691,475 results match your criteria progression


[Addicted During Pandemic? - COVID-19 and Addictive Disorders].

Gesundheitswesen 2021 Sep 24. Epub 2021 Sep 24.

Bay. Zentrum für Prävention und Gesundheitsförderung, LGL, Bad Kissingen, Deutschland.

Aim: To describe changes in consumer behavior, particularly in Germany, and the population groups affected due to in-creased substance use or are at greater risk of being infected by SARS-CoV-2 and are also in danger of suffering from a more severe course of disease.

Methods: The literature search used databases from PubMed and PubPsych, along with expert opinions.

Results: A slight increase in daily use of alcohol and tobacco was seen, whereas the consumption of illegal drugs decreased in European countries. Read More

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September 2021

Prediction of diabetic foot ulcer progression: a computational study.

Biomed Phys Eng Express 2021 Sep 24. Epub 2021 Sep 24.

Biomedical Engineering, IIT Delhi, IIT Delhi, Hauz Khas, New Delhi, New Delhi, 110016, INDIA.

The development of foot ulcers is a common consequence of severe diabetes. Due to vascular disorders and impeded healing caused by the disease, most foot ulcers have been reported to be affected by body weight and progress with time. Also, abnormal distribution of plantar pressures has been observed to cause the formation of additional ulcers, which may collectively lead to traumatic amputations. Read More

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September 2021

Dynamic lung compliance imaging from 4DCT-derived volume change estimation.

Phys Med Biol 2021 Sep 24. Epub 2021 Sep 24.

Department of Radiation Oncology, Beaumont Health Research Institute, 3601 W. Thirteen Mile Road, Royal Oak, Michigan, 48073, UNITED STATES.

Background: Lung compliance is the ability of the lung to expand with changes in pressure and is one of the earliest physiological measurements to be altered in patients with parenchymal lung disease. Therefore, compliance monitoring could potentially identify patients at risk for disease progression. However, in clinical practice, compliance measurements are prohibitively invasive for use as a routine monitoring tool. Read More

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September 2021

Nesfatin-1 facilitates IL-1β production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-κB pathways.

Aging (Albany NY) 2021 Sep 24;13(undefined). Epub 2021 Sep 24.

Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan.

The progression of osteoarthritis (OA) is mediated by adipokines, one of which is nesfatin-1, which is responsible for the production of inflammatory cytokines. However, how this molecule may affect the synthesis of the proinflammatory cytokine interleukin 1 beta (IL-1β) in OA is unclear. Our analyses of records from the Gene Expression Omnibus (GEO) dataset and clinical specimens of synovial tissue revealed higher levels of nesfatin-1 and IL-1β in OA samples compared with normal healthy tissue. Read More

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September 2021

Clinical and radiologic outcomes after stereotactic radiosurgery for meningiomas in direct contact with the optic apparatus: an international multicenter study.

J Neurosurg 2021 Sep 24:1-7. Epub 2021 Sep 24.

17Department of Radiation Oncology, University of Southern California, Los Angeles, California.

Objective: Resection of meningiomas in direct contact with the anterior optic apparatus carries risk of injury to the visual pathway. Stereotactic radiosurgery (SRS) offers a minimally invasive alternative. However, its use is limited owing to the risk of radiation-induced optic neuropathy. Read More

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September 2021

Preoperative pelvic obliquity: possible relation to postoperative coronal decompensation in thoracolumbar/lumbar adolescent idiopathic scoliosis.

J Neurosurg Spine 2021 Sep 24:1-10. Epub 2021 Sep 24.

1Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka.

Objective: Pelvic obliquity is frequently observed in patients with adolescent idiopathic scoliosis with thoracolumbar/lumbar (TL/L) curve. This study aimed to assess pelvic obliquity changes and their effects on clinical outcomes of posterior fusion surgery.

Methods: Data in 80 patients (69 with type 5C and 11 with type 6C adolescent idiopathic scoliosis) who underwent posterior fusion surgery were retrospectively analyzed. Read More

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September 2021

Predicting the herbal medicine triggering innate anti-tumor immunity from a system pharmacology perspective.

Biomed Pharmacother 2021 Sep 21;143:112105. Epub 2021 Sep 21.

Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi'an, China; Lab of Systems Pharmacology, Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, China. Electronic address:

Although the main focus of immuno-oncology has been manipulating the adaptive immune system, tumor associated macrophages (TAMs) are the main infiltrating component in the tumor microenvironment (TME) and play a critical role in cancer progression. TAMs are mainly divided into two different subtypes: macrophages with antitumor or killing activity are called M1 while tumor-promoting or healing macrophages are named M2. Therefore, controlling the polarization of TAMs is an important strategy for cancer treatment, but there is no particularly effective means to regulate the polarization process. Read More

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September 2021

Regulatory interplay between microRNAs and WNT pathway in glioma.

Biomed Pharmacother 2021 Sep 21;143:112187. Epub 2021 Sep 21.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Glioma is one of the most common neoplasms of the central nervous system with a poor survival. Due to the obstacles in treating this disease, a part of recent studies mainly focuses on identifying the underlying molecular mechanisms that contribute to its malignancy. Altering microRNAs (miRNAs) expression pattern has been identified obviously in many cancers. Read More

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September 2021

Sphk1 promotes salivary adenoid cystic carcinoma progression via PI3K/Akt signaling.

Pathol Res Pract 2021 Sep 16;227:153620. Epub 2021 Sep 16.

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Depatment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address:

The progression of salivary adenoid cystic carcinoma (SACC) is closely related to abnormal gene expression. Herein, the role of Sphk1 in SACC was explored. Sphk1 was overexpressed in SACC tissues. Read More

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September 2021

Tumor-associated macrophages modulate angiogenesis and tumor growth in a xenograft mouse model of multiple myeloma.

Leuk Res 2021 Sep 20;110:106709. Epub 2021 Sep 20.

Department of Pathology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Dong Road, Zhengzhou, 450052, Henan, People's Republic of China; Henan Province Key Laboratory of Tumor Pathology, Department of Pathology of The First Affiliated Hospital of Zhengzhou University, No. 40 Daxue Road, Zhengzhou, 450003, Henan, People's Republic of China. Electronic address:

Tumor-associated macrophages (TAMs) are closely associated with poor multiple myeloma (MM) prognosis. Therefore, in-depth understanding of the mechanism by which TAM supports MM progression may lead to its effective treatment. We used the MM nude mouse subcutaneous xenograft model to evaluate the efficacy of the macrophage-depleting agent clodronate liposome (Clo) against MM and elucidate the mode of action of this therapy. Read More

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September 2021

The impact of MDSCs on the efficacy of preventive and therapeutic HIV vaccines.

Cell Immunol 2021 Sep 10;369:104440. Epub 2021 Sep 10.

Department of Biotechnology and Genetic Engineering, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid 22110, Jordan.

In spite of four decades of research on human immunodeficiency virus (HIV), the virus remains a major health problem, affecting tens of millions of people around the world. As such, developing an effective preventive/protective and therapeutic vaccines against HIV are essential to prevent/limit the continuous spread of the virus as well as to control the disease progression and to completely eradicate the virus from HIV infected patients, respectively. There are several factors that have impeded the development of such vaccines, and we need to gain further insight into these factors in order to enhance our knowledge concerning the proper immune activation pathways in the hope of accelerating the development of the highly sought-after vaccine. Read More

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September 2021

Inhibition of extracellular regulated kinase (ERK)-1/2 signaling pathway in the prevention of ALS: Target inhibitors and influences on neurological dysfunctions.

Eur J Cell Biol 2021 Sep 17;100(7-8):151179. Epub 2021 Sep 17.

Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India. Electronic address:

Cell signal transduction pathways are essential modulators of several physiological and pathological processes in the brain. During overactivation, these signaling processes may lead to disease progression. Abnormal protein kinase activation is associated with several biological dysfunctions that facilitate neurodegeneration under different biological conditions. Read More

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September 2021

Neurotensin regulates proliferation and stem cell function in the small intestine in a nutrient-dependent manner.

Cell Mol Gastroenterol Hepatol 2021 Sep 21. Epub 2021 Sep 21.

Markey Cancer Center, University of Kentucky, Lexington, KY 40536; Department of Surgery, University of Kentucky, Lexington, KY 40536. Electronic address:

Background & Aims: Intestinal stem cells (ISCs) are sensitive to dietary alterations and nutrient availability. Neurotensin (NT), a gut peptide localized predominantly to the small bowel and released by fat ingestion, stimulates the growth of intestinal mucosa under basal conditions and during periods of nutrient deprivation, suggesting a possible role for NT on ISC function.

Methods: Lgr5-EGFP, NT wild type (Nt) and Lgr5-EGFP, NT knockout (Nt) mice were fed ad libitum (AL) or fasted for 48 h. Read More

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September 2021

The Impact of Insurance Provider on Postoperative Hospital Length of Stay Following Spine Surgery.

World Neurosurg 2021 Sep 21. Epub 2021 Sep 21.

UT Southwestern, Department of Neurological Surgery; UT Southwestern, Department of Orthopedic Surgery.

Objective: Differences in insurer and payer status have been shown to increase patient hospital LOS by delaying the approval of transfer to a rehabilitation facility. The aim of the current study is to determine the impact of the type of insurance provider on postoperative hospital length of stay (LOS) after spine surgery.

Methods: In our single institution retrospective study, all patients undergoing elective spine surgery between August 2018 and August 2019 as part of an Enhanced Recovery After Surgery (ERAS) protocol were enrolled into a prospectively collected registry. Read More

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September 2021

A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults.

Clin Immunol 2021 Sep 21:108857. Epub 2021 Sep 21.

Section of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

Aging can alter immunity affecting host defense. COVID-19 has the most devastating clinical outcomes in older adults, raising the implication of immune aging in determining its severity and mortality. We investigated biological predictors for clinical outcomes in a dataset of 13,642 ambulatory and hospitalized adult COVID-19 patients, including younger (age < 65, n = 566) and older (age ≥ 65, n = 717) subjects, with in-depth analyses of inflammatory molecules, cytokines and comorbidities. Read More

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September 2021

TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors.

Pharmacol Res 2021 Sep 21:105911. Epub 2021 Sep 21.

Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Brazil. Electronic address:

In melanomas, therapy resistance can arise due to a combination of genetic, epigenetic and phenotypic mechanisms. Due to its crucial role in DNA supercoil relaxation, TOP1 is often considered an essential chemotherapeutic target in cancer. However, how TOP1 expression and activity might differ in therapy sensitive versus resistant cell types is unknown. Read More

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September 2021

A ROS-responsive fluorescent probe detecting experimental colitis by functional polymeric nanoparticles.

Int J Pharm 2021 Sep 21:121125. Epub 2021 Sep 21.

Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China; Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China; Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Current evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of inflammatory bowel disease (IBD). TotalROX (λabs/λem = 425/525 nm) is a ratiometric probe with high detection sensitivity and a superior capacity to monitor total cellular oxidative capacity. Herein, we investigated the potential of combining totalROX with an oral nanoparticle delivery system to detect the degree of colitis. Read More

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September 2021

Contribution of CXCR3-mediated signaling in the metastatic cascade of solid malignancies.

Biochim Biophys Acta Rev Cancer 2021 Sep 21:188628. Epub 2021 Sep 21.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, United States of America. Electronic address:

Metastasis is a significant cause of the mortality resulting from solid malignancies. The process of metastasis is complex and is regulated by numerous cancer cell-intrinsic and -extrinsic factors. CXCR3 is a chemokine receptor that is frequently expressed by cancer cells, endothelial cells and immune cells. Read More

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September 2021

Kidney disease in diabetes: from mechanisms to clinical presentation and treatment strategies.

Metabolism 2021 Sep 21:154890. Epub 2021 Sep 21.

School of Cardiovascular Medicine & Science, King's College London, London, UK. Electronic address:

Metabolic and haemodynamic perturbations and their interaction drive the development of diabetic kidney disease (DKD) and its progression towards end stage renal disease (ESRD). Increased mitochondrial oxidative stress has been proposed as the central mechanism in the pathophysiology of DKD, but other mechanisms have been implicated. In parallel to increased oxidative stress, inflammation, cell apoptosis and tissue fibrosis drive the relentless progressive loss of kidney function affecting both the glomerular filtration barrier and the renal tubulointestitium. Read More

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September 2021

Simultaneous analyses of urinary eicosanoids and related mediators identified tetranor-prostaglandin E metabolite as a novel biomarker of diabetic nephropathy.

J Lipid Res 2021 Sep 21:100120. Epub 2021 Sep 21.

Department of Clinical Laboratory, University of Tokyo Hospital, Tokyo, Japan; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Diabetic nephropathy is a major complication of diabetes mellitus, and thus novel biomarkers are desired to evaluate the presence and progression of diabetic nephropathy. In this study, we sought to identify possible metabolites related to diabetic nephropathy among urinary eicosanoids and related mediators. Using liquid chromatogram-tandem mass spectrometry, we optimized the lipid extraction from urine using the Monospin C18 as a solid-phase extraction cartridge, and measured the urinary lipid mediators in 111 subjects with type 2 diabetes mellitus as well as 33 heathy subjects. Read More

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September 2021

Estrogen receptor gets a grip on RNA.

Cell 2021 Sep 18. Epub 2021 Sep 18.

Departments of Molecular and Integrative Physiology and Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:

The nuclear hormone receptor estrogen receptor alpha (ERα) is a well-known transcription factor present in many breast cancers, where it promotes cancer progression. In this issue of Cell, Xu et al. report that ERα is also an RNA-binding protein and that its post-transcriptional activity enables cancer cell fitness and survival. Read More

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September 2021

ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance.

Cell 2021 Sep 18. Epub 2021 Sep 18.

Department of Urology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

Estrogen receptor α (ERα) is a hormone receptor and key driver for over 70% of breast cancers that has been studied for decades as a transcription factor. Unexpectedly, we discover that ERα is a potent non-canonical RNA-binding protein. We show that ERα RNA binding function is uncoupled from its activity to bind DNA and critical for breast cancer progression. Read More

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September 2021

Downregulation of acylglycerol kinase suppresses high glucose-induced endothelial-mesenchymal transition in HRECs through regulating the LPAR1/TGF-β/Notch signaling pathway.

Can J Physiol Pharmacol 2021 Sep 24. Epub 2021 Sep 24.

First Affiliated Hospital of Harbin Medical University, 74559, Harbin, Heilongjiang, China;

The endothelial-mesenchymal transition (EndMT) participates in the progression of diabetic retinopathy (DR), but cell-intrinsic factors modulating this process remain elusive. In this study, we explored the role of lysophosphatidic acid (LPA)-producing enzyme, acylglycerol kinase (AGK) in the EndMT of human retinal microvascular endothelial cells (HRECs) under high glucose (HG) conditions. We found that AGK was significantly elevated in HG-treated cells. Read More

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September 2021

LINC00662 facilitates osteosarcoma progression via sponging miR-103a-3p and regulating SIK2 expression.

J Tissue Eng Regen Med 2021 Sep 24. Epub 2021 Sep 24.

Shengli Clinical Medical College of Fujian Medical University, Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, Fujian, China, Fuzhou, 350001, Fujian, China.

Aims: Long non-coding RNA (lncRNA) involvement in regulating assorted cancers has been determined. Long intergenic non-protein coding RNA 662 (LINC00662) has been studied in gastric cancer. However, its function was not elucidated in osteosarcoma (OS). Read More

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September 2021

Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.

IUBMB Life 2021 Sep 24. Epub 2021 Sep 24.

School of Life and Pharmaceutical Sciences, Dalian University of Technology.

Abnormal sialylation is a distinctive feature of human hepatocellular carcinoma (HCC) and is closely related to its malignant properties. Exosomes have characteristic protein and lipid composition, however, the results concerning glycoprotein composition and glycosylation are scarce. In this study, LC-MS/MS identified multiple microvesicle-related sialylated proteins including CD63, a classic marker of exosomes. Read More

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September 2021

A phase I/II study of ixazomib, pomalidomide and dexamethasone for lenalidomide and proteasome inhibitor refractory multiple myeloma. (Alliance A061202).

Am J Hematol 2021 Sep 24. Epub 2021 Sep 24.

Division of Hematology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.

Preclinical studies demonstrated activity of the oral proteasome inhibitor (PI) ixazomib (IXA) in bortezomib-resistant multiple myeloma (MM) and synergy with immunomodulatory drugs. We therefore conducted a phase I/II study to establish the safety and preliminary efficacy of IXA with pomalidomide (POM) and dexamethasone (DEX) in lenalidomide (LEN)/PI-refractory MM. Dose escalation established a 4 mg dose of POM and IXA and 20/40 mg dose of DEX as the maximum tolerated dose. Read More

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September 2021

Somatostatin analog therapy effectiveness on the progression of polycystic kidney and liver disease: A systematic review and meta-analysis of randomized clinical trials.

PLoS One 2021 24;16(9):e0257606. Epub 2021 Sep 24.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States of America.

Background: Uncertainty underlies the effectiveness of somatostatin analogues for slowing the progression of polycystic kidney or liver disease.

Methods: Eligible studies included randomized controlled trials (RCTs) evaluating somatostatin analog as therapy for patients with polycystic kidney disease (PKD) or polycystic liver disease (PLD) compared to placebo or standard therapy. Two reviewers independently screened studies identified from databases (MEDLINE, EMBASE, Cochrane Database), clinical trial registries, and references from pertinent articles and clinical practice guidelines. Read More

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September 2021

Tumor growth rate during re-challenge chemotherapy with previously used agents as salvage treatment for metastatic colorectal cancer: A retrospective study.

PLoS One 2021 24;16(9):e0257551. Epub 2021 Sep 24.

Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

Background: In clinical practice, the same chemotherapeutic agents are occasionally reused (re-challenge) after failure of all available standard chemotherapy options for metastatic colorectal cancer (mCRC). However, the benefits of re-challenge chemotherapy (Re-Cx) are unclear. This retrospective study evaluated the efficacy of Re-Cx, focusing on the tumor growth rate (TGR). Read More

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September 2021

The Effect of Exercise Training on Lean Body Mass in Breast Cancer Patients: A Systematic Review and Meta-analysis.

Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.

Purpose: Reduced lean body mass (LBM) is common during and following treatment for breast cancer, and is associated with increased treatment-induced toxicity, shorter time to tumour progression and decreased survival. Exercise training is a potential intervention for maintaining or increasing LBM. We conducted a systematic review and meta-analysis to investigate the effects of exercise training on LBM in breast cancer. Read More

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September 2021

A Quantitative Assessment of Wound Healing With Oxygenated Micro/Nanobubbles in a Preclinical Burn Model.

Ann Plast Surg 2021 Oct;87(4):421-426

From the Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine, Orange.

Background: Burns are devastating injuries, carry significant morbidity, and require long-term treatment or multiple reconstructive procedures. Wound healing and secondary insults caused by burn wound conversion are amendable to therapeutic intervention, where ischemia has been cited as one of the major factors (Dermatol Surg. 2008;34:1159-1169). Read More

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October 2021