18,620 results match your criteria progression eye

Retinopathy of prematurity screening and risk mitigation during the COVID-19 pandemic.

J AAPOS 2021 Apr 18. Epub 2021 Apr 18.

Boston Children's Hospital, Boston, Massachusetts;; Harvard Medical School, Boston, Massachusetts.

Background: The coronavirus disease 2019 (COVID-19) pandemic has significantly disrupted the delivery of healthcare. Although most nonurgent ophthalmology visits at Boston Children's Hospital were canceled, premature infants at risk for retinopathy of prematurity (ROP) still required timely, in-person care during the initial 3-month period of the infection surge in Massachusetts. The purpose of the current study was to report our protocols for mitigating risk of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between infants and eye care providers and to compare examination rates and results with the same 3-month period in 2019. Read More

View Article and Full-Text PDF

Wnt/β-catenin Antagonists: Exploring New Avenues to Trigger Old Drugs in Alleviating Glioblastoma Multiforme.

Curr Mol Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

Central Inter-Disciplinary Research Facility, School of Biological Sciences, Sri Balaji Vidyapeeth (Deemed to-be University), Puducherry, India.

Background: Glioblastoma multiforme is one of the most heterogenous primary brain tumor with high mortality. Nevertheless, of the current therapeutic approaches, survival rate remains poor with 12 to 15 months following preliminary diagnosis, this warrants the need for effective treatment modality. Wnt/β-catenin pathway is presumably the most noteworthy pathway up-regulated in almost 80% GBM cases contributing to tumor-initiation, progression and survival. Read More

View Article and Full-Text PDF

Predictors of Vision-Related Quality of Life After Endothelial Keratoplasty in the Descemet Endothelial Thickness Comparison Trials.

Cornea 2021 Apr;40(4):449-452

*F. I. Proctor Foundation, University of California, San Francisco, CA; †Casey Eye Institute, Oregon Health Sciences University, Portland, OR; ‡Byers Eye Institute, Stanford University, Palo Alto, CA; §Lions VisionGift, Portland, OR; ¶Department of Ophthalmology, University of California, San Francisco, CA; ‖Department of Epidemiology and Biostatistics, University of California, San Francisco, CA; and **Department of Research, Kaiser Permanente Northern California.

Purpose: To determine which baseline characteristics are associated with vision-related quality of life (QOL) after endothelial keratoplasty.

Methods: A patient- and outcome-masked randomized clinical trial. Consecutive patients presenting with isolated endothelial disease requiring endothelial keratoplasty at Oregon Health Sciences University and Stanford University. Read More

View Article and Full-Text PDF

Measuring optic nerve head perfusion to monitor glaucoma: a study on structure-function relationships using laser speckle flowgraphy.

Acta Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

Purpose: We aimed to describe the global and localized correlations among visual field (VF) sensitivity, optic nerve head (ONH) perfusion measured by laser speckle flowgraphy (LSFG) and neural structure measured by optical coherence tomography (OCT) in open-angle glaucoma (OAG) and to compare the floor effect for LSFG and OCT.

Methods: Cross-sectional, multicenter study including one eye each from fifty OAG patients (mean age 69.3 years; average VF mean deviation, MD, -8. Read More

View Article and Full-Text PDF

Mitochondrial quality control protects photoreceptors against oxidative stress in the HO-induced models of retinal degeneration diseases.

Cell Death Dis 2021 Apr 20;12(5):413. Epub 2021 Apr 20.

Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Retinal degeneration diseases (RDDs) are common and devastating eye diseases characterized by the degeneration of photoreceptors, which are highly associated with oxidative stress. Previous studies reported that mitochondrial dysfunction is associated with various neurodegenerative diseases. However, the role of mitochondrial proteostasis mainly regulated by mitophagy and mitochondrial unfolded protein response (mtUPR) in RDDs is unclear. Read More

View Article and Full-Text PDF

Natural immunoglobulin M-based delivery of a complement alternative pathway inhibitor in mouse models of retinal degeneration.

Exp Eye Res 2021 Apr 17:108583. Epub 2021 Apr 17.

Departments of Ophthalmology, USA; Ralph H. Johnson VA Medical Center, Division of Research, Charleston, SC, USA; Neurosciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

Purpose: Age-related macular degeneration is a slowly progressing disease. Studies have tied disease risk to an overactive complement system. We have previously demonstrated that pathology in two mouse models, the choroidal neovascularization (CNV) model and the smoke-induced ocular pathology (SIOP) model, can be reduced by specifically inhibiting the alternative complement pathway (AP). Read More

View Article and Full-Text PDF

Coadministration With Carbidopa Enhances the Antimyopic Effects of Levodopa in Chickens.

Invest Ophthalmol Vis Sci 2021 Apr;62(4):25

Centre for Research in Therapeutic Solutions, Faculty of Science and Technology, University of Canberra, Canberra, Australia.

Purpose: Topical application of levodopa inhibits the development of form-deprivation myopia (FDM) and lens-induced myopia (LIM) in chicks. Here we examine whether coadministration with carbidopa enhances this protection and compare the effectiveness of topical versus systemic administration. We also investigate the degree to which topical and systemic administration of these compounds alters retinal dopamine release and examine whether this is the mechanism by which they inhibit experimental myopia. Read More

View Article and Full-Text PDF

Androgen receptor activation decreases proliferation in thyroid cancer cells.

J Cell Biochem 2021 Apr 20. Epub 2021 Apr 20.

Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.

The American Cancer Society predicted more than 52 000 new cases of thyroid cancer in 2020, making it the most prevalent endocrine malignancy. Due to the approximately threefold higher incidence of thyroid cancer in women, we hypothesize that androgens and/or androgen receptors play a protective role and that thyroid cancer in men represents an escape from androgen-mediated cell regulation. The analysis of androgen receptor (AR) expression in patient tissue samples identified a 2. Read More

View Article and Full-Text PDF

Review on current concepts of myopia and its control strategies.

Int J Ophthalmol 2021 18;14(4):606-615. Epub 2021 Apr 18.

Nepal Eye Hospital, Kathmandu 44600, Nepal.

Myopia poses a significant burden on the healthcare system, economy and quality of life. It is an emerging global public health challenge and requires interventions to delay or stop onset and progression. With changing times and evidence, the concepts of myopia are changing along with the treatment and control strategies. Read More

View Article and Full-Text PDF

Evaluating the long-term efficacy and effectiveness of Viscocanalostomy and combined phacoemulsification with Viscocanalostomy in the treatment of patients with uveitic glaucoma: 5-year follow up data.

BMC Surg 2021 Apr 19;21(1):200. Epub 2021 Apr 19.

Stanley Eye Unit, Abergele Hospital, Llanfair Road, Abergele, Conwy, Wales, UK.

Background: Uveitic glaucoma commonly leads to a more intense optic nerve damage than other types of glaucoma, causing glaucomatous optic nerves and visual field defects. Anterior uveitis is the most commonly associated risk factor. Surgical intervention is usually indicated when all medical treatment has failed. Read More

View Article and Full-Text PDF

[Crosslinking and Keratoconus].

Klin Monbl Augenheilkd 2021 Apr 19. Epub 2021 Apr 19.

Keratoconus leads to a progressive protrusion and thinning of the cornea. In order to stop this, corneal crosslinking can be performed if the progression of the disease is proven. Crosslinking according to the "Dresden protocol" includes abrasion of the corneal epithelium, application of riboflavin eye drops and irradiation with UV-A light of an intensity of 3 mW/cm² for 30 minutes. Read More

View Article and Full-Text PDF

Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload.

Mol Metab 2021 Apr 16:101235. Epub 2021 Apr 16.

Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg, Germany. Electronic address:

Objective: The molecular pathogenesis of late complications associated with type 2 diabetes mellitus (T2DM) is not yet fully understood. While high glucose levels indicated by increased HbA1c only poorly explain disease progression and late complications, a pro-inflammatory status, oxidative stress and reactive metabolites generated by metabolic processes were postulated to be involved. Individuals with metabolic syndrome (MetS) frequently progress to T2DM, whereby 70% of T2DM patients show non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of MetS, and insulin resistance (IR). Read More

View Article and Full-Text PDF

Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.

Neurochem Res 2021 Apr 19. Epub 2021 Apr 19.

Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Alzheimer's disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. Read More

View Article and Full-Text PDF

Cognitive Performance of Patients With Multiple Sclerosis and Optic Neuritis at Presentation.

J Neuroophthalmol 2021 Apr 14. Epub 2021 Apr 14.

Goldschleger Eye Institute (AL, OS, AS, RH-B), Sheba Medical Center, Tel-Hashomer, Israel; Department of Behavioral Sciences and Psychology (RA), Ariel University, Ariel, Israel; Multiple Sclerosis Center (RA, AA), Sheba Medical Center, Tel Hashomer, Israel; and Sackler Faculty of Medicine (RA, AA, AL, OS, AS, RH-B), Tel Aviv University, Tel Aviv, Israel.

Background: Cognitive dysfunction is common among patients with multiple sclerosis (MS), but the effect of coexisting optic neuritis (ON) at the first presentation of multiple sclerosis on the course of cognitive decline is unknown. The purpose of this study was to assess whether ON at presentation has any effect on the progression of cognitive decline in MS.

Methods: Historical cohort study. Read More

View Article and Full-Text PDF

Disruption of ingrown epithelium via Nd:YAG laser or DIEYAG. A retrospective case series of Post-LASIK patients.

Am J Ophthalmol Case Rep 2021 Jun 23;22:101071. Epub 2021 Mar 23.

Michigan State University, Department of Neurology and Ophthalmology, 804 Service Rd, East Lansing, 48824, MI, USA.

Purpose: To describe in detail the technique used and results of disruption of ingrown epithelium via Nd:YAG laser (DIEYAG) after LASIK treatment and enhancement.

Observations: Epithelial ingrowth following laser in situ keratomileusis (LASIK) enhancement has the potential to cause significant refractive error and discomfort when allowed to progress. This retrospective case series following seven eyes after LASIK enhancement and one eye with flap trauma, assessed the effectiveness and safety of the disruption of ingrown epithelium via Nd:YAG laser. Read More

View Article and Full-Text PDF

MAFG-driven osteosarcoma cell progression is inhibited by a novel miRNA miR-4660.

Mol Ther Nucleic Acids 2021 Jun 13;24:385-402. Epub 2021 Mar 13.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China.

Osteosarcoma (OS) is the most common primary bone malignancy in the adolescent population. MAFG (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) forms a heterodimer with Nrf2 (NF-E2-related factor 2), binding to antioxidant response element (ARE), which is required for Nrf2 signaling activation. We found that mRNA and protein expression is significantly elevated in human OS tissues as well as in established and primary human OS cells. Read More

View Article and Full-Text PDF

Rapid growth of primary uveal melanoma following intravitreal bevacizumab injection: a case report and review of the literature.

Digit J Ophthalmol 2021 Feb 3;26(3):27-30. Epub 2020 Jul 3.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alberta, Canada.

Uveal melanoma size is a significant predictor of tumor metastasis. Although the relationship between antivascular endothelial growth factors (VEGF) and uveal melanoma growth has been studied, results are paradoxical, and the relationship remains controversial. We report the case of a 65-year-old man who presented with elevated intraocular pressure in his right eye, neovascularization of his iris, and significant corneal edema, which obscured the view of the angle. Read More

View Article and Full-Text PDF
February 2021

Acquired Optic Pits Associated with Laser-assisted Keratomileusis: A Case Series.

J Curr Glaucoma Pract 2020 Sep-Dec;14(3):106-108

Department of Ophthalmology, University of California, Gavin Herbert Eye Institute, Irvine, California, USA; University of California, Irvine School of Medicine, Irvine, California, USA.

Purpose: To present an association between acquired pits of the optic nerve (APON) and prior laser-assisted keratomileusis (LASIK).

Materials And Methods: A retrospective case series of patients with an optic disc pit on clinical exam and a history of LASIK. Spectralis Optical Coherence Tomography images and Humphrey Visual Fields were reviewed from prior visits. Read More

View Article and Full-Text PDF

Detecting Progression in Patients with Different Clinical Presentations of Primary Open-angle Glaucoma.

J Glaucoma 2021 Apr 12. Epub 2021 Apr 12.

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, AL 35233, USA Computational Optometry, Atarfe, Spain.

Prcis: Glaucoma progression was more frequently identified by assessing retinal fiber layer thickness than by monitoring visual field loss for different baseline classifications in primary open-angle glaucoma.

Purpose: To compare the detection of glaucoma progression by retinal nerve fiber layer thickness (RNFLT) and visual field (VF) assessments for different baseline classifications of primary open-angle glaucoma (POAG).

Methods: This study included 194 eyes from 194 patients with a minimum of 9 follow-up visits selected from the Diagnostic Innovation in Glaucoma Study and the African Descent and Glaucoma Evaluation Study. Read More

View Article and Full-Text PDF

Current Status of Familial LCAT Deficiency in Japan.

J Atheroscler Thromb 2021 Apr 18. Epub 2021 Apr 18.

Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute.

Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin. Familial LCAT deficiency is an intractable autosomal recessive disorder caused by inherited dysfunction of the LCAT enzyme. The disease appears in two different phenotypes depending on the position of the gene mutation: familial LCAT deficiency (FLD, OMIM 245900) that lacks esterification activity on both HDL and ApoB-containing lipoproteins, and fish-eye disease (FED, OMIM 136120) that lacks activity only on HDL. Read More

View Article and Full-Text PDF

Plumage development and environmental factors influence surface temperature gradients and heat loss in wandering albatross chicks.

J Therm Biol 2021 Apr 6;97:102777. Epub 2020 Nov 6.

Scottish Centre for Ecology and the Natural Environment, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Rowardennan, G63 OAW, UK.

Young birds in cold environments face a range of age-specific thermal challenges. Studying the thermal biology of young birds throughout ontogeny may further our understanding of how such challenges are met. We investigated how age and environmental parameters influenced surface temperature gradients across various body regions of wandering albatross (Diomedea exulans) chicks on Bird Island, South Georgia. Read More

View Article and Full-Text PDF

Predicting eyes at risk for rapid glaucoma progression based on an initial visual field test using machine learning.

PLoS One 2021 16;16(4):e0249856. Epub 2021 Apr 16.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

Objective: To assess whether machine learning algorithms (MLA) can predict eyes that will undergo rapid glaucoma progression based on an initial visual field (VF) test.

Design: Retrospective analysis of longitudinal data.

Subjects: 175,786 VFs (22,925 initial VFs) from 14,217 patients who completed ≥5 reliable VFs at academic glaucoma centers were included. Read More

View Article and Full-Text PDF

Fulminant Hepatic Failure after Chemosaturation with Percutaneous Hepatic Perfusion and Nivolumab in a Patient with Metastatic Uveal Melanoma.

Case Rep Oncol Med 2021 29;2021:8870334. Epub 2021 Mar 29.

Texas Oncology, Austin, Texas, USA.

Immune checkpoint inhibitors, such as nivolumab, a programmed death receptor-1 (PD-1) inhibitor, have dramatically improved the treatment of advanced melanomas. Chemosaturation with percutaneous hepatic perfusion (PHP) delivers chemotherapy in high doses directly to the liver and is a potentially effective treatment modality in metastatic uveal melanoma with liver metastases. Its safety and effectiveness have not been studied in patients also receiving immunotherapy. Read More

View Article and Full-Text PDF

Relationship between Myopia Progression and School Entrance Age: A 2.5-Year Longitudinal Study.

J Ophthalmol 2021 30;2021:7430576. Epub 2021 Mar 30.

The Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: To investigate the association between myopia progression and school entrance age among Chinese schoolchildren and to suggest a more appropriate school age.

Methods: 1,463 children aged six to nine years from Wenzhou, China, were examined and followed up for two and a half consecutive years. Their noncycloplegic refraction was measured twice each year by using an automatic refractometer; axial length (AL) and corneal radius of curvature (CRC) were tested annually by using the IOLMaster for 2. Read More

View Article and Full-Text PDF

Outcomes After Corneal Crosslinking for Keratoconus in Children and Young Adults.

Cornea 2021 Apr 14. Epub 2021 Apr 14.

Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA.

Purpose: The aim of this study was to assess the effect of corneal crosslinking on vision and keratometry in children and young adults with progressive keratoconus.

Methods: A retrospective medical records review of patients aged 22 years or younger with keratoconus who underwent corneal crosslinking between January 2013 and November 2019 at Byers Eye Institute at Stanford University was conducted. Outcome measures included logarithm of the Minimum Angle of Resolution corrected distance visual acuity (CDVA); keratometry, including maximum keratometry (Kmax); pachymetry; and total wavefront aberration. Read More

View Article and Full-Text PDF

Aggressive progression of a facial super giant basal cell carcinoma.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Internal Medicine, Jackson Memorial Hospital, Miami, Florida, USA

Super giant basal cell carcinoma (BCC) is a rare oncological entity. A 52-year-old man with a history of a left upper facial lesion for 11 years was transferred to our facility seeking an evaluation. He frequented multiple hospitals where he was treated with antibiotics for this condition. Read More

View Article and Full-Text PDF

Keratoconus in a child with partial trisomy 13.

Ophthalmic Genet 2021 Apr 16:1-4. Epub 2021 Apr 16.

UPMC Eye Center, Pittsburgh, Pennsylvania, USA.

Clinical studies suggest the importance of genetic components in the etiology of keratoconus. However, the contributing genes and variants remain elusive. We present a case of bilateral keratoconus in a child with partial trisomy 13, with a trisomic region spanning loci that have been associated with keratoconus. Read More

View Article and Full-Text PDF

[Clinical observation and analysis on the effect of orthokeratology in myopic anisometropic children].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Apr;55(4):471-477

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University/Beijing Institute of Ophthalmology/Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China.

To evaluate the clinical effects of orthokeratology lens on children with myopic anisometropia. Retrospective case series study. The data of 226 myopic anisometropia children, (10. Read More

View Article and Full-Text PDF

COVID-19 Quarantine Reveals Behavioral Changes Effect on Myopia Progression.

Ophthalmology 2021 Apr 12. Epub 2021 Apr 12.

School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, 325027, China.

COVID-19 quarantine provides the largest intervention data of myopia progression in schoolchildren. We found grade is an important risk factor, and COVID-19-induced modifications of student's online time and outdoor activity time sufficiently change myopia progression. Read More

View Article and Full-Text PDF

Speech biomarkers in rapid eye movement sleep behaviour disorder and Parkinson's disease.

Ann Neurol 2021 Apr 15. Epub 2021 Apr 15.

Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

Objective: This multi-language study employed simple speech recording and high-end pattern analysis to provide sensitive and reliable non-invasive biomarkers of prodromal vs. manifest alpha-synucleinopathy in patients with idiopathic rapid eye movement sleep behaviour disorder (iRBD) and early-stage Parkinson's disease (PD).

Methods: We performed a multicentre study across the Czech, English, German, French and Italian languages at seven centres in Europe and North America. Read More

View Article and Full-Text PDF