Acta Biomater 2021 Apr 5. Epub 2021 Apr 5.
Department of Materials, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester, UK.; Manchester Institute of Biotechnology (MIB), The University of Manchester, Manchester, UK.. Electronic address:
Intervertebral disc (IVD) degeneration is a process that starts in the central nucleus pulposus (NP) and leads to inflammation, extracellular matrix (ECM) degradation, and progressive loss of disc height. Early treatment of IVD degeneration is critical to the reduction of low back pain and related disability. As such, minimally invasive therapeutic approaches that can halt and reverse NP degeneration at the early stages of the disease are needed. Read More