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The Economic Impact of Providing Evidence-Based Pediatric Mental Health Literacy Training to Primary Care Physicians.

Psychiatry Investig 2021 Jul 22;18(7):695-700. Epub 2021 Jul 22.

Alberta Health Services, Child and Adolescent Addiction and Mental Health and Psychiatry Program, Calgary, Canada.

Objective: This paper presents a review of the current state of child and adolescent mental health literacy and provides current evidence of the economic impact of a pediatric mental health literacy (MHL) training program.

Methods: Employing a case-series-comparison design, physician referrals to urgent and specialized mental health services were linked with patient-specific information comparing referrals from MHL participants and non-participating physicians. The economic impact analysis was based on changes in the admitted referral frequency and lengths of stay for the MHL group, compared to themselves pretraining, and over the same time period compared to non-participating physicians. Read More

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Neurocomputational models of altruistic decision-making and social motives: Advances, pitfalls, and future directions.

Wiley Interdiscip Rev Cogn Sci 2021 Aug 2:e1571. Epub 2021 Aug 2.

Department of Psychology, Queen's University, Ontario, Kingston, Canada.

This article discusses insights from computational models and social neuroscience into motivations, precursors, and mechanisms of altruistic decision-making and other-regard. We introduce theoretical and methodological tools for researchers who wish to adopt a multilevel, computational approach to study behaviors that promote others' welfare. Using examples from recent studies, we outline multiple mental and neural processes relevant to altruism. Read More

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Mesoporous silica nanoparticles loaded with fluorescent coumarin-5-fluorouracil conjugates as mitochondrial-targeting theranostic probes for tumor cells.

Nanotechnology 2021 Aug 2. Epub 2021 Aug 2.

Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Jinming Road, Kaifeng, Henan, 475004, CHINA.

Chemotherapy is currently a principal method for treating tumors. Selective delivery of chemotherapeutic drugs to the subcellular organs of cancer cells is an attractive treatment strategy for cancer. Mitochondria are important organelles that play complex roles in cancer, such as providing energy and controlling various cell death mechanisms. Read More

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Recent Advances in Anticancer and Antimicrobial Activity of Silver Nanoparticles Synthesized Using Phytochemicals and Organic Polymers.

Nanotechnology 2021 Aug 2. Epub 2021 Aug 2.

Department of Mechanical Systems Engineering, Yamagata University, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata, Yamagata, Yamagata, 992-8510, JAPAN.

Development of eco-friendly synthetic methods has resulted in the production of biocompatible Ag NPs for applications in medical sector. To overcome the prevailing antibiotic resistance in bacteria, Ag NPs are being extensively researched over the past few years due to their broad spectrum & robust antimicrobial properties. Silver nanoparticles are also being studied widely in advanced anticancer therapy as an alternative anticancer agent to combat cancer in an effective manner. Read More

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Design and engineering of artificial microbial consortia for biohydrogen production.

Curr Opin Biotechnol 2021 Jul 30;73:74-80. Epub 2021 Jul 30.

Archaea Physiology & Biotechnology Group, Department of Functional and Evolutionary Ecology, Universität Wien, Wien, Austria. Electronic address:

In natural microbial ecosystems the metabolic diversity of the organisms enables interaction among the community members and allows them to engage in syntrophic interactions. With regard to biotechnology, artificial microbial consortium engineering is used to improve productivities and yields of bioprocesses. However, to achieve supreme productivity or efficiency at industrial scale, defined ecosystems must be physiologically well-selected to meet eco-biotechnological demands. Read More

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Improved soil-crop system management aids in NH emission mitigation in China.

Environ Pollut 2021 Jul 26;289:117844. Epub 2021 Jul 26.

Rothamsted Research, North Wyke, Devon, EX20 2SB, UK.

High ammonia (NH) emissions from fertilized soil in China have led to various concerns regarding environmental safety and public health. In response to China's blue skies protection campaign, effective NH reduction measures need to consider both mitigation efficiency and food security. In this context, we conducted a meta-analysis (including 2980 observations from 447 studies) to select effective measures based on absolute (AV) and yield-scaled (YSAV) NH volatilization reduction potential, with the aim of establishing a comprehensive NH mitigation framework covering various crop production sectors, and offering a range of potential solutions. Read More

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An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis.

Environ Pollut 2021 Jul 28;289:117855. Epub 2021 Jul 28.

Faculty of Science, RECETOX, Masaryk University, Kamenice 5, CZ62500, Brno, Czech Republic. Electronic address:

A wide range of novel replacement flame retardants (nFRs) is consistently detected in increasing concentrations in the environment and human matrices. Evidence suggests that nFRs exposure may be associated with disruption of the endocrine system, which has been linked with the etiology of various metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). NAFLD is a multifactorial disease characterized by the uncontrolled accumulation of fats (lipids) in the hepatocytes and involves multiple-hit pathogenesis, including exposure to occupational and environmental chemicals such as organophosphate flame retardants (OPFRs). Read More

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Effectiveness and implementability of state-level naloxone access policies: Expert consensus from an online modified-Delphi process.

Int J Drug Policy 2021 Jul 30;98:103383. Epub 2021 Jul 30.

Department of Social & Behavioral Sciences, Indiana University Richard M. Fairbanks School of Public Health, 1050 Wishard Blvd, RG 6046, Indianapolis, IN 46202, USA.

Background: Naloxone distribution, a key global strategy to prevent fatal opioid overdose, has been a recent target of legislation in the U.S., but there is insufficient empirical evidence from causal inference methods to identify which components of these policies successfully reduce opioid-related harms. Read More

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The effect of next day responsibilities and an adaptive purchase task on cannabis demand.

Drug Alcohol Depend 2021 Jul 28;227:108919. Epub 2021 Jul 28.

Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; Center for Pain Research and Behavioral Health, University of Florida, Gainesville, FL, USA. Electronic address:

Background: The marijuana purchase task (MPT) is a commonly used behavioral economic measure of relative cannabis value (i.e. demand) that presents specific methodological concerns due to non-standardized measurement, variability in modality of use, and evolving legalization policies. Read More

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Artemisia ordosica Polysaccharide Alleviated Lipopolysaccharide-induced Oxidative Stress of Broilers via Nrf2/Keap1 and TLR4/NF-κB Pathway.

Ecotoxicol Environ Saf 2021 Jul 30;223:112566. Epub 2021 Jul 30.

College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, PR China. Electronic address:

Artemisia ordosica is one of the main shrubby perennials belonging to Artemisia species of Asteraceae and could be used in folk Chinese/Mongolian medicine to treat symptoms of various inflammatory ailments. The present study was conducted to investigate the protective effects of dietary Artemisia ordosica polysaccharide (AOP) against lipopolysaccharide (LPS) induced oxidative stress in broilers via Nrf2/Keap1 and TLR4/NF-κB pathway. A total of 192 1-day-old Arbor Acres male broilers were randomly allotted to four treatments with 6 replicates (n = 8): (1) CON group, non-challenged broilers fed basal diet; (2) LPS group, LPS-challenged broilers fed basal diet; (3) AOP group, non-challenged broilers fed basal diet supplemented with 750 mg/kg AOP; (4) LPS+AOP group, LPS-challenged broilers fed basal diet supplemented with 750 mg/kg AOP. Read More

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Performance and carcass quality traits of Iberian × Duroc crossbred pig subject to gender and age at the beginning of the free-range finishing phase.

Animal 2021 Jul 30;15(9):100324. Epub 2021 Jul 30.

Department of Animal Production and Food Science, Research Institute of Agricultural Resources (INURA), University of Extremadura, Avda. Adolfo Suarez, s/n, 06007 Badajoz, Spain.

The traditional production of the Iberian breed pig involves a long production cycle. It might be shortened by using Iberian pigs crossed with Duroc and by reducing the growing phase, but the age-related changes on productive performance and carcass quality should be addressed. Thus, productive performance, live measurements and carcass and primal cut traits were evaluated on Iberian × Duroc 50:50 crossed pigs according to animal age at the beginning of the free-range finishing phase (Montanera): 10, 12 and 14 months old (IBxD10 (n = 15), IBxD12 (n = 17) and IBxD14 (n = 18) animal batches, respectively) and gender (immunologically castrated female -consisted of the Improvac® vaccination- and surgically castrated males). Read More

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First report on embryonic and larval development of 2n/3n mosaic sterlet.

Animal 2021 Jul 30;15(9):100317. Epub 2021 Jul 30.

Department of Ichthyology and Aquaculture, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.

Mosaicism is frequently observed in aquaculture practices, and it adversely affects the production as well as the restoration programme of the sturgeon. The purpose of the present study was the induction of 2n/3n mosaic in sterlet, Acipenser ruthenus L., and compare their embryonic and larval development with diploid control sterlet. Read More

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Effects of oxygen concentration during incubation and broiler breeder age on embryonic heat production, chicken development, and 7-day performance.

Animal 2021 Jul 30;15(9):100323. Epub 2021 Jul 30.

Adaptation Physiology Group, Wageningen University and Research, P.O. Box 338, 6700 AH Wageningen, the Netherlands.

Older breeder flocks produce eggs with a relatively larger yolk and thereby a higher nutrient availability than young breeder flocks. To optimise nutrient utilisation and embryonic development throughout incubation and posthatch period, embryos originating from older breeder flocks may require a higher oxygen availability. The current study investigated effects of broiler breeder flock age and incubational oxygen concentration on embryonic metabolism and chicken development until 7-day posthatch. Read More

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Effects of dietary protein, energy and β-mannanase on laying performance, egg quality, and ileal amino acid digestibility in laying hens.

Poult Sci 2021 Jun 5;100(9):101312. Epub 2021 Jun 5.

Department of Poultry Science, University of Georgia, Athens, GA, USA. Electronic address:

β-mannan is a nonstarch polysaccharide found in hulled and dehulled soybeans that can survive drying-toasting phase of processing soybeans and have antinutritive effects in poultry. β-mannanase is an active enzyme (endohydrolase) that can hydrolyze β-mannan to reduce its antinutritional effects. Two experiments were conducted to evaluate the effects of β-mannanase supplementation in low energy/protein diets on egg production, egg quality, and apparent ileal digestibility of the dry matter (DM), crude protein (CP), and amino acids in 21-week-old Single Comb White Leghorn hens (Hy-Line W-36). Read More

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Eco-friendly performance as a determining factor of the Adoption of Virtual Reality Applications in National Parks.

Sci Total Environ 2021 Jul 23;798:148990. Epub 2021 Jul 23.

Department of Business Management and Marketing, University of Sevilla, Sevilla, Spain; NECE-UBI Research Unit in Business Sciences, University of Beira Interior (UBI), Portugal.

The purpose of this study is to find the key factors of influence for the use and acceptance of Virtual Reality (VR) by tourists visiting National Parks in Costa Rica. The aim is to find whether tourists are willing to use VR to contribute to the eco-friendly performance of the area they visit and to determine whether they are willing to use VR in environmental tourism to protect flora and fauna. This study is quantitative and uses the theoretical Unified Theory of Acceptance and Use of Technology (UTAUT) Model and a survey as the research instrument to obtain data. Read More

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Reverse osmosis concentrate treatment by microbubble ozonation-biological activated carbon process: Organics removal performance and environmental impact assessment.

Sci Total Environ 2021 Jul 28;798:149289. Epub 2021 Jul 28.

National University of Singapore, Sembcorp-NUS Corporate Laboratory c/o FoE, Block E1A, #04-01, 1 Engineering Drive 2, 117576, Singapore; Department of Civil & Environmental Engineering, Faculty of Engineering, National University of Singapore, Block E1A, #07-01, 1 Engineering Drive 2, 117576, Singapore. Electronic address:

Reverse osmosis (RO) is being used in many water reclamation facilities to produce high quality water that can be reused for different purposes. As a part of the RO process, a reject stream is produced as the reverse osmosis concentrate (ROC), which contains elevated levels of contaminants compared to the source water. Effective treatment and safe disposal of ROC via cost-effective means is very challenging. Read More

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Abnormalities of the type I interferon signaling pathway in lupus autoimmunity.

Cytokine 2021 Jul 30;146:155633. Epub 2021 Jul 30.

Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic condition linked to inflammation. Both IFNα and IFNβ trigger a signaling cascade that, through the activation of JAK1, TYK2, STAT1 and STAT2, initiates gene transcription of IFN stimulated genes (ISGs). Noteworthy, other STAT family members and IFN Responsive Factors (IRFs) can also contribute to the activation of the IFN response. Read More

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Fragment-interconnected nitrogen-doped porous carbon nanosheets loaded with platinum group metals for highly boosted hydrogen evolution reaction in alkaline solution.

J Colloid Interface Sci 2021 Jul 23;605:528-536. Epub 2021 Jul 23.

Institute of Materials, China Academy of Engineering Physics, Jiangyou 621908, China. Electronic address:

The rational design and preparation of advanced electrocatalysts for the hydrogen evolution reaction (HER) under alkaline conditions is the key to achieving sustainable hydrogen production. Herein, a new type of nitrogen-doped porous carbon nanosheets (NPCN) loaded with platinum group metals (Pd, Pt or Ru) were prepared. The introduction of melamine not only realized the doping of N-species, but also optimized the morphology and surface functional groups of the prepared catalysts. Read More

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Permissive action of HO mediated ClUGT75 expression for auxin glycosylation and Al- tolerance in watermelon.

Plant Physiol Biochem 2021 Jul 24;167:77-90. Epub 2021 Jul 24.

Laboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, PR China; Hainan Institute of Zhejiang University, Yazhou District, Sanya, 572025, PR China; Key Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Ministry of Agriculture, Hangzhou, 310058, PR China.

Although Al-toxicity is one of the limiting factors for crop production in acidic soils, little is known about the Al-tolerance mechanism in watermelon, a fairly acid-tolerant crop. This work aimed to identify the interaction between the HO scavenging pathway and auxin glycosylation relevant to watermelon Al-tolerance. By analyzing expressions of hormone-related ClUGTs and antioxidant enzyme genes in Al-tolerant (ZJ) and Al-sensitive (NBT) cultivars, we identified ClUGT75s (B1, B2, and D1) and ClSOD1-2-ClCAT as crucial components associated with Al-tolerance. Read More

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Hydrogen sulfide and nitric oxide are involved in melatonin-induced salt tolerance in cucumber.

Plant Physiol Biochem 2021 Jul 28;167:101-112. Epub 2021 Jul 28.

School of Life Sciences, Northwest Normal University, Lanzhou, 730070, China. Electronic address:

Hydrogen sulfide (HS) is a novel gaseous signaling molecule in response to adversity stress. Melatonin (MT) is a multifunctional molecule that plays an important role in regulating plant stress resistance. However, the interactions between HS and MT are still unknown. Read More

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Characterization of eight unknown impurities and analysis of their source in xinfujunsu and injection by liquid chromatography coupled with ion trap/time-of-flight mass spectrometry.

J Pharm Biomed Anal 2021 Jul 24;204:114279. Epub 2021 Jul 24.

Zhejiang Institute for Food and Drug Control, National Medical Product Administration Key Laboratory for Core Technology of Generic Drug Evaluation, Hangzhou 310052, China. Electronic address:

Eight unknown impurities in xinfujunsu and its injection were characterized by liquid chromatography coupled with ion trap/time-of-flight mass spectrometry (LC-IT-TOF MS). In order to determine the m/z values of the molecular ions and predict the formulas of all detected impurities, full scan LC-MS in positive ion mode was firstly executed to obtain the m/z value of the molecules. Then LC-MS, LC-MS and LC-MS were carried out on target compounds to obtain as much structural information as possible. Read More

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Improving stability of mainstream Anammox in an innovative two-stage process for advanced nitrogen removal from mature landfill leachate.

Bioresour Technol 2021 Jul 21;340:125617. Epub 2021 Jul 21.

China Architecture Design and Research Group, Beijing 100044, PR China. Electronic address:

This study presents an innovative mainstream Anammox based on multiple NO-N supplement pathways to treat actual mature landfill leachate over 180 days. Desirable effluent quality of 11.8 mg/L total nitrogen (TN) and nitrogen removal efficiency of 98. Read More

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Algal biomass production by phosphorus recovery and recycling from wastewater using amorphous calcium silicate hydrates.

Bioresour Technol 2021 Jul 27;340:125678. Epub 2021 Jul 27.

Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. Electronic address:

The phosphorous supply crisis is a major challenge for a sustainable society, and the algal industry is not unrelated to this crisis. Recycling phosphorus from sewage wastewater is a potential way to address this issue. We previously developed amorphous calcium silicate hydrates (aCSH) as excellent phosphorus recovery materials. Read More

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Human iPSC-derived neural crest stem cells can produce EPO and induce erythropoiesis in anemic mice.

Stem Cell Res 2021 Jul 25;55:102476. Epub 2021 Jul 25.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy; University of Nicosia Medical School, Nicosia, Cyprus. Electronic address:

Inadequate production of erythropoietin (EPO) leads to anemia. Although erythropoiesis-stimulating agents can be used to treat anemia, these approaches are limited by high costs, adverse effects, and the need for frequent injections. Developing methods for the generation and transplantation of EPO-producing cells would allow for the design of personalized and complication-free therapeutic solutions. Read More

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Technical and environmental assessment of laboratory scale approach for sustainable management of marine plastic litter.

J Hazard Mater 2021 Jul 21;421:126717. Epub 2021 Jul 21.

Residues and Resource Reclamation Centre (R3C), Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, Clean Tech One, 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. Electronic address:

Laboratory scale recycling of marine plastic litter consisting of polyethylene terephthalate (PET) bottle sorting, pyrolysis and chemical vapor deposition (CVD) was conducted to identify the technical and environmental implications of the technology when dealing with real waste streams. Collected seashore and underwater plastics (SP and UP, respectively) contained large quantities of PET bottles (33.2 wt% and 61. Read More

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The biogas dilemma: An analysis on the social approval of large new plants.

Waste Manag 2021 Jul 30;133:10-18. Epub 2021 Jul 30.

Sustainability Environmental Economics and Dynamics Studies (SEEDS) - Research Centre, Ferrara, Italy; Ministry of Economy and Finance - Directorate of Economic and Fiscal Studies, Via dei Normanni, 5, 00184 Rome, Italy(1). Electronic address:

The degree of social acceptance of biogas as a renewable green energy source is still somewhat disregarded. Although many initiatives have focused on the construction of new biogas plants around the world, local protests on the construction of new plants often arise. This study aims to analyse the determinants of citizens' perceptions regarding the construction of new biomass plants in their neighbouring areas. Read More

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Cost-effectiveness of point-of-care creatinine testing to assess kidney function prior to contrast-enhanced computed tomography imaging.

Eur J Radiol 2021 Jul 27;142:109872. Epub 2021 Jul 27.

Centre for Health Economics, University of York, Heslington, UK.

Background: Patients undergoing contrast-enhanced computed tomography (CECT) imaging in a non-emergency outpatient setting often lack a recent estimated Glomerular Filtration Rate measurement. This may lead to inefficiencies in the CECT pathway. The use of point-of-care (POC) creatinine tests to evaluate kidney function in these patients may provide a safe and cost-effective alternative to current practice, as these can provide results within the same CECT appointment. Read More

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Metacognitive blindness in temporal selection during the deployment of spatial attention.

Cognition 2021 Jul 30;216:104864. Epub 2021 Jul 30.

Laboratoire des systèmes perceptifs, Département d'études cognitives, École normale supérieure, PSL University, CNRS, Paris, France.

How does orienting attention in space affect the quality of our confidence judgments? Orienting attention to a particular location is known to boost visual performance, but the deployment of attention is far from being instantaneous. Whether observers are able to monitor the time needed for attention to deploy remains largely unknown. To address this question, we adapted a "Wundt clocks" paradigm, asking observers (N=140) to reproduce the phase of a rotating clock at the time of an attentional cue, and to evaluate their confidence in their responses. Read More

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Application of the Dimeric G-Quadruplex and toehold-mediated strand displacement reaction for fluorescence biosensing of ochratoxin A.

Biosens Bioelectron 2021 Jul 28;192:113537. Epub 2021 Jul 28.

State Key Laboratory of Bioelectronics, Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 210009, PR China.

Ochratoxin A (OTA) is one of the most toxic mycotoxins that exists in various agro-products and foods. Here, a non-label and enzyme-free fluorescence biosensor for highly specific detection of OTA has been developed by the combination of toehold-mediated strand displacement reaction (TMSD) and G-quadruplex dimer/ThT (G-dimer/ThT). The DNA duplex (aptamer-IP) is composed of the anti-OTA aptamer and a single stranded initiation probe (IP). Read More

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