32,261 results match your criteria prominent role


Social media and public perception as core aspect of public health: The cautionary case of @realdonaldtrump and COVID-19.

PLoS One 2021 5;16(5):e0251179. Epub 2021 May 5.

Department of Anthropology, University of Notre Dame, Notre Dame, IN, United States of America.

The social media milieu in which we are enmeshed has substantive impacts on our beliefs and perceptions. Recent work has established that this can play a role in influencing understanding of, and reactions to, public health information. Twitter, in particular, appears to play a substantive role in the public health information ecosystem. Read More

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Human cell receptors: potential drug targets to combat COVID-19.

Amino Acids 2021 May 5. Epub 2021 May 5.

ICMR-National Institute of Cancer Prevention & Research, Noida, 201301, India.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19). The World Health Organization (WHO) has announced that COVID-19 is a pandemic having a higher spread rate rather than the mortality. Identification of a potential approach or therapy against COVID-19 is still under consideration. Read More

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Rediscovering potential molecular targets for glioma therapy through the analysis of the cell of origin, microenvironment, and metabolism.

Curr Cancer Drug Targets 2021 May 3. Epub 2021 May 3.

Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University (SYSU), No.628, Zhenyuan Rd, Guangming Dist., Shenzhen 518107. China.

Gliomas are the most common type of malignant brain tumors. Despite significant medical advances, gliomas remain incurable and are associated with high mortality. Although numerous biomarkers of diagnostic value have been identified and significant progress in the prognosis of the outcome has been made, the treatment has not been parallelly improved during the last three decades. Read More

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The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes.

Org Biomol Chem 2021 May;19(17):3776-3790

Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.

The transition-metal-aided stereoselective construction of sp3-carbon-rich heterocyclic scaffolds using strained-ring systems has received considerable attention in recent years due to the prominent presence of these scaffolds in myriad natural products, bioactive molecules, and pharmaceutical components. In this area, the catalytic ring-enlargement of vinylaziridines and vinyloxiranes plays a predominant role when synthesizing high sp3-content biorelevant heterocyclic compounds. This article aims to portray recent advancements in the ring-expansion of vinylaziridines and vinyloxiranes for accessing densely functionalized stereoselective heterocycles that have been developed over the past five years, with an emphasis on the substrate scopes and mechanistic insights into the key methodologies, and it is arranged based on the transition metals used and the ring sizes of the heterocyclic scaffolds. Read More

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Accumulation of geranylgeranylated chlorophylls in the pigment-protein complexes of Arabidopsis thaliana acclimated to green light: effects on the organization of light-harvesting complex II and photosystem II functions.

Photosynth Res 2021 May 4. Epub 2021 May 4.

Department of Physics, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00, Ostrava, Czech Republic.

Light quality significantly influences plant metabolism, growth and development. Recently, we have demonstrated that leaves of barley and other plant species grown under monochromatic green light (500-590 nm) accumulated a large pool of chlorophyll a (Chl a) intermediates with incomplete hydrogenation of their phytyl chains. In this work, we studied accumulation of these geranylgeranylated Chls a and b in pigment-protein complexes (PPCs) of Arabidopsis plants acclimated to green light and their structural-functional consequences on the photosynthetic apparatus. Read More

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Exploring the role of immunotherapeutic drugs in autoimmune diseases: A comprehensive review.

J Oral Biol Craniofac Res 2021 Apr-Jun;11(2):291-296. Epub 2021 Feb 23.

Department of Oral Medicine & Radiology, Government Dental College & Hospital, Nagpur, Maharashtra, India.

Autoimmune diseases are group of disorders where an immune response is mounted against the self. The prevalence and burden of this well established and recognised entity is on the rise. Irrespective of being a systemic or organ specific autoimmune disorder, the common underlying mechanism of action, is the imbalance in immune system resulting in loss of tolerance to self-antigens. Read More

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February 2021

Micro-scale technologies propel biology and medicine.

Biomicrofluidics 2021 Mar 27;15(2):021302. Epub 2021 Apr 27.

IBM Research-Europe, Säumerstrasse 4, Rüschlikon CH-8803, Switzerland.

Historically, technology has been central to new discoveries in biology and progress in medicine. Among various technologies, microtechnologies, in particular, have had a prominent role in the revolution experienced by the life sciences in the last few decades, which will surely continue in the years to come. In this Perspective, we illustrate how microtechnologies, with a focus on microfluidics, have evolved in trends/waves to tackle the boundary of knowledge in the life sciences. Read More

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Biosynthetic gold nanoparticles of Hibiscus syriacus L. callus potentiates anti-inflammation efficacy via an autophagy-dependent mechanism.

Mater Sci Eng C Mater Biol Appl 2021 May 11;124:112035. Epub 2021 Mar 11.

Graduate School of Biotechnology, College of Life Science, Kyung Hee University, Yongin-si 17104, Gyeonggi-do, Republic of Korea. Electronic address:

Biological applications of gold nanoparticles (AuNps) have potentially explored an efficient agent attributed to their biocompatibility and high efficiency in drug delivery. Our study applied an extract of Hibiscus syriacus L. callus (HCE) with a pioneer implementation on the induction of mass production. Read More

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Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson's disease brain.

Mol Neurodegener 2021 May 5;16(1):31. Epub 2021 May 5.

Neuro-SysMed Center of Excellence for Clinical Research in Neurological Diseases, Department of Neurology, Haukeland University Hospital, 5021, Bergen, Norway.

Background: Parkinson's disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and specifically altered histone acetylation. Nevertheless, and despite the emerging role of epigenetics in age-related brain disorders, the question of whether aberrant histone acetylation is involved in PD remains unresolved. Read More

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Severe COVID-19 in pediatric age: an update on the role of the anti-rheumatic agents.

Pediatr Rheumatol Online J 2021 May 4;19(1):68. Epub 2021 May 4.

Section of Rheumatology and Clinical Immunology, Division of Pediatrics, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126, Pisa, Italy.

Background: SARS-CoV-2 can induce an immune impairment and dysregulation, finally resulting in the massive release of inflammatory mediators (cytokine storm), strongly contributing to the pulmonary and systemic manifestations in severe coronavirus disease 2019 (COVID-19). As a consequence, different drugs active on the immune system have been proposed for the treatment of the disease in adults.

Role Of The Anti-rheumatic Agents In Children: Children are more likely to develop a mild disease course, as the severe form of COVID-19 is identified in less than 5% of the pediatric patients. Read More

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Comparison of Anticancer Activity of Extract on MCF-7 and MCF-12A Cell Line: Correlation with Invasion and Adhesion.

Biomolecules 2021 Apr 30;11(5). Epub 2021 Apr 30.

Department of Pharmacy, Università degli Studi "Gabriele d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy.

subsp. is an important medicinal plant in several countries, including Turkey. This study aimed to evaluate the cytotoxicity of a crude extract of subsp. Read More

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Understanding COVID-19 misinformation and vaccine hesitancy in context: Findings from a qualitative study involving citizens in Bradford, UK.

Health Expect 2021 May 4. Epub 2021 May 4.

Department of Health Sciences, University of York, York, UK.

Background: COVID-19 vaccines can offer a route out of the pandemic, yet initial research suggests that many are unwilling to be vaccinated. A rise in the spread of misinformation is thought to have played a significant role in vaccine hesitancy. To maximize uptake, it is important to understand why misinformation has been able to take hold at this time and why it may pose a more significant problem within certain contexts. Read More

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Chemical communication in lizards and a potential role for vasotocin in modulating social interactions.

Integr Comp Biol 2021 May 3. Epub 2021 May 3.

Neuroscience Institute and Center for Behavioral Neuroscience, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA 30303.

Lizards use chemical communication to mediate many reproductive, competitive, and social behaviors, but the neuroendocrine mechanisms underlying chemical communication in lizards are not well understood and understudied. By implementing a neuroendocrine approach to the study of chemical communication in reptiles, we can address a major gap in our knowledge of the evolutionary mechanisms shaping chemical communication in vertebrates. The neuropeptide arginine vasotocin (AVT) and its mammalian homologue vasopressin are responsible for a broad spectrum of diversity in competitive and reproductive strategies in many vertebrates, mediating social behavior through the chemosensory modality. Read More

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Testing dependence patterns of energy consumption with economic expansion and trade openness through wavelet transformed coherence in top energy-consuming countries.

Environ Sci Pollut Res Int 2021 May 3. Epub 2021 May 3.

Department of Economics, COMSATS University Islamabad, Islamabad, Pakistan.

Economic growth and trade openness are closely linked with energy consumption and hence have environmental consequences. Many studies have investigated the relationship between these variables. Two weaknesses in empirical literature on energy-growth nexus are prominent. Read More

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Stigma as a Barrier to Participant Recruitment of Minority Populations in Diabetes Research: Development of a Community-Centered Recruitment Approach.

JMIR Diabetes 2021 May 3;6(2):e26965. Epub 2021 May 3.

Department of Family Medicine and Community Health, University of Massachusetts Medical School, Worcester, MA, United States.

Background: The development of evidence-based care geared towards Black and Latina women living with uncontrolled type 2 diabetes is contingent upon their active recruitment into clinical interventions. Well-documented impediments to recruitment include a historical mistrust of the research community and socioeconomic factors that limit awareness and access to research studies. Although sociocultural and socioeconomic factors deter minorities from participating in clinical research, it is equally important to consider the role of stigma in chronic disease intervention studies. Read More

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Comprehensive Metabolomics Identified the Prominent Role of Glycerophospholipid Metabolism in Coronary Artery Disease Progression.

Front Mol Biosci 2021 14;8:632950. Epub 2021 Apr 14.

Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China.

Coronary stenosis severity determines ischemic symptoms and adverse outcomes. The metabolomic analysis of human fluids can provide an insight into the pathogenesis of complex disease. Thus, this study aims to investigate the metabolomic and lipidomic biomarkers of coronary artery disease (CAD) severity and to develop diagnostic models for distinguishing individuals at an increased risk of atherosclerotic burden and plaque instability. Read More

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Impact of Individual versus Geographic-Area Measures of Socioeconomic Status on Health Associations Observed in the Behavioral Risk Factor Surveillance System.

AMIA Annu Symp Proc 2020 25;2020:707-716. Epub 2021 Jan 25.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, United States.

Efforts to enhance Electronic Health Record (EHR) data for the study of conditions in which social and economic variables play a prominent role include linking clinical data to sources of external information via patient-specific geocodes. This approach is convenient, but whether geographic-area-level information from secondary sources is adequate as a surrogate of individual-level information is not fully understood. We used Behavioral Risk Factor Surveillance System (BRFSS) epidemiologic data to compare associations of individual income, median aggregate income, and Area Deprivation Index (ADI)-a validated score of U. Read More

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January 2021

Elevated microRNA-21 Is a Brake of Inflammation Involved in the Development of Nasal Polyps.

Front Immunol 2021 15;12:530488. Epub 2021 Apr 15.

Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: CRSwNP is an inflammatory disease but the mechanism is not yet fully understood. MiR-21, a member of miRNAs, has been reported to play roles in mediating inflammation. However, the expression of miR-21 and its role in patients with CRSwNP remain elusive. Read More

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GABA Production by Human Intestinal spp.: Prevalence, Regulation, and Role in Acid Stress Tolerance.

Front Microbiol 2021 15;12:656895. Epub 2021 Apr 15.

Laboratory of Food Biotechnology, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.

The high neuroactive potential of metabolites produced by gut microbes has gained traction over the last few years, with metagenomic-based studies suggesting an important role of microbiota-derived γ-aminobutyric acid (GABA) in modulating mental health. Emerging evidence has revealed the presence of the glutamate decarboxylase (GAD)-encoding gene, a key enzyme to produce GABA, in the prominent human intestinal genus . Here, we investigated GABA production by in culture and metabolic assays combined with comparative genomics and phylogenetics. Read More

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College Students' Digital Media Preferences for future HPV Vaccine Campaigns.

J Cancer Educ 2021 May 2. Epub 2021 May 2.

College of Health Solutions, Arizona State University, 425 N. 5thStreet, Phoenix, AZ, 85004, USA.

In the USA, although college-aged populations are at the greatest risk for initial infection with human papillomavirus (HPV), they are one of the age-based populations with lower HPV vaccine rates, largely due to their lack of perceived need to vaccinate against HPV. Health communication campaigns can help address this perception. This research identifies college students' preferred digital media channels for future HPV vaccine communication campaigns. Read More

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Role of MicroRNAs, Aptamers in Neuroinflammation and Neurodegenerative Disorders.

Cell Mol Neurobiol 2021 May 1. Epub 2021 May 1.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Balanagar, Hyderabad, Telangana, 500037, India.

Exploring the microRNAs and aptamers for their therapeutic role as biological drugs has expanded the horizon of its applicability against various human diseases, explicitly targeting the genetic materials. RNA-based therapeutics are widely being explored for the treatment and diagnosis of multiple diseases, including neurodegenerative disorders (NDD). Latter includes microRNA, aptamers, ribozymes, and small interfering RNAs (siRNAs), which control the gene expression mainly at the transcriptional strata. Read More

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HLA class II presentation is specifically altered at elevated temperatures in the B-lymphoblastic cell line JY.

Mol Cell Proteomics 2021 Apr 29:100089. Epub 2021 Apr 29.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands; Netherlands Proteomics Centre, Padualaan 8, 3584 CH Utrecht, the Netherlands. Electronic address:

HLA class I and HLA class II molecules play critical roles in our adaptive immune system by signaling a cell's health status to the immune system, through presentation of small peptides. Understanding HLA biology is important due to its prominent implication in auto-immune diseases and role in cancer immuno-therapy. Although both the HLA class I and class II antigen processing and presentation pathways have been studied extensively, the fundamental rules in HLA class II antigen presentation still remain less understood. Read More

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Dual specific phosphatases (DUSPs) in cardiac hypertrophy and failure.

Authors:
M Mutlak I Kehat

Cell Signal 2021 Apr 29:110033. Epub 2021 Apr 29.

The Rappaport Institute and the Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 31096, Israel; Department of Cardiology and the Clinical Research Institute at Rambam, Rambam Medical Center, Haifa 31096, Israel. Electronic address:

Pressure overload and other stress stimuli elicit a host of adaptive and maladaptive signaling cascades that eventually lead to cardiac hypertrophy and heart failure. Among those, the mitogen-activated protein kinase (MAPK) signaling pathway has been shown to play a prominent role. The dual specificity phosphatases (DUSPs), also known as MAPK specific phosphatases (MKPs), that can dephosphorylate the MAPKs and inactivate them are gaining increasing attention as potential drug targets. Read More

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Untrained birds' ability to recognise predators with changed body size and colouration in a field experiment.

BMC Ecol Evol 2021 May 1;21(1):74. Epub 2021 May 1.

Faculty of Science, Charles University in Prague, Albertov 6, 12800, Praha 2, Czech Republic.

Background: During recognition process, multiple parameters of the encountered stimulus may play a role. Previous studies with wild birds identified the importance of several salient features (e.g. Read More

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Vertebral multiple myeloma with pathological fracture: the most common etiology for emergency spine surgery in patients with no cancer diagnosis on admission.

Neurosurg Focus 2021 May;50(5):E2

Objective: Vertebral compression fractures are common in multiple myeloma (MM). Modern treatment paradigms place emphasis on treatment with radiation, with surgery reserved for cases involving frank instability or severe neural compression. However, experience at the authors' institution has led them to suspect a more prominent role for surgical intervention in some settings. Read More

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A comprehensive study of the effects of phthalates on marine mussels: Bioconcentration, enzymatic activities and metabolomics.

Mar Pollut Bull 2021 Apr 28;168:112393. Epub 2021 Apr 28.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China; School of Marine Sciences, Ningbo University, Ningbo 315211, PR China. Electronic address:

In this study, marine mussels (Mytilus coruscus) were exposed to three typical PAEs (dimethyl phthalate [DMP], dibutyl phthalate [DBP] and di(2-ethylhexyl) phthalate [DEHP]) at a range of doses for different times to investigate the ecotoxicological effects. The accumulation of the three PAE congeners in M. coruscus exhibited the following trend: DEHP > DBP > DMP. Read More

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Intestinal guard: human CXCL17 modulates protective response against mycotoxins and CXCL17-mimetic peptides development.

Biochem Pharmacol 2021 Apr 28:114586. Epub 2021 Apr 28.

Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, Guangdong 510642, China. Electronic address:

Mycotoxin contamination is an ongoing and growing issue that can create health risks and even cause death. Unfortunately, there is currently a lack of specific therapy against mycotoxins with few side effects. On the other hand, the strategic expression of CXCL17 in mucosal tissues suggests that it may be involved in immune response when exposed to mycotoxins, but the exact role of CXCL17 remains largely unknown. Read More

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Nonlinear radiative Maxwell nanofluid flow in a Darcy-Forchheimer permeable media over a stretching cylinder with chemical reaction and bioconvection.

Sci Rep 2021 Apr 30;11(1):9391. Epub 2021 Apr 30.

Division of Computational Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

Studies accentuating nanomaterials suspensions and flow traits in the view of their applications are the focus of the present study. Especially, the usage of such materials in biomedical rheological models has achieved great importance. The nanofluids' role is essential in the cooling of small electronic gizmos like microchips and akin devices. Read More

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mTORC1 Inhibition in Metastatic Breast Cancer Patients Negatively Affects Peripheral NK Cell Maturation and Number.

J Immunol 2021 Apr 30. Epub 2021 Apr 30.

Centre International de Recherche en Infectiologie, Equipe Activation et Transduction du Signal dans les Lymphocytes, Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Lyon, France

NK cells are cytotoxic lymphocytes displaying strong antimetastatic activity. Mouse models and in vitro studies suggest a prominent role of the mechanistic target of rapamycin (mTOR) kinase in the control of NK cell homeostasis and antitumor functions. However, mTOR inhibitors are used as chemotherapies in several cancer settings. Read More

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S1PR1 signaling in cancer: A current perspective.

Adv Protein Chem Struct Biol 2021 10;125:259-274. Epub 2021 Apr 10.

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, KL, India. Electronic address:

Sphingosine-1-phosphate receptor 1 (S1PR1) is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P). S1PR1 belongs to the sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). It has prominent roles in regulating endothelial cell cytoskeletal structure, cell migration, immunomodulation, vasculogenesis during embryogenesis, T cell egress and Multiple sclerosis. Read More

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