1,404 results match your criteria profile opportunistic

Occurrence, antimicrobial susceptibility, and pathogenic factors of in canine clinical samples.

Vet World 2021 Apr 23;14(4):978-985. Epub 2021 Apr 23.

Department of Veterinary Medicine, University of Teramo, Loc. Piano d'Accio, 64100, Teramo, Italy.

Background And Aim: is a relevant opportunistic and difficult to treat pathogen due to its widespread environmental diffusion, intrinsic resistance to many classes of antimicrobials, high ability to acquire additional resistance mechanisms, and wide range of pathogenic factors. The present study aimed to investigate the prevalence of in canine clinical samples, the antimicrobial susceptibility against antipseudomonal antibiotics, and the presence of extracellular pathogenic factors of the isolates, as well as their ability to produce biofilm.

Materials And Methods: Overall, 300 clinical specimens from dogs with pyoderma or abscesses (n=58), otitis (n=59), and suspected bladder infection (n=183) were analyzed by standard bacteriological methods. Read More

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Pan-Resistome Insights into the Multidrug Resistance of .

Antibiotics (Basel) 2021 May 18;10(5). Epub 2021 May 18.

Laboratory of Cellular and Molecular Genetics, Universidade Federal de Minas GeraisBelo Horizonte, Belo Horizonte 31270-901, MG, Brazil.

is an important Gram-negative opportunistic pathogen that is responsible for many nosocomial infections. This etiologic agent has acquired, over the years, multiple mechanisms of resistance to a wide range of antimicrobials and the ability to survive in different environments. In this context, our study aims to elucidate the resistome from the strains based on phylogenetic, phylogenomic, and comparative genomics analyses. Read More

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Coordination of microbe-host homeostasis by crosstalk with plant innate immunity.

Nat Plants 2021 Jun 24;7(6):814-825. Epub 2021 May 24.

Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany.

Plants grown in natural soil are colonized by phylogenetically structured communities of microbes known as the microbiota. Individual microbes can activate microbe-associated molecular pattern (MAMP)-triggered immunity (MTI), which limits pathogen proliferation but curtails plant growth, a phenomenon known as the growth-defence trade-off. Here, we report that, in monoassociations, 41% (62 out of 151) of taxonomically diverse root bacterial commensals suppress Arabidopsis thaliana root growth inhibition (RGI) triggered by immune-stimulating MAMPs or damage-associated molecular patterns. Read More

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Single-cell profiling identifies impaired adaptive NK cells expanded after HCMV reactivation in haploidentical-HSCT.

JCI Insight 2021 May 18. Epub 2021 May 18.

Unit of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.

Haploidentical hematopoietic stem cell transplantation (h-HSCT) represents an efficient curative approach for patients affected by hematologic malignancies in which the reduced intensity conditioning induces a state of immunologic tolerance between donor and recipient. However, opportunistic viral infections greatly affect h-HSCT clinical outcomes. Natural Killer (NK) cells are the first lymphocytes recovering after transplant and provide a prompt defense against human Cytomegalovirus (HCMV) infection/reactivation. Read More

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Direct Comparison of Risankizumab and Fumaric Acid Esters in Systemic-Therapy-Naive Patients With Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial.

Br J Dermatol 2021 May 15. Epub 2021 May 15.

Dermatologikum, Hamburg, Germany.

Background: Fumaric acid esters (FAEs; Fumaderm ) are the most frequently prescribed first-line systemic treatment for moderate-to-severe plaque psoriasis in Germany. Risankizumab (Skyrizi ) is a humanized IgG1 monoclonal antibody that specifically binds to the p19 subunit of interleukin-23.

Objective: This study compared risankizumab treatment with FAEs in psoriasis patients. Read More

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Presentation and outcome of COVID-19 in HIV patients with high viral loads and opportunistic infections: a case series.

Ghana Med J 2020 Dec;54(4 Suppl):121-124

Ashanti Regional Health Directorate, Ghana Health Service, Kumasi, Ghana.

Coronavirus disease 2019 (COVID-19) is especially severe in patients with underlying chronic conditions, with increased risk of mortality. There is concern that people living with HIV (PLWH), especially those with severe immunosuppression, and COVID-19 may have severe disease and a negative clinical outcome. Most studies on COVID-19 in PLWH are from Asia, Europe and America where population dynamics, antiretroviral treatment coverage and coexisting opportunistic infections may differ from that in sub-Saharan Africa. Read More

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December 2020

Risk of Hospitalized Serious Infection After Initiating Ustekinumab or Other Biologics for Psoriasis or Psoriatic Arthritis.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.

Objective: To compare the risk of serious infections requiring hospitalization in patients with psoriasis (PsO) or psoriatic arthritis (PsA) initiating ustekinumab versus other biologics or apremilast.

Methods: In this multi-database cohort study, we identified patients with PsO/PsA who initiated adalimumab, apremilast, certolizumab, etanercept, golimumab, ixekizumab, secukinumab, or ustekinumab between 2009 and 2018. The primary outcome was hospitalized serious infections including bacterial, viral, or opportunistic infections. Read More

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Detection of virulence genes and antimicrobial susceptibility profile of Listeria monocytogenes isolates recovered from artisanal cheese produced in the Southern region of Brazil.

An Acad Bras Cienc 2021 30;93(3):e20190200. Epub 2021 Apr 30.

Universidade do Estado de Santa Catarina, Centro de Diagnóstico Microbiológico Animal, Centro de Ciências Agroveterinárias, Av. Luiz de Camões, 2090, Bairro Conta Dinheiro, 88520-000 Lages, SC, Brazil.

Listeria monocytogenes is an opportunistic pathogen that causes listeriosis, a foodborne disease with low incidence but with high mortality rate in humans. This microorganism has been recovered from several dairy products, especially those produced with raw milk. The objective of this work was to investigate the presence of virulence genes, and also to define the antimicrobial susceptibility profile of L. Read More

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Prevalence, Genetic Diversity, Antimicrobial Resistance, and Toxigenic Profile of Isolated from Aquatic Environments in Taiwan.

Antibiotics (Basel) 2021 Apr 29;10(5). Epub 2021 Apr 29.

Department of Internal Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan.

is a gram-negative, opportunistic human pathogen associated with life-threatening wound infections and is commonly found in warm coastal marine water environments, globally. In this study, two fishing harbors and three tributaries of the river basin were analyzed for the prevalence of in the water bodies and shellfish that are under the pressure of external pollutions. The average detection rate of in the river basins and fishing harbors was 8. Read More

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Microbe profile: : an opportunistic pathogen with multiple personalities.

Steve J Charette

Microbiology (Reading) 2021 May;167(5)

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), Quebec City, QC G1V 4G5, Canada.

The bacterial species is a fish pathogen. Feared by fish farmers everywhere on Earth over the past century, this species has turned out to be more diverse than initially suspected. While some psychrophilic subspecies cannot grow at temperatures above 25 °C or 30 °C, other mesophilic strains growing up to 37 °C and above are now characterized. Read More

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Carbapenem Resistance in Non-Fermentative Gram-Negative Bacilli Isolated from Intensive Care Unit Patients of a Referral Hospital.

J Nepal Health Res Counc 2021 Apr 23;19(1):55-61. Epub 2021 Apr 23.

Department of Clinical Microbiology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Background: Non-fermentative Gram-negative bacilli or non-fermenters are opportunistic pathogens associated with serious infections in intensive care unit patients. Although carbapenems were considered as a backbone of treatment for life-threatening infections, these bacteria are increasingly acquiring resistance to carbapenems. Carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa are prioritized as critical pathogens by the World Health Organization. Read More

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Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa.

PLoS One 2021 30;16(4):e0250977. Epub 2021 Apr 30.

Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.

Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen that causes considerable human morbidity and mortality, particularly in nosocomial infections and individuals with cystic fibrosis. P. aeruginosa can adapt to surface growth by undergoing swarming motility, a rapid multicellular movement that occurs on viscous soft surfaces with amino acids as a nitrogen source. Read More

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biofilms produce an extracellular matrix and have a distinct mycolic acid profile.

Cell Surf 2021 Dec 6;7:100051. Epub 2021 Apr 6.

School of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

A non-tuberculous mycobacterium, is an emerging opportunistic pathogen associated with difficult to treat pulmonary infections, particularly in patients suffering from cystic fibrosis. It is capable of forming biofilms that result in an increase of already high levels of antibiotic resistance in this bacterium. Evidence that forms biofilm-like microcolonies in patient lungs and on medical devices further implicated the need to investigate this biofilm in detail. Read More

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December 2021

IV and oral fosfomycin pharmacokinetics in neonates with suspected clinical sepsis.

J Antimicrob Chemother 2021 Jun;76(7):1855-1864

Infection, Immunity and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK.

Background: Fosfomycin has the potential to be re-purposed as part of a combination therapy to treat neonatal sepsis where resistance to current standard of care (SOC) is common. Limited data exist on neonatal fosfomycin pharmacokinetics and estimates of bioavailability and CSF/plasma ratio in this vulnerable population are lacking.

Objectives: To generate data informing the appropriate dosing of IV and oral fosfomycin in neonates using a population pharmacokinetic analysis of plasma and CSF data. Read More

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Clinical and immunological profile of children with Mendelian Susceptibility to Mycobacterial Diseases (MSMD) from an Indian tertiary care hospital.

Indian J Tuberc 2021 Apr 30;68(2):292-297. Epub 2020 Jul 30.

University of Paris, Imagine Institute, Laboratory of Human Genetics of Infectious Diseases, Institut National de La Santé et de La Recherche Médicale U1163 and Study Center of Immunodeficiencies, Necker Hospital for Sick Children, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, the Rockefeller University, New York, NY, USA.

Inherited disorders of interferon gamma (IFN) γ, also known as Mendelian Susceptibility to Mycobacterial Diseases (MSMD), have been classified as Primary Immuno Deficiency 6, ie, defect in intrinsic and innate immunity. As IFN-γ plays an important role in conferring immunity to mycobacterial infections, its disorders have been increasingly reported in association with disseminated BCG/Non Tubercular Mycobacterial infections. So far germline mutations in 16 genes have been reported, most common being IL12RB1 followed by IFNGR1 and IFNGR2. Read More

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Extended Safety Analysis of Baricitinib 2 mg in Adult Patients with Atopic Dermatitis: An Integrated Analysis from Eight Randomized Clinical Trials.

Am J Clin Dermatol 2021 May 7;22(3):395-405. Epub 2021 Apr 7.

Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.

Background: Baricitinib, a selective Janus kinase 1/Janus kinase 2 inhibitor, is indicated in the European Union and Japan for the treatment of moderate-to-severe atopic dermatitis (AD) in adults who are candidates for systemic therapy.

Objective: The objective of this study was to evaluate the safety of baricitinib 2 mg in the AD clinical program.

Methods: Six double-blind, randomized, placebo-controlled studies, and two long-term extension studies were summarized in two datasets. Read More

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Co-infection with Pseudomonas aeruginosa impacts virulence of Staphylococcus aureus and intensifies the severity of infection.

Pak J Pharm Sci 2020 Sep;33(5):1933-1937

Department of Biotechnology, Dalian Medical University, Dalian, PR China.

Multi-specie infections display diverse interactions among pathogens that influence the severity of disease. Staphylococcus aureus and Pseudomonas aeruginosa are the two most important opportunistic, nosocomial and drug-resistant pathogens. Poly-infections due to S. Read More

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September 2020

Assessment of clinical and behavioral profile of clients attending integrated counseling and testing centers of a tertiary care institute in Eastern India: A secondary data analysis.

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):149-155. Epub 2020 Nov 11.

Department of Community and Family Medicine, AIIMS, Bhubaneswar, Odisha, India.

Introduction: Integrated counseling and testing center (ICTC) forms the major forum under the National AIDS Control Organization (NACO) for counseling and testing of HIV-suspected patients. ICTC setup in a tertiary care institute also provides a chance for opportunistic screening of large number of individuals.

Aims: The study was done to assess and to profile the ICTC clients with respect to their seropositivity rate, their biological and behavioral risk factors, and seroconcordance rate. Read More

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November 2020

Farfantepenaeus gene-encoded antimicrobial peptides: Identification, molecular characterization and gene expression in response to fungal infections.

J Invertebr Pathol 2021 Jun 1;182:107586. Epub 2021 Apr 1.

Laboratory of Immunology Applied to Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil. Electronic address:

The aim of this study was to identify and characterize, at the molecular and transcriptional levels, sequences encoding the different members of the four families of shrimp antimicrobial peptides (AMPs) in species of the genus Farfantepenaeus. The identification of the AMP sequences was performed by in silico analysis as well as by molecular cloning and nucleotide sequencing. We identified all seven shrimp ALFs (ALF-A to ALF-G), both Type IIa and Type IIb crustins as well as two stylicins (STY1 and STY2) in Farfantepenaeus. Read More

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The Formation of Biofilm and Bacteriology in Otitis Media with Effusion in Children: A Prospective Cross-Sectional Study.

Int J Environ Res Public Health 2021 03 30;18(7). Epub 2021 Mar 30.

Independent Otoneurological Laboratory, Medical University of Lublin, 20-093 Lublin, Poland.

Background: Otitis media with effusion (OME) can cause serious complications such as hearing impairment or development delays. The aim of the study was to assess the microbiological profile of organisms responsible for OME and to determine if a biofilm formation can be observed.

Methods: Ninety-nine samples from 76 patients aged from 6 months to 12 years were collected for microbiological and molecular studies. Read More

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Metagenomics Approaches to Investigate the Gut Microbiome of COVID-19 Patients.

Bioinform Biol Insights 2021 12;15:1177932221999428. Epub 2021 Mar 12.

Department of fundamental sciences, School of Medicine, Mohammed VI University of Health Sciences, Casablanca, Morocco.

Over the last decade, it has become increasingly apparent that the microbiome is a central component in human well-being and illness. However, to establish innovative therapeutic methods, it is crucial to learn more about the microbiota. Thereby, the area of metagenomics and associated bioinformatics methods and tools has become considerable in the study of the human microbiome biodiversity. Read More

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Leclercia adecarboxylata Bacteremia without a Focus in a Non-Immunosuppressed Patient.

Am J Case Rep 2021 Mar 30;22:e929537. Epub 2021 Mar 30.

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

BACKGROUND Leclercia adecarboxylata is a gram-negative rod, which is normally found in water and food. It is an emerging pathogen that affects immunocompromised patients, including patients with hematological malignancies or those receiving chemotherapy. Generally, L. Read More

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Use of granulocyte/monocytapheresis in ulcerative colitis: A practical review from a European perspective.

World J Gastroenterol 2021 Mar;27(10):908-918

Department of Medicine I, Agaplesion Markus Hospital, Goethe-University, Frankfurt am Main 60431, Germany.

Half of the patients with ulcerative colitis require at least one course of systemic corticosteroids in their lifetime. Approximately 75% of these patients will also require immunosuppressive drugs (, thiopurines or biological agents) in the mid-term to avoid colectomy. Immunosuppressive drugs raise some concerns due to an increased risk of serious and opportunistic infections and cancer, particularly in elderly and co-morbid patients, underlining the unmet need for safer alternative therapies. Read More

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Characterization of naphthenic acid fraction compounds in water from Athabasca oil sands wetlands by Orbitrap high-resolution mass spectrometry.

Sci Total Environ 2021 Aug 20;780:146342. Epub 2021 Mar 20.

Watershed Hydrology and Ecology Research Division, Science and Technology Branch, Environment and Climate Change Canada, 11 Innovation Boulevard, Saskatoon, Saskatchewan, S7N 3H5, Canada. Electronic address:

Classical naphthenic acids (NAs) are known to be primary aquatic toxicants of concern in the Athabasca oil sands region (AOSR), and are a component of naphthenic acid fraction compounds (NAFCs). Recent studies conducted in the AOSR have examined metals and polycyclic aromatic hydrocarbons in regional wetlands. However, few studies have described NAs and/or NAFCs in AOSR wetlands. Read More

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Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis.

Sci Rep 2021 Mar 23;11(1):6677. Epub 2021 Mar 23.

Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.

Gallstone disease affects up to twenty percent of the population in western countries and is a significant contributor to morbidity and health care expenditure. Intestinal microbiota have variously been implicated as either contributing to gallstone formation or to be affected by cholecystectomy. We conducted a large-scale investigation on 404 gallstone carriers, 580 individuals post-cholecystectomy and 984 healthy controls with similar distributions of age, sex, body mass index, smoking habits, and food-frequency-score. Read More

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Peripheral immune profile of children with Talaromyces marneffei infections: a retrospective analysis of 21 cases.

BMC Infect Dis 2021 Mar 20;21(1):287. Epub 2021 Mar 20.

Department of Respiratory Infection, Guangzhou Medical University, No.9, Jinsui Road, Zhujiang New City, Tianhe District, Guangzhou, 510120, Guangdong, China.

Background: Talaromyces marneffei (T. marneffei) is an opportunistic pathogen that infects immunodeficient children. The aim of the study is to determine the clinical features and peripheral immune state of Talaromyces marneffei (T. Read More

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Hit the Road JAK! The Role of New Oral Treatment in Inflammatory Bowel Disease.

Inflamm Bowel Dis 2021 Mar 20. Epub 2021 Mar 20.

Gastroenterology and Hepatology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.

Crohn disease (CD) and ulcerative colitis (UC) are considered chronic disorders of the gastrointestinal tract, lifelong medication often being necessary. Furthermore, they have significant implications on the quality of life. In the past few years, major advances have been achieved concerning the treatment of inflammatory bowel disease. Read More

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Quorum Sensing-Mediated and Growth Phase-Dependent Regulation of Metabolic Pathways in H4.

Front Microbiol 2021 2;12:567942. Epub 2021 Mar 2.

School of Food Science and Technology, Dalian Polytechnic University, Dalian, China.

Quorum sensing (QS) is a widespread regulatory mechanism in bacteria used to coordinate target gene expression with cell density. Thus far, little is known about the regulatory relationship between QS and cell density in terms of metabolic pathways in H4. In this study, transcriptomics analysis was performed under two conditions to address this question. Read More

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Drug-Induced Myelosuppression in Kidney Transplant Patients.

Exp Clin Transplant 2021 Mar 16. Epub 2021 Mar 16.

From the Jaber El Ahmed Military Hospital, Nephrology Department, Safat, Kuwait.

Renal transplant is considered the best therapeutic option for suitable patients with end-stage kidney failure. Hematological complications that occur after kidney transplant include posttransplant anemia, leukopenia, neutropenia, and thrombocytopenia. Severely persistent leukopenia and neutropenia events predispose patients to infection, including opportunistic infections. Read More

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Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen .

J Med Microbiol 2021 Mar 18;70(3). Epub 2021 Mar 18.

Service de Bactériologie-Hygiène hospitalière, CHU de Rennes, Rennes, France.

Even though has been described in 2002, this species has long been underestimated due to the unreliability of conventional identification methods and only a few cases of infections have been reported. Little is known about clinical significance and antimicrobial susceptibility profile of this uncommon species. To evaluate the clinical relevance of and its antimicrobial susceptibility profile. Read More

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