643 results match your criteria projected uniform


Optimal diuretic strategies in heart failure.

Ann Transl Med 2021 Mar;9(6):517

Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.

Heart failure (HF) is one of the major causes of morbidity and mortality in the world. According to a 2019 American Heart Association report, about 6.2 million American adults had HF between 2013 and 2016, being responsible for almost 1 million admissions. Read More

View Article and Full-Text PDF

A case study of Covid-19 epidemic in India via new generalised Caputo type fractional derivatives.

Math Methods Appl Sci 2021 Feb 17. Epub 2021 Feb 17.

Department of Mathematics Ondokuz Mayis University Samsun 55200 Atakum Turkey.

The first symptomatic infected individuals of coronavirus (Covid-19) was confirmed in December 2020 in the city of Wuhan, China. In India, the first reported case of Covid-19 was confirmed on 30 January 2020. Today, coronavirus has been spread out all over the world. Read More

View Article and Full-Text PDF
February 2021

Prioritising COVID-19 vaccination in changing social and epidemiological landscapes: a mathematical modelling study.

Lancet Infect Dis 2021 Mar 31. Epub 2021 Mar 31.

Department of Applied Mathematics, University of Waterloo, Waterloo, ON, Canada. Electronic address:

Background: During the COVID-19 pandemic, authorities must decide which groups to prioritise for vaccination in a shifting social-epidemiological landscape in which the success of large-scale non-pharmaceutical interventions requires broad social acceptance. We aimed to compare projected COVID-19 mortality under four different strategies for the prioritisation of SARS-CoV-2 vaccines.

Methods: We developed a coupled social-epidemiological model of SARS-CoV-2 transmission in which social and epidemiological dynamics interact with one another. Read More

View Article and Full-Text PDF

Technical Note: Self-shielding evaluation and radiation leakage measurement of a jawless ring gantry linac with a beam stopper.

Med Phys 2021 Mar 24. Epub 2021 Mar 24.

Department of Radiation Oncology, Washington University, St. Louis, MO, 63110, USA.

Purpose: To characterize the shielding design and leakage radiation from a newly released ring gantry linac (Halcyon, Varian Medical Systems).

Methods: To assess the radiation leakage surrounding headshield and the radiation level after the beam stopper, measurements were made with GafChromic films. To evaluate the in-room radiation levels, the radiation leakage in the isocenter plane was measured with a large volume spherical ionization chamber (Exradin A6, Standard Imaging). Read More

View Article and Full-Text PDF

Applicability, potential and limitations of TSPO PET imaging as a clinical immunopsychiatry biomarker.

Eur J Nucl Med Mol Imaging 2021 Mar 18. Epub 2021 Mar 18.

Department of Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RA, Groningen, The Netherlands.

Purpose: TSPO PET imaging may hold promise as a single-step diagnostic work-up for clinical immunopsychiatry. This review paper on the clinical applicability of TSPO PET for primary psychiatric disorders discusses if and why TSPO PET imaging might become the first clinical immunopsychiatry biomarker and the investment prerequisites and scientific advancements needed to accommodate this transition from bench to bedside.

Methods: We conducted a systematic search of the literature to identify clinical studies of TSPO PET imaging in patients with primary psychiatric disorders. Read More

View Article and Full-Text PDF

Microplastic pollution and quantitative source apportionment in the Jiangsu coastal area, China.

Mar Pollut Bull 2021 Mar 9;166:112237. Epub 2021 Mar 9.

Ministry of Education Key Laboratory for Coastal and Island Development, School of Geography and Ocean Science, Nanjing University, Nanjing 210023, China. Electronic address:

We investigated the pollution characteristics, the spatial distributions of microplastics, and the source compositions in the Jiangsu Coastal Area, China. The average abundance of microplastics in the surface water and sediment were 0.0998 ± 0. Read More

View Article and Full-Text PDF

Photoperiod decelerates the advance of spring phenology of six deciduous tree species under climate warming.

Glob Chang Biol 2021 Mar 2. Epub 2021 Mar 2.

NASA Goddard Space Flight Center, Greenbelt, MD, USA.

Vegetation phenology in spring has substantially advanced under climate warming, consequently shifting the seasonality of ecosystem process and altering biosphere-atmosphere feedbacks. However, whether and to what extent photoperiod (i.e. Read More

View Article and Full-Text PDF

3-D shape reconstruction of non-uniform reflectance surface based on pixel intensity, pixel color and camera exposure time adaptive adjustment.

Sci Rep 2021 Feb 25;11(1):4700. Epub 2021 Feb 25.

School of Information and Control Engineering, Qingdao University of Technology, Qingdao, 266520, China.

High dynamic range 3-D shape measurement is a challenge. In this work, we propose a novel method to solve the 3-D shape reconstruction of high-reflection and colored surfaces. First, we propose a method to establish a fast pixel-level mapping between the projected image and the captured image. Read More

View Article and Full-Text PDF
February 2021

Different climate sensitivity for radial growth, but uniform for tree-ring stable isotopes along an aridity gradient in Polylepis tarapacana, the world's highest elevation tree-species.

Tree Physiol 2021 Feb 18. Epub 2021 Feb 18.

Laboratorio de Dendrocronología, Universidad Continental. Huancayo, Peru.

Tree growth is generally considered to be temperature-limited at upper elevation treelines. Yet, climate factors controlling tree growth at semiarid treelines are poorly understood. We explored the influence of climate on stem growth and stable isotopes for Polyepis tarapacana, the world's highest elevation tree-species found only in the South American Altiplano. Read More

View Article and Full-Text PDF
February 2021

Common architectures in cyanobacteria Prochlorococcus cells visualized by X-ray diffraction imaging using X-ray free electron laser.

Sci Rep 2021 Feb 16;11(1):3877. Epub 2021 Feb 16.

Department of Physics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa, 223-8522, Japan.

Visualization of intracellular structures and their spatial organization inside cells without any modification is essential to understand the mechanisms underlying the biological functions of cells. Here, we investigated the intracellular structure of cyanobacteria Prochlorococcus in the interphase by X-ray diffraction imaging using X-ray free-electron laser. A number of diffraction patterns from single cells smaller than 1 µm in size were collected with high signal-to-noise ratio with a resolution of up to 30 nm. Read More

View Article and Full-Text PDF
February 2021

Designing a smart incentive-based recycling system for household recyclable waste.

Waste Manag 2021 Mar 12;123:142-153. Epub 2021 Feb 12.

China Institute for Urban Governance, Shanghai Jiao Tong University, Shanghai 200030, PR China. Electronic address:

Household waste recycling is a significant challenge for society. Cities worldwide have been exploring how to reduce waste through recycling. Incentive mechanism is one of the promising measures to improve the participation of residents in waste recycling activities. Read More

View Article and Full-Text PDF

US women in thoracic surgery: reflections on the past and opportunities for the future.

J Thorac Dis 2021 Jan;13(1):473-479

Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.

Herein, we examine the state of women in thoracic surgery from the United States (US) perspective in terms of our past, present, and opportunities for the future. We explore the achievements of the first three women certified in thoracic surgery in 1961 and describe the progress made resulting in the current state. Women constitute slightly more than 50% of all medical students in the US, yet women remain underrepresented in thoracic surgery. Read More

View Article and Full-Text PDF
January 2021

Preoperative planning for intraoperative navigation guidance.

Ann Transl Med 2021 Jan;9(1):87

Department of Orthopedic Surgery, University of Colorado School of Medicine, Aurora, CO, USA.

Intraoperative navigation for spinal procedures has continued to gain popularity. Numerous platforms are currently on the market and offer a spectrum of features. Preoperative considerations when utilizing this technology begin with understanding the fundamental concepts and methods of navigation. Read More

View Article and Full-Text PDF
January 2021

Research Note: Indian poultry industry vis-à-vis coronavirus disease 2019: a situation analysis report.

Poult Sci 2021 Mar 19;100(3):100828. Epub 2020 Nov 19.

School of Extension and Development Studies, Indira Gandhi National Open University, New Delhi 110068, India.

Originating in Wuhan city, Hubei province of China, and rapid spread to multiple countries, severe acute respiratory syndrome coronavirus 2 has emerged as a novel public health emergence. During early February, spread of misinformation and rumors driven by the fear of linking chicken meat and eggs in the transmission of coronavirus disease 2019 (COVID-19) among human population is witnessed in India. This resulted drastic reduction in consumption of poultry products with subsequent fall in demand thereby prices. Read More

View Article and Full-Text PDF

The predictive capacity of GARCH-type models in measuring the volatility of crypto and world currencies.

PLoS One 2021 29;16(1):e0245904. Epub 2021 Jan 29.

Department of Accounting and Finance, Faculty of Business Administration and Economics, Notre Dame University - Louaize, Zouk Mosbeh, Lebanon.

This paper provides a thorough overview and further clarification surrounding the volatility behavior of the major six cryptocurrencies (Bitcoin, Ripple, Litecoin, Monero, Dash and Dogecoin) with respect to world currencies (Euro, British Pound, Canadian Dollar, Australian Dollar, Swiss Franc and the Japanese Yen), the relative performance of diverse GARCH-type specifications namely the SGARCH, IGARCH (1,1), EGARCH (1,1), GJR-GARCH (1,1), APARCH (1,1), TGARCH (1,1) and CGARCH (1,1), and the forecasting performance of the Value at Risk measure. The sampled period extends from October 13th 2015 till November 18th 2019. The findings evidenced the superiority of the IGARCH model, in both the in-sample and the out-of-sample contexts, when it deals with forecasting the volatility of world currencies, namely the British Pound, Canadian Dollar, Australian Dollar, Swiss Franc and the Japanese Yen. Read More

View Article and Full-Text PDF
January 2021

Complement activation and coagulopathy - an ominous duo in COVID19.

Expert Rev Hematol 2021 02 22;14(2):155-173. Epub 2021 Jan 22.

Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Introduction: COVID-19 has similarities to the Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, as severe patients and non-survivors have frequently shown abnormal coagulation profiles. Immune-mediated pathology is a key player in this disease; hence, the role of the complement system needs assessment. The complement system and the coagulation cascade share an intricate network, where multiple mediators maintain a balance between both pathways. Read More

View Article and Full-Text PDF
February 2021

SUSCC: Secondary Construction of Feature Space based on UMAP for Rapid and Accurate Clustering Large-scale Single Cell RNA-seq Data.

Interdiscip Sci 2021 Mar 21;13(1):83-90. Epub 2021 Jan 21.

College of Mathematics and System Sciences, Xinjiang University, Urumqi, China.

Clustering is a common method to identify cell types in single cell analysis, but the increasing size of scRNA-seq datasets brings challenges to single cell clustering. Therefore, it is an urgent need to design a faster and more accurate clustering method for large-scale scRNA-seq data. In this paper, we proposed a new method for single cell clustering. Read More

View Article and Full-Text PDF

miR-125b prevent the progression of esophageal squamous cell carcinoma through the p38-MAPK signaling pathway.

J Gastrointest Oncol 2020 Dec;11(6):1113-1122

Department of Thoracic Surgery, Affiliated Tumor Hospital Nantong University, Nantong, China.

Background: To examine the clinical significance of miR-125b in esophageal squamous cell carcinoma (ESCC) and to research the effect of miR-125b on the biological function of ESCC cells and the relevant underlying mechanism.

Methods: The expression of miR-125b in ESCC tissues and cell lines were discovered by RT-PCR assay. The interrelation between miR-125b expression and clinicopathological parameters and the forecasting of ESCC patients were analyzed. Read More

View Article and Full-Text PDF
December 2020

Feasibility of microscope-integrated swept-source optical coherence tomography in canaloplasty.

Ann Transl Med 2020 Dec;8(23):1577

Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, China.

Background: Several researchers have used commercial microscope-integrated optical coherence tomography (OCT) systems in glaucoma surgery, including trabeculectomy and canaloplasty. However, the 840 nm wavelength light source of the OCT systems is not ideal for imaging the anterior chamber angle structures because of its limited penetration. We evaluated the potential value of a microscope-integrated swept-source OCT system with a 1,310 nm center-wavelength light in canaloplasty for glaucoma. Read More

View Article and Full-Text PDF
December 2020

Functional Gene Expression Differentiation of the Notch Signaling Pathway in Female Reproductive Tract Tissues-A Comprehensive Review With Analysis.

Front Cell Dev Biol 2020 15;8:592616. Epub 2020 Dec 15.

Department of Molecular Carcinogenesis, Medical University of Lodz, Lodz, Poland.

The Notch pathway involves evolutionarily conserved signaling regulating the development of the female tract organs such as breast, ovary, cervix, and uterine endometrium. A great number of studies revealed Notch aberrancies in association with their carcinogenesis and disease progression, the management of which is still challenging. The present study is a comprehensive review of the available literature on Notch signaling during the normal development and carcinogenesis of the female tract organs. Read More

View Article and Full-Text PDF
December 2020

Interassociation consensus recommendations for pitch-side emergency care and personal protective equipment for elite sport during the COVID-19 pandemic.

Br J Sports Med 2020 Dec 24. Epub 2020 Dec 24.

Wits Institute for Sport and Health (WISH), School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg-Braamfontein, South Africa

The COVID-19 pandemic has necessitated many novel responses in healthcare including sport and exercise medicine. The cessation of elite sport almost globally has had significant economic implications and resulted in pressure to resume sport in very controlled conditions. This includes protecting pitch-side medical staff and players from infection. Read More

View Article and Full-Text PDF
December 2020

Improved cyber-physical system captured post-flowering high night temperature impact on yield and quality of field grown wheat.

Sci Rep 2020 12 17;10(1):22213. Epub 2020 Dec 17.

Department of Agronomy, Kansas State University, 1712 Claflin Road, Manhattan, KS, 66506-5501, USA.

Winter wheat (Triticum aestivum L.) is essential to maintain food security for a large proportion of the world's population. With increased risk from abiotic stresses due to climate variability, it is imperative to understand and minimize the negative impact of these stressors, including high night temperature (HNT). Read More

View Article and Full-Text PDF
December 2020

Segmented Generative Networks: Data Generation in the Uniform Probability Space.

IEEE Trans Neural Netw Learn Syst 2020 Dec 17;PP. Epub 2020 Dec 17.

Recent advancements in generative networks have shown that it is possible to produce real-world-like data using deep neural networks. Some implicit probabilistic models that follow a stochastic procedure to directly generate data have been introduced to overcome the intractability of the posterior distribution. However, the ability to model data requires deep knowledge and understanding of its statistical dependence--which can be preserved and studied in appropriate latent spaces. Read More

View Article and Full-Text PDF
December 2020

Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis.

BMJ 2020 12 15;371:m4750. Epub 2020 Dec 15.

Innovation+Design Enabling Access (IDEA) Initiative, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Objective: To analyze the premarket purchase commitments for coronavirus disease 2019 (covid-19) vaccines from leading manufacturers to recipient countries.

Design: Cross sectional analysis.

Data Sources: World Health Organization's draft landscape of covid-19 candidate vaccines, along with company disclosures to the US Securities and Exchange Commission, company and foundation press releases, government press releases, and media reports. Read More

View Article and Full-Text PDF
December 2020

Biocompatible PCL-nanofibers scaffold with immobilized fibronectin and laminin for neuronal tissue regeneration.

Mater Sci Eng C Mater Biol Appl 2021 Feb 28;119:111550. Epub 2020 Sep 28.

Nanotechnology Program, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, Egypt; Energy Materials Laboratory, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, Egypt. Electronic address:

Recent advances in regenerative medicine have given hope in overcoming and rehabilitating complex medical conditions. In this regard, the biopolymer poly-ε-caprolactone (PCL) may be a promising candidate for tissue regeneration, despite lacking the essential bioactivity. The present study used PCL nanofibers (NFs) scaffold decorated with the extracellular matrix proteins fibronectin and laminin combined for neuronal regeneration. Read More

View Article and Full-Text PDF
February 2021

Music to Our Ears: Are Dancers at Risk for High Sound Level Exposure?

Med Probl Perform Art 2020 Dec;35(4):227-232

Hospital for Special Surgery, Florida, 300 Palm Beach Lakes Blvd., West Palm Beach, FL 33401, USA. Tel 561-657-4600.

Enduring exposure to high sound pressure levels (SPLs) can lead to noise-induced hearing loss (NIHL). In the performing arts population, NIHL has been studied primarily in the context of sound exposure experienced by musicians and less so by dancers. This research aimed to identify sound exposure that dancers may experience in some dance classes. Read More

View Article and Full-Text PDF
December 2020

The effect of PD-L1 categories-directed pembrolizumab plus chemotherapy for newly diagnosed metastatic non-small-cell lung cancer: a cost-effectiveness analysis.

Authors:
Bin Wu Shun Lu

Transl Lung Cancer Res 2020 Oct;9(5):1770-1784

Shanghai Lung Cancer Center, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.

Background: The effectiveness of adding pembrolizumab to chemotherapy improve outcomes in newly diagnosed metastatic non-small-cell lung cancer (NSCLC). We aimed to evaluate the economic outcomes of first-line treatment by adding pembrolizumab to chemotherapy with and without the use of PD-L1 testing for patient selection.

Methods: A decision-analytic model was adopted to project the disease course of newly diagnosed metastatic nonsquamous and squamous NSCLC without EGFR or ALK mutations. Read More

View Article and Full-Text PDF
October 2020

Impact of increased inflammation biomarkers on periprocedural myocardial infarction in patients undergoing elective percutaneous coronary intervention: a cohort study.

J Thorac Dis 2020 Oct;12(10):5398-5410

Department of Cardiovascular Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: The fact that each inflammatory indicator has a forecasting capacity on the occurrence of periprocedural myocardial infarction (PMI) has a controversial existence. The purpose of this study was to explore the role of inflammation biological indicators on PMI in a group of patients undergoing selective percutaneous coronary intervention (PCI).

Methods: The study was carried out both in a retrospective and prospective manner in 7,413 and 1,189 subjects, respectively. Read More

View Article and Full-Text PDF
October 2020

Uniforming spring phenology under non-uniform climate warming across latitude in China.

Sci Total Environ 2021 Mar 22;762:143177. Epub 2020 Oct 22.

Zhejiang Tiantong Forest Ecosystem National Observation and Research Station, Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, China; Research Center for Global Change and Ecological Forecasting, East China Normal University, Shanghai 200000, China. Electronic address:

Temperature is the primary factor controlling plant phenology. As temperature changes with latitude, leaf phenology in spring always shows a significant latitudinal pattern. However, under asymmetric warming at the low and high latitudes, the variability of the spring leaf phenology with latitude is becoming unclear. Read More

View Article and Full-Text PDF

Accuracy of UK Rapid Test Consortium (UK-RTC) "AbC-19 Rapid Test" for detection of previous SARS-CoV-2 infection in key workers: test accuracy study.

BMJ 2020 11 11;371:m4262. Epub 2020 Nov 11.

Public Health England, London, UK

Objective: To assess the accuracy of the AbC-19 Rapid Test lateral flow immunoassay for the detection of previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Design: Test accuracy study.

Setting: Laboratory based evaluation. Read More

View Article and Full-Text PDF
November 2020