4,221 results match your criteria profile reflected


Genetic Overlap Profiles of Cognitive Ability in Psychotic and Affective Illnesses: A Multisite Study of Multiplex Pedigrees.

Biol Psychiatry 2021 Mar 17. Epub 2021 Mar 17.

Department of Psychiatry, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.

Background: Cognitive impairment is a key feature of psychiatric illness, making cognition an important tool for exploring of the genetics of illness risk. It remains unclear which measures should be prioritized in pleiotropy-guided research. Here, we generate profiles of genetic overlap between psychotic and affective disorders and cognitive measures in Caucasian and Hispanic groups. Read More

View Article and Full-Text PDF

Implications of Low-grade Inflammation in SARS-CoV-2 Immunopathology.

MEDICC Rev 2021 Apr 30;23(2):42. Epub 2021 Apr 30.

Immunology Laboratory, National Oncology and Radiobiology Institute (INOR), Havana, Cuba.

Introduction: Advanced age and chronic disease comorbidities are indicators of poor prognosis in COVID-19 clinical progression. Fatal outcomes in patients with these characteristics are due to a dysfunctional immune response. Understanding COVID-19's immunopathogenesis helps in designing strategies to prevent and mitigate complications during treatment. Read More

View Article and Full-Text PDF

Freestream velocity-profile measurement in a large-scale, high-enthalpy reflected-shock tunnel.

Exp Fluids 2021 5;62(5):118. Epub 2021 May 5.

California Institute of Technology, Pasadena, CA 91125 USA.

Abstract: We apply Krypton Tagging Velocimetry (KTV) to measure velocity profiles in the freestream of a large, national-scale high-enthalpy facility, the T5 Reflected-Shock Tunnel at Caltech. The KTV scheme utilizes two-photon excitation at 216.67 nm with a pulsed dye laser, followed by re-excitation at 769. Read More

View Article and Full-Text PDF

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers.

World J Hepatol 2021 Apr;13(4):433-455

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, United States.

Background: Hepatobiliary diseases result in the accumulation of toxic bile acids (BA) in the liver, blood, and other tissues which may contribute to an unfavorable prognosis.

Aim: To discover and validate diagnostic biomarkers of cholestatic liver diseases based on the urinary BA profile.

Methods: We analyzed urine samples by liquid chromatography-tandem mass spectrometry and compared the urinary BA profile between 300 patients with hepatobiliary diseases 103 healthy controls by statistical analysis. Read More

View Article and Full-Text PDF

Impurity profiling of Compound Amino Acid Injection (6AA) using ion-pair high performance liquid chromatography coupled with corona-charged aerosol detection and high resolution mass spectrometry.

J Pharm Biomed Anal 2021 Apr 24;201:114099. Epub 2021 Apr 24.

Institute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 1, Tian Tan Xi Li, 100050, Beijing, PR China. Electronic address:

The complex industrial production process of amino acids (AAs) leads to the existence of a certain amount of impurities in Compound Amino Acid Injection (6AA). It is difficult to obtain its comprehensive and systematic impurity profile using conventional ultraviolet (UV) detectors due to lack of a suitable chromophore in the structures of AAs and their impurities. In our study, a universal ion-pair high performance liquid chromatography (HPLC) method combined with high resolution mass spectrometer (HRMS) and charged aerosol detection (CAD) was developed to identify and determine the content of impurities in Compound Amino Acid Injection (6AA), respectively. Read More

View Article and Full-Text PDF

Molecular characterization and epidemiology of Streptococcus pneumoniae serotype 8 in Denmark.

BMC Infect Dis 2021 May 5;21(1):421. Epub 2021 May 5.

Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.

Background: Streptococcus pneumoniae serotype 8 incidence has increased in Denmark after the introduction of pneumococcal conjugated vaccines (PCV). The mechanism behind the serotype 8 replacement is not well understood. In this study, we aimed to present epidemiological data on invasive pneumococcal disease (IPD) and molecular characterization of 96 serotype 8 clinical isolates. Read More

View Article and Full-Text PDF

The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.

Cell Mol Life Sci 2021 May 5. Epub 2021 May 5.

Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.

Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional requirements to promote the transport of the iRhom-ADAM17 complex have not yet been thoroughly investigated. Read More

View Article and Full-Text PDF

Blood Transcriptomics of Turbot : A Tool for Health Monitoring and Disease Studies.

Animals (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Departamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, Spain.

Blood transcriptomics is emerging as a relevant tool to monitor the status of the immune system and assist in diagnosis, prognosis, treatment and pathogenesis studies of diseases. In fish pathology, the potential of transcriptome profiling of blood is still poorly explored. Here, RNA sequencing was applied to analyze the blood transcriptional profile of turbot (), the most important farmed flatfish. Read More

View Article and Full-Text PDF

Characterization of topographic effects on sonic boom reflection by resolution of the Euler equations.

J Acoust Soc Am 2021 Apr;149(4):2437

Ecole Centrale de Lyon, Institut National des Sciences Appliquées de Lyon, Centre National de la Recherche Scientifique, Laboratoire de Mécanique des Fluides et d'Acoustique, Université Claude Bernard Lyon I, Unité Mixte de Recherche 5509, 36 Avenue Guy de Collongue, F-69134, Ecully, France.

The influence of topography on sonic boom propagation is investigated. The full two-dimensional Euler equations in curvilinear coordinates are solved using high-order finite-difference time-domain techniques. Simple ground profiles, corresponding to a terrain depression, a hill, and a sinusoidal terrain, are examined for two sonic boom waves: a classical N-wave and a low-boom. Read More

View Article and Full-Text PDF

Gut bacterial profile in Indian children of varying nutritional status: a comparative pilot study.

Eur J Nutr 2021 Apr 30. Epub 2021 Apr 30.

Molecular Biology Unit, Dairy Microbiology Division, ICAR-National Dairy Research Institute, Karnal, Haryana, 132001, India.

Purpose: Childhood malnutrition is a multifactorial disease, responsible for nearly half of all deaths in children under five. Lately, the probable association of a dysbiotic gut to malnutrition is also being eagerly investigated. The current study is an attempt to investigate this purported association through assessing the abundance of major gut bacterial phyla (Firmicutes, Bacteroidetes, Actinobacteria and Proteobacteria), probionts (Bifidobacteria and Lactobacillus), butyrogens (Faecalibacterium and Roseburia) and pathogens (Escherichia and Klebsiella). Read More

View Article and Full-Text PDF

Antioxidants in Smokers.

Nutr Res Rev 2021 Apr 30:1-77. Epub 2021 Apr 30.

Department of Biosciences (Department of Excellence 2018-2022), Università degli Studi di Milano, via Celoria 26, I-20133 Milan, Italy.

Cigarette smoke (CS) is likely the most common preventable cause of human morbidity and mortality worldwide. Consequently, inexpensive interventional strategies for preventing CS-related diseases would positively impact health systems. Inhaled CS is a powerful inflammatory stimulus and produces a shift in the normal balance between antioxidants and oxidants inducing oxidative stress in both the respiratory system and throughout the body. Read More

View Article and Full-Text PDF

Nasal Turbinate Mesenchymal Stromal Cells Preserve Characteristics of Their Neural Crest Origin and Exert Distinct Paracrine Activity.

J Clin Med 2021 Apr 20;10(8). Epub 2021 Apr 20.

Catholic High-Performance Cell Therapy Center, Department of Medical Lifescience, College of Medicine, The Catholic University, Seoul 06591, Korea.

The sources of mesenchymal stromal cells (MSCs) for cell therapy trials are expanding, increasing the need for their characterization. Here, we characterized multi-donor, turbinate-derived MSCs (TB-MSCs) that develop from the neural crest, and compared them to bone marrow-derived MSCs (BM-MSCs). TB-MSCs had higher proliferation potential and higher self-renewal of colony forming cells, but lower potential for multi-lineage differentiation than BM-MSCs. Read More

View Article and Full-Text PDF

Assessment of Bioactive Compounds under Simulated Gastrointestinal Digestion of Bee Pollen and Bee Bread: Bioaccessibility and Antioxidant Activity.

Antioxidants (Basel) 2021 Apr 23;10(5). Epub 2021 Apr 23.

Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.

Bee pollen and bee bread have always been regarded as excellent natural resources for application in food and pharmaceutical fields due to their rich nutrient content and diversity of bioactive compounds with health-improving properties. Extensive studies on both bee products as ingredients for a healthy diet were reported, although the data concerning their metabolization on the gastrointestinal tract is quite limited. Here, we report, at each digestive stage, the bioactive profile for both bee products, their bioaccessibility levels and the antioxidant activity evaluation. Read More

View Article and Full-Text PDF

Formation Mechanism and Control Method of Residual Stress Profile by Laser Shock Peening in Thin Titanium Alloy Component.

Materials (Basel) 2021 Apr 9;14(8). Epub 2021 Apr 9.

Science and Technology on Plasma Dynamics Laboratory, Air Force Engineering University, Xi'an 710038, Shaanxi, China.

In the laser shock peening process of titanium alloy thin blades, a shock wave will be repeatedly reflected and coupled in the blades, resulting in the failure of the formation of a gradient residual compressive stress layer, which is the key to improve fatigue performance and resist foreign object impact. This paper takes TC17 titanium alloy sheet as the research object to reveal the influence mechanism on residual stress-strain profile of shock wave reflection-coupling by shock wave propagation and key position dynamic response. Based on the result of influence mechanism, two wave transmission methods are proposed to regulate shock wave in order to reduce the intensity of shock wave reflection. Read More

View Article and Full-Text PDF

Comparative analysis of human bone marrow mesenchymal stem cells, articular cartilage derived chondroprogenitors and chondrocytes to determine cell superiority for cartilage regeneration.

Acta Histochem 2021 Apr 21;123(4):151713. Epub 2021 Apr 21.

Department of Physiology, Christian Medical College, Vellore, 632002, India. Electronic address:

Introduction: Chondroprogenitors, a promising therapeutic modality in cell-based therapy, are routinely isolated from articular cartilage by fibronectin differential adhesion assay. However, there is paucity of information regarding their biological profile and the lack of a marker that can reliably distinguish them from cultured chondrocytes due to possible dedifferentiation. Since chondroprogenitors have been classified as mesenchymal stem cells(MSCs), the aim of our study was to compare bone marrow-MSCs, chondroprogenitors and chondrocytes, and assess superiority for cartilage repair. Read More

View Article and Full-Text PDF

Quantity - but not diversity - of secreted peptides and proteins increases with age in the tree frog .

J Venom Anim Toxins Incl Trop Dis 2021 Apr 2;27:e20200105. Epub 2021 Apr 2.

Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil.

Background: Amphibians inhabit the terrestrial environment, a conquest achieved after several evolutionary steps, which were still insufficient to make them completely independent of the aquatic environment. These processes gave rise to many morphological and physiological changes, making their skin (and cutaneous secretion) rich in bioactive molecules. Among the tree frogs, the secretion is composed mainly of peptides; but alkaloids, proteins and steroids can also be found depending on the species. Read More

View Article and Full-Text PDF

Albumin-to-globulin ratio before dry-off as a possible index of inflammatory status and performance in the subsequent lactation in dairy cows.

J Dairy Sci 2021 Apr 14. Epub 2021 Apr 14.

Department of Animal Science, Food and Nutrition (DIANA), Faculty of Agricultural, Food and Environmental Sciences, Università Cattolica del Sacro Cuore, 29122 Piacenza, Italy.

The dry-off of dairy cows represents an important phase of the lactation cycle, influencing the outcome of the next lactation. Among the physiological changes, the severity of the inflammatory response can vary after the dry-off, and this response might have consequences on cow adaptation in the transition period. The plasma protein profile is a diagnostic tool widely used in humans and animals to assess the inflammatory status and predict the outcome of severe diseases. Read More

View Article and Full-Text PDF

Autism Spectrum Disorder and Mental Health Problems: Patterns of Difficulties and Longitudinal Trajectories in a Population-Based Twin Sample.

J Autism Dev Disord 2021 Apr 17. Epub 2021 Apr 17.

Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, PO80, Denmark Hill, London, SE5 8AF, UK.

There is increasing concern regarding additional psychiatric problems that co-occur with Autism Spectrum Disorder (ASD), as reflected in recent changes to diagnostic schemes. However, there remains little research with population-based samples across childhood. We report on additional problems, as measured by the Strengths and Difficulties Questionnaire, in a population-based sample of 135 twins with ASD, 55 non-ASD co-twins, and 144 comparison twins low in ASD traits. Read More

View Article and Full-Text PDF

Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma.

Neuro Oncol 2021 Apr 17. Epub 2021 Apr 17.

Translational NeuroOncology Research Group, Medical Center University of Freiburg, Germany.

Background: Glioblastoma cells assemble to a syncytial communicating network based on tumor microtubes (TMs) as ultra-long membrane protrusions. The relationship between network architecture and transcriptional profile remains poorly investigated. Drugs that interfere within this syncytial connectivity such as meclofenamate (MFA) may be highly attractive for glioblastoma therapy. Read More

View Article and Full-Text PDF

Cancer immune control dynamics: a clinical data driven model of systemic immunity in patients with metastatic melanoma.

BMC Bioinformatics 2021 Apr 16;22(1):197. Epub 2021 Apr 16.

Department of Medical Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: Recent clinical advances in cancer immuno-therapeutics underscore the need for improved understanding of the complex relationship between cancer and the multiple, multi-functional, inter-dependent, cellular and humoral mediators/regulators of the human immune system. This interdisciplinary effort exploits engineering analysis methods utilized to investigate anomalous physical system behaviors to explore immune system behaviors. Cancer Immune Control Dynamics (CICD), a systems analysis approach, attempts to identify differences between systemic immune homeostasis of 27 healthy volunteers versus 14 patients with metastatic malignant melanoma based on daily serial measurements of conventional peripheral blood biomarkers (15 cell subsets, 35 cytokines). Read More

View Article and Full-Text PDF

Facial Skin Biophysical Profile of Women in Malaysia: Significance of Facial Skincare Product Use.

Skin Pharmacol Physiol 2021 Apr 14:1-12. Epub 2021 Apr 14.

Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Introduction: At present, there is a lack of baseline data on the facial skin biophysical profile of women in Malaysia. The implications related to the daily habits and facial skincare product use on the skin biophysical condition are, thus, unknown. In this study, we aim to evaluate facial skin biophysical parameters of Malaysian women and examine the influence of demographic characteristics, daily habits, and facial skincare product use on these parameters. Read More

View Article and Full-Text PDF

ARTICLE: Compromised Skin Barrier and Sensitive Skin in Diverse Populations.

J Drugs Dermatol 2021 Apr;20(4):s17-s22

The most important function of the stratum corneum (SC), the uppermost layer of the human epidermis, is the formation of the epidermal permeability barrier. Lipids, particularly ceramides, cholesterol, and free fatty acids, together form lamellar membranes in the extracellular spaces of the SC that limit the loss of water and electrolytes. In addition to preventing water and electrolyte loss, the SC as a permeability barrier prevents the entry of harmful irritants, allergens, and microorganisms into the skin. Read More

View Article and Full-Text PDF

Age profile of NHS workers in occupational physician clinics.

Authors:
W A Telling

Occup Med (Lond) 2021 Apr 13. Epub 2021 Apr 13.

Occupational Health Department, Leicester Royal Infirmary, Infirmary Square, Leicester, UK.

Background: The population in the UK is predicted to increase in size and age. The National Health Service (NHS) is the largest employer in the UK and demographic changes in the working population would be expected to be reflected in the NHS workforce. Such changes may present different challenges to an NHS occupational physician (OP). Read More

View Article and Full-Text PDF

UPLC-orbitrap-MS-based metabolic profiling of HaCaT cells exposed to withanolides extracted from Datura metel.L: Insights from an untargeted metabolomics.

J Pharm Biomed Anal 2021 May 16;199:113979. Epub 2021 Feb 16.

Heilongjiang University of Traditional Chinese Medicine, Heping Road 24, Harbin, 150040, China. Electronic address:

In recent decades, more and more attention to the withanolides extracted from Datura metel.L has been paid due to their anti-psoriatic effects. Withanolides have also been reported to exhibit anti-inflammatory and anti-proliferative properties. Read More

View Article and Full-Text PDF

The Antidepressant Mirtazapine Rapidly Shifts Hepatic B Cell Populations and Functional Cytokine Signatures in the Mouse.

Front Immunol 2021 25;12:622537. Epub 2021 Mar 25.

Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, AB, Canada.

Introduction: B cells are important regulators of both adaptive and innate immunity. The normal liver contains significant numbers of B cells, and their numbers increase dramatically in immune-mediated liver diseases. Our previous observations suggest a hepatoprotective effect of the antidepressant mirtazapine in human and experimental immune-mediated liver disease. Read More

View Article and Full-Text PDF

The PROMIS®-Plus-Osteoarthritis of the Knee (OAK) Profile Measure integrates generic and condition-specific content to enhance relevance and efficiency.

J Clin Epidemiol 2021 Apr 8. Epub 2021 Apr 8.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 625 N. Michigan Avenue, Chicago, IL 60611. Electronic address:

Objective: The Patient-Reported Outcomes Measurement Information System® (PROMIS®)-Plus-Osteoarthritis of the Knee (OAK) profile integrates universal PROMIS items with knee-specific items across 13 domains. We evaluated the psychometric properties of a subset of six domains associated with quality of life in people with OAK.

Study Design And Setting: In a cross-sectional study of OAK patients (n=600), we estimated reliability using Pearson and Spearman correlations with Knee Injury and Osteoarthritis Outcome Score (KOOS) subscores and known-groups validity with PROMIS Global Health. Read More

View Article and Full-Text PDF

Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method: In Vitro and In Vivo Evaluation-a Potential Approach for HIV Therapy.

AAPS PharmSciTech 2021 Apr 9;22(3):127. Epub 2021 Apr 9.

Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, 382481, India.

Being a candidate of BCS class II, dolutegravir (DTG), a recently approved antiretroviral drug, possesses solubility issues. The current research was aimed to improve the solubility of the DTG and thereby enhance its efficacy using the solid dispersion technique. In due course, the miscibility study of the drug was performed with different polymers, where Poloxamer 407 (P407) was found suitable to move forward. Read More

View Article and Full-Text PDF

Potential Alteration of Statin-Related Pharmacological Features in Diabetes Mellitus.

Biomed Res Int 2021 26;2021:6698743. Epub 2021 Mar 26.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Type 2 diabetes mellitus is a chronic metabolic disease caused by insulin resistance or insulin deficiency resulting in elevated blood glucose levels. Poorly controlled diabetes is associated with the development of cardiovascular disease and dyslipidemia. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statin) are an important class of therapeutic agents used to control hyperlipidemia and prevent cardiovascular disease in diabetic and nondiabetic patients. Read More

View Article and Full-Text PDF

Metabolic profiling of 19 amino acids in triptolide-induced liver injured rats by gas chromatography-triple quadrupole mass spectrometry.

Hum Exp Toxicol 2021 Apr 9:9603271211006167. Epub 2021 Apr 9.

Jiangxi Province Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, People's Republic of China.

The liver is an important organ for amino acid metabolism, and its damage can be reflected in the changes of amino acid level in the body. Triptolide (TP) has broad anti-inflammatory and anti-tumor activities, but its clinical application is limited due to hepatotoxicity. In this work, a simple, accurate and sensitive gas chromatography-triple quadrupole mass spectrometry (GC-QqQ-MS/MS) method was developed and validated for evaluating the serum levels of amino acids from control and TP-induced liver injured rats, and chemometric analysis was employed for amino acid metabolic profiles analysis. Read More

View Article and Full-Text PDF

Characterization of micrometer-size laser beam using a vibrating wire as a miniature scanner.

Rev Sci Instrum 2021 Mar;92(3):033303

Ulsan National Institute of Science and Technology, 44919 Ulsan, South Korea.

A new method for profile measurements of small transverse size beams by means of a vibrating wire is presented. A vibrating wire resonator with a new magnetic system was developed and manufactured to ensure that the wire oscillated in a single plane. Presented evidence gives us confidence that the autogenerator creates vibrations at the natural frequency of the wire in a plane of the magnetic system, and these vibrations are sinusoidal. Read More

View Article and Full-Text PDF