1,585 results match your criteria prokinetic therapy

Esophageal manifestation in patients with scleroderma.

World J Clin Cases 2021 Jul;9(20):5408-5419

Department of Gastroenterology and Hepatology, Laiko General Hospital, National and Kapodistian University of Athens, Athens 11527, Greece.

The esophagus is the most commonly affected part of the gastrointestinal system in patients with systemic sclerosis (SSc). Esophageal involvement may lead to a significant reduction in patient quality of life. The exact pathophysiology is complex and not yet fully elucidated. Read More

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Focus on Pharmacotherapy for Irritable Bowel Syndrome with Constipation.

Gastroenterol Clin North Am 2021 Sep;50(3):639-653

Division of Gastroenterology/Hepatology, Department of Medicine, Northwestern University, 676 North St Clair Street, Suite 1400, Chicago, IL 60611, USA. Electronic address:

Irritable bowel syndrome with constipation is a common disorder that significantly impairs quality of life. There are now multiple classes of therapeutics that have been shown via rigorous clinical testing to improve the abdominal and bowel symptoms attributed to irritable bowel syndrome with constipation. These include the secretagogues (lubiprostone, linaclotide, plecanatide, tenapenor) and the prokinetic agent tegaserod. Read More

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September 2021

Bedside methods for transpyloric feeding tube insertion in hospitalized children: A systematic review of randomized and non-randomized trials.

J Pediatr Nurs 2021 Jul 22;60:238-246. Epub 2021 Jul 22.

Seattle Children's Hospital, Pediatric Intensive Care Unit & Clinical Effectiveness, 4800 Sand Point Way NE, Seattle, WA 98105, United States of America. Electronic address:

Problem: Enteral nutrition is a critical component of therapy for many hospitalized children. Some children, especially those with critical illness, require post-pyloric enteral nutrition, but placement of post-pyloric feeding tubes poses challenges, necessitating costly fluoroscopy procedures and delaying initiation of enteral nutrition. There is no established standard method for pediatric transpyloric tube placement at the bedside. Read More

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Digestion-Specific Acupuncture Effect on Feeding Intolerance in Critically Ill Post-Operative Oral and Hypopharyngeal Cancer Patients: A Single-Blind Randomized Control Trial.

Nutrients 2021 Jun 19;13(6). Epub 2021 Jun 19.

Graduate Institute of Acupuncture Science, China Medical University, Taichung 404, Taiwan.

Malnourishment is prevalent in patients suffering from head and neck cancer. The postoperative period is crucial in terms of nutritional support, especially after composite resection and reconstruction surgery. These patients present with a number of risk factors that aggravate feeding intolerance, including postoperative status, prolonged immobility, decreased head elevation, mechanical ventilation, and applied sedative agents. Read More

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Efficacy comparison between oral erythromycin versus domperidone for the treatment of feeding intolerance in preterm neonates.

Pediatr Neonatol 2021 Jun 5. Epub 2021 Jun 5.

Department of Pharmacy, Queen Sirikit National Institute of Child Health, Bangkok, Thailand.

Background: Domperidone and erythromycin are commonly used as prokinetic agents for feeding intolerance in preterm neonates; however, no data from a previous study have compared their efficacy. This study aimed to compare the efficacy of orally administered domperidone and erythromycin for the treatment of feeding intolerance in preterm infants.

Methods: This retrospective cohort study included preterm neonates with a birthweight of <1800 g and gestational age <37 weeks. Read More

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A population pharmacokinetic-pharmacodynamic model of YH12852, a highly selective 5-hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation.

CPT Pharmacometrics Syst Pharmacol 2021 Jun 4. Epub 2021 Jun 4.

Department of Applied Biomedical Engineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.

YH12852, a novel, highly selective 5-hydroxytryptamine 4 (5-HT ) receptor agonist, is currently under development to treat patients with functional constipation. In this study, we aimed to develop a pharmacokinetic (PK)-pharmacodynamic (PD) model that adequately described the time courses of the plasma concentrations of YH12852 and its prokinetic effect as assessed by the Gastric Emptying Breath Test (GEBT) and to predict the prokinetic effect of YH12852 at higher doses through PD simulation. We used the plasma concentrations of YH12852 from patients with functional constipation and healthy subjects and the GEBT results from healthy subjects obtained from a phase I/IIa trial. Read More

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A meta-analysis of randomized controlled trials of a traditional Chinese medicine prescription, modified RunChang-Tang, in treating functional constipation.

Medicine (Baltimore) 2021 May;100(20):e25760

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu.

Background: Modified Runchang-Tang (MRCT), a Chinese herbal medicine, is widely used to treat functional constipation (FC), which is a common digestive system disease. However, its efficacy has not been evaluated systematically and objectively. Thus, a meta-analysis was conducted to assess the efficacy and safety of MRCT for treating functional constipation. Read More

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Georgian Med News 2021 Mar(312):61-67

1Bogomolets National Medical University, Kyiv; Ukraine.

Functional dyspepsia - postprandial distress-syndrome (FD-PDS) is one of the most common reasons for seeking medical attention of general practitioners, internists and gastroenterologists worldwide. Standard approaches to the treatment of patients with postprandial distress syndrome are only effective in small amount of cases. Aim of the study - comparative assessment of the effectiveness of combined eradication and prokinetic therapy and eradication therapy only in the treatment of FD-PDS by studying their effect on the clinical manifestations of the disease, patients' psychological status and quality of life. Read More

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United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.

United European Gastroenterol J 2021 Apr;9(3):287-306

Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.

Background: Gastroparesis is a condition characterized by epigastric symptoms and delayed gastric emptying (GE) rate in the absence of any mechanical obstruction. The condition is challenging in clinical practice by the lack of guidance concerning diagnosis and management of gastroparesis.

Methods: A Delphi consensus was undertaken by 40 experts from 19 European countries who conducted a literature summary and voting process on 89 statements. Read More

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Review article: diagnosis, management and patient perspectives of the spectrum of constipation disorders.

Aliment Pharmacol Ther 2021 06 28;53(12):1250-1267. Epub 2021 Apr 28.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.

Background: Chronic constipation is a common, heterogeneous disorder with multiple symptoms and pathophysiological mechanisms. Patients are often referred to a gastroenterology provider after laxatives fail. However, there is limited knowledge of the spectrum and management of constipation disorders. Read More

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From High-Throughput Screening to Target Validation: Benzo[]isothiazoles as Potent and Selective Agonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 5 Possessing In Vivo Gastrointestinal Prokinetic Activity in Rodents.

J Med Chem 2021 05 23;64(9):5931-5955. Epub 2021 Apr 23.

Takeda Pharmaceuticals, 9625 Towne Centre Drive, San Diego, California 92121, United States.

Transient receptor potential cation channel subfamily M member 5 (TRPM5) is a nonselective monovalent cation channel activated by intracellular Ca increase. Within the gastrointestinal system, TRPM5 is expressed in the stoma, small intestine, and colon. In the search for a selective agonist of TRPM5 possessing in vivo gastrointestinal prokinetic activity, a high-throughput screening was performed and compound was identified as a promising hit. Read More

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Editorial: felcisetrag-forward movement as a novel prokinetic for gastroparesis.

Aliment Pharmacol Ther 2021 05;53(10):1158-1159

Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA.

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Safe Use of Erythromycin For Refractory Gastroparesis After Small Bowel Transplantation.

Exp Clin Transplant 2021 Apr 16. Epub 2021 Apr 16.

From the the Intestinal Rehabilitation and Transplant Center, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Current therapeutic options with prokinetic agents for posttransplant gastroparesis are limited. Erythromycin is associated with adverse reactions, including corrected QT interval prolongation and cytochrome P450 3A4 isoenzyme inhibition. The use of erythromycin has been avoided in patients undergoing treatment with cyclosporine or tacrolimus because of significant fluctuations in therapeutic immunosuppression levels. Read More

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The efficacy and safety of itopride in feeding intolerance of critically ill patients receiving enteral nutrition: a randomized, double-blind study.

BMC Gastroenterol 2021 Mar 19;21(1):126. Epub 2021 Mar 19.

Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Background: Enteral feeding intolerance (EFI) is a frequent problem in the Intensive care unit (ICU) and is associated with poor clinical outcomes leading to worse prognosis in terms of mortality and ICU stay. Nowadays, prokinetic drugs are the mainstay of therapy in EFI. However, available prokinetics have uncertain efficacy and safety profiles. Read More

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Gastrointestinal dysfunction in movement disorders.

Ryuji Sakakibara

Neurol Sci 2021 Apr 4;42(4):1355-1365. Epub 2021 Feb 4.

Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura, 285-8741, Japan.

Purpose Of Review: This article provides an overview of the clinical presentation, investigations, and treatment options for gastrointestinal tract (GIT) dysfunction in patients with Parkinson's disease (PD) and other movement disorders.

Recent Findings: GIT dysfunction commonly appears as constipation and fecal incontinence (mostly overflow, accompanied with sphincter failure in multiple system atrophy [MSA]). Bowel dysfunction (underactive) occurs irrespectively from the site of the neurologic lesion, which is in contrast to site-dependent bladder dysfunction (brain, overactive; periphery, underactive). Read More

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Optimal dose and duration of enteral erythromycin as a prokinetic: A surgical intensive care experience.

Qatar Med J 2020 12;2020(3):36. Epub 2021 Jan 12.

Communicable Disease Center, Hamad Medical Corporation, Doha, Qatar.

Background: Enteral feeding has various advantages over parenteral feeding in critically ill patients. Acutely ill patients are at risk of developing enteral feeding intolerance. Prokinetic medications improve gastrointestinal mobility and enteral feed migration and absorption. Read More

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January 2021

The efficacy and safety of prokinetics in critically ill adults receiving gastric feeding tubes: A systematic review and meta-analysis.

PLoS One 2021 11;16(1):e0245317. Epub 2021 Jan 11.

Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Intolerance to gastric feeding tubes is common among critically ill adults and may increase morbidity. Administration of prokinetics in the ICU is common. However, the efficacy and safety of prokinetics are unclear in critically ill adults with gastric feeding tubes. Read More

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Chinese herbal medicine for the treatment of small intestinal bacterial overgrowth (SIBO): A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Dec;99(51):e23737

The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang City, Hebei, China.

Background: Chinese medicine has a unique theory and the Chinese herbal medicine treatment is based on the integral concepts and syndrome differentiation of the Traditional Chinese Medicine system. Although antibiotics remain the mainstay of SIBO treatment, various alternative or adjunctive therapies are available, including prokinetic agents, dietary interventions, probiotics, and herbal combinations. There is accumulating evidence demonstrating the antimicrobial properties of a growing number of herbs including garlic, black cumin, cloves, cinnamon, thyme, all-spices, bay leaves, mustard, and rosemary. Read More

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December 2020

The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia.

J Pharmacol Sci 2021 Jan 11;145(1):122-129. Epub 2020 Nov 11.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba, 283-8555, Japan; Center of Pharmacological Kampo Research, Josai International University, 1 Gumyo, Togane, Chiba, 283-8555, Japan.

Functional dyspepsia (FD) is thought to be mainly based on gastric motility dysfunction and chronic hypersensitivity, yet FD animal models has been reported a few. We studied to establish the mouse model of impaired gastric motility induced by a pungent ingredient of wasabi allyl isothiocyanate (AITC), which is reliable to evaluate prokinetic agents. Male ddY mice were used. Read More

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January 2021

Medical Management of Inoperable Malignant Bowel Obstruction.

Ann Pharmacother 2021 Sep 21;55(9):1134-1145. Epub 2020 Dec 21.

Sun Yat-sen University Sixth Affiliated Hospital, Guangzhou, Guangdong, China.

Objective: To review medical management of inoperable malignant bowel obstruction.

Data Sources: A literature review using PubMed and MEDLINE databases searching , , , , , , , , , , , , , , , , , , , and .

Study Selection And Data Extraction: Randomized or observational studies, cohorts, case reports, or reviews written in English between 1983 and November 2020 were evaluated. Read More

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September 2021

Gastroparesis in the Hospital Setting.

Nutr Clin Pract 2021 Feb 18;36(1):50-66. Epub 2020 Dec 18.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Gastroparesis (GP) is commonly seen in hospitalized patients. Refractory vomiting and related dehydration, electrolyte abnormalities, and malnutrition are indications for hospital admission. In addition, tube feeding intolerance is a common sign of gastric dysmotility in critically ill patients. Read More

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February 2021

Effect of appetite-conditioned reflex stimulation on early enteral nutrition tolerance after surgery.

Acta Gastroenterol Belg 2020 Oct-Dec;83(4):527-531

Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.

Objective: This study aimed to discuss the effects of appetite-conditioned reflex stimulation on the early enteral nutrition (EEN) tolerance, complications, and postoperative hospital stay in patients who underwent surgery.

Methods: Seventy patients who underwent laparoscopic radical resection of colorectal cancer surgery in our hospital between February and December 2017 were randomly divided into a stimulated appetite group (experimental group, including visual stimulation, nasal stimulation, taste stimulation and hearing stimulation) and a control group (n = 35). Both groups received EEN. Read More

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December 2020

Update on Indigestion.

Alia Chisty

Med Clin North Am 2021 Jan 7;105(1):19-30. Epub 2020 Nov 7.

Division of General Internal Medicine, Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center, 500 University Drive, PO Box 850, Hershey, PA 17033, USA. Electronic address:

Dyspepsia affects a large percentage of the general population and can lead to lost work productivity and reduced quality of life. Patients with dyspepsia younger than 60 should not routinely undergo endoscopy but instead should pursue Helicobacter pylori test-and-treat approach. For patients 60 and older, endoscopy should be performed. Read More

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January 2021

Ethnopharmacological basis for folkloric claims of Anagallis arvensis Linn. (Scarlet Pimpernel) as prokinetic, spasmolytic and hypotensive in province of Punjab, Pakistan.

J Ethnopharmacol 2021 Mar 25;267:113634. Epub 2020 Nov 25.

Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. Electronic address:

Ethnopharmacological Relevance: The conventional naturopaths of Punjab Province (Pakistan) have trivial usage of Anagallis arvensis Linn.(Primulaceae) for cure of diarrhea, constipation, asthma as well as hypertension.

Aim: Present research was focused to discover comprehensive mechanism of spasmogenic, spasmolytic, bronchorelaxant and hypotensive folkloric usage of Anagallis arvensis Linn. Read More

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Gastric Motility Disorders in Dogs and Cats.

Vet Clin North Am Small Anim Pract 2021 Jan;51(1):43-59

Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA.

Gastric motility disorders present both diagnostic and therapeutic challenges and likely are under-recognized in small animal practice. This review includes a comparative overview of etiopathogenesis and clinical presentation of gastric motility disorders, suggests a practical approach to the diagnosis of these conditions, and provides an update on methods to evaluate gastric motor function. Furthermore, management of gastric dysmotility is discussed, including a review of the documented effect of gastric prokinetics. Read More

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January 2021

Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease.

Brain 2020 12;143(11):3393-3407

Section of Movement Disorders and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing Unit, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

The disruption of pathologically enhanced beta oscillations is considered one of the key mechanisms mediating the clinical effects of deep brain stimulation on motor symptoms in Parkinson's disease. However, a specific modulation of other distinct physiological or pathological oscillatory activities could also play an important role in symptom control and motor function recovery during deep brain stimulation. Finely tuned gamma oscillations have been suggested to be prokinetic in nature, facilitating the preferential processing of physiological neural activity. Read More

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December 2020

Safety considerations when managing gastro-esophageal reflux disease in infants.

Expert Opin Drug Saf 2021 Jan 25;20(1):37-49. Epub 2020 Nov 25.

KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel , Brussels, Belgium.

: Gastro-esophageal reflux disease (GERD) in infants is worldwide diagnosed with increasing frequency, resulting in an increasing number of infants exposed to treatment. In this review, we focus on the safety of therapeutic options. : English articles were searched from 1990 until May 2020 in PubMed and Google Scholar. Read More

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January 2021

Effects of L. on Gastrointestinal Motility and Gastric Cancer Cell Proliferation.

Cancer Biother Radiopharm 2020 Oct 28. Epub 2020 Oct 28.

Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, School of Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

To research the influences of a Chinese traditional medicine ( L.) on gastric cancer proliferation and mice gastrointestinal motility. The intestinal transit rates (ITRs) and gastric emptying (GE) values in mice with experimentally induced gastrointestinal motility dysfunction (GMD) and in normal mice were calculated to research the influences of L. Read More

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October 2020

The Multimodal Serotonergic Agent Vilazodone Inhibits L-DOPA-Induced Gene Regulation in Striatal Projection Neurons and Associated Dyskinesia in an Animal Model of Parkinson's Disease.

Cells 2020 10 9;9(10). Epub 2020 Oct 9.

Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.

Levodopa (L-DOPA) treatment in Parkinson's disease is limited by the emergence of L-DOPA-induced dyskinesia. Such dyskinesia is associated with aberrant gene regulation in neurons of the striatum, which is caused by abnormal dopamine release from serotonin terminals. Previous work showed that modulating the striatal serotonin innervation with selective serotonin reuptake inhibitors (SSRIs) or 5-HT1A receptor agonists could attenuate L-DOPA-induced dyskinesia. Read More

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October 2020

[Intestinal motility disorders in multimorbidity: between constipation and diarrhea].

Dtsch Med Wochenschr 2020 10 6;145(20):1456-1459. Epub 2020 Oct 6.

Klinik Wartenberg, Prof. Dr. Selmair GmbH & Co.KG, Wartenberg.

Diagnostic Strategy: The Rome IV criteria for primary chronic obstipation help to distinguish between short-term ailments and a chronic pattern of complaints 1. In general, there are several causes of defecation disorder in the age group of the elderly. Anamnesis and observance of red flags in addition to a geriatric basic assessment make it possible to narrow down the causes. Read More

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October 2020