5,322 results match your criteria progressive external

Primary squamous cell carcinoma of the thyroid: a case report.

J Int Med Res 2021 Apr;49(4):3000605211004702

Department of Endocrinology, Peking University International Hospital, Beijing, China.

Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare and rapidly progressive malignancy that carries a poor prognosis. PSCCT is easily misdiagnosed as acute thyroiditis or as another thyroid malignancy. We have reported a 76-year-old woman who presented with progressive neck pain for 1 month. Read More

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Effects of different severities of disc degeneration on the range of motion of cervical spine.

J Craniovertebr Junction Spine 2020 Oct-Dec;11(4):269-275. Epub 2020 Nov 26.

Center for NeuroTrauma Research, Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Aims And Objectives: The human spine degenerates with age. Intervertebral disc degeneration occurs in the cervical spine. The objective of this study is to determine the effects of degenerative disc diseases on the range of motion (ROM) of the human cervical spinal column using a validated finite-element model. Read More

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November 2020

Aural Polyp or Temporal Bone Carcinoma: Lesson to Learn.

Cureus 2021 Mar 1;13(3):e13629. Epub 2021 Mar 1.

Department of Otorhinolaryngology - Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Temporal bone carcinoma is a rare malignant tumor of the head and neck region. Its clinical presentations can mimic benign ear diseases, leading to inaccurate diagnosis and substandard management. We present the case of a 53-year-old female with a three-month history of progressive right otalgia, otorrhea, and hearing loss. Read More

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Regulation of Fruit Growth in a Peach Slow Ripening Phenotype.

Genes (Basel) 2021 Mar 26;12(4). Epub 2021 Mar 26.

Department of Agronomy, Food, Natural Resources, Animals and Environment (DAFNAE), University of Padova, Agripolis-Viale dell'Università 16, 35020 Legnaro, Italy.

Consumers' choices are mainly based on fruit external characteristics such as the final size, weight, and shape. The majority of edible fruit are by tree fruit species, among which peach is the genomic and genetic reference for Prunus. In this research, we used a peach with a slow ripening (SR) phenotype, identified in the Fantasia (FAN) nectarine, associated with misregulation of genes involved in mesocarp identity and showing a reduction of final fruit size. Read More

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Muscle Oxygen Desaturation and Re-Saturation Capacity Limits in Repeated Sprint Ability Performance in Women Soccer Players: A New Physiological Interpretation.

Int J Environ Res Public Health 2021 Mar 27;18(7). Epub 2021 Mar 27.

Faculty of Sports Sciences, University of Extremadura, 10003 Cáceres, Spain.

Muscle oxygen consumption could provide information on oxidative metabolism in women soccer players. Therefore, the objective of this study was to analyze muscle oxygenation dynamics during repeated sprint ability (RSA): (8 sprint × 20 s recovery) by near-infrared spectroscopy (NIRS). The sample was made up of 38 professional women soccer players. Read More

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Compounding Pearls -- Wound Care: Drugs and Formulations for Dermal Healing.

Mike Riepl

Int J Pharm Compd 2021 Mar-Apr;25(2):100-103

Retired Compounding Pharmacist, Bismarck, North Dakota.

Healthy human skin performs a constellation of functions essential to good health, and the consequences of disruption to that effective external defense system have been recognized since antiquity. The earliest treatments for dermal injuries and diseases were compounded: They were prepared for each patient and could be modified to address progressive phases of healing. The benefits of that therapeutic approach continue today, made immeasurably more effective by modern pharmaceutical compounding. Read More

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Hemicraniectomy and externalized ventricular drain placement in a pediatric patient with myelin oligodendrocyte glycoprotein-associated tumefactive demyelinating disease.

Childs Nerv Syst 2021 Apr 2. Epub 2021 Apr 2.

Division of Neurosurgery, Children's Hospital of Philadelphia, Department of Neurosurgery, University of Pennsylvania, Perelman School of Medicine, 3401 Civic Center Blvd, 6 Wood Center, Philadelphia, PA, 19104, USA.

Background: Acquired demyelination of the central nervous system in children can manifest as multiple sclerosis, neuromyelitis optica, myelin oligodendrocyte glycoprotein (MOG)-associated demyelination, or as an acute monophasic illness without serum antibodies. Rarely do patients with demyelinating disease need surgical intervention for fulminant crises.

Case: We report a case of anti-MOG antibody-related tumefactive demyelination in a 10-year-old female who required urgent hemicraniectomy and external ventricular drain placement for progressive white matter edema with obstructive hydrocephalus, subfalcine, and transtentorial herniation. Read More

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Cost Effectiveness and Budget Impact of Siponimod Compared to Interferon Beta-1a in the Treatment of Adult Patients with Secondary Progressive Multiple Sclerosis with Active Disease in Switzerland.

Pharmacoeconomics 2021 Apr 1. Epub 2021 Apr 1.

University of Basel, Basel, Switzerland.

Objective: The study aim was to evaluate the cost effectiveness and budget impact of siponimod compared to interferon beta-1a for adult patients with secondary progressive multiple sclerosis (SPMS) with active disease, from a Swiss health insurance perspective.

Methods: We conducted an analysis using a Markov cohort model with a cycle length of 1 year, life-long time horizon, and discount rate of 3% for cost and health outcomes. We used a matching-adjusted indirect comparison to estimate clinical outcomes using data from the EXPAND randomised controlled trial of siponimod vs placebo and the Nordic SPMS randomised controlled trial of interferon beta-1a vs placebo as the basis for estimates of disability progression and relapse outcomes. Read More

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Morbidity, Mortality, and Conversion to Neurodegenerative Diseases in Patients with REM Sleep Behavior Disorder and REM Sleep without Atonia.

Neuroepidemiology 2021 Mar 29:1-13. Epub 2021 Mar 29.

Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, Faculty of Health Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Introduction: The underlying pathophysiology of idiopathic REM sleep behavior disorder (iRBD) is not fully understood, although the condition is currently recognized as an early-stage alpha-synuclein disorder. We evaluated the morbidity, mortality, and rate of conversion to a neurodegenerative disorder in a national group of patients.

Methods: All patients in Denmark with a diagnosis of RBD between 2006 and 2013 were identified from the Danish National Patient Registry (NPR) records. Read More

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Fournier's gangrene: its management remains a challenge.

Pan Afr Med J 2021 12;38:23. Epub 2021 Jan 12.

Department of General and Digestive Surgery, University Hospital Fattouma Bourguiba, University of Monastir, Monastir, Tunisia.

Fournier's gangrene (FG) is a rapidly progressive necrotizing bacterial dermo-hypodermitis of the perineum and external genitalia. It represents a real medical and surgical emergency requiring multidisciplinary care. Our study was based on the retrospective analysis of 18 cases of FG, collected in the Department of General and Visceral Surgery of Fattouma Bourguiba University Hospital in Monastir over an 18-year period extending from January 2000 to December 2018. Read More

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Radiotherapy as Salvage Treatment in Intraocular Lymphoma: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):184-189. Epub 2021 Mar 1.

Radiotherapy Department, Instituto Português de Oncologia Francisco Gentil E.P.E, Lisbon, Portugal.

A 67-year-old previously healthy woman presented with progressive visual impairment including bitemporal hemianopsia. A brain magnetic resonance imaging revealed a contrast-enhancing mass in the optic chiasm, spreading along the left optic tract. The patient underwent a transcranial biopsy of the left optical tract that yielded a diagnosis of diffuse large B-cell lymphoma. Read More

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Fournier Gangrene as a Complication of a Perinephric Abscess After Kidney Transplant: A Case Report.

Transplant Proc 2021 Mar 25. Epub 2021 Mar 25.

Division of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.

Fournier gangrene is a progressive necrotizing infection of the external genitalia or perineum that constitutes a urologic emergency. Incidence of Fournier gangrene is rising because of population aging, increasing comorbidities, and widespread use of immunosuppressive therapy, including immunosuppressive regimens used in kidney transplants. This is a rapidly progressive and potentially lethal disease without treatment, and early recognition of the disease, proper management of the predisposing factors, and aggressive surgical debridement are the most essential interventions. Read More

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Fungal abscess after intra-orbital steroid injection: a case report.

Orbit 2021 Mar 26:1-5. Epub 2021 Mar 26.

Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

A 28-year-old male presented with gradually progressive swelling of the right lower eyelid along with a prominence of the eye for 6 months. He had received oral steroids and intraorbital triamcinolone acetonide injection in the inferior quadrant for active thyroid eye disease. External examination revealed right eye proptosis and swelling along the inferior orbital region. Read More

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Neuro-ophthalmic manifestations of mitochondrial disorders and their management.

Taiwan J Ophthalmol 2021 Jan-Mar;11(1):39-52. Epub 2020 Dec 4.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.

The visual system has high metabolic requirements and is therefore particularly vulnerable to mitochondrial dysfunction. The most commonly affected tissues include the extraocular muscles, photoreceptors, retinal pigment epithelium, optic nerve and visual cortex. Hence, the most common manifestations of mitochondrial disorders are progressive external ophthalmoplegia, macular pattern dystrophy, pigmentary retinopathy, optic neuropathy and retrochiasmal visual field loss. Read More

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December 2020

Pre-operative embolization followed by clipping of Cognard type V dural arteriovenous fistula.

J Neurointerv Surg 2021 Mar 25. Epub 2021 Mar 25.

Department of Neurological Surgery, Rush University Medical Center, Chicago, Illinois, USA.

Cognard type V dural arteriovenous fistulas (DAVFs) are a rare type of cerebrovascular malformation characterized by congestion of the perimedullary venous system and often lead to devastating spinal cord pathology if left untreated. We present a unique case in which a middle-aged patient presented with history of gradually progressive weakness in both lower limbs for 6 months and sudden onset of weakness in both upper limbs and face over 3 days. Magnetic resonance imaging (MRI) showed edema in the cervicomedullary junction. Read More

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Diagnosing instability of ligamentous syndesmotic injuries: A biomechanical perspective.

Clin Biomech (Bristol, Avon) 2021 Mar 13;84:105312. Epub 2021 Mar 13.

Department of Orthopaedics and Trauma Surgery, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127 Bonn, Germany. Electronic address:

Background: High ankle sprains are insidious injuries associated with a long recovery period, functional impairment and long-term sequelae if mistreated. This systematic review investigates the biomechanical knowledge on the kinematic consequences of sequential syndesmotic ligamentous injuries, aiming to furnish an updated and objective contribution for the critical appraisal and further elaboration of current diagnostic algorithms for high ankle sprains.

Methods: A systematic review was performed to identify human biomechanical studies evaluating the stabilizing role of the syndesmotic ligaments. Read More

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Idiopathic Pediatric Tibial Nerve Palsy.

Plast Reconstr Surg Glob Open 2021 Mar 15;9(3):e3484. Epub 2021 Mar 15.

Department of Plastic Surgery and Reconstructive Surgery, Children's National Hospital, Washington, D.C.

Tibial nerve entrapment is uncommon in the pediatric population, and presents diagnostic and treatment challenges. We present the unusual case of a 3-year-old male child with progressive lower leg atrophy of an unknown etiology. Preoperative electrodiagnostic testing and magnetic resonance imaging suggested proximal tibial neuropathy. Read More

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A warning machine learning algorithm for early knee osteoarthritis structural progressor patient screening.

Ther Adv Musculoskelet Dis 2021 23;13:1759720X21993254. Epub 2021 Feb 23.

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), 900 Saint-Denis, Suite R11.412, Montreal, QC H2X 0A9, Canada.

Aim: In osteoarthritis (OA) there is a need for automated screening systems for early detection of structural progressors. We built a comprehensive machine learning (ML) model that bridges major OA risk factors and serum levels of adipokines/related inflammatory factors at baseline for early prediction of at-risk knee OA patient structural progressors over time.

Methods: The patient- and gender-based model development used baseline serum levels of six adipokines, three related inflammatory factors and their ratios (36), as well as major OA risk factors [age and bone mass index (BMI)]. Read More

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February 2021

Survival impact on triple-modal strategy comprising hyperthermia, external radiation, and chemotherapy for unresectable locally advanced (UR-LA) pancreatic ductal adenocarcinoma.

Surg Oncol 2021 Mar 13;37:101542. Epub 2021 Mar 13.

Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Background: Present treatment strategy for unresectable locally advanced (UR-LA) pancreatic ductal adenocarcinoma (PDAC) patients is controversial. Hence, a triple-modal therapy, which is a multidisciplinary strategy, was designed for patients with UR-LA PDAC by adding hyperthermia to conventional chemoradiotherapy at our institution. In this study we aimed to evaluate the effectiveness of this strategy. Read More

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Mitophagy: An Emerging Target in Ocular Pathology.

Invest Ophthalmol Vis Sci 2021 Mar;62(3):22

Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States.

Mitochondrial function is essential for the viability of aerobic eukaryotic cells, as mitochondria provide energy through the generation of adenosine triphosphate (ATP), regulate cellular metabolism, provide redox balancing, participate in immune signaling, and can initiate apoptosis. Mitochondria are dynamic organelles that participate in a cyclical and ongoing process of regeneration and autophagy (clearance), termed mitophagy specifically for mitochondrial (macro)autophagy. An imbalance in mitochondrial function toward mitochondrial dysfunction can be catastrophic for cells and has been characterized in several common ophthalmic diseases. Read More

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A Nomogram Predicting the Prognosis of Children With Biliary Atresia After Hepatoportoenterostomy.

Front Pediatr 2021 24;9:641318. Epub 2021 Feb 24.

Department of Ultrasound, The Second Xiangya Hospital of Central South University, Changsha, China.

Although Kasai portoenterostomy (KPE) is performed timely for most children with biliary atresia (BA), the native liver survival (NLS) is still poor due to the progressive liver fibrosis. Many children have to receive liver transplantation (LT) within 2 years after KPE. Early prediction of the prognosis permits the implementation of prophylactic treatments for BA children. Read More

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February 2021

Clinical and molecular characterization of mitochondrial DNA disorders in a group of Argentinian pediatric patients.

Mol Genet Metab Rep 2021 Jun 25;27:100733. Epub 2021 Feb 25.

Department of Medical Genetics, Hospital de Pediatría "Juan P. Garrahan", Combate de los Pozos 1881, Buenos Aires 1245, Argentina.

Objective: To describe the clinical and molecular features of a group of Argentinian pediatric patients with mitochondrial DNA (mtDNA) disorders, and to evaluate the results of the implementation of a classical approach for the molecular diagnosis of mitochondrial diseases.

Methods: Clinical data from 27 patients with confirmed mtDNA pathogenic variants were obtained from a database of 89 patients with suspected mitochondrial disease, registered from 2014 to 2020. Clinical data, biochemical analysis, neuroimaging findings, muscle biopsy and molecular studies were analyzed. Read More

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Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.

Cancer Cell 2021 Mar 9. Epub 2021 Mar 9.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

The tumor immune microenvironment plays a critical role in cancer progression and response to immunotherapy in clear cell renal cell carcinoma (ccRCC), yet the composition and phenotypic states of immune cells in this tumor are incompletely characterized. We performed single-cell RNA and T cell receptor sequencing on 164,722 individual cells from tumor and adjacent non-tumor tissue in patients with ccRCC across disease stages: early, locally advanced, and advanced/metastatic. Terminally exhausted CD8 T cells were enriched in metastatic disease and were restricted in T cell receptor diversity. Read More

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Diffusion tensor imaging analysis in three progressive supranuclear palsy variants.

J Neurol 2021 Mar 12. Epub 2021 Mar 12.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Background: Clinical variants of progressive supranuclear palsy (PSP) include the classic Richardson's syndrome (PSP-RS), as well as cortical presentations such as PSP-speech/language (PSP-SL) and subcortical presentations such as PSP-parkinsonism (PSP-P). Patterns of white matter tract degeneration underlying these variants, and the degree to which white matter patterns could differentiate these variants, is unclear.

Methods: Forty-nine PSP patients (28 PSP-RS, 12 PSP-P, and 9 PSP-SL) were recruited by the Neurodegenerative Research Group and underwent diffusion tensor imaging. Read More

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Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.

Int Immunopharmacol 2021 Mar 7;95:107519. Epub 2021 Mar 7.

Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:

Long-term exposure to crystalline silica (CS) results in silicosis, which is characterized by progressive pulmonary fibrosis. The endoplasmic reticulum (ER) plays a critical role in protein processing, and the accumulation of unfolded proteins triggered by external stimuli often leads to ER stress. In the present study, we found that inhibition of ER stress alleviated CS-induced pulmonary fibrosis. Read More

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Persons with pre-dementia have no Kantian duty to die.

Bioethics 2021 Mar 8. Epub 2021 Mar 8.

Peking University Health Science Centre, Beijing, China.

Cooley's argument that persons with pre-dementia have a Kantian duty to die has led to much debate. Cooley gives two reasons for his claim, the first being that a person with pre-dementia should end his/her life when he/she will inevitably and irreversibly lose rationality and be unable to live morally as a result. This paper argues that this reason derives from an unsubstantiated premise and general confusion regarding the condition for a Kantian duty to die. Read More

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Assessment of the corneal collagen organization after chemical burn using second harmonic generation microscopy.

Biomed Opt Express 2021 Feb 11;12(2):756-765. Epub 2021 Jan 11.

Dpto. Biología Celular, Histología y Farmacología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.

The organization of the corneal stoma is modified due to different factors, including pathology, surgery or external damage. Here the changes in the organization of the corneal collagen fibers during natural healing after chemical burn are investigated using second harmonic generation (SHG) imaging. Moreover, the structure tensor (ST) was used as an objective tool for morphological analyses at different time points after burn (up to 6 months). Read More

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February 2021

Acute Myocardial Infarction due to External Compression of the Left Main Coronary Artery by a Large Pulmonary Artery Aneurysm.

Case Rep Cardiol 2021 22;2021:8850044. Epub 2021 Feb 22.

Cardiology Department, Queen Elizabeth Hospital, Birmingham, UK.

Background: Although rare, external compression of the left main coronary artery (LMCA) by a pulmonary arterial aneurysm (PAA) as a consequence of pulmonary arterial hypertension causing stable angina pectoris is well described. However, acute myocardial infarction is extremely rare, particularly with a full array of electrocardiographic, biochemical, and echocardiographic features, as in this scenario.

Case: In this case, a 62-year-old man with a past history of severe fibrotic lung disease was hospitalised with chest pain. Read More

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February 2021

The Relationship Between Selected Load-Velocity Profile Parameters and 50 m Front Crawl Swimming Performance.

Front Physiol 2021 19;12:625411. Epub 2021 Feb 19.

Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.

The purpose of the present study was to establish relationships between sprint front crawl performance and a swimming load-velocity profile. Fourteen male national-level swimmers performed 50 m front crawl and semi-tethered swimming with three progressive loads. The 50 m performance was recorded with a multi-camera system, with which two-dimensional head displacement and the beginning of each arm-stroke motion were quantified. Read More

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February 2021