98,518 results match your criteria prognostic marker

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma-A Systematic Review and Meta-Analysis.

Curr Issues Mol Biol 2021 Aug 28;43(2):1019-1035. Epub 2021 Aug 28.

Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.

Objective: To qualitative and quantitatively review published literature assessing the oxidative stress marker malondialdehyde (MDA) in oral squamous cell carcinoma (OSCC).

Methodology: Pubmed (MeSH), Science Direct, Scopus, Web of Science, Willey Online Library, Cochrane, and Cross Reference were searched for studies assessing MDA levels in OSCC samples.

Results: From the 1008 articles identified, 849 were excluded based on title and abstract screening due to duplication and irrelevance to the topic of interest. Read More

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Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures.

Clin Pract 2021 Sep 3;11(3):587-597. Epub 2021 Sep 3.

Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Poznan, Poland.

Background: Off-pump coronary artery bypass grafting (OPCAB) is believed to limit inflammatory reaction. Neutrophil to lymphocyte ratio (NLR) is one of the more common and easily accessible markers of inflammatory response. The aim of the study was to compare postoperative results of NLR with mid-term OPCAB results. Read More

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September 2021

Real-Time Detection of Tumor Cells during Capture on a Filter Element Significantly Enhancing Detection Rate.

Biosensors (Basel) 2021 Sep 3;11(9). Epub 2021 Sep 3.

Robert Bosch GmbH, Corporate Sector Research and Advanced Engineering, Robert-Bosch-Campus 1, 71272 Renningen, Germany.

Circulating tumor cells (CTCs) that enter the bloodstream play an important role in the formation of metastases. The prognostic significance of CTCs as biomarkers obtained from liquid biopsies is intensively investigated and requires accurate methods for quantification. The purpose of this study was the capture of CTCs on an optically accessible surface for real-time quantification. Read More

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September 2021

Predicting if lung cancer will relapse-The role of neutrophil/lymphocyte ratio.

Hematol Oncol Stem Cell Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Hematology and Medical Oncology, Sinai Hospital of Baltimore, Baltimore, MD 21215, USA.

Objective/background: Baseline neutrophil/lymphocyte ratio (NLR), a surrogate marker for systemic inflammation and immunosuppression, is a well-studied prognostic marker in non-small cell lung cancer (NSCLC). This study tests if interim NLR is prognostic in NSCLC patients in remission.

Methods: This single-center, retrospective cohort study analyzed 131 NSCLC patients treated from 2010 to 2015 who achieved complete remission. Read More

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September 2021

Prognostic nutritional index is a predictor of mortality in elderly patients with chronic kidney disease.

Int Urol Nephrol 2021 Sep 25. Epub 2021 Sep 25.

Division of Nephrology, Department of Internal Medicine, School of Medicine, Marmara University, Pendik Teaching and Training Hospital, Fevzi Cakmak Mah. MuhsinYazicioglu Cad. No: 10 Ust Kaynarca-Pendik, Istanbul, Turkey.

Purpose: Prognostic nutritional index (PNI), a composite indicator of inflammation and nutritional status, has recently been recognized as an independent prognostic marker for chronic kidney disease (CKD). We aimed to investigate PNI and its relationship with mortality in elderly patients with CKD.

Methods: Three hundred and fifty-nine patients over the age of 80 years with stage 3-4 CKD were enrolled in this retrospective study. Read More

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September 2021

Predictive value of gadoxetic acid-enhanced MRI for posthepatectomy liver failure: a systematic review.

Eur Radiol 2021 Sep 25. Epub 2021 Sep 25.

Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Objectives: Effective and non-invasive biomarkers to predict and avoid posthepatectomy liver failure (PHLF) are urgently needed. This systematic review aims to evaluate the efficacy of gadoxetic acid-enhanced MRI-derived parameters as an imaging biomarker in preoperative prediction of PHLF.

Methods: A systematic literature search was performed in the databases of PubMed/Medline, Web of Science, Embase, and Cochrane Library up to 11 December 2020. Read More

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September 2021

Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations.

Mov Disord 2021 Sep 25. Epub 2021 Sep 25.

Department of Clinical Neurosciences, UCL Institute of Neurology University College London, London, United Kingdom.

Mild parkinsonian signs (MPS) have been widely studied during the past 3 decades and proposed as a risk marker for neurodegenerative disease. This systematic review explores the epidemiology, clinical and prognostic associations, radiological features, and pathological findings associated with MPS in older adults free from neurodegenerative disease. We find that MPS as currently defined are strongly associated with increasing age and increased risk of development of Parkinson's disease (PD), all-cause dementia, disability, and death. Read More

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September 2021

CircRNAs in gastric cancer: current research and potential clinical implications.

FEBS Lett 2021 Sep 24. Epub 2021 Sep 24.

Department & institute of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing, China, 100853.

Gastric cancer (GC) has a dismal prognosis and is also one of the most commonly diagnosed malignancies worldwide. CircRNAs are covalently closed circular RNA molecules without 5'-cap and a 3'-tail, currently listed among the broad non-coding RNA family. CircRNAs participate in a variety of pathophysiological processes relevant to human diseases, especially malignancies, including GC. Read More

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September 2021

Dissection of the bone marrow microenvironment in hairy cell leukaemia identifies prognostic tumour and immune related biomarkers.

Sci Rep 2021 Sep 24;11(1):19056. Epub 2021 Sep 24.

ACRF Translational Research Laboratory, Royal Melbourne Hospital, Melbourne, Australia.

Hairy cell leukaemia (HCL) is a rare CD20+ B cell malignancy characterised by rare "hairy" B cells and extensive bone marrow (BM) infiltration. Frontline treatment with the purine analogue cladribine (CDA) results in a highly variable response duration. We hypothesised that analysis of the BM tumour microenvironment would identify prognostic biomarkers of response to CDA. Read More

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September 2021

Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma.

Chin Med J (Engl) 2021 Sep 21. Epub 2021 Sep 21.

National Engineering Research Center for Miniaturized Detection Systems, The College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China Department of Surgical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Background: Nucleolar protein 6 (NOL6) is a nucleolar RNA-associated protein that is highly conserved between species. It has been proved to be associated with the prognosis of liver cancer. However, the underlying mechanism has not been fully established. Read More

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September 2021

Current strategies for intratumoural immunotherapy - Beyond immune checkpoint inhibition.

Eur J Cancer 2021 Sep 21. Epub 2021 Sep 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA. Electronic address:

Immunotherapy has revolutionised cancer treatment through restoration of host antitumour immune response. Immune checkpoint inhibitors (ICIs) confer durable responses in only a subset of patients. Mechanisms of ICI resistance to improve durable response rates and overall survival are an area of intense clinical research. Read More

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September 2021

Impact of admission hyperglycemia on short and long-term prognosis in acute myocardial infarction: MINOCA versus MIOCA.

Cardiovasc Diabetol 2021 Sep 24;20(1):192. Epub 2021 Sep 24.

Department of Experimental, Diagnostic and Specialty Medicine-DIMES, IRCCS Policlinico S. Orsola - Malpighi, University of Bologna, Via Giuseppe Massarenti 9, 40138, Bologna, Italy.

Background: The prognostic role of hyperglycemia in patients with myocardial infarction and obstructive coronary arteries (MIOCA) is acknowledged, while data on non-obstructive coronary arteries (MINOCA) are still lacking. Recently, we demonstrated that admission stress-hyperglycemia (aHGL) was associated with a larger infarct size and inflammatory response in MIOCA, while no differences were observed in MINOCA. We aim to investigate the impact of aHGL on short and long-term outcomes in MIOCA and MINOCA patients. Read More

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September 2021

Prognostic impact of liver fibrosis and steatosis by transient elastography for cardiovascular and mortality outcomes in individuals with nonalcoholic fatty liver disease and type 2 diabetes: the Rio de Janeiro Cohort Study.

Cardiovasc Diabetol 2021 Sep 24;20(1):193. Epub 2021 Sep 24.

Department of Internal Medicine, School of Medicine and Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rua Croton, 72, Jacarepagua, Rio de Janeiro, RJ, CEP: 22750-240, Brazil.

Background: Liver stiffness measurement (LSM, which reflects fibrosis) and controlled attenuation parameter (CAP, which reflects steatosis), two parameters derived from hepatic transient elastography (TE), have scarcely been evaluated as predictors of cardiovascular complications and mortality in individuals with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).

Methods: Four hundred type 2 diabetic patients with NAFLD had TE examination (by Fibroscan) performed at baseline. Multivariate Cox analyses evaluated the associations between TE parameters and the occurrence of cardiovascular events (CVEs) and mortality. Read More

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September 2021

Cancer driver gene and non-coding RNA alterations as biomarkers of brain metastasis in lung cancer: A review of the literature.

Biomed Pharmacother 2021 Sep 21;143:112190. Epub 2021 Sep 21.

Zimagene Medical Genetics Laboratory, Avicenna St., Hamedan, Iran. Electronic address:

Brain metastasis (BM) is the most common event in patients with lung cancer. Despite multimodal treatments and advances in systemic therapies, development of BM remains one of the main factors associated with poor prognosis and mortality in patients with lung cancer. Therefore, better understanding of mechanisms involved in lung cancer brain metastasis (LCBM) is of great importance to suppress cancer cells and to improve the overall survival of patients. Read More

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September 2021

Soluble interleukin-2 receptor as a predictive and prognostic marker for patients with familial breast cancer.

Sci Prog 2021 Jul-Sep;104(3):368504211039590

Department of Bioregulation and Pharmacological Medicine, 12775Fukushima Medical University, Japan.

The incidence of breast cancer increases annually, and it has become common within families of breast cancer patients. Interleukin-2 activates cytotoxic T lymphocytes, which are important for cancer immunity. To identify markers of increased familial breast cancer risk, soluble interleukin-2 receptor levels and immunologic factors were investigated in familial breast cancer and non-familial breast cancer patients. Read More

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September 2021

Calcitonin receptor-like (CALCRL) is a marker of stemness and an independent predictor of outcome in pediatric AML.

Blood Adv 2021 Sep 24. Epub 2021 Sep 24.

University Children's Hospital Münster, Muenster, Germany.

We have recently identified the G protein-coupled neuropeptide receptor Calcitonin receptor-like (CALCRL) as an independent prognostic biomarker and a therapeutic target in more than 1500 adult patients with acute myeloid leukemia (AML). Here, we confirmed CALCRL expression as a prognostic factor in a cohort of 284 pediatric patients with AML. High CALCRL expression was independently associated with event free survival (EFS) (hazard ratio [HR], 1. Read More

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September 2021

Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma.

Hepatol Commun 2021 Aug 24. Epub 2021 Aug 24.

Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Recent studies support the development of cancer therapeutics to target Globo H-ceramide, the most prevalent tumor-associated carbohydrate antigen in epithelial cancers. Herein, we evaluated the expression of Globo H and its prognostic significance in intrahepatic cholangiocarcinoma (ICC) and conducted preclinical studies to assess the antitumor activity of Globo H-specific antibody in thioacetamide (TAA)-induced ICC in rats. Globo H-ceramide in tumor specimens was detected by immunohistochemistry (IHC) and mass spectrometry. Read More

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Dynamic changes in human single-cell transcriptional signatures during fatal sepsis.

J Leukoc Biol 2021 Sep 24. Epub 2021 Sep 24.

Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California, USA.

Systemic infections, especially in patients with chronic diseases, may result in sepsis: an explosive, uncoordinated immune response that can lead to multisystem organ failure with a high mortality rate. Patients with similar clinical phenotypes or sepsis biomarker expression upon diagnosis may have different outcomes, suggesting that the dynamics of sepsis is critical in disease progression. A within-subject study of patients with Gram-negative bacterial sepsis with surviving and fatal outcomes was designed and single-cell transcriptomic analyses of peripheral blood mononuclear cells (PBMC) collected during the critical period between sepsis diagnosis and 6 h were performed. Read More

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September 2021

Expression of fatty acid-binding protein-4 in gastrointestinal stromal tumors and its significance for prognosis.

J Clin Lab Anal 2021 Sep 24:e24017. Epub 2021 Sep 24.

Department of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Nantong, China.

Background: Fatty acid-binding proteins (FABPs) have been found to be involved in tumorigenesis and development. However, the role of FABP4, a member of the FABPs, in GISTs (Gastrointestinal stromal tumors) remains unclear. This study aimed to investigate the expression of FABP4 and its prognostic value in GISTs. Read More

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September 2021

The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas.

Turk Patoloji Derg 2021 Sep 24. Epub 2021 Sep 24.

Department of Pathology, University of Health Sciences Gaziosmanpasa Research and Training Hospital, ISTANBUL, TURKEY.

Objective: Diffuse gliomas, the most common primary malignant brain tumors, have been classified by the World Health Organization as class II-IV gliomas. After 2016, two mutations in the promoter region of the telomerase reverse transcriptase (TERT) gene were identified in addition to the IDH, 1p / 19q, and ATRX status.

Material And Method: We identified 84 patients with grade II-IV glioma with IDH, ATRX, 1p / 19q and TERT status. Read More

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September 2021

Controversial roles of cold‑inducible RNA‑binding protein in human cancer (Review).

Int J Oncol 2021 Nov 24;59(5). Epub 2021 Sep 24.

Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology, Gachon University, Incheon 21999, Republic of Korea.

Cold‑inducible RNA‑binding protein (CIRBP) is a cold‑shock protein comprised of an RNA‑binding motif that is induced by several stressors, such as cold shock, UV radiation, nutrient deprivation, reactive oxygen species and hypoxia. CIRBP can modulate post‑transcriptional regulation of target mRNA, which is required to control DNA repair, circadian rhythms, cell growth, telomere integrity and cardiac physiology. In addition, the crucial function of CIRBP in various human diseases, including cancers and inflammatory disease, has been reported. Read More

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November 2021

Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury.

Neural Regen Res 2022 May;17(5):963-971

Department of Orthopedics; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin; Department of Orthopedics, Qilu Hospital; Shandong University Center for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.

Recent studies in patients with spinal cord injuries (SCIs) have confirmed the diagnostic potential of biofluid-based biomarkers, as a topic of increasing interest in relation to SCI diagnosis and treatment. This paper reviews the research progress and application prospects of recently identified SCI-related biomarkers. Many structural proteins, such as glial fibrillary acidic protein, S100-β, ubiquitin carboxy-terminal hydrolase-L1, neurofilament light, and tau protein were correlated with the diagnosis, American Spinal Injury Association Impairment Scale, and prognosis of SCI to different degrees. Read More

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Detection and utility of cell-free and circulating tumour DNA in bone and soft-tissue sarcomas.

Bone Joint Res 2021 Sep;10(9):602-610

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.

Aims: Cell-free DNA (cfDNA) and circulating tumour DNA (ctDNA) are used for prognostication and monitoring in patients with carcinomas, but their utility is unclear in sarcomas. The objectives of this pilot study were to explore the prognostic significance of cfDNA and investigate whether tumour-specific alterations can be detected in the circulation of sarcoma patients.

Methods: Matched tumour and blood were collected from 64 sarcoma patients (n = 70 samples) prior to resection of the primary tumour (n = 57) or disease recurrence (n = 7). Read More

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September 2021

Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth.

J Magn Reson Imaging 2021 Sep 24. Epub 2021 Sep 24.

Neurovascular Surgery Program, Department of Neurosurgery, University of Chicago Medicine and Biological Sciences, Chicago, Illinois, USA.

Background: Cerebral cavernous angioma (CA) is a capillary vasculopathy affecting more than a million Americans with a small fraction of cases demonstrating lesional bleed or growth with major clinical sequelae. Perfusion and permeability are fundamental features of CA pathophysiology, but their role as prognostic biomarkers is unclear.

Purpose: To investigate whether perfusion or permeability lesional descriptors derived from dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging (MRI) can predict subsequent lesional bleed/growth in the year following imaging. Read More

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September 2021

Antimicrobial Protein REG3A and Signaling Networks are Predictive of Stroke Outcomes.

J Neurochem 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.

Regenerating Family Member 3 Alpha (REG3A) is a multifunctional protein with antimicrobial activity, and primarily secreted by the intestine and pancreas. Studies have shown an increased expression of REG3A in systemic inflammatory responses to acute injury and infection, but studies investigating REG3A during the pathogenesis of ischemic stroke are limited. The aims of this study were to examine the associations between arterial expression of REG3A and other arterial inflammatory proteins implicated in stroke pathogenesis, as well as associations between REG3A and markers of poor outcome for ischemic stroke. Read More

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September 2021

Bioinformatics analysis of key genes and potential mechanism in cadmium-induced breast cancer progression.

Environ Sci Pollut Res Int 2021 Sep 23. Epub 2021 Sep 23.

Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, China.

Cadmium (Cd) may be associated with breast cancer progression, but the detailed molecular mechanism has not been fully elucidated. In this study, one public dataset (GSE136595) was used to identify differentially expressed genes (DEGs) in Cd-treated MCF-7 breast cancer cells. We determined a total of 2077 DEGs, and Ingenuity Pathway Analysis (IPA) software showed that 246 of them were related to tumor progression. Read More

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September 2021

Multiomics Analysis of Neuroblastoma Cells Reveals a Diversity of Malignant Transformations.

Front Cell Dev Biol 2021 7;9:727353. Epub 2021 Sep 7.

Department of Biological DNA Modification, Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.

Neuroblastoma (NB) is a pediatric cancer of the developing sympathetic nervous system that exhibits significant variation in the stage of differentiation and cell composition of tumors. Global loss of DNA methylation and genomic 5-hydroxymethylcytosine (5hmC) is a hallmark of human cancers. Here, we used our recently developed single-base resolution approaches, hmTOP-seq and uTOP-seq, for construction of 5hmC maps and identification of large partially methylated domains (PMDs) in different NB cell subpopulations. Read More

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September 2021

Integrative Analysis of mA Regulator-Mediated RNA Methylation Modification Patterns and Immune Characteristics in Lupus Nephritis.

Front Cell Dev Biol 2021 7;9:724837. Epub 2021 Sep 7.

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: There is growing evidence to demonstrate that the epigenetic regulation of immune characteristics, especially for N6-methyladenosine (mA) RNA methylation. However, how mA methylation is involved in lupus nephritis (LN) is still unclear. This study aimed to determine the role of mA RNA methylation and their association with the immune microenvironment in LN. Read More

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September 2021

Radiomic Features Associated With HPV Status on Pretreatment Computed Tomography in Oropharyngeal Squamous Cell Carcinoma Inform Clinical Prognosis.

Front Oncol 2021 7;11:744250. Epub 2021 Sep 7.

Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, OH, United States.

Purpose: There is a lack of biomarkers for accurately prognosticating outcome in both human papillomavirus-related (HPV+) and tobacco- and alcohol-related (HPV-) oropharyngeal squamous cell carcinoma (OPSCC). The aims of this study were to i) develop and evaluate radiomic features within (intratumoral) and around tumor (peritumoral) on CT scans to predict HPV status; ii) investigate the prognostic value of the radiomic features for both HPV- and HPV+ patients, including within individual AJCC eighth edition-defined stage groups; and iii) develop and evaluate a clinicopathologic imaging nomogram involving radiomic, clinical, and pathologic factors for disease-free survival (DFS) prediction for HPV+ patients.

Experimental Design: This retrospective study included 582 OPSCC patients, of which 462 were obtained from The Cancer Imaging Archive (TCIA) with available tumor segmentation and 120 were from Cleveland Clinic Foundation (CCF, denoted as S) with HPV+ OPSCC. Read More

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September 2021

Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Among Kinesin Superfamily of Proteins in Pancreatic Ductal Adenocarcinoma.

Front Oncol 2021 7;11:708900. Epub 2021 Sep 7.

Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, China.

Background: Kinesin superfamily of proteins (KIFs) has been broadly reported to play an indispensable role in the biological process. Recently, emerging evidence reveals its oncogenic role in various cancers. However, the prognostic, oncological, and immunological values of KIFs have not been comprehensively explored in pancreatic ductal adenocarcinoma (PDAC) patients. Read More

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September 2021