75,234 results match your criteria prolonged disease


Clinical Outcomes of Patients Taking First-generation EGFR-TKIs May Predict the Benefits Afforded by Osimertinib in EGFR T790M-mutant NSCLC Patients.

Int J Clin Pract 2021 Sep 15:e14877. Epub 2021 Sep 15.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are widely used to treat patients with EGFR-mutated non-small cell lung cancers (NSCLCs). The association between the clinical outcomes of patients on first-line EGFR-TKIs and the efficacy of osimertinib as second-line treatment has not been previously assessed. This is our topic here. Read More

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September 2021

Symptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study.

Reprod Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University Department, Liverpool Women's Hospital, University of Liverpool, Member of Liverpool Health Partners, Crown Street, Liverpool, L8 7SS, UK.

Endometriosis is a common, chronic inflammatory condition, thought to have a higher incidence in symptomatic women, yet, commonly associated symptoms do not always correlate with the presence or severity of disease and diagnosis requires surgery. We prospectively collected data and assessed symptomology and NMR spectroscopy-based metabolomics of 102 women undergoing laparoscopic sterilisation at a tertiary referral centre in a cross-sectional study. Twelve women were incidentally diagnosed with endometriosis (11. Read More

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September 2021

Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elements.

Ann Intensive Care 2021 Sep 15;11(1):136. Epub 2021 Sep 15.

Department of Surgical Sciences, University of Turin, 10126, Turin, Italy.

Invasive pulmonary aspergillosis (IPA) has always been a challenging diagnosis and risk factors an important guide to investigate specific population, especially in Intensive Care Unit. Traditionally recognized risk factors for IPA have been haematological diseases or condition associated with severe immunosuppression, lately completed by chronic conditions (such as obstructive pulmonary disease, liver cirrhosis, chronic kidney disease and diabetes), influenza infection and Intensive Care Unit (ICU) admission. Recently, a new association with SARS-CoV2 infection, named COVID-19-associated pulmonary aspergillosis (CAPA), has been reported worldwide, even if its basic epidemiological characteristics have not been completely established yet. Read More

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September 2021

A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia.

Curr Top Microbiol Immunol 2021 Sep 16. Epub 2021 Sep 16.

Department of Ophthalmology, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA, 15213, USA.

Reactivation of latent varicella-zoster virus (VZV) causes herpes zoster (HZ), which is commonly accompanied by acute pain and pruritus over the time course of a zosteriform rash. Although the rash and associated pain are self-limiting, a considerable fraction of HZ cases will subsequently develop debilitating chronic pain states termed postherpetic neuralgia (PHN). How VZV causes acute pain and the mechanisms underlying the transition to PHN are far from clear. Read More

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September 2021

Genetic Determinants of Intrinsic Antibiotic Tolerance in Mycobacterium avium.

Microbiol Spectr 2021 Sep 15:e0024621. Epub 2021 Sep 15.

Center for Systems Approaches to Infectious Diseases (C-SAID), Johns Hopkins University School of Medicinegrid.471401.7, Baltimore, Maryland, USA.

The Mycobacterium avium complex (MAC) is one of the most prevalent causes of nontuberculous mycobacteria pulmonary infection in the United States, and yet it remains understudied. Current MAC treatment requires more than a year of intermittent to daily combination antibiotic therapy, depending on disease severity. In order to shorten and simplify curative regimens, it is important to identify the innate bacterial factors contributing to reduced antibiotic susceptibility, namely, antibiotic tolerance genes. Read More

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September 2021

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Am Fam Physician 2021 Sep;104(3):244-252

Wake Forest School of Medicine, Winston-Salem, NC, USA.

Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) are inflammatory conditions that present diagnostic and therapeutic challenges to the physician. Although many of their features overlap, they are two distinct conditions. KD is a febrile illness most commonly affecting children younger than five years. Read More

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September 2021

The use of tracheostomy to support critically ill children receiving orthotopic liver transplantation: a single-center experience.

Pediatr Transplant 2021 Sep 14:e14140. Epub 2021 Sep 14.

Department of Pediatrics, Section of Pediatric Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA.

Background: Children with end-stage liver disease and multi-organ failure, previously considered as poor surgical candidates, can now benefit from liver transplantation (LT). They often need prolonged mechanical ventilation (MV) post-LT and may need tracheostomy to advance care. Data on tracheostomy after pediatric LT are lacking. Read More

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September 2021

Incidence And Predictors Of Textbook Outcome After Simultaneous Liver And Rectal Surgeries For Stage Iv Rectal Cancer.

Colorectal Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy.

Aim: Textbook outcome [TO] is a new surgical quality measure that combines structure, process, and surgical outcomes into a single element. Our study aimed to determine the incidence of TO after simultaneous rectal and liver surgery and to use the achievement of TO as a tool to identify the best candidates for these complex procedures.

Methods: In total, 256 patients who underwent simultaneous liver and rectal surgery for stage IV rectal cancer between January 2004 and August 2019 at five tertiary centers were enrolled. Read More

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September 2021

Influence of nursing staff working hours on stress levels during the COVID-19 pandemic: A cross-sectional online survey.

HeilberufeScience 2021 Sep 10:1-7. Epub 2021 Sep 10.

Institute of Nursing Science, Medical University of Graz, Universitaetsplatz4/3, 8010 Graz, Austria.

Background: Working as a nurse means being able to provide high-quality care 24/7. Studies have shown that the average number of working hours per week is a significant predictor of stress and that the severity of the coronavirus disease 2019 (COVID-19) pandemic has increased the nurses' stress levels.

Objective: The aim of this study was to investigate the influence of the nursing staff's working hours during the COVID-19 pandemic on the perceived level of stress. Read More

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September 2021

Owren's Disease: A Rare Deficiency.

Cureus 2021 Aug 10;13(8):e17047. Epub 2021 Aug 10.

Internal Medicine, Holy Family Hospital, Rawalpindi, PAK.

Factor V deficiency is a rare bleeding disorder, which may be due to acquired inhibitors or biallelic mutations. Factor V deficiency due to homozygous or compound heterozygous mutation (also known as Owren's disease or parahemophilia) has an estimated prevalence of one in one million people. A 22-year-old female was admitted for evaluation of longstanding menorrhagia. Read More

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13q14 Deletion and Its Effect on Prognosis of Chronic Lymphocytic Leukemia.

Cureus 2021 Aug 2;13(8):e16839. Epub 2021 Aug 2.

Internal Medicine, Advent Health and Orlando Health Hospital/JC Medical Center, Orlando, USA.

Chronic lymphocytic leukemia (CLL) is the most common leukemia affecting adults. CLL results due to uncontrolled accumulation of B lymphocytes in the body with the clinical spectrum ranging from comparatively benign disease to an aggressive form. The disease pathogenesis lies in molecular genetics, the most common alteration being the deletion in the long arm of chromosome 13, at position 14 (13q14) region. Read More

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A Rare Case of Septic Knee Arthritis Caused by Clostridium perfringens in a Patient With Colostomy.

Cureus 2021 Aug 2;13(8):e16823. Epub 2021 Aug 2.

Sports Medicine, Active Orthopedics & Sports Medicine, Hackensack, USA.

Septic arthritis of the knee is commonly caused by aerobic organisms. Rarely, it can be caused by , usually due to penetrating trauma. This is a rare case of septic arthritis in a patient with colostomy due to hematogenous spread. Read More

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High expression of CD38 and MHC class II on CD8 T cells during severe influenza disease reflects bystander activation and trogocytosis.

Clin Transl Immunology 2021 8;10(9):e1336. Epub 2021 Sep 8.

Department of Microbiology and Immunology University of Melbourne, at the Peter Doherty Institute for Infection and Immunity Parkville VIC Australia.

Objectives: Although co-expression of CD38 and HLA-DR reflects T-cell activation during viral infections, high and prolonged CD38HLA-DR expression is associated with severe disease. To date, the mechanism underpinning expression of CD38HLA-DR is poorly understood.

Methods: We used mouse models of influenza A/H9N2, A/H7N9 and A/H3N2 infection to investigate mechanisms underpinning CD38MHC-II phenotype on CD8 T cells. Read More

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September 2021

Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys.

Theranostics 2021 2;11(18):8660-8673. Epub 2021 Aug 2.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Ureteral obstruction-induced hydronephrosis is associated with renal fibrosis and progressive chronic kidney disease (CKD). Exosome-mediated cell-cell communication has been suggested to be involved in various diseases, including renal fibrosis. However, little is known regarding how exosomes regulate renal fibrosis in obstructed kidneys. Read More

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Lymph node stromal cells: subsets and functions in health and disease.

Trends Immunol 2021 Sep 11. Epub 2021 Sep 11.

Department of Rheumatology and Clinical Immunology, Department of Experimental Immunology, Amsterdam UMC, Amsterdam Infection and Immunity Institute, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Rheumatology and Immunology Center (ARC), Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

Lymph nodes (LNs) aid the interaction between lymphocytes and antigen-presenting cells, resulting in adequate and prolonged adaptive immune responses. LN stromal cells (LNSCs) are crucially involved in steering adaptive immune responses at different levels. Most knowledge on LNSCs has been obtained from mouse studies, and few studies indicate similarities with their human counterparts. Read More

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September 2021

Microencapsulated phages show prolonged stability in gastrointestinal environments and high therapeutic efficiency to treat Escherichia coli O157:H7 infection.

Vet Res 2021 Sep 14;52(1):118. Epub 2021 Sep 14.

MOE Joint International Research Laboratory of Animal Health and Food Safety, Key Lab of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.

Escherichia coli (E. coli) O157:H7 bacterial infection causes severe disease in mammals and results in substantial economic losses worldwide. Due to the development of antibiotic resistance, bacteriophage (phage) therapy has become an alternative to control O157:H7 infection. Read More

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September 2021

[Intra-abdominal pressure measurement].

Dtsch Med Wochenschr 2021 Sep 14;146(18):1211-1217. Epub 2021 Sep 14.

An elevated intra-abdominal pressure (IAP) above 12 mmHg is a pathological finding in critically ill patients. IAP are classified into different degrees of intra-abdominal hypertension and, in the presence of associated organ failure, as abdominal compartment syndrome. Both disease entities represent an underestimated factor in intensive care patients and are associated with increased mortality and prolonged intensive care and hospital stay. Read More

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September 2021

CAMK2G is identified as a novel therapeutic target for myelofibrosis.

Blood Adv 2021 Sep 14. Epub 2021 Sep 14.

The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.

Although JAK1/2 inhibition is effective into alleviating symptoms of myelofibrosis (MF), it does not result in the eradication of MF clones, which can lead to inhibitor-resistant clones emerging during the treatment. Here we established iPS cells derived from MF patient samples (MF-iPSCs) harboring JAK2 V617F, CALR type 1, or CALR type 2 mutations. We demonstrated that these cells faithfully recapitulate the drug sensitivity of the disease. Read More

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September 2021

COVID-19-associated school closures and related efforts to sustain education and subsidized meal programs, United States, February 18-June 30, 2020.

PLoS One 2021 14;16(9):e0248925. Epub 2021 Sep 14.

Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Pre-emptive school closures are frontline community mitigation measures recommended by the US Centers for Disease Control and Prevention (CDC) for implementation during severe pandemics. This study describes the spatiotemporal patterns of publicly announced school closures implemented in response to the coronavirus disease 2019 (COVID-19) pandemic and assesses how public K-12 districts adjusted their methods of education delivery and provision of subsidized meals. During February 18-June 30, 2020, we used daily systematic media searches to identify publicly announced COVID-19-related school closures lasting ≥1 day in the United States (US). Read More

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September 2021

A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.

PLoS One 2021 14;16(9):e0251895. Epub 2021 Sep 14.

Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.

Obesity and diabetes have strong heritable components, yet the genetic contributions to these diseases remain largely unexplained. In humans, a missense variant in Creb3 regulatory factor (CREBRF) [rs373863828 (p.Arg457Gln); CREBRFR457Q] is strongly associated with increased odds of obesity but decreased odds of diabetes. Read More

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September 2021

Consolidation and Maintenance in Newly Diagnosed Multiple Myeloma.

J Clin Oncol 2021 Sep 14:JCO2101045. Epub 2021 Sep 14.

Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Purpose: To address the role of consolidation treatment for newly diagnosed, transplant eligible patients with multiple myeloma in a controlled clinical trial.

Patients And Methods: The EMN02/HOVON95 trial compared consolidation treatment with two cycles of bortezomib, lenalidomide, and dexamethasone (VRD) or no consolidation after induction and intensification therapy, followed by continuous lenalidomide maintenance. Primary study end point was progression-free survival (PFS). Read More

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September 2021

Antioxidative and Angiogenic Hyaluronic Acid-Based Hydrogel for the Treatment of Peripheral Artery Disease.

ACS Appl Mater Interfaces 2021 Sep 14. Epub 2021 Sep 14.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Peripheral arterial disease (PAD) is a progressive atherosclerotic disorder characterized by blockages of the arteries supplying the lower extremities. Ischemia initiates oxidative damage and mitochondrial dysfunction in the legs of PAD patients, causing injury to the tissues of the leg, significant decline in walking performance, leg pain while walking, and in the most severe cases, nonhealing ulcers and gangrene. Current clinical trials based on cells/stem cells, the trophic factor, or gene therapy systems have shown some promising results for the treatment of PAD. Read More

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September 2021

Clinical characteristics and outcomes of patients with haematologic malignancies and COVID-19 suggest that prolonged SARS-CoV-2 carriage is an important issue.

Ann Hematol 2021 Sep 13. Epub 2021 Sep 13.

Department of Internal Medicine and Clinical Immunology, CHU La Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), 145 Boulevard Baille, Marseille, 13005, France.

Specificities of COVID-19 disease course in patients with haematologic malignancies are still poorly studied. So, we aimed to compare patients with haematologic malignancies to patients without malignancies, matched by sex and age and hospitalised for COVID-19 at the same time and in the same centre. Among 25 patients with haematologic malignancies, we found that mortality (40% versus 4%, p < 0. Read More

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September 2021

Denosumab-Induced Hypocalcemia and Hyperparathyroidism in de novo Kidney Transplant Recipients.

Am J Nephrol 2021 Sep 8:1-9. Epub 2021 Sep 8.

Nephrology, Dialysis and Renal Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Introduction: Denosumab represents a realistic treatment option to increase bone mineral density in kidney transplant recipients (KTRs). It is still unknown how and at what extent posttransplantation bone disease and graft function influence the effects of denosumab on mineral metabolism indexes. In this study, we analyze risk factors of hypocalcemia and parathyroid hormone (PTH) increase after denosumab administration in eighteen de novo KTRs and its management before and after this treatment. Read More

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September 2021

Pelvic exenteration for recurrent or persistent gynecologic malignancies: Clinical and histopathologic factors predicting recurrence and survival in a modern cohort.

Gynecol Oncol 2021 Sep 10. Epub 2021 Sep 10.

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Medical College of Cornell University, USA. Electronic address:

Objectives: To explore pre-operative factors and their impact on overall survival (OS) in a modern cohort of patients who underwent pelvic exenteration (PE) for gynecologic malignancies.

Methods: A retrospective review was performed for all patients who underwent a PE from 1/1/2010 through 12/31/2018 at our institution. Inclusion criteria were exenteration due to recurrent or progressive carcinoma of the uterus, cervix, vagina or vulva, with histologically confirmed complete surgical resection of the malignancy. Read More

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September 2021

Impact of COVID-19 on autoimmune blistering diseases.

Clin Dermatol 2021 May-Jun;39(3):359-368. Epub 2021 Feb 2.

Department of Dermatology, Rouen University Hospital and INSERM U905, Centre de référence des maladies bulleuses autoimmunes, Normandie University, Rouen, France.

Since the beginning of the COVID-19 outbreak, attention has gradually moved from the respiratory manifestations of the disease toward its dermatologic aspects. The need for wearing personal protective measures and their cutaneous side effects, detection of related or specific COVID-19 skin eruptions, and the evaluation of certain risk groups of immunosuppressed dermatologic patients have initiated significant discussions about various therapeutic interventions and, in particular, about biologic therapy for psoriasis and for autoinflammatory, orphan, or malignant cutaneous disorders. Autoimmune bullous dermatoses have been of concern due to their chronic course, at times life-threatening prognosis, and the need for prolonged and often aggressive immunomodulatory therapy. Read More

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February 2021

[Epidemiological and clinical profile of chronic venous disease in the hotel-catering sector of the Setif region, Algeria, during the period 2016-2018].

Ann Cardiol Angeiol (Paris) 2021 Sep 10. Epub 2021 Sep 10.

Service de médecine du travail Centre de Pierre et Marie Curie (CPMC), Alger Algérie. Electronic address:

The purpose of our work is to carry out an epidemiological study among the workers of 18 hotels in the region of Setif, in order to estimate the prevalence of this pathology, to identify the risk factors and to propose prevention recommendations. The study population concerned a total workforce of 628 male-dominated workers, interesting 18 hotels in the region of Setif, whose hotel staff consists of floor staff, kitchen and catering, reception and security reception and maintenance. Workers responded to a pre-established questionnaire to collect socio-demographic and occupational data, reviewing all venous risk factors and functional symptoms. Read More

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September 2021

Management of autoimmune complications in patients with lymphoid cancer.

Blood 2021 Sep 13. Epub 2021 Sep 13.

Medical University of Vienna, Vienna, Austria.

Autoimmune conditions can occur at any temporary relationship with malignant lymphomas. In many instances, treatment at diagnosis is not required, but symptomatic autoimmune conditions represent an indication for treatment particularly in chronic lymphoproliferative diseases. Treatment is selected depending on the predominant condition - autoimmune disease (immunosuppression) or lymphoma (anti-lymphoma therapy). Read More

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September 2021

Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients.

Aging (Albany NY) 2021 Sep 13;13(undefined). Epub 2021 Sep 13.

Gustave Roussy Comprehensive Cancer Institute, Villejuif 94805, France.

Cancer patients are particularly susceptible to the development of severe Covid-19, prompting us to investigate the serum metabolome of 204 cancer patients enrolled in the ONCOVID trial. We previously described that the immunosuppressive tryptophan/kynurenine metabolite anthranilic acid correlates with poor prognosis in non-cancer patients. In cancer patients, we observed an elevation of anthranilic acid at baseline (without Covid-19 diagnosis) and no further increase with mild or severe Covid-19. Read More

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September 2021

Continuity of care in acute survivorship phase, and short and long-term outcomes in prostate cancer patients.

Prostate 2021 Sep 13. Epub 2021 Sep 13.

Division of Urology, Department of Surgery, Perelman School of Medicine, University of Pennsylvania.

Continuity of care is important for prostate cancer care due to multiple treatment options, and prolonged disease history. We examined the association between continuity of care and outcomes in Medicare beneficiaries with localized prostate cancer, and the moderating effect of race using Surveillance, Epidemiological, and End Results (SEER) - Medicare data between 2000 and 2016. Continuity of care was measured as visits dispersion (continuity of care index or COCI), and density (usual provider care index or UPCI) in acute survivorship phase. Read More

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September 2021