD Compositions.

Materials (Basel) 2019 Oct 17;12(20). Epub 2019 Oct 17.

College of Mechanical & Electrical Engineering, Hohai University, Changzhou 213022, China.

The interactions between substrate materials and cells usually play an important role in the hydrogel-based 3D cell cultures. However, the hydrogels that are usually used could not be parametrically regulated, especially for quantitatively regulating the spatial distribution of the adhesion sites for cells in 3D. Here, we employed the semisynthetic hydrogel consisting of maleimide-dextran, Arg-Gly-Asp (RGD) peptides, and cell degradable crosslinkers to biochemically characterize the evolutionary behaviors of NIH-3T3 fibroblasts and C2C12 cells in 3D. Read More

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October 2019

Evaluating platelet activation related to the degradation of biomaterials using molecular markers.

Colloids Surf B Biointerfaces 2019 Dec 20;184:110516. Epub 2019 Sep 20.

National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, China. Electronic address:

The effective assessment of platelet activation is an important component of the evaluation of cardiovascular implants. Currently, most evaluation is performed based on the ISO 10993-4 international standard. However, the methods specified in this standard were originally designed for non-degradable materials, and the applicability of these methods to evaluate degradable materials has not been carefully assessed. Read More

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December 2019

Stochastic dynamics of dissolving active particles.

Eur Phys J E Soft Matter 2019 Jul 16;42(7):88. Epub 2019 Jul 16.

Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, CB3 0WA, Cambridge, UK.

The design of artificial microswimmers has generated significant research interest in recent years, for promise in applications such as nanomotors and targeted drug-delivery. However, many current designs suffer from a common problem, namely the swimmers remain in the fluid indefinitely, posing risks of clogging and damage. Inspired by recently proposed experimental designs, we investigate mathematically the dynamics of degradable active particles. Read More

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Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound.

Sci Rep 2019 07 3;9(1):9612. Epub 2019 Jul 3.

School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637459, Singapore.

Ultrasound-enhanced drug delivery has shown great promise in providing targeted burst release of drug at the site of the disease. Yet current solid ultrasound-responsive particles are non-degradable with limited potential for drug-loading. Here, we report on an ultrasound-responsive multi-cavity poly(lactic-co-glycolic acid) microparticle (mcPLGA MP) loaded with rhodamine B (RhB) with or without 4',6-diamidino-2-phenylindole (DAPI) to represent small molecule therapeutics. Read More

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Poly(amine-co-ester) nanoparticles for effective Nogo-B knockdown in the liver.

J Control Release 2019 06 1;304:259-267. Epub 2019 May 1.

Department of Biomedical Engineering, Yale University, New Haven, CT 06511, United States of America; Department of Chemical & Environmental Engineering, Yale University, New Haven, CT 06511, United States of America; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, United States of America; Department of Dermatology, Yale School of Medicine, New Haven, CT 06510, United States of America. Electronic address:

Degradable poly(amine-co-ester) (PACE) terpolymers hold tremendous promise for siRNA delivery because these materials can be formulated into delivery vehicles with highly efficient siRNA encapsulation, providing effective knockdown with low toxicity. Here, we demonstrate that PACE nanoparticles (NPs) provide substantial protein knockdown in human embryonic kidney cells (HEK293) and hard-to-transfect primary human umbilical vein endothelial cells (HUVECs). After intravenous administration, NPs of solid PACE (sPACE)-synthesized with high monomer content of a hydrophobic lactone-accumulated in the liver and, to a lesser extent, in other tissues. Read More

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