16,008 results match your criteria progressive degeneration


[Possibilities and limits of conservative treatment for osteoarthritis : Sport advice, training therapy, orthotics and cartilage therapeutics].

Orthopade 2021 Apr 9. Epub 2021 Apr 9.

Zentrum für Regenerative Medizin, Donau-Universität Krems, Dr. Karl-Dorrek-Straße 30, 3500, Krems, Österreich.

Background: Osteoarthritis (OA)-the progressive degeneration of synovial joints-is a worldwide problem that affects society, is associated with age and is the dominant reason for pain and immobility of the locomotor system. In the population, 70% of people over the age of 70 show some signs of OA. Overall, up to 25% of the total population is affected, due to the general aging of the population itself, and this is an increasing tendency. Read More

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Bioengineered3D model of myotonic dystrophy type 1 human skeletal muscle.

Biofabrication 2021 Apr 9. Epub 2021 Apr 9.

Biosensors for Bioengineering, IBEC, c/ Baldiri Reixac 10-12, Parc Científic de Barcelona (PCB), Edifici Clúster, Barcelona, Barcelona, E08028, SPAIN.

Myotonic dystrophy type 1 (DM1) is the most common hereditary myopathy in the adult population. The disease is characterized by progressive skeletal muscle degeneration that produces severe disability. At present, there is still no effective treatment for DM1 patients, but the breakthroughs in understanding the molecular pathogenic mechanisms in DM1 have allowed the testing of new therapeutic strategies. Read More

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Chronic Demyelination and Axonal Degeneration in Multiple Sclerosis: Pathogenesis and Therapeutic Implications.

Curr Neurol Neurosci Rep 2021 Apr 9;21(6):26. Epub 2021 Apr 9.

Department of Neurology, Oregon Health and Science University, 3181S W Sam Jackson Rd L226, Portland, OR, 97239, USA.

Purpose Of Review: Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). Inflammatory attacks in MS lead to both demyelination and axonal damage. However, due to incomplete remyelination most MS lesions remain chronically demyelinated. Read More

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In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration.

Hum Genet 2021 Apr 9. Epub 2021 Apr 9.

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.

We investigated the clinical, genetic, and pathological characteristics of a previously unknown severe juvenile brain disorder in several litters of Parson Russel Terriers. The disease started with epileptic seizures at 6-12 weeks of age and progressed rapidly to status epilepticus and death or euthanasia. Histopathological changes at autopsy were restricted to the brain. Read More

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Acteoside Counteracts Interleukin-1-Induced Catabolic Processes through the Modulation of Mitogen-Activated Protein Kinases and the NFB Cellular Signaling Pathway.

Oxid Med Cell Longev 2021 24;2021:8684725. Epub 2021 Mar 24.

Institute of Dental Science, Chosun University, Gwangju 61452, Republic of Korea.

Osteoarthritis (OA) is the most common degenerative joint disease with chronic joint pain caused by progressive degeneration of articular cartilage at synovial joints. Acteoside, a caffeoylphenylethanoid glycoside, has various biological activities such as antimicrobial, anti-inflammatory, anticancer, antioxidative, cytoprotective, and neuroprotective effect. Further, oral administration of acteoside at high dosage does not cause genotoxicity. Read More

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The History of Gene Hunting in Hereditary Spinocerebellar Degeneration: Lessons From the Past and Future Perspectives.

Front Genet 2021 23;12:638730. Epub 2021 Mar 23.

Institut du Cerveau, INSERM U1127, CNRS UMR7225, Sorbonne Université, Paris, France.

Hereditary spinocerebellar degeneration (SCD) encompasses an expanding list of rare diseases with a broad clinical and genetic heterogeneity, complicating their diagnosis and management in daily clinical practice. Correct diagnosis is a pillar for precision medicine, a branch of medicine that promises to flourish with the progressive improvements in studying the human genome. Discovering the genes causing novel Mendelian phenotypes contributes to precision medicine by diagnosing subsets of patients with previously undiagnosed conditions, guiding the management of these patients and their families, and enabling the discovery of more causes of Mendelian diseases. Read More

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Multiple concurrent and convergent stages of genome reduction in bacterial symbionts across a stink bug family.

Sci Rep 2021 Apr 8;11(1):7731. Epub 2021 Apr 8.

Department of Evolution, Ecology and Organismal Biology, Ohio State University, 318 W. 12th Avenue, Columbus, OH, 43210, USA.

Nutritional symbioses between bacteria and insects are prevalent and diverse, allowing insects to expand their feeding strategies and niches. A common consequence of long-term associations is a considerable reduction in symbiont genome size likely influenced by the radical shift in selective pressures as a result of the less variable environment within the host. While several of these cases can be found across distinct insect species, most examples provide a limited view of a single or few stages of the process of genome reduction. Read More

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TGF-β3-loaded Graphene Oxide - Self-assembling Peptide Hybrid Hydrogels as Functional 3D Scaffolds for the Regeneration of the Nucleus Pulposus.

Acta Biomater 2021 Apr 5. Epub 2021 Apr 5.

Department of Materials, School of Natural Sciences, Faculty of Science and Engineering, The University of Manchester, Manchester, UK.; Manchester Institute of Biotechnology (MIB), The University of Manchester, Manchester, UK.. Electronic address:

Intervertebral disc (IVD) degeneration is a process that starts in the central nucleus pulposus (NP) and leads to inflammation, extracellular matrix (ECM) degradation, and progressive loss of disc height. Early treatment of IVD degeneration is critical to the reduction of low back pain and related disability. As such, minimally invasive therapeutic approaches that can halt and reverse NP degeneration at the early stages of the disease are needed. Read More

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Tau strains shape disease.

Acta Neuropathol 2021 Apr 8. Epub 2021 Apr 8.

Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Tauopathies consist of over 25 different neurodegenerative diseases that include argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick's disease (PiD). Tauopathies are defined by brain accumulation of microtubule-associated protein tau in fibrillar aggregates, whose prevalence strongly correlates with dementia. Dominant mutations in tau cause neurodegenerative diseases, and most increase its aggregation propensity. Read More

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Functional decline in the aphasic variant of Alzheimer's disease.

Alzheimers Dement 2021 Apr 8. Epub 2021 Apr 8.

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Introduction: Primary progressive aphasia (PPA) is a clinical dementia syndrome associated with frontotemporal lobar degeneration (FTLD) or Alzheimer's disease (AD). Impairment in activities of daily living is essential for dementia diagnosis, yet less is known about the neuropathologic impact on functional decline in PPA, especially over time.

Methods: Activities of Daily Living Questionnaire (ADLQ) ratings were compared by suspected underlying pathology between 17 PPA and 11 PPA participants at 6-month intervals for 2 years using a linear mixed-effects model. Read More

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Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial.

Trials 2021 Apr 7;22(1):255. Epub 2021 Apr 7.

Faculty of Kinesiology and Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, 2500 University Dr. NW, Calgary, Alberta, Canada.

Background: Osteoarthritis (OA) is a chronic and painful condition where the articular cartilage surfaces progressively degenerate, resulting in loss of function and progressive disability. Obesity is a primary risk factor for the development and progression of knee OA, defined as the "metabolic OA" phenotype. Metabolic OA is associated with increased fat deposits that release inflammatory cytokines/adipokines, thereby resulting in systemic inflammation which can contribute to cartilage degeneration. Read More

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Voltage-Gated Calcium Channel Antibody-Induced Oropharyngeal Dysphagia Presenting as a Paraneoplastic Neurological Complication in Breast Cancer.

Cureus 2021 Mar 3;13(3):e13677. Epub 2021 Mar 3.

Hematology/Oncology, Magee Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, USA.

Paraneoplastic neurologic syndromes (PNS) are a group of disorders characterized by an autoimmune response against the nervous system due to cross-reactivity between malignant and normal neural tissue. The most commonly associated malignancies include small cell lung cancer, ovarian cancer, breast cancer, and lymphoma. Multiple PNS have been reported including paraneoplastic cerebellar degeneration, retinopathy, sensorimotor peripheral neuropathy, encephalopathy, opsoclonus-myoclonus syndrome, and stiff-person syndrome. Read More

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Effects of different severities of disc degeneration on the range of motion of cervical spine.

J Craniovertebr Junction Spine 2020 Oct-Dec;11(4):269-275. Epub 2020 Nov 26.

Center for NeuroTrauma Research, Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Aims And Objectives: The human spine degenerates with age. Intervertebral disc degeneration occurs in the cervical spine. The objective of this study is to determine the effects of degenerative disc diseases on the range of motion (ROM) of the human cervical spinal column using a validated finite-element model. Read More

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November 2020

An autopsy-proven case of Corticobasal degeneration heralded by Pontine infarction.

BMC Neurol 2021 Apr 6;21(1):148. Epub 2021 Apr 6.

Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

Background: Neurodegenerative disorders are characterized by insidious progression with poorly-delineated long latent period. Antecedent clinical insult could rarely unmask latent neurodegenerative disorders. Here, we report an autopsy-proven case of corticobasal degeneration which was preceded by a lacunar infarction. Read More

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Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice.

Hum Mol Genet 2021 Apr 5. Epub 2021 Apr 5.

Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by progressive muscular weakness due to the loss of dystrophin. Extracellular Ca2+ flows into the cytoplasm through membrane tears in dystrophin-deficient myofibers, which leads to muscle contracture and necrosis. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) takes up cytosolic Ca2+ into the sarcoplasmic reticulum (SR), but its activity is decreased in dystrophic muscle. Read More

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Protective effect of Actinidia arguta in MPTP-induced Parkinson's disease model mice.

Biochem Biophys Res Commun 2021 Apr 2;555:154-159. Epub 2021 Apr 2.

Graduated School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress-induced neuronal death has been identified as one of the major causes of nigrostriatal degeneration in PD. The fruit of Actinidia arguta (A. Read More

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Cone-Enriched Cultures from the Retina of Chicken Embryos to Study Rod to Cone Cellular Interactions.

J Vis Exp 2021 Mar 20(169). Epub 2021 Mar 20.

Department of Genetics - Sorbonne Université, INSERM, CNRS, Institut de la Vision;

Human daytime vision relies on the function of cone photoreceptors at the center of the retina, the fovea. Patients suffering from the most prevalent form of inherited retinal degeneration, retinitis pigmentosa, lose night vision because of mutation driven loss of rod photoreceptors, a phenomenon followed by a progressive loss of function and death of cones leading to blindness. Geneticists have identified many genes with mutations causing this disease, but the first mutations identified questioned the mechanisms of secondary cone degeneration and how a dominant mutation in the rhodopsin gene encoding for the visual pigment expressed exclusively in rods can trigger cone degeneration. Read More

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Oliver McFarlane syndrome: two new cases and a review of the literature.

Ophthalmic Genet 2021 Apr 5:1-10. Epub 2021 Apr 5.

Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet , Copenhagen, Denmark.

: Oliver McFarlane syndrome is a rare syndrome. Clinical presentations include trichomegaly, chorioretinal degeneration, pituitary hormone deficits, and neurological manifestations. Genetic analysis has recently placed this syndrome within the group of -related disorders. Read More

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Cervical spinal degenerative disease in multiple sclerosis.

Eur J Neurol 2021 Apr 5. Epub 2021 Apr 5.

Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK.

Background And Purpose: Root and cord irritation from cervical spinal degenerative disease may share clinical features with progressive multiple sclerosis (MS), so diagnostic overshadowing may occur. We hypothesized that cervical stenotic spinal degenerative disease is commoner in progressive MS, compared to controls.

Methods: A retrospective case-control study of 111 cases (56 with progressive MS and 55 controls) was conducted. Read More

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Illuminating ALS Motor Neurons With Optogenetics in Zebrafish.

Front Cell Dev Biol 2021 18;9:640414. Epub 2021 Mar 18.

Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Japan.

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of motor neurons in the brain and spinal cord. Spinal motor neurons align along the spinal cord length within the vertebral column, and extend long axons to connect with skeletal muscles covering the body surface. Due to this anatomy, spinal motor neurons are among the most difficult cells to observe . Read More

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The Role of miR-31-5p in the Development of Intervertebral Disc Degeneration and Its Therapeutic Potential.

Front Cell Dev Biol 2021 18;9:633974. Epub 2021 Mar 18.

Department of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, China.

Intervertebral disc degeneration (IDD) refers to the abnormal response of cell-mediated progressive structural failure. In order to understand the molecular mechanism of the maintenance and destruction of the intervertebral disc, new IDD treatment methods are developed. Here, we first analyzed the key regulators of IDD through microRNAs microarrays. Read More

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Targeting non-coding RNAs for the treatment of retinal diseases.

Mol Ther Nucleic Acids 2021 Jun 1;24:284-293. Epub 2021 Mar 1.

Department of Biochemistry, Chonnam National University Medical School, Hwasun 58128, Jeollanam-do, Republic of Korea.

Maintaining visual function is key to establishing improved longevity. However, the numbers of patients with diseases of the retina, the most important tissue for vision and the key to age-related blindness, are not declining due to the increase in the number of aging subjects worldwide and the technological advances in the delivery of premature infants. The primary treatment option for retinal diseases is still surgical intervention and includes laser or photocoagulation, which are associated with various complications and side effects. Read More

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Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction.

Aging Dis 2021 Apr 1;12(2):494-514. Epub 2021 Apr 1.

1Biodonostia, Tissue Engineering Group, Paseo Dr. Begiristain, s/n, San Sebastian 20014, Spain.

Action potential is transmitted to muscle fibers through specialized synaptic interfaces called neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells (tSCs), which play essential roles during formation and maintenance of the NMJ. tSCs are implicated in the correct communication between nerves and muscles, and in reinnervation upon injury. Read More

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Fixel-Based Analysis of White Matter Degeneration in Patients With Progressive Supranuclear Palsy or Multiple System Atrophy, as Compared to Parkinson's Disease.

Front Aging Neurosci 2021 16;13:625874. Epub 2021 Mar 16.

Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan.

White matter degeneration may contribute to clinical symptoms of parkinsonism. We used fixel-based analysis (FBA) to compare the extent and patterns of white matter degeneration in different parkinsonian syndromes-including idiopathic Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). This is a retrospective interpretation of prospectively acquired data of patients recruited in previous studies during 2008 and 2019. Read More

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Metals associated neurodegeneration in Parkinson's disease: Insight to physiological, pathological mechanisms and management.

Neurosci Lett 2021 Apr 1;753:135873. Epub 2021 Apr 1.

Neuroscience Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, 142001, India. Electronic address:

Parkinson's disease (PD) is a deliberately progressive neurological disorder, arises due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The loss of dopaminergic nerves and dopamine deficiency leads to motor symptoms characterized by rigidity, tremor, and bradykinesia. Heavy metals and trace elements play various physiological and pathological roles in the nervous system. Read More

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Contribution of TMS and TMS-EEG to the Understanding of Mechanisms Underlying Physiological Brain Aging.

Brain Sci 2021 Mar 22;11(3). Epub 2021 Mar 22.

Department of Neuroscience, University of Padua, 35122 Padua, Italy.

In the human brain, aging is characterized by progressive neuronal loss, leading to disruption of synapses and to a degree of failure in neurotransmission. However, there is increasing evidence to support the notion that the aged brain has a remarkable ability to reorganize itself, with the aim of preserving its physiological activity. It is important to develop objective markers able to characterize the biological processes underlying brain aging in the intact human, and to distinguish them from brain degeneration associated with many neurological diseases. Read More

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Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.

Cells 2021 Mar 16;10(3). Epub 2021 Mar 16.

Department of Neurology, Faculty of Heath Science, Medical University of Warsaw, 03-285 Warsaw, Poland.

Parkinson's disease (PD), dementia with Lewy body (DLB), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA) belong to a group of neurodegenerative diseases called parkinsonian syndromes. They share several clinical, neuropathological and genetic features. Neurodegenerative diseases are characterized by the progressive dysfunction of specific populations of neurons, determining clinical presentation. Read More

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Dopamine D3 Receptor Plasticity in Parkinson's Disease and L-DOPA-Induced Dyskinesia.

Biomedicines 2021 Mar 19;9(3). Epub 2021 Mar 19.

Department of Psychology, Binghamton University, Binghamton, NY 13902, USA.

Parkinson's Disease (PD) is characterized by primary and secondary plasticity that occurs in response to progressive degeneration and long-term L-DOPA treatment. Some of this plasticity contributes to the detrimental side effects associated with chronic L-DOPA treatment, namely L-DOPA-induced dyskinesia (LID). The dopamine D3 receptor (D3R) has emerged as a promising target in LID management as it is upregulated in LID. Read More

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Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degenerations: Similarities in Genetic Background.

Diagnostics (Basel) 2021 Mar 13;11(3). Epub 2021 Mar 13.

Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer University Hospital, 14059 Prague, Czech Republic.

Amyotrophic lateral sclerosis (ALS) is a devastating, uniformly lethal progressive degenerative disorder of motor neurons that overlaps with frontotemporal lobar degeneration (FTLD) clinically, morphologically, and genetically. Although many distinct mutations in various genes are known to cause amyotrophic lateral sclerosis, it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neuronal degeneration. Many of the gene mutations are in proteins that share similar functions. Read More

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Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models.

Cells 2021 Mar 20;10(3). Epub 2021 Mar 20.

Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy.

Microglia, besides being able to react rapidly to a wide range of environmental changes, are also involved in shaping neuronal wiring. Indeed, they actively participate in the modulation of neuronal function by regulating the elimination (or "pruning") of weaker synapses in both physiologic and pathologic processes. Mounting evidence supports their crucial role in early synaptic loss, which is emerging as a hallmark of several neurodegenerative diseases, including multiple sclerosis (MS) and its preclinical models. Read More

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