1,969,854 results match your criteria prognostic factors

[The Current Therapy of Asbestos-Associated Malignant Pleural Mesothelioma - An Expert Consensus Paper].

Pneumologie 2021 May 4. Epub 2021 May 4.

Internistische Onkologie der Thoraxtumoren, Thoraxklinik - Universitätsklinikum Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL).

Asbestos-related mesotheliomas belong to the group of the most frequent occupational diseases in Germany, reaching about 1,000 new cases per year. The disease has a dismal prognosis because most tumors remain asymptomatic for a long time and therefore are diagnosed as incidental findings at later stages.During the last decade the German Social Accident Insurance (DGUV) has made considerable efforts to prepone the diagnosis in order to detect the disease at earliest possible stages. Read More

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The Poor Prognosis of Patients with Stage III Gastric Cancer after D2 Dissection Is Mainly due to Lymphatic Metastasis, Especially the Metastasis of No.12a LN: A Nested Case-Control Study.

Oncol Res Treat 2021 May 4:1-7. Epub 2021 May 4.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: The prognosis of stage III gastric cancer (GC) patients based on the 8th edition TNM staging system after D2 dissection was still heterogeneous. We aimed to explore clinicopathological reasons that led to the poor prognosis of these patients, especially from a surgical aspect.

Methods: We divided 320 stage III GC patients who underwent distal or total gastrectomy with D2 lymphadenectomy into group 1 and group 2, according to the disease-free survival (DFS), and compared the clinicopathological features between these 2 groups. Read More

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Retrospective Analysis of the Clinical Presentation, Treatment and Outcome of Angiosarcoma in a Sarcoma Referral Center.

Oncol Res Treat 2021 May 4:1-10. Epub 2021 May 4.

Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

Introduction: Angiosarcoma (AS) is a rare subtype of soft tissue sarcoma. We performed a retrospective analysis of patient characteristics, treatments and prognostic factors in patients treated in a single sarcoma center.

Methods: We reviewed records of patients treated between 1987 and 2018, categorized in 7 different subtypes according to tissue of origin and underlying risk factors. Read More

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Evaluation of the Quality of Perinatal Trials: Making the GRADE.

Neonatology 2021 May 4:1-6. Epub 2021 May 4.

Department of Child Health, Queen's University, Belfast, United Kingdom.

Background: Assessing the quality of clinical research is a key evidence-based practice skill. Clinicians, guideline producers, policy makers, service commissioners, and families need to have a sense of the validity, applicability, and certainty of research evidence when determining how it should inform their decision-making and practice.

Methods: We consider the various methodological and study design factors that contribute to the validity and applicability of clinical research findings. Read More

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Efficacy and Safety of Lenvatinib-Transcatheter Arterial Chemoembolization Sequential Therapy for Patients with Intermediate-Stage Hepatocellular Carcinoma.

Oncology 2021 May 4:1-11. Epub 2021 May 4.

Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Introduction: We evaluated the efficacy and safety of lenvatinib-transcatheter arterial chemoembolization (LEN-TACE) sequential therapy for patients (n = 88) with intermediate-stage hepatocellular carcinoma (HCC).

Methods: Eighty-eight patients who obtained tumor control by LEN treatment were analyzed; 30 received LEN followed by TACE (LEN-TACE sequential therapy), and 58 received LEN monotherapy. Propensity score matching was performed, and the outcomes of 19 patients in the LEN-TACE group and 19 patients in the LEN-alone group were compared. Read More

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Aging-related genes are potential prognostic biomarkers for patients with gliomas.

Aging (Albany NY) 2021 May 4;13. Epub 2021 May 4.

Department of Neurosurgery, Xiangya Hospital, Central South University, Hunan, China.

Aging has a significant role in the proliferation and development of cancers. This study explored the expression profiles, prognostic value, and potential roles of aging-related genes in gliomas. We designed risk score and cluster models based on aging-related genes and glioma cases using LASSO Cox regression analysis, consensus clustering analysis and univariate cox regression analyses. Read More

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PDGFR-β fibroblasts deteriorate survival in human solid tumors: a meta-analysis.

Aging (Albany NY) 2021 May 3;13. Epub 2021 May 3.

Department of General Surgery III, Affiliated Hospital of Shaoxing University, Zhejiang 312000, China.

Fibroblasts are a highly heterogeneous population in tumor microenvironment. PDGFR-β fibroblasts, a subpopulation of activated fibroblasts, have proven to correlate with cancer progression through multiple of mechanisms including inducing angiogenesis and immune evasion. However, the prognostic role of these cells in solid tumors is still not conclusive. Read More

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Identification of an immune subtype predicting survival risk and immune activity in hepatocellular carcinoma.

Aging (Albany NY) 2021 May 3;13. Epub 2021 May 3.

Toxicology and Functional Laboratory, Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, China.

Immune checkpoint inhibitors (ICI) prolong the survival for advanced/metastatic patients with lung cancer or melanoma; however, for hepatocellular carcinoma (HCC) patients, a durable response has not been reported. Herein, we used a total of 719 HCC patients with public genomic data to determine potential prognostic and immunogenic subtypes. The non-negative matrix factorization (NMF) method was applied to identify the immune classes and potential subtypes. Read More

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Gene expression profiles for an immunoscore model in bone and soft tissue sarcoma.

Aging (Albany NY) 2021 May 4;13. Epub 2021 May 4.

Department of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Background: Immune infiltration is a prognostic marker to clinical outcomes in various solid tumors. However, reports that focus on bone and soft tissue sarcoma are rare. The study aimed to analyze and identify how immune components influence prognosis and develop a novel prognostic system for sarcomas. Read More

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Integrative analysis identifies key mRNA biomarkers for diagnosis, prognosis, and therapeutic targets of HCV-associated hepatocellular carcinoma.

Aging (Albany NY) 2021 May 4;13. Epub 2021 May 4.

Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, P.R. China.

Hepatitis C virus-associated HCC (HCV-HCC) is a prevalent malignancy worldwide and the molecular mechanisms are still elusive. Here, we screened 240 differentially expressed genes (DEGs) of HCV-HCC from Gene expression omnibus (GEO) and the Cancer Genome Atlas (TCGA), followed by weighted gene coexpression network analysis (WGCNA) to identify the most significant module correlated with the overall survival. 10 hub genes (CCNB1, AURKA, TOP2A, NEK2, CENPF, NUF2, CDKN3, PRC1, ASPM, RACGAP1) were identified by four approaches (Protein-protein interaction networks of the DEGs and of the significant module by WGCNA, and diagnostic and prognostic values), and their abnormal expressions, diagnostic values, and prognostic values were successfully verified. Read More

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A novel tailored immune gene pairs signature for overall survival prediction in lower-grade gliomas.

Transl Oncol 2021 May 1;14(7):101109. Epub 2021 May 1.

Department of Neurosurgery, The affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, 68 Gehu Road, Changzhou, Jiangsu 213000, China. Electronic address:

Lower-grade gliomas (LGGs) have a good prognosis with a wide range of overall survival (OS) outcomes. An accurate prognostic system can better predict survival time. An RNA-Sequencing (RNA-seq) prognostic signature showed a better predictive power than clinical predictor models. Read More

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Epidemiology and prognostic factors of pediatric brain tumor survival in the US: Evidence from four decades of population data.

Cancer Epidemiol 2021 May 1;72:101942. Epub 2021 May 1.

Program of Epidemiology, College of Health Sciences, University of Delaware, 100 Discovery Blvd, Newark, DE, 19713, United States.

Brain tumors, a group of heterogeneous diseases, are the second most common cancer and the leading cause of cancer-related deaths in children. Insight into the prognosis of pediatric brain tumor survival has led to improved outcomes and could be further advanced through precision in prognosis. We analyzed the United States SEER population-based dataset of 15,723 pediatric brain tumor patients diagnosed and followed between 1975 and 2016 using a stratified Cox proportional hazards model. Read More

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FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma.

Biochem Biophys Res Commun 2021 May 1;559:183-190. Epub 2021 May 1.

Department of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, 300041, China. Electronic address:

Oral squamous cell carcinoma (OSCC) is one of the causes of cancer-related death worldwide. The abnormal proliferation ability of OSCC has become one of the major reasons for its poor prognosis. FK-506 binding protein 11 (FKBP11) is abnormally expressed in malignant tumors and affects many biological processes. Read More

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Article Topic/Title: Primary cutaneous T-cell lymphomas other than Mycosis Fungoides and Sezary Syndrome. Part II: Prognosis and Management.

J Am Acad Dermatol 2021 May 1. Epub 2021 May 1.

Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Primary cutaneous T-cell lymphomas (CTCLs) other than Mycosis Fungoides (MF) and Sézary syndrome (SS) encompass a heterogenous group of non-Hodgkin lymphomas with variable clinical course, prognoses, and management. With morphologic and histologic overlap among the CTCL subtypes and other T-cell lymphomas with cutaneous manifestations, thorough evaluation with clinicopathologic correlation and exclusion of systemic involvement are essential prior to initiating therapy. Staging and treatment recommendations vary depending on the subtype, clinical behavior, and treatment response. Read More

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Longitudinal proteomic profiling provides insights into host response and proteome dynamics in COVID-19 progression.

Proteomics 2021 May 4:e2000278. Epub 2021 May 4.

Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.

In managing patients with coronavirus disease 2019 (COVID-19), early identification of those at high risk and real-time monitoring of disease progression to severe COVID-19 is a major challenge. We aimed to identify potential early prognostic protein markers and to expand understanding of proteome dynamics during clinical progression of the disease. We performed in-depth proteome profiling on 137 sera, longitudinally collected from 25 patients with COVID-19 (non-severe patients, n = 13; patients who progressed to severe COVID-19, n = 12). Read More

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Histopathologic synoptic reporting of invasive melanoma: How reliable are the data?

Cancer 2021 May 4. Epub 2021 May 4.

Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

Background: Synoptic reporting is recommended by many guideline committees to encourage the thorough histologic documentation necessary for optimal management of patients with melanoma.

Methods: One hundred fifty-one pathologists from 40 US states interpreted 41 invasive melanoma cases. For each synoptic reporting factor, the authors identified cases with "complete agreement" (all participants recorded the same value) versus any disagreement. Read More

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Cardiometabolic therapy and mortality in very old patients with diabetes hospitalized due to COVID-19.

J Gerontol A Biol Sci Med Sci 2021 May 4. Epub 2021 May 4.

Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), Málaga, Spain.

Background: The effects of cardiometabolic drugs on the prognosis of diabetic patients with COVID-19, especially very old patients, are not well-known. This work aims to analyze the association between preadmission cardiometabolic therapy (antidiabetic, antiaggregant, antihypertensive, and lipid-lowering drugs) and in-hospital mortality among patients ≥80 years with type 2 diabetes mellitus hospitalized for COVID-19.

Methods: We conducted a nationwide, multicenter, observational study in patients ≥80 years with type 2 diabetes mellitus hospitalized for COVID-19 between March 1 and May 29, 2020. Read More

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GADD45g acts as a novel tumor suppressor and its activation confers new combination regimens for the treatment of AML.

Blood 2021 May 4. Epub 2021 May 4.

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy for which there is an unmet need for novel treatment strategies. Here, we characterize the growth arrest and DNA damage-inducible gene gamma (GADD45g) as a novel tumor suppressor in AML. We show that GADD45g is preferentially silenced in AML, especially in AML with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations and mixed-lineage leukemia (MLL)-rearrangements, and reduced expression of GADD45g is correlated with poor prognosis in AML patients. Read More

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Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells.

PLoS One 2021 4;16(5):e0250649. Epub 2021 May 4.

Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States of America.

Treatment for the lethal primary adult brain tumor glioblastoma (GBM) includes the chemotherapy temozolomide (TMZ), but TMZ resistance is common and correlates with promoter methylation of the DNA repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). To improve treatment of GBMs, including those resistant to TMZ, we explored the potential of targeting dopamine receptor signaling. We found that dopamine receptor 3 (DRD3) is expressed in GBM and is also a previously unexplored target for therapy. Read More

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Assessment of circulating microRNA specific for patients with familial adenomatous polyposis.

PLoS One 2021 4;16(5):e0250072. Epub 2021 May 4.

Division of Lower GI Surgery, Department of Surgery, Hyogo College of Medicine, Hyogo, Japan.

Circulating microRNAs (miRNAs) are considered promising biomarkers for diagnosis, prognosis, and treatment efficacy of diseases. However, usefulness of circulating miRNAs as biomarkers for hereditary gastrointestinal diseases have not been confirmed yet. We explored circulating miRNAs specific for patients with familial adenomatous polyposis (FAP) as a representative hereditary gastrointestinal disease. Read More

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Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes.

PLoS Genet 2021 May 4;17(5):e1009557. Epub 2021 May 4.

School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures of single base substitution (SBS) have been extensively studied in different types of cancer. Copy number alterations are important drivers for the progression of multiple cancer. Read More

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Development and validation of a set of novel and robust 4-lncRNA-based nomogram predicting prostate cancer survival by bioinformatics analysis.

PLoS One 2021 4;16(5):e0249951. Epub 2021 May 4.

Department of Urology, Weihai Central Hospital, Weihai, Shandong, China.

Background And Objective: Accumulating evidence shows that long noncoding RNAs (lncRNAs) possess great potential in the diagnosis and prognosis of prostate cancer (PCa). Therefore, this study aimed to construct an lncRNA-based signature to more accurately predict the prognosis of different PCa patients, so as to improve patient management and prognosis.

Methods: Through univariate and multivariate Cox regression analysis, this study constructed a 4 lncRNAs-based prognosis nomogram for the classification and prediction of survival risk in patients with PCa based on TCGA data. Read More

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An evaluation of isatuximab, pomalidomide and dexamethasone for adult patients with relapsed and refractory multiple myeloma.

Expert Rev Hematol 2021 May 4. Epub 2021 May 4.

Molecular Oncology and Cancer Immunology, Epworth Healthcare, Melbourne, Australia.

Introduction: Despite therapeutic advances, myeloma remains an essentially incurable disease, with a median survival of approximately 8 -10 years. Most patients will develop disease that is refractory to immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs), and treatment regimens containing drugs with different mechanisms of action are necessary. Isatuximab is one such novel agent, an anti-CD38 monoclonal antibody (MoAb), and is the second drug in this class after daratumumab. Read More

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Proteomic approaches to assist in diagnosis and prognosis of oral cancer.

Expert Rev Proteomics 2021 May 4. Epub 2021 May 4.

Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, 13083-100, São Paulo, Brazil.

: Oral squamous cell carcinoma (OSCC) ranks in the top ten leading causes of cancer worldwide, with 5-year survival rate of about 50%, high lymph node metastasis, and relapse rates. The OSCC diagnosis, prognosis, and treatment are mostly based on the clinical TNM classification. There is an urgent need for the discovery of biomarkers and therapeutic targets to assist in the clinical decision-making process. Read More

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Docetaxel and cisplatin induction chemotherapy with or without fluorouracil in locoregionally advanced nasopharyngeal carcinoma: A retrospective propensity score matching analysis.

Asia Pac J Clin Oncol 2021 May 4. Epub 2021 May 4.

Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangdong, P.R. China.

Purpose: To investigate whether the addition of fluorouracil to docetaxel and cisplatin induction chemotherapy (IC) can truly improve the prognosis of patients with locoregionally advanced nasopharyngeal carcinoma (NPC).

Methods: A total of 801 patients newly diagnosed with non-metastatic locoregionally advanced NPC were included as the subjects. In this study, propensity score matching (PSM) was used for analysis of overall survival (OS), distant metastasis-free survival (DMFS), progression-free survival (PFS) and locoregional relapse-free survival (LRRFS), and the chi-squared test or Fisher's exact test was used to investigate toxic reactions. Read More

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Adhesion GPR123 is an indicator for recurrence and prognosis in bladder cancer.

Genes Genomics 2021 May 4. Epub 2021 May 4.

Department of Health Care, Jinan Municipal Hospital of Traditional Chinese Medicine, 76 Gongqingtuan road, Jinan, Shandong, China.

Background: Bladder cancer is a common urinary cancer, and most patients suffer tumor recurrence after surgery. Identifying more prognostic biomarkers is an essential task for precious treatment.

Objective: To evaluate the expression and clinical significance of GPR123, Angiotensin-I a type of adhesion G protein-coupled receptors (aGPCRs), in bladder cancer. Read More

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Laboratory Evaluation and Pathological Workup of Neoplastic Monocytosis - Chronic Myelomonocytic Leukemia and Beyond.

Curr Hematol Malig Rep 2021 May 4. Epub 2021 May 4.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose Of Review: Monocytosis is a distinct but non-specific manifestation of various physiologic and pathologic conditions. Among hematopoietic stem cell neoplasms, depending on the criteria used for disease classification, monocytosis may be a consistent and integral component of diseases such as chronic myelomonocytic leukemia or acute myeloid leukemia with monocytic differentiation, or it may represent an inconsistent finding that often provides a clue to the underlying genetic changes driving the neoplasm. The purpose of this review is to provide the readers with a laboratory-based approach to neoplastic monocytosis. Read More

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Retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after orbital decompression for dysthyroid optic neuropathy.

Int Ophthalmol 2021 May 4. Epub 2021 May 4.

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1277, Wuhan, 430022, Hubei Province, China.

Purpose: To determine the prognostic value of optical coherence tomography (OCT) measurement of the peripapillary retinal nerve fiber layer (RNFL) thickness in visual recovery after orbital decompression of patients with dysthyroid optic neuropathy (DON).

Methods: A total of 52 eyes of 37 patients who underwent orbital decompression for DON between 2013 and 2019 were retrospectively reviewed. We examined peripapillary RNFL thickness, best-corrected visual acuity (BCVA), visual field (VF) for mean deviation (MD) and pattern standard deviation (PSD), and pattern-reversed visual evoked potential (PVEP) for P100 latency and amplitude before and after surgery. Read More

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Echocardiographic parameters of left ventricular structure and diastolic function and their relation to coronary artery calcification.

Int J Cardiovasc Imaging 2021 May 4. Epub 2021 May 4.

Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Mdicine, 67, Sejong-daero, Jung-gu, Seoul, 04514, Republic of Korea.

Alteration in left ventricular (LV) structure and diastolic function is associated with poor cardiovascular (CV) prognosis. Coronary artery calcium score (CACS) is a reliable marker for coronary artery calcification, predicting adverse CV events. However, evidence is still insufficient to establish the association between alteration in LV structure and diastolic function and CACS. Read More

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LINC02308 promotes the progression of glioma through activating mTOR/AKT-signaling pathway by targeting miR-30e-3p/TM4SF1 axis.

Cell Biol Toxicol 2021 May 4. Epub 2021 May 4.

Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun City, Jilin Province, 130031, People's Republic of China.

Background: Glioma is a common brain malignancy, and the purpose of this study is to investigate the function of LINC02308 in glioma.

Methods: The differentially expressed lncRNAs were screened by microarray. The expression of LINC02308 in glioma tissues and cells was evaluated. Read More

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