Cell Tissue Res 2021 May 8. Epub 2021 May 8.
Department of Orthopedic Surgery, 909th Hospital of People's Liberation Army, Affiliated Southeast Hospital of Xiamen University, 269 Zhanghua Middle Road, Fujian Province, 363000, Zhangzhou, People's Republic of China.
In this study, effects of combining optimized tissue engineering bone (TEB) implantation with heel-strike like mechanical loading to repair segmental bone defect in New Zealand rabbits were investigated. Physiological characteristics of bone marrow mesenchymal stem cells (BMMSCs), compact bone cells (CBCs), and bone marrow and compact bone coculture cells (BMMSC-CBCs) were compared to select the optimal seed cells for optimized TEB construction. Rabbits with segmental bone defects were treated in different ways (cancellous bone scaffold for group A, cancellous bone scaffold and mechanical loading for group B, optimized TEB for group C, optimized TEB and mechanical loading for group D, n = 4), and the bone repair were compared. Read More