469,564 results match your criteria profile

Ameliorating activity of polyphenolic-rich extracts of L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats.

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Department of Biochemistry, Phytomedicine, Natural Products, Drug and Biochemical Toxicology Group, Landmark University, Omu Aran, PMB 1001, Kwara State, Nigeria.

Objectives: To assess the ameliorative activity of polyphenolic-rich extracts of leaves on β-cell dysfunction in type-II diabetes (T2DM).

Methods: Total phenolic and flavonoid contents; α-amylase and α-glucosidase inhibitory actions and qualitative analysis of the bioactive compounds of the polyphenolic-rich extract of leaves were investigated using gas chromatography-mass spectroscopy (GC-MS). Diabetes mellitus (DM) was induced by single intraperitoneal injection of streptozotocin (60 mg/kg body weight) and the rats were orally given bound phenolic (BPE) and free phenolic extracts (FPE) of (B. Read More

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A systematic review on the metabolic effects of chlorpyrifos.

Rev Environ Health 2021 May 7. Epub 2021 May 7.

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Organophosphate (OP) pesticides, including chlorpyrifos (CPF), can alter metabolic hemostasis. The current systematic study investigated blood glucose, lipid profiles, and body weight alterations in rodents and fish exposed to CPF. The systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Guidelines, querying online databases, including Web of Science, PubMed, and Scopus and also search engine including Google Scholar, through January 2021. Read More

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The safety profile and angioarchitectural changes after acute targeted embolization of ruptured arteriovenous malformations.

J Neurosurg 2021 May 7:1-10. Epub 2021 May 7.

2Division of Neuroradiology, Department of Medical Imaging, and.

Objective: The aim of this study was to 1) compare the safety and efficacy of acute targeted embolization of angiographic weak points in ruptured brain arteriovenous malformations (bAVMs) versus delayed treatment, and 2) explore the angioarchitectural changes that follow this intervention.

Methods: The authors conducted a retrospective analysis of a prospectively acquired database of ruptured bAVMs. Three hundred sixteen patients with ruptured bAVMs who presented to the hospital within 48 hours of ictus were included in the analysis. Read More

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Enhanced Recovery After Surgery strategies for elective craniotomy: a systematic review.

J Neurosurg 2021 May 7:1-25. Epub 2021 May 7.

1Machine Intelligence in Clinical Neuroscience (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Switzerland.

Objective: Enhanced Recovery After Surgery (ERAS) has led to a paradigm shift in perioperative care through multimodal interventions. Still, ERAS remains a relatively new concept in neurosurgery, and there is no summary of evidence on ERAS applications in cranial neurosurgery.

Methods: The authors systematically reviewed the literature using the PubMed/MEDLINE, Embase, Scopus, and Cochrane Library databases for ERAS protocols and elements. Read More

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Pulse wave velocity is decreased in acromegaly compared to non-acromegaly study participants with similar cardiovascular risk profile.

Growth Horm IGF Res 2021 Apr 29;57-58:101395. Epub 2021 Apr 29.

Almazov National Medical Research Centre, Ulica Akkuratova 2, St. Petersburg 197341, Russia.

Objective: Acromegaly patients were reported to have an increased arterial stiffness that could contribute to the frequent cardiovascular complications in this population. The chronic excess of GH and IGF-1 may lead to arterial stiffening via different mechanisms, including hypertension, impaired glucose tolerance and dyslipidemia, however, it is not known whether the activation of GH/IGF-1 axis might influence arterial stiffening independently of cardiovascular risk factors. The objective of this prospective case-control study was to compare arterial stiffness assessed with pulse-wave velocity (PWV) in acromegaly versus non-acromegaly group with similar cardiovascular risk profile. Read More

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Pre-clinical evaluation of immunoPET imaging using agonist CD40 monoclonal antibody in pancreatic tumor-bearing mice.

Nucl Med Biol 2021 Apr 21;98-99:8-17. Epub 2021 Apr 21.

Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, CA, USA. Electronic address:

Background: A novel [Cu]Cu-NOTA-aCD40 immunoPET tracer was developed to image a CD40 pancreatic tumor model in C57BL/6 mice and to study the biodistribution profile of the agonist CD40 (aCD40) monoclonal antibody (mAb) alone or combined with other mAbs.

Procedures: Copper-64 ([Cu]Cu) labeled NOTA-aCD40 and NOTA-IgG (10 μg; 7 MBq) were injected intravenously into C57BL/6 mice with subcutaneous mT4 tumors to assess specificity 48 h post injection (p.i. Read More

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Do animal slaughter age and pre-cure freezing have a significant impact on the quality of Iberian dry-cured pork loin?

Meat Sci 2021 May 1;179:108531. Epub 2021 May 1.

Scientific and Technological Research Centre of Extremadura (CICYTEX-La Orden), Meat Quality Area, Junta de Extremadura, Ctra. A-V, Km372, 06187 Guadajira, Badajoz, Spain.

The influence of various animal slaughter age and of pre-cure freezing times on the quality traits of dry-cured loins from Iberian × Duroc (IBxD) crossbreed animals was assessed. Three animal batches (n = 15) were selected (IBxD8, IBxD10 and IBxD12) to be slaughtered at the age of 8, 10 and 12 months, respectively. Following slaughter, longissimus thoracis et lumborum muscles were extracted and submitted to curing (T0) or freezing storage during three (T3) or six (T6) months prior to curing. Read More

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Metabolic syndrome and its related biochemical derangements in breast cancer patients who received neoadjuvant chemotherapy: A study from a tertiary care oncology centre from Puducherry, South India.

Diabetes Metab Syndr 2021 Apr 27;15(3):975-980. Epub 2021 Apr 27.

Department of Biochemistry, JIPMER, Puducherry, India.

Background And Aims: Comparison of the existence of metabolic syndrome, its components and their related biochemical complications between newly diagnosed and treated breast cancer patients.

Methods: Forty newly diagnosed untreated breast cancer patients and forty breast cancer patients who had received 7 cycles of neoadjuvant chemotherapy were recruited as group 1 and group 2 respectively. Height, weight, blood pressure, hormonal status, and tumor size were noted. Read More

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Effect of the TEACCH program on the rehabilitation of preschool children with autistic spectrum disorder: A randomized controlled trial.

J Psychiatr Res 2021 Apr 30;138:420-427. Epub 2021 Apr 30.

School of Health Sciences, Wuhan University, Wuhan, China; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Population and Health Research Center, Wuhan University, Wuhan, China. Electronic address:

Objectives: This study aimed to explore the effect of Treatment and Education of Autistic and Communication Handicapped Children (TEACCH) intervention on the rehabilitation of preschool children having autism spectrum disorder (ASD) in China.

Methods: Sixty children with ASD were randomly assigned to the intervention group (n = 30) or the control group (n = 30). The intervention group received TEACCH training plus Discrete Trial Teaching (DTT) for six months, while the control group received only DTT. Read More

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Internet Gaming Disorder profiles and their associations with social engagement behaviours.

J Psychiatr Res 2021 May 1;138:393-403. Epub 2021 May 1.

Victoria University Australia. Electronic address:

Internet Gaming Disorder (IGD), describes the abuse of Internet games with detrimental impact to the real-life social engagement of some gamers. Indeed, evidence suggests that gamers differ on the severity and way in which they express IGD symptoms, as well as their social engagement behaviours. The present study aimed to: a) profile gamers regarding their experience of IGD symptoms and; b) examine how different IGD profiles varied on social engagement behaviours. Read More

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A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing.

Mol Metab 2021 May 4:101240. Epub 2021 May 4.

MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Electronic address:

Objective: The area postrema (AP) and the nucleus tractus solitaris (NTS), located in the hindbrain, are key nuclei that sense and integrate peripheral nutritional signals and, consequently, regulate feeding behaviour. While single cell transcriptomics have been used in mice to reveal the gene expression profile and heterogeneity of key hypothalamic populations, similar in-depth studies have not yet been performed in the hindbrain.

Methods: Using single-nucleus RNA sequencing, we provide a detailed survey of 16,034 cells within the AP and NTS of the mouse, in the fed and fasted state. Read More

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Pharmacotherapy of obesity: an update.

Pharmacol Res 2021 May 4:105649. Epub 2021 May 4.

Center for the Study and the Integrated Management of Obesity, Padova University Hospital; and Department of Medicine, Internal Medicine 3, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.

Several pharmacological approaches to controlling body weight have been developed over the last decades, albeit with limited success. Currently available agents include centrally acting appetite suppressants and peripherally acting compounds. Efficacy and safety of these agents in the clinical setting require a difficult balance. Read More

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Molecular cloning and functional characterization of TaIRI9 gene in wheat (Triticum aestivum L.).

Gene 2021 May 4:145694. Epub 2021 May 4.

National Engineering Research Center for Wheat, College of Agronomy, National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou 450002, China. Electronic address:

The vernalization of wheat is one of the important factors that determine the planting region, introduction and cultivation techniques of wheat. However, the known vernalization genes (molecular marker) cannot precisely distinguish the vernalization requirement of winter wheat cultivars. Therefore, it is important to explore new vernalization genes and elucidate the mechanism of vernalization regulation. Read More

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Development and optimization of hot-melt extruded moxifloxacin hydrochloride inserts, for ocular applications, using the design of experiments.

Int J Pharm 2021 May 4:120676. Epub 2021 May 4.

Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS - 38677, USA; Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA. Electronic address:

The current study sought to formulate sustained-release hot-melt extruded (HME) ocular inserts of moxifloxacin hydrochloride (MOX; MOX-HME) for the treatment of bacterial keratitis. The concentration of Eudragit™ FS-100 (FS) and propylene glycol (PG) used as polymer and plasticizer, respectively, in the inserts were optimized using the central composite design (CCD) to achieve sustained release. The inserts were characterized for weight, thickness, surface characteristics, pH, and in vitro release profile. Read More

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Lipid nanocapsules loaded with prilocaine and lidocaine and incorporated in gel for topical application.

Int J Pharm 2021 May 4:120675. Epub 2021 May 4.

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas - São Paulo, Brazil. Electronic address:

Lipid nanocapsules (LNC) are special drug delivery system (DDS) carriers obtained by the phase-inversion temperature method (PIT). This study describes the encapsulation of the local anesthetics (LA) prilocaine (PLC) and lidocaine (LDC) in lipid nanocapsules (LNC) optimized by 2 factorial design, characterized through DLS, NTA, CRYO-EM and release kinetics and incorporated in carbopol gel (Gel) prior to in vivo anesthetic effect (in mice) evaluation. A very homogeneous population of small (50 nm; polydispersity index = 0. Read More

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COVID-19 optimal vaccination policies: A modeling study on efficacy, natural and vaccine-induced immunity responses.

Math Biosci 2021 May 4:108614. Epub 2021 May 4.

Departamento de Matemáticas, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Hermosillo, Sonora, C.P. 83000, Mexico. Electronic address:

About a year into the pandemic, COVID-19 accumulates more than two million deaths worldwide. Despite non-pharmaceutical interventions as social distance, mask-wearing, and restrictive lockdown, the daily confirmed cases remain growing. Vaccine developments from Pfizer, Moderna, and Gamaleya Institute reach more than 90% efficacy and sustain the vaccination campaigns in multiple countries. Read More

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Effect of turmeric on adiponectin, sexual function and sexual hormones in stressed mice.

Life Sci 2021 May 4:119575. Epub 2021 May 4.

Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran 14115111, Iran.

Sexual function is essential for species survival. Melanocortin, progesterone, and estrogen can improve sexual function and they are modulated by adiponectin hormone which can be increased by Turmeric. In various studies shows Turmeric ability that is easily accessible to increase serum adiponectin levels. Read More

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Detection of blood flow perfusion and post occlusive reactive hyperemia in the skeletal muscle of rats.

Life Sci 2021 May 4:119571. Epub 2021 May 4.

Laboratory of Cardiovascular Biology and Department of Pharmacology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-970 Florianópolis, Santa Catarina, Brazil. Electronic address:

Aims: Post-occlusive reactive hyperemia (PORH) remains poorly understood in the skeletal muscle system. This study was designed to validate an alternative strategy of PORH detection in rodents. Additionally, we explored the hypothesis that PORH is influenced by experimental models associated with impaired function of the skeletal muscle. Read More

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Conjugates of Human Serum Butyrylcholinesterase and Nerve Agents are Behaviorally Safe in Rhesus Macaques.

Chem Biol Interact 2021 May 4:109499. Epub 2021 May 4.

US Army War College, Carlisle, PA 17013, USA.

Exogenously administered human serum butyrylcholinesterase (Hu BChE) affords protection by binding to organophosphorus (OP) nerve agents and pesticides in circulation. The resulting Hu BChE-OP conjugate undergoes 'aging' and the conjugate circulates until cleared from the body. Thus, we evaluated the effects of Hu BChE-OP conjugates on the general health and operant behavior of macaques. Read More

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Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial.

Lancet Oncol 2021 May 4. Epub 2021 May 4.

National Cancer Center Hospital East, Kashiwa, Japan. Electronic address:

Background: HER2 amplification has been identified in 2-3% of patients with colorectal cancer, although there are currently no approved HER2-targeted therapies for colorectal cancer. We aimed to study the antitumour activity and safety of trastuzumab deruxtecan (an antibody-drug conjugate of humanised anti-HER2 antibody with topoisomerase I inhibitor payloads) in patients with HER2-expressing metastatic colorectal cancer.

Methods: DESTINY-CRC01 is an open-label, phase 2 study that recruited patients from 25 clinics and hospitals in Italy, Japan, Spain, the UK, and the USA. Read More

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Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2.

EMBO Mol Med 2021 May 7:e14045. Epub 2021 May 7.

A*STAR Infectious Disease Labs (A*STAR ID Labs), Agency for Science, Technology and Research, 8A Biomedical Grove, Immunos, Singapore, 138648.

The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169+ expressing monocytes in the peripheral blood. Read More

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A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells.

PLoS One 2021 7;16(5):e0251172. Epub 2021 May 7.

Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada.

Within the classical eye-blink conditioning, Purkinje cells within the cerebellum are known to suppress their tonic firing rates for a well defined time period in response to the conditional stimulus after training. The temporal profile of the drop in tonic firing rate, i.e. Read More

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Darcy-Forchheimer hybrid nanofluid flow over a stretching curved surface with heat and mass transfer.

PLoS One 2021 7;16(5):e0249434. Epub 2021 May 7.

Faculty of Science and Technology, Department of Mathematics and Computer Science, Program in Applied Statistics, Rajamangala University of Technology Thanyaburi, Thanyaburi, Pathumthani, Thailand.

The present article provides a detailed analysis of the Darcy Forchheimer flow of hybrid nanoliquid past an exponentially extending curved surface. In the porous space, the viscous fluid is expressed by Darcy-Forchheimer. The cylindrical shaped carbon nanotubes (SWCNTs and MWCNTs) and Fe3O4 (iron oxide) are used to synthesize hybrid nanofluid. Read More

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ICTV Virus Taxonomy Profile: .

J Gen Virol 2021 May;102(5)

Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK.

Members of the family produce particles that are non-enveloped rigid rods (70-280×10-16 nm). The supercoiled, circular, single-stranded DNA genome of about 4.5-8. Read More

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Stool dynamics after extrinsic nerve injury during right colectomy with extended D3-mesenterectomy.

Scand J Gastroenterol 2021 May 7:1-7. Epub 2021 May 7.

Department of Clinical Medicine, University of Oslo, Oslo, Norway.

Introduction: To improve oncological outcome in right colon cancer surgery, an extended mesenterectomy (D3) is under evaluation. In this procedure, all tissue anterior and posterior to the superior mesenteric vessels from the middle colic to ileocolic artery origin is removed, causing injury to the superior mesenteric nerve plexus. The aim was to study the effects of this injury on bowel dynamics and quality of life (QoL). Read More

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Open-Label, Single-Arm, Multicenter, Phase II Trial of Lenvatinib for the Treatment of Patients With Anaplastic Thyroid Cancer.

J Clin Oncol 2021 May 7:JCO2003093. Epub 2021 May 7.

The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Anaplastic thyroid cancer (ATC), an aggressive malignancy, is associated with a poor prognosis and an unmet need for effective treatment, especially for patients without mutations or or fusions. Lenvatinib is US Food and Drug Administration-approved for radioiodine-refractory differentiated thyroid cancer and has previously demonstrated activity in a small study of patients with ATC (n = 17). We aimed to further evaluate lenvatinib in ATC. Read More

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Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand.

J Med Chem 2021 May 7. Epub 2021 May 7.

Dipartimento di Farmacia, Università degli Studi di Napoli "Federico II", Via D. Montesano 49, 80131 Naples, Italy.

Over recent years, αvβ6 and αvβ8 Arg-Gly-Asp (RGD) integrins have risen to prominence as interchangeable co-receptors for the cellular entry of herpes simplex virus-1 (HSV-1). In fact, the employment of subtype-specific integrin-neutralizing antibodies or gene-silencing siRNAs has emerged as a valuable strategy for impairing HSV infectivity. Here, we shift the focus to a more affordable pharmaceutical approach based on small RGD-containing cyclic pentapeptides. Read More

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Microbiome and osteoarthritis: New insights from animal and human studies.

Int J Rheum Dis 2021 May 7. Epub 2021 May 7.

Department of Rheumatology & Immunology, Singapore General Hospital, Singapore City, Singapore.

Osteoarthritis (OA) is a common cause of disability, especially among the elderly. With an ageing and increasingly obese population, OA will become more prevalent. Obesity and metabolic syndrome are risk factors for OA and have been implicated in its pathogenesis. Read More

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Supervised exercises versus telerehabilitation. Benefits for persons with multiple sclerosis.

Acta Neurol Scand 2021 May 7. Epub 2021 May 7.

Department of Ergotherapy, School of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.

Objectives: The purpose of this study was to investigate the effectiveness of structured telerehabilitation on fatigue, health status, quality of life (QoL), and activities of daily living (ADL) and compare the possible effects with structured supervised exercise programs in patients with Multiple Sclerosis.

Materials And Methods: This study was a randomized, single-blind trial. Thirty patients with relapsing-remitting Multiple Sclerosis were included in the study and randomly divided into two groups; structured supervised exercise group (Group 1) and telerehabilitation group (Group 2). Read More

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Genomic appraisal of Klebsiella PGPB isolated from soil to enhance the growth of barley.

Genes Genomics 2021 May 7. Epub 2021 May 7.

Department of Microbiology and Biotechnology, School of Sciences, Gujarat University, Ahmedabad, 380009, India.

Background: PGPR has substituted chemical fertilizers to enhance the nutrient profile of the soil. Although gene encoding for PGP activity is present in PGPB their activity changes in response to conditions.

Objective: To study comparative genomics for three Klebsiella strains and their PGPR activity in response to in vitro and soil condition. Read More

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