8,413 results match your criteria production scenario


In vitro and in silico analysis reveals antifungal activity and potential targets of curcumin on Paracoccidioides spp.

Braz J Microbiol 2021 Jul 29. Epub 2021 Jul 29.

Laboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Avenida Esperança, s/n, ICB2, Sala 206, Goiânia, Goiás, 74690-900, Brazil.

The search for new compounds with activity against Paracoccidioides, etiologic agents of Paracoccidioidomycosis (PCM), is extremely necessary due to the current scenario of the available therapeutic arsenal. Treatment is restricted to three classes of antifungals with side effects. Curcumin is a polyphenol with antifungal effects that is extracted from Curcuma longa. Read More

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Biofuels from wastes in Marmara Region, Turkey: potentials and constraints.

Environ Sci Pollut Res Int 2021 Jul 29. Epub 2021 Jul 29.

School of Applied Disciplines, Boğaziçi University, Istanbul, Turkey.

Turkey, as an energy importing country, is heavily dependent on fossil fuels, bringing about an escalation in environmental problems and raising concerns regarding energy security. However, biowastes offer a potential solution to these woes, especially in Marmara Region of the country. In this study, the region's potential in terms of the use of waste for energy production is analyzed. Read More

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Raman Spectroscopy as a Robust New Tool for Rapid and Accurate Evaluation of Drought Tolerance Levels in Both Genetically Diverse and Near-Isogenic Maize Lines.

Front Plant Sci 2021 12;12:621711. Epub 2021 Jul 12.

Electrical and Computer Engineering Department, Texas A&M University, College Station, TX, United States.

Improving drought tolerance of crops has become crucial due to the current scenario of rapid climate change. In particular, development of new maize germplasm with increased drought tolerance is viewed as a major breeding goal to ensure sustainable food and feed production. Therefore, accurate rapid phenotyping techniques for selection of superior maize genotypes are required. Read More

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A temperature binning approach for multi-sector climate impact analysis.

Clim Change 2021 Mar;165

US Environmental Protection Agency, Washington, D.C, USA.

Characterizing the future risks of climate change is a key goal of climate impacts analysis. Temperature binning provides a framework for analyzing sector-specific impacts by degree of warming as an alternative or complement to traditional scenario-based approaches in order to improve communication of results, comparability between studies, and flexibility to facilitate scenario analysis. In this study, we estimate damages for nine climate impact sectors within the contiguous United States (US) using downscaled climate projections from six global climate models, at integer degrees of US national warming. Read More

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An Economic Analysis of the Impact of Homecare Drug Administration for Biologic Interventions Available for Plaque Psoriasis in the UK.

Dermatol Ther (Heidelb) 2021 Jul 23:1-8. Epub 2021 Jul 23.

York Health Economics Consortium, York, UK.

Introduction: In the UK, biologic interventions for plaque psoriasis can either be administered in a hospital setting or following delivery to a patient's home. To date, limited research has been undertaken on how the administration route affects the overall treatment costs and the implications for this on UK clinical practice. The objective was to explore the cost implications of different administration routes for plaque psoriasis biologic interventions in the UK. Read More

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Mitigation of methane gas emission in rice by drip irrigation.

F1000Res 2019 28;8:2023. Epub 2019 Nov 28.

Netafim Irrigation Ltd, Kibbutz Mahal, Israel.

Rice farming faces major challenges, including water limitation, drought and climate change in the current scenario of agriculture. Among the innovative water-saving techniques, drip irrigation is a forerunner, with maximized water-saving potential, increased grain yield and methane mitigation. A field experiment was conducted comprising four different drip irrigation practices: (i) sub-surface drip irrigation (SDI) with 1. Read More

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November 2019

Economic Valuation of Coccidioidomycosis (Valley Fever) Projections in the United States in Response to Climate Change.

Weather Clim Soc 2021 ;13(1):107-123

U.S. Environmental Protection Agency, Washington, D.C.

Coccidioidomycosis, or valley fever, is an infectious fungal disease currently endemic to the southwestern United States. Symptoms of valley fever range in severity from flu-like illness to severe morbidity and mortality. Warming temperatures and changes in precipitation patterns may cause the area of endemicity to expand northward throughout the western United States, putting more people at risk for contracting valley fever. Read More

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January 2021

Assessment of carbon emissions of building interior decoration and renovation waste disposal in the fast-growing Greater Bay Area, China.

Sci Total Environ 2021 Jul 23;798:149158. Epub 2021 Jul 23.

College of Civil & Transportation Engineering, Underground Polis Academy, Shenzhen University, Shenzhen 518060, China. Electronic address:

Continuing urbanization and significant improvement of lifestyle have ushered in high demand for building floor area, inevitably leading to a rapid increase of interior decoration and renovation activities, which in turn produce a massive quantity of decoration and renovation waste (DRW). However, like many other countries with unremitting demand for building space and infrastructure, China has failed to attach adequate attention to DRW management. Using the yield-per-area method and life cycle assessment approach, this study aims to characterize the generation, flows, management and environmental impacts of DRW from commercial housing in nine cities in the Greater Bay Area (GBA), a highly developed economic zone in China. Read More

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Review: Trends for meat, milk and egg consumption for the next decades and the role played by livestock systems in the global production of proteins.

Animal 2021 Jul 23:100287. Epub 2021 Jul 23.

Teagasc Food Research Centre, Ashtown, Dublin 15 D15 KN3K, Ireland.

Meeting the food demands of a growing global population within planetary boundaries is a challenge. Sustainably producing animal-sourced foods while supplying sufficient protein to meet the requirements of a healthy diet is a particular challenge. This paper informs the development of pathways to sustainable animal production by examining trends in animal-sourced foods since 2000, including the significance of animal- relative to plant-protein sources. Read More

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An Economic Analysis of the Impact of Homecare Drug Administration for Biologic Interventions Available for Plaque Psoriasis in the UK.

Dermatol Ther (Heidelb) 2021 Jul 23. Epub 2021 Jul 23.

York Health Economics Consortium, York, UK.

Introduction: In the UK, biologic interventions for plaque psoriasis can either be administered in a hospital setting or following delivery to a patient's home. To date, limited research has been undertaken on how the administration route affects the overall treatment costs and the implications for this on UK clinical practice. The objective was to explore the cost implications of different administration routes for plaque psoriasis biologic interventions in the UK. Read More

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Which pro-environmental farming behaviors should be priorities for funding? An approach based on matching ecosystem services (ESs) demand and supply.

J Environ Manage 2021 Jul 23;297:113368. Epub 2021 Jul 23.

School of Business Administration, Zhongnan University of Economics and Law, Wuhan, PR China.

Eco-compensation (EC) for farmland conservation being implemented in China is a type of payments for ecosystem services (PES) scheme that seeks to balance ecosystem services (ESs) consumption and supply. Despite the growing body of literature on the integration of the demand for, and supply of ESs or the identification of mismatches between them, still many challenges remain to structurally integrate them in policy making facing fund-saving. Therefore, integrating ESs demand and supply at the micro-scale to provide novel insights into using compensation funds efficiently and optimizing the design of PES schemes deserves increasing attention. Read More

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[Analysis of Ultraviolet Aerosol Index in Guangdong-Hong Kong-Macao Greater Bay Area].

Huan Jing Ke Xue 2021 Aug;42(8):3652-3662

Key Laboratory of Resource Environment and Sustainable Development of Oasis, Gansu Province, College of Geography and Environmental Science, Northwest Normal University, Lanzhou 730070, China.

This study examines the current aerosol pollution scenario in the Guangdong-Hong Kong-Macao (GHM) Greater Bay Area, based on OMAERUV daily data products, to define the spatial and temporal distribution from 2008 to 2019 and predict variation trends of the ultraviolet aerosol index (UVAI). Changes and potential source areas were analyzed, and their influencing factors were identified. The annual time series of UVAI in the GHM Greater Bay Area showed a downward trend, with an average annual decrease of 2. Read More

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Agricultural land resource allocation to develop food crop commodities: lesson from Indonesia.

Heliyon 2021 Jul 8;7(7):e07520. Epub 2021 Jul 8.

Faculty of Economics, Universitas Negeri Malang, Indonesia.

This study estimates agricultural land resource allocation to develop food-crop commodities in order to safeguard food security in Indonesia in the middle of the coronavirus pandemic. The recommended commodities to be developed in Indonesia are corn, soybean, mungbean, peanut, and rice that are produced with advanced technology and input-output coefficient. There are five introduced scenarios namely, basic scenario, I, II, III, and IV. Read More

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Sustainability assessment of organic waste management in three EU Cities: Analysing stakeholder-based solutions.

Waste Manag 2021 Jul 22;132:44-55. Epub 2021 Jul 22.

Ghent University, Faculty of Bioscience Engineering, Department of Green Chemistry and Technology, Sustainable Systems Engineering Group (STEN), Coupure Links 653, Ghent, Belgium.

This study focuses on a comprehensive sustainability assessment of the management of the organic fraction of municipal solid waste in Ghent (Belgium), Hamburg (Germany) and Pécs (Hungary). A sustainability assessment framework has been applied to analyse social, environmental, and economic consequences at the midpoint level (25 impact categories) and at the endpoint level (5 areas-of-protection). For each case study, the reference scenario was analysed, along with three solutions to improve the sustainability performance, which were selected and developed with the collaboration of local stakeholders. Read More

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Environmental life cycle assessment of polyhydroxyalkanoates production from cheese whey.

Waste Manag 2021 Jul 22;132:31-43. Epub 2021 Jul 22.

Department of Civil and Environmental Engineering and Architecture, University of Cagliari, Via Marengo 2, 09123 Cagliari, Italy.

Cheese whey (CW) is the main by-product of the dairy industry and is often considered one of the main agro-industrial biowaste streams to handle, especially within the European Union, where the diary activities play an essential role in the agrarian economy. In the paper, Life Cycle Assessment (LCA) is used to analyse the feasibility of producing polyhydroxyalkanoates (PHA) as the main output of an innovative CW valorisation route which is benchmarked against a conventional anaerobic digestion (AD) process. To this aim, the LCA inventory data are derived from lab-scale PHA accumulation tests performed on real CW, while data from the literature of concern are used for modelling both the PHA extraction from the accumulating biomass and for the alternative CW valorisation through AD. Read More

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A two-stage Bayesian adaptive design for minimum effective dose (MinED)-based dosing-finding trials.

Contemp Clin Trials 2021 Jul 22;108:106504. Epub 2021 Jul 22.

Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

Conventional phase I designs for finding a phase II recommended dose (P2RD) based on toxicity alone is problematic because the maximum tolerated dose (MTD) is not necessarily the optimal dose. Instead, recently attention has been given to find the minimum effective dose (MinED) - defined as the lowest effective dose. Traditional paradigms for the MinED studies are conducted as dose-ranging or dose-response trials which involve several doses and randomize patients among doses to find the MinED. Read More

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Data-Driven Dispatching Rules Mining and Real-Time Decision-Making Methodology in Intelligent Manufacturing Shop Floor with Uncertainty.

Sensors (Basel) 2021 Jul 15;21(14). Epub 2021 Jul 15.

Yonsei Frontier Lab, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.

In modern manufacturing industry, the methods supporting real-time decision-making are the urgent requirement to response the uncertainty and complexity in intelligent production process. In this paper, a novel closed-loop scheduling framework is proposed to achieve real-time decision making by calling the appropriate data-driven dispatching rules at each rescheduling point. This framework contains four parts: offline training, online decision-making, data base and rules base. Read More

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The Adjustment of China's Grain Planting Structure Reduced the Consumption of Cropland and Water Resources.

Int J Environ Res Public Health 2021 Jul 9;18(14). Epub 2021 Jul 9.

Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

Driven by technological progress and market demand, the optimization and adjustment of grain planting structure played an important role in increasing grain output. Due to the great difference between the yield per unit area of different types of food crops, the consumption of cropland and water resources has a significant change during the grain growth. From the perspective of structural adjustment, rather than the usual productive factor input, we analyze the process of adjustment for grain planting structure in China and its effect on the consumption of cropland and water resources by using the scenario comparative analysis method. Read More

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Redox Imbalance and Mitochondrial Release of Apoptogenic Factors at the Forefront of the Antitumor Action of Mango Peel Extract.

Molecules 2021 Jul 17;26(14). Epub 2021 Jul 17.

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Laboratory of Biochemistry, University of Palermo, 90127 Palermo, Italy.

Today, an improved understanding of cancer cell response to cellular stress has become more necessary. Indeed, targeting the intracellular pro-oxidant/antioxidant balance triggering the tumor commitment to cell demise could represent an advantageous strategy to develop cancer-tailored therapies. In this scenario, the present study shows how the peel extract of mango-a tropical fruit rich in phytochemicals with nutraceutical properties-can affect the cell viability of three colon cancer cell lines (HT29, Caco-2 and HCT116), inducing an imbalance of cellular redox responses. Read More

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Direct and Indirect Costs of Influenza-Like Illness Treated with and Without Oseltamivir in 15 European Countries: A Descriptive Analysis Alongside the Randomised Controlled ALICE Trial.

Clin Drug Investig 2021 Jul 22. Epub 2021 Jul 22.

Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.

Background And Objective: Influenza-like illness (ILI) leads to a substantial disease burden every winter in Europe; however, oseltamivir is not frequently prescribed to ILI patients in the primary-care setting. An open-label, multi-country, multi-season, randomised controlled trial investigated the effectiveness of oseltamivir for treating ILI in 15 European countries. We aimed to evaluate whether patients presenting with ILI in primary care and being managed with the addition of oseltamivir to usual care had lower average direct and indirect costs compared to patients with usual care alone. Read More

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Mitochondrial dysfunction: A hidden trigger of autism?

Genes Dis 2021 Sep 16;8(5):629-639. Epub 2020 Jul 16.

Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu 641043, India.

Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with no precise etiology. Deficits in cognitive functions uncover at early stages and are known to have an environmental and genetic basis. Since autism is multifaceted and also linked with other comorbidities associated with various organs, there is a possibility that there may be a fundamental cellular process responsible for this. Read More

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September 2021

Poultry litter stabilization by two-stage composting-vermicomposting process: Environmental, energetic and economic performance.

Chemosphere 2021 Oct 15;281:130872. Epub 2021 May 15.

Instituto de Desarrollo Tecnológico para la Industria Química (INTEC, UNL-CONICET), Güemes N(◦) 3450, Santa Fe, S3000GLN, Argentina; Facultad de Ingeniería y Ciencias Hídricas, Universidad Nacional del Litoral, Ruta Nacional N° 168 Km 472.4, 3000, Santa Fe, Argentina.

Poultry litter (PL) is a heterogeneous mixture that contains bedding materials, antibiotics, dead skin, feed scraps, water, feathers and the resulting microbiota from poultry production cycle. Although its treatment does not receive attention, it is an important organic resource generated in the north-east region of Santa Fe Province since animal primary production is one of the main economic activities there and in the whole country. The objective of this work was to analyse the economic and energy aspects and the environmental impact of two scenarios corresponding to treat two different mixtures of organic wastes: Eucalyptus sp. Read More

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October 2021

Interdependence between lignocellulosic biomasses, enzymatic hydrolysis and yeast cell factories in biorefineries.

Microb Biotechnol 2021 Jul 21. Epub 2021 Jul 21.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, Milano, 20126, Italy.

Biorefineries have a pivotal role in the bioeconomy scenario for the transition from fossil-based processes towards more sustainable ones relying on renewable resources. Lignocellulose is a prominent feedstock since its abundance and relatively low cost. Microorganisms are often protagonists of biorefineries, as they contribute both to the enzymatic degradation of lignocellulose complex polymers and to the fermentative conversion of the hydrolyzed biomasses into fine and bulk chemicals. Read More

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Time- and dose-dependent allelopathic effects and mechanisms of kaempferol on toxigenic Microcystis growth.

Ecotoxicol Environ Saf 2021 Jul 17;222:112508. Epub 2021 Jul 17.

College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China; Beijing Key Laboratory of Biodiversity and Organic Farming, China Agricultural University, Beijing 100193, China. Electronic address:

This study determined time-dependent IC and confirmed 3.5 mg/L as IC value for kaempferol inhibiting toxigenic Microcystis growth, based on which algicidal effects and mechanisms against toxigenic Microcystis exposed to various kaempferol doses (0.5-2 × IC) were explored along 14 day-test. Read More

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Silicon mitigates nutritional stress in quinoa (Chenopodium quinoa Willd.).

Sci Rep 2021 Jul 19;11(1):14665. Epub 2021 Jul 19.

Universidade Federal do Mato Grosso do Sul, Campus de Chapadão do Sul - UFMS/CPCS, Chapadão do Sul, MS, Brazil.

Nutritional deficiency is common in several regions of quinoa cultivation. Silicon (Si) can attenuate the stress caused by nutritional deficiency, but studies on the effects of Si supply on quinoa plants are still scarce. Given this scenario, our objective was to evaluate the symptoms in terms of tissue, physiological and nutritional effects of quinoa plants submitted to nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), and magnesium (Mg) deficiencies under Si presence. Read More

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Harnessing Sorghum Landraces to Breed High-Yielding, Grain Mold-Tolerant Cultivars With High Protein for Drought-Prone Environments.

Front Plant Sci 2021 30;12:659874. Epub 2021 Jun 30.

Regional Agricultural Research Station, Palem - Professor Jayashankar Telangana State Agricultural University, Hyderabad, India.

Intermittent drought and an incidence of grain mold disease are the two major constraints affecting sorghum production and productivity. The study aimed at developing drought-tolerant sorghum varieties possessing a high protein content and tolerance to grain mold with stable performance using additive main effects and multiplicative interaction (AMMI) and genotype and genotype × environment interaction (GGE) biplot methods. Systematic hybridization among the 11 superior landraces resulted in subsequent pedigree-based breeding and selection from 2010 to 2015 evolved 19 promising varieties of grains such as white, yellow, and brown pericarp grains. Read More

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The cost effectiveness and optimal configuration of HIV self-test distribution in South Africa: a model analysis.

BMJ Glob Health 2021 Jul;6(Suppl 4)

Department of Global Health, School of Public Health, Boston University, Boston, Massachusetts, USA.

Background: HIV self-testing (HIVST) has been shown to be acceptable, feasible and effective in increasing HIV testing uptake. Novel testing strategies are critical to achieving the UNAIDS target of 95% HIV-positive diagnosis by 2025 in South Africa and globally.

Methods: We modelled the impact of six HIVST kit distribution modalities (community fixed-point, taxi ranks, workplace, partners of primary healthcare (PHC) antiretroviral therapy (ART) patients), partners of pregnant women, primary PHC distribution) in South Africa over 20 years (2020-2039), using data collected alongside the Self-Testing AfRica Initiative. Read More

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Decision-making interaction among stakeholders regarding construction and demolition waste recycling under different power structures.

Waste Manag 2021 Jul 15;131:491-502. Epub 2021 Jul 15.

School of Economics and Management, Tongji University, Shanghai, China.

The market power and competition scenario of recycling enterprises and landfills may change in the future due to the environmental pressure caused by landfills and the environmental potential of construction and demolition waste (C&DW) recycling. In this context, how these changes will affect the economic performance of enterprises and the environmental performance of the whole society remains unclear, along with how the willingness to pay and the environmental awareness of contractors will affect the pricing decisions of recycling enterprises and landfills. This study investigates the charging and recycling problem under different power structures in the reverse supply chain of C&DW, which is composed of waste generators (construction contractors) and two disposers (recycling enterprises and landfills). Read More

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Biological nutrient removal enhancement using fermented primary and rotating belt filter biosolids.

Sci Total Environ 2021 Jul 10;796:148947. Epub 2021 Jul 10.

Department of Civil and Environmental Engineering, Western University, London, ON N6A 5B9, Canada; Department of Chemical and Biochemical Engineering, Western University, London, ON N6A 5B9, Canada.

This research compared the impact of two primary treatment options (i.e. primary clarification and rotating belt filtration (RBF)) on biological nutrients removal (BNR) process, using sludge fermentation liquid (SFL) as a carbon source. Read More

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Deterrence against Terrorist Attacks in Sports-Mega Events: A Method to Identify the Optimal Portfolio of Defensive Countermeasures.

Risk Anal 2021 Jul 16. Epub 2021 Jul 16.

Departamento de Gestão e Apoio à Decisão, Instituto Tecnológico da Aeronáutica, Brazil.

Sports mega-events, such as the Olympic Games or the Super Bowl, are attractive targets for terrorist organizations, due to their visibility, size, and number of people involved. Two characteristics of sports mega-events, however, make them distinctive in comparison with other well-studied target protection problems in counterterrorism analysis (such as transportation hubs or infrastructure facilities). First, defensive measures are often publicly known. Read More

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