21,995 results match your criteria progress outcome


A transfer learning with structured filter pruning approach for improved breast cancer classification on point-of-care devices.

Comput Biol Med 2021 Apr 30;134:104432. Epub 2021 Apr 30.

Missouri University of Science and Technology, Rolla, MO, 65409, USA. Electronic address:

Background And Objective: A significant progress has been made in automated medical diagnosis with the advent of deep learning methods in recent years. However, deploying a deep learning model for mobile and small-scale, low-cost devices is a major bottleneck. Further, breast cancer is more prevalent currently, and ductal carcinoma being its most common type. Read More

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The current progress and critical analysis of three-dimensional scanning and three-dimensional printing applications in breast surgery.

BJS Open 2021 May;5(3)

UCL Division of Surgery & Interventional Science, Royal Free Hospital, London, UK.

Background: Several attempts have been made to develop a tool capable of evaluating breast shape and volume to aid surgical planning and outcome assessment. More recently, newer technologies such as three-dimensional (3D) scanning and 3D printing have been applied in breast assessment. The aim of this study was to review the literature to assess the applicability of 3D scanning and 3D printing in breast surgery. Read More

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How Can Clinical Outcomes among Adolescents Living with HIV in Ethiopia be Improved? Healthcare Professionals' Perspectives.

Compr Child Adolesc Nurs 2021 May 7:1-10. Epub 2021 May 7.

Department of Health Sciences, Lund University, Lund, Sweden.

While successes in the prevention of mother-to-child transmission program are believed to lead to substantial reductions in new perinatal infections, new sexually acquired infections among the older adolescent group seem to fuel the HIV epidemic. That is why adolescents are the only age group in which an increase in new HIV infections was reported in the latest global HIV progress update. Increase in the number of perinatally HIV infected children growing to adolescence adds to this pool. Read More

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Current Therapy for Metastatic Urothelial Carcinoma.

Hematol Oncol Clin North Am 2021 Jun 10;35(3):469-493. Epub 2021 Apr 10.

Department of Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, KS 118, Boston, MA 02215, USA. Electronic address:

Urothelial carcinoma (UC) is a highly lethal malignancy in the metastatic state. Platinum-based chemotherapy regimens have been the backbone treatment for patients with advanced UC in the first-line setting. However, a large subset of patients are suboptimal candidates for these combinations owing to poor renal function and/or other comorbidities. Read More

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From Bench to Keyboard and Back Again: A Brief History of Lambda Phage Modeling.

Annu Rev Biophys 2021 May;50:117-134

The Louis and Beatrice Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794, USA; email:

Cellular decision making is the process whereby cells choose one developmental pathway from multiple possible ones, either spontaneously or due to environmental stimuli. Examples in various cell types suggest an almost inexhaustible plethora of underlying molecular mechanisms. In general, cellular decisions rely on the gene regulatory network, which integrates external signals to drive cell fate choice. Read More

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Content validity of the tinnitus outcome questionnaire for sound management.

PLoS One 2021 6;16(5):e0251244. Epub 2021 May 6.

Hearing Research Laboratory, Samsung Medical Center, Seoul, Korea.

Standardized instruments are often used to monitor one's progress in tinnitus relief although they were developed to screen and diagnose tinnitus. The need for the development for a tinnitus outcome assessment tool is high in the field of audiology and otolaryngology. The purpose of this study was to develop a tinnitus outcome questionnaire for sound management (listening to sound stimuli for tinnitus relief) and assess its content validity. Read More

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The impact of intraoperative frozen section analysis on final resection margin status, recurrence, and patient outcome with oral squamous cell carcinoma.

Clin Oral Investig 2021 May 6. Epub 2021 May 6.

Department of Oral and Maxillofacial Surgery, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany.

Background: The objective of this study was to evaluate the diagnostic value of intraoperative frozen section analysis (IFSA) of tumor bed margins in patients with oral squamous cell carcinoma (OSCC).

Methods: This retrospective study includes 194 primary OSCC cases. The impact of intraoperative information by IFSA on final margin status, local recurrence, and disease-specific survival were analyzed. Read More

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What can lifespan variation reveal that life expectancy hides? Comparison of five high-income countries.

J R Soc Med 2021 May 6:1410768211011742. Epub 2021 May 6.

London School of Hygiene and Tropical Medicine, London, UK.

Objectives: In most countries, life expectancy at birth (e0) has improved for many decades. Recently, however, progress has stalled in the UK and Canada, and reversed in the USA. Lifespan variation, a complementary measure of mortality, increased a few years before the reversal in the USA. Read More

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An Insight Into the Driver Mutations and Molecular Mechanisms Underlying Mucinous Adenocarcinoma of the Rectum.

Dis Colon Rectum 2021 Jun;64(6):677-688

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

Background: Mucinous adenocarcinoma of the rectum accounts for 10% of all rectal cancers and has an impaired response to neoadjuvant chemoradiotherapy and worse overall survival. To date, insufficient genomic research has been performed on this histological subtype.

Objective: This study aims to define the mismatch repair deficiency rate and the driver mutations underpinning mucinous adenocarcinoma of the rectum and to compare it with rectal adenocarcinoma not otherwise specified. Read More

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The road to zero nosocomial infections in neonates-a narrative review.

Acta Paediatr 2021 May 6. Epub 2021 May 6.

Division of Neonatology, Department of Pediatrics, Willem Alexander Children's Hospital - Leiden University Medical Center (LUMC), Leiden, The Netherlands.

Aim: Nosocomial infections (NI) in neonates are associated with prolonged hospitalisation, adverse neurodevelopmental outcome and high mortality. Over the past decade, numerous prevention strategies have resulted in significant reductions in NI rates. In this review, we aim to provide an overview of current NI rates from large, geographically defined cohorts. Read More

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Identification of a ferroptosis-related gene signature (FRGS) for predicting clinical outcome in lung adenocarcinoma.

PeerJ 2021 13;9:e11233. Epub 2021 Apr 13.

Department of Thoracic Surgery, Taizhou Hospital, Taizhou, Zhejiang, China.

Background: Lung adenocarcinoma (LUAD) is the most common pathological subtype of lung cancer. Ferroptosis, an oxidative, iron-dependent form of necrotic cell death, is highly associated with tumorigenesis and cancer progression. However, the prognostic value of ferroptosis progress in LUAD was still rarely be investigated. Read More

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Romanian Guidelines for Nonpharmacological Therapy of IBS.

J Gastrointestin Liver Dis 2021 May 3. Epub 2021 May 3.

Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca; 2nd Department of Internal Medicine, Cluj-Napoca, Romania.

Background And Aims: The nonpharmacological therapy in irritable bowel syndrome (IBS) is expanding rapidly. Practitioners and medical educators need to be aware of progress and changes in knowledge of this topic. The Romanian Society of Neurogastroenterology aimed to create guidelines based on best evidence on the use of nonpharmacological therapy in IBS. Read More

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Dynamic α-Fetoprotein Response and Outcomes After Liver Transplant for Hepatocellular Carcinoma.

JAMA Surg 2021 May 5. Epub 2021 May 5.

Multi-Organ Transplant and HPB Surgical Oncology, Division of General Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.

Importance: Accurate preoperative prediction of hepatocellular carcinoma (HCC) recurrence after liver transplant is the mainstay of selection tools used by transplant-governing bodies to discern candidacy for patients with HCC. Although progress has been made, few tools incorporate objective measures of tumor biological characteristics, resulting in inclusion of patients with high recurrence rates and exclusion of others who could otherwise be cured.

Objective: To externally validate the New York/California (NYCA) score, a recently published multi-institutional US HCC selection tool that was the first model incorporating a dynamic α-fetoprotein response (AFP-R) and compare the validated score with currently accepted HCC selection tools, namely, the Milan Criteria (MC), the French-AFP (F-AFP), and Metroticket 2. Read More

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Rediscovering potential molecular targets for glioma therapy through the analysis of the cell of origin, microenvironment, and metabolism.

Curr Cancer Drug Targets 2021 May 3. Epub 2021 May 3.

Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University (SYSU), No.628, Zhenyuan Rd, Guangming Dist., Shenzhen 518107. China.

Gliomas are the most common type of malignant brain tumors. Despite significant medical advances, gliomas remain incurable and are associated with high mortality. Although numerous biomarkers of diagnostic value have been identified and significant progress in the prognosis of the outcome has been made, the treatment has not been parallelly improved during the last three decades. Read More

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FACTORS AFFECTING THE EFFECTIVENESS OF CONSERVATIVE MANAGEMENT OF APPENDICULAR MASS.

Authors:
Haithem Ali

Pol Przegl Chir 2021 Jun;93(3):1-5

University of Basrah, Al-Zahraa College of Medicine, Basrah, Iraq.

INTRODUCTION/ PURPOSE Acute appendicitis is the most common surgical emergency in children. Appendicular mass is a relatively common complication in improperly treated patients. The management of appendicular mass remains controversial. Read More

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EXPRESS: Longer term patient management following stroke A systematic review.

Int J Stroke 2021 May 5:17474930211016963. Epub 2021 May 5.

Medical University of Innsbruck, Neurology, Innsbruck, Tirol, Austria.

Tremendous progress in acute stroke therapy has improved short-term outcome but part of this achievement may be lost in the long run. Concepts for a better long-term management of stroke survivors are needed to address their unmet needs and to reduce the burden of post-stroke complications, residual deficits and recurrent vascular events. This review summarizes current knowledge on post-hospital care and the scientific evidence supporting individual programs. Read More

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Evaluation of initial progress to implement Common Metrics across the NIH Clinical and Translational Science Awards (CTSA) Consortium.

J Clin Transl Sci 2020 Jul 28;5(1):e25. Epub 2020 Jul 28.

Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.

Introduction: The Clinical and Translational Science Awards (CTSA) Consortium, about 60 National Institutes of Health (NIH)-supported CTSA hubs at academic health care institutions nationwide, is charged with improving the clinical and translational research enterprise. Together with the NIH National Center for Advancing Translational Sciences (NCATS), the Consortium implemented Common Metrics and a shared performance improvement framework.

Methods: Initial implementation across hubs was assessed using quantitative and qualitative methods over a 19-month period. Read More

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Developing a core set of outcome measure domains to study Raynaud's phenomenon and digital ulcers in systemic sclerosis: Report from OMERACT 2020.

Semin Arthritis Rheum 2021 Apr 21. Epub 2021 Apr 21.

Division of Rheumatology, Department of Medicine, Division of Clinical Epidemiology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Raynaud's phenomenon (RP) and digital ulcers (DUs) are important disease manifestations of systemic sclerosis (SSc) that can lead to significant pain and disability. It is essential when studying these disease features to utilize outcome measures that fully evaluate the complexities of RP and DUs . The Outcome Measures in Rheumatology (OMERACT) Vascular Disease in SSc Working Group is applying the OMERACT filter 2. Read More

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Assessment of the tuberculosis case-finding and prevention cascade among people living with HIV in Zambia - 2018: a cross-sectional cluster survey.

BMC Public Health 2021 May 4;21(1):859. Epub 2021 May 4.

Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop US1-1, Atlanta, GA, 30030, USA.

Background: The Ministry of Health Zambia recommends tuberculosis preventive treatment (TPT) with 6 months daily isoniazid for all people living with human immunodeficiency virus (HIV) after ruling out active tuberculosis disease. We sought to estimate the percentage of people living with HIV who progress through each stage of the tuberculosis case-finding and prevention cascade in two provinces with the highest tuberculosis burden in Zambia.

Methods: In this cross-sectional survey, we used a two-stage cluster sampling method. Read More

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A review on radiation induced nausea and vomiting: "Current management strategies and prominence of radio sensitizers".

J Oncol Pharm Pract 2021 May 4:10781552211011539. Epub 2021 May 4.

Department of Radiation Oncology, Amrita Vishwa Vidyapeetham, Kochi, India.

Radiations dissipated are high energy waves used mostly as treatment intervention in controlling the unwanted multiplication of cell. About 60%-65% of cancer treatment requires radiation therapy and 40%-80% of radiation therapy causes RINV which are true troublemakers. Radiation therapy (RT) is targeted therapy mostly used to treat early stages of tumour and prevent their reoccurrence. Read More

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Challenges in translational research: MDMA in the laboratory versus therapeutic settings.

J Psychopharmacol 2021 May 4:2698811211015221. Epub 2021 May 4.

The Lundquist Institute and Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, CA, USA.

Despite substantial progress in the use of mind-altering drugs to treat psychiatric disorders, the psychological processes through which these drugs change mood or behavior are poorly understood. Controlled laboratory studies with well-defined psychological constructs are valuable to understand how these drugs manifest their therapeutic benefit. However, there are substantial methodological differences between clinical studies investigating therapeutic outcome and laboratory studies investigating the processes that might underlie the therapeutic effects. Read More

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MFA and ASA-MF: A Psychometric Analysis of Attitudes Towards Measurement-Based Care.

Adm Policy Ment Health 2021 May 3. Epub 2021 May 3.

Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave, Suite 1600, Seattle, WA, 98101, USA.

Measurement based care (MBC) improves client outcomes by providing clinicians with routine mental health outcome data that can be used to inform treatment planning but is rarely used in practice. The Monitoring and Feedback Attitudes Scale (MFA) and Attitudes Towards Standardized Assessment Scales-Monitoring and Feedback (ASA-MF) (Jensen-Doss et al., 2016) may identify attitudinal barriers to MBC, which could help trainings and implementation strategies. Read More

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Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing.

Proc Natl Acad Sci U S A 2021 May;118(19)

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030;

The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal development and in cancer progression. EMT is induced by various signaling pathways, including TGF-β, BMP, Wnt-β-catenin, NOTCH, Shh, and receptor tyrosine kinases. In this study, we performed single-cell RNA sequencing on MCF10A cells undergoing EMT by TGF-β1 stimulation. Read More

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Stakeholder-engaged process for refining the design of a clinical trial in home hospice.

BMC Med Res Methodol 2021 Apr 30;21(1):92. Epub 2021 Apr 30.

University of Rhode Island School of Nursing, Kingston, RI, USA.

Background: Clinical trials in home hospice settings are important to build the evidence base for practice, but balancing the burden and benefit of clinical trial conduct for clinicians, patients, and family caregivers is challenging. A stakeholder-engaged process can help inform and refine key aspects of home hospice clinical trials. The aim of this study was to describe a stakeholder-engaged process to refine, design, and implement aspects of an educational intervention trial in home hospice, including recommendations for refining intervention content and delivery, recruitment and enrollment strategies, and content and frequency of outcome measurement. Read More

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New Drugs Approved in 2020.

Am J Med 2021 Apr 30. Epub 2021 Apr 30.

Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL. Electronic address:

In 2020, the US Food and Drug Administration (FDA) approved 53 novel drugs. Thirty six of the 53 (68%) novel drug approvals were reviewed and approved through an expedited review pathway while 31 of the 53 (58%) were approved for treatment of a rare disease. This review includes a summary of the novel drugs approved by the FDA in 2020. Read More

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PR interval prolongation is significantly associated with aortic root abscess: An age- And gender-matched study.

Ann Noninvasive Electrocardiol 2021 May 3:e12849. Epub 2021 May 3.

Heart & Vascular Center, Pritzker School of Medicine of the University of Chicago, Chicago, IL, USA.

Background: Electrocardiographic abnormalities, such as PR interval prolongation, have been anecdotally reported in patients with aortic root abscess (ARA). An electrocardiographic marker may be useful in identifying those patients with aortic valve endocarditis who may progress to ARA. The objective of this study is to evaluate the change in the PR interval in patients with surgically confirmed ARA and compare it to age- and gender-matched controls with echocardiographically or surgically confirmed aortic valve endocarditis but without aortic root abscess and those hospitalized with diagnoses other than endocarditis. Read More

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Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.

Biochim Biophys Acta Rev Cancer 2021 Apr 29;1876(1):188555. Epub 2021 Apr 29.

Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, California, USA; Department of Bioengineering and Therapeutic Sciences, and UCSF Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA; Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, USA. Electronic address:

Breast ductal carcinoma in situ (DCIS) is a preinvasive lesion that is considered to be a precursor to invasive breast cancer. Nevertheless, not all DCIS will progress to invasion. Current histopathological classification systems are unable to predict which cases will or will not progress, and therefore many women with DCIS may be overtreated. Read More

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Exploring wellbeing in first year medical students amidst a curriculum change.

BMC Med Educ 2021 May 1;21(1):252. Epub 2021 May 1.

School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

Background: The support of student wellbeing features highly in all higher education institutional agendas. For medical students good physical and mental health can help prevent burnout, equip students for their future healthcare setting and indirectly improve patient care. At the University of Nottingham (UK), we were keen to explore undergraduate medical students perceived wellbeing before, during, and after an early years' (years 1-3) curriculum change. Read More

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Operative list of genes associated with autism and neurodevelopmental disorders based on database review.

Mol Cell Neurosci 2021 Apr 28:103623. Epub 2021 Apr 28.

Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris, F-75015, Paris, France. Electronic address:

The genetics of neurodevelopmental disorders (NDD) has made tremendous progress during the last few decades with the identification of more than 1500 genes associated with conditions such as intellectual disability and autism. The functional roles of these genes are currently studied to uncover the biological mechanisms influencing the clinical outcome of the mutation carriers. To integrate the data, several databases and curated gene lists have been generated. Read More

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Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION): 10-Year Update.

Curr Rheumatol Rep 2021 May 1;23(6):45. Epub 2021 May 1.

Haemostasis Research Unit, Department of Haematology, University College London, London, UK.

Purpose Of Review: APS ACTION is an international research network created to design and conduct large-scale, multicenter research in persistently antiphospholipid antibody (aPL)-positive patients. Given the expanding research activities of the network in the last decade since its creation, the purpose of this article is to review the scientific contributions of APS ACTION as well as future directions.

Recent Findings: APS ACTION has achieved increased international collaboration with internal and external investigators for outcome, interventional, and mechanistic antiphospholipid syndrome (APS) studies. Read More

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