81,433 results match your criteria production chain

Multi-product strategy to enhance the environmental profile of the canning industry towards circular economy.

Sci Total Environ 2021 Jun 5;791:148249. Epub 2021 Jun 5.

CRETUS, Department of Chemical Engineering, Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain.

The sustainable and continued production of enough food to feed the entire world's population is one of the main concerns in the food industry. Spain, and in particular Galicia, which is an eminently fishing region characterised by the consumption of large quantities of fish, both fresh and processed, must face the challenge of shifting its seafood productive fabric towards a circular economy. To achieve this objective, the first task is to demonstrate that circular economy principles allow to reduce the environmental impacts associated with seafood production. Read More

View Article and Full-Text PDF

Detection of ultrashort-chain and other per- and polyfluoroalkyl substances (PFAS) in U.S. bottled water.

Water Res 2021 May 27;201:117292. Epub 2021 May 27.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA. Electronic address:

Per- and polyfluoroalkyl substances (PFAS) are compounds of emerging concern due to their persistence in the global water cycle and detection in drinking water sources. However, PFAS have been poorly studied in bottled water, especially in the United States. This study investigated the occurrence of PFAS and related factors in 101 uniquely labelled bottled water products for sale in the U. Read More

View Article and Full-Text PDF

Generation of recombinant antibodies by mammalian expression system for detecting S-metolachlor in environmental waters.

J Hazard Mater 2021 Jun 5;418:126305. Epub 2021 Jun 5.

Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Current immunoassays for herbicide detection are usually based on polyclonal or monoclonal antibodies (MAbs) raised in animals. The mammalian expression system allows the procurement of specific and highly sensitive antibodies, avoiding animal immunization. In this study, S-metolachlor-specific IgG vectors bearing either Thosea asigna virus 2A or internal ribosome entry site (S-T2A or S-IRES) and single-chain variable fragment (scFv) vectors were designed and expressed. Read More

View Article and Full-Text PDF


Food Chem Toxicol 2021 Jun 9:112334. Epub 2021 Jun 9.

Department of Veterinary Medicine and Animal Production, University of Naples, Via F. Delpino, 1, 80137, Napoli, Italy. Electronic address:

The occurrence of analogues of bisphenol A (BPA), including bisphenol F(BPF) in milk is still not well known. BPF may enter the milk chain at the farm and during milk processing at the dairy company. This study identified the main BPF contamination pathways using a monitoring model based on the identification of the hazard at three stages along the dairy chain: raw milk from the storage tank, pasteurized milk from the storage tank, and cardboard packaged milk. Read More

View Article and Full-Text PDF

4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors.

Bioorg Chem 2021 May 26;113:105024. Epub 2021 May 26.

Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie, 34093 Montpellier Cedex 5, France. Electronic address:

In Gram-negative bacteria, the major mechanism of resistance to β-lactam antibiotics is the production of one or several β-lactamases (BLs), including the highly worrying carbapenemases. Whereas inhibitors of these enzymes were recently marketed, they only target serine-carbapenemases (e.g. Read More

View Article and Full-Text PDF

Extent of bioleaching and bioavailability reduction of potentially toxic heavy metals from sewage sludge through pH-controlled fermentation.

Water Res 2021 May 27;201:117303. Epub 2021 May 27.

Department of Environmental Engineering, Marmara University, Goztepe, Istanbul 34722, Turkey. Electronic address:

Utilization of anaerobically stabilized sewage sludge on arable lands serve as a renewable alternative to chemical fertilizers as it enables recycling of valuable nutrients to food chain. However, probable presence of heavy metals in sewage sludge restricts the use of stabilized sludge on lands. In this study, a novel approach based on pH-controlled fermentation and anaerobic metal bioleaching was developed to reduce ecotoxicity potential of fermented sludge prior to its land application. Read More

View Article and Full-Text PDF

Selenium mitigated aflatoxin B1-induced cardiotoxicity with potential regulation of 4 selenoproteins and ferroptosis signaling in chicks.

Food Chem Toxicol 2021 Jun 8:112320. Epub 2021 Jun 8.

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. Electronic address:

The aim of the present study was to explore the underlying mechanism of selenium (Se)-mediated detoxification of aflatoxin B (AFB)-induced cardiotoxicity in chicks. A Se-deficient, corn-soybean meal-basal diet (36 μg Se/kg, BD) and three test diets (BD+1.0 mg AFB/kg, 0. Read More

View Article and Full-Text PDF

Leached starch content and molecular size during sorghum steaming for baijiu production is not determined by starch fine molecular structures.

Int J Biol Macromol 2021 Jun 8. Epub 2021 Jun 8.

School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Institutes of Agricultural Science and Technology Development of Yangzhou University, Yangzhou 225009, Jiangsu, China. Electronic address:

Sorghum steaming properties are important for both flavor and brewing efficiency of baijiu (Chinese alcohol liquor). However, it is currently unclear with respects to structural factors that affect sorghum steaming properties during baijiu production. In this study, starch fine molecular structures were characterized by size-exclusion chromatography and fluorophore-assisted carbohydrate electrophoresis for 8 sorghum varieties used in baijiu production. Read More

View Article and Full-Text PDF

Cassava starch-processing residue utilization for packaging development.

Int J Biol Macromol 2021 Jun 8. Epub 2021 Jun 8.

Laboratory of Packaging Technology and Membrane Development, LATEM, Department of Chemical Engineering, Universidade Federal do Rio Grande do Sul (UFRGS), Street Ramiro Barcellos, 2777 Anexo I, ZC: 90035-007 Porto Alegre, RS, Brazil.

The starch-based film development has been extensively studied since, in general, it is possible to obtain transparent, non-toxic, odorless, good gas barrier, biodegradable, and tasteless samples. However, world hunger-related problems are a reality and the use of starches, a recognized carbohydrate source, in the packaging industry should be avoided. Thus, the use of different residual starchy can minimize the costs of production, promoting the development of innovative biomaterials, eliminating the competition with the food chain. Read More

View Article and Full-Text PDF

Interleukine-22 gene variants are associated with susceptibility to visceral leishmaniasis.

Exp Parasitol 2021 Jun 8:108122. Epub 2021 Jun 8.

Department of Immunology, Fasa University of Medical Sciences, Fasa, Iran. Electronic address:

Visceral leishmaniasis (VL) is an infectious disease caused by an intracellular protozoan belonging to Leishmania species. Interleukin (IL)-22 plays an important role in inflammatory response, chemotaxis, regulation of cellular proliferation and tissue repair. Considering the role of IL-22 in control of leishmaniasis and the effect of its single nucleotide polymorphisms (SNPs) on respective function and production, this study aimed to investigate the probable association of IL-22 SNPs with VL. Read More

View Article and Full-Text PDF

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.

Immunity 2021 Jun 10. Epub 2021 Jun 10.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA.

Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exerting its anti-inflammatory effect. We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. Read More

View Article and Full-Text PDF

Wet vs. dry inoculation methods have a significant effect of Listeria monocytogenes growth on many types of whole intact fresh produce.

J Food Prot 2021 Jun 11. Epub 2021 Jun 11.

Rutgers University Food Science 65 Dudley Road UNITED STATES New Brunswick NJ 08901 732-407-7729.

L. monocytogenes causes relatively few outbreaks linked to whole fresh produce but triggers recalls each year in the US. There are limited data on the influence of wet vs. Read More

View Article and Full-Text PDF

Zhuifeng Tougu capsules improve rheumatoid arthritis symptoms in rats by regulating the toll-like receptor 2/4-nuclear factor kappa-B signaling pathway.

J Tradit Chin Med 2021 Jun;41(3):447-454

Postdoctoral Research Workstation, Hinye Pharmaceutical Co. Ltd., Hinye Pharmaceutical Co., Ltd., Changsha 410331, China.

Objective: To investigate the efficacy of Zhuifeng tougu capsules (, ZFTG) in the treatment of rheumatoid arthritis (RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B (TLR2/4-NF-κB) signaling pathway.

Methods: Type Ⅱ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-, and low-dose ZFTG groups. Read More

View Article and Full-Text PDF

Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion.

J Tradit Chin Med 2021 Jun;41(3):406-413

Department of Korean Medicine Rehabilitation, College of Korean Medicine, Daejeon University, Daejeon 34520, Republic of Korea.

Objective: To investigate the effects of Gyejibokryeong-Hwan (Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle contusion.

Methods: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH (50, 100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. Read More

View Article and Full-Text PDF

Hydrophobic-modified metal-hydroxide nanoflocculants enable one-step removal of multi-contaminants for drinking water production.

iScience 2021 May 30;24(5):102491. Epub 2021 Apr 30.

Department of Civil and Environmental Engineering, Imperial College London, London, SW7 2AZ, UK.

Flocculation is a mainstream technology for the provision of safe drinking water but is limited due to the ineffectiveness of conventional flocculants in removing trace low-molecular-weight emerging contaminants. We described a synthesis strategy for the development of high-performance nanoflocculants (hydrophobic-organic-chain-modified metal hydroxides [HOC-M]), imitating surfactant-assembling nano-micelles, by integration of long hydrophobic chains with traditional inorganic metal (Fe/Al/Ti)-based flocculants. The core-shell nanostructure was highly stable in acidic stock solution and transformed to meso-scale coagulation nuclei in real surface water. Read More

View Article and Full-Text PDF

Mechanisms of Cotranslational Protein Maturation in Bacteria.

Front Mol Biosci 2021 25;8:689755. Epub 2021 May 25.

Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, Germany.

Growing cells invest a significant part of their biosynthetic capacity into the production of proteins. To become functional, newly-synthesized proteins must be N-terminally processed, folded and often translocated to other cellular compartments. A general strategy is to integrate these protein maturation processes with translation, by cotranslationally engaging processing enzymes, chaperones and targeting factors with the nascent polypeptide. Read More

View Article and Full-Text PDF

Emerging mutant populations of Listeria monocytogenes EGD-e under selective pressure of Thymbra capitata essential oil question its use in food preservation.

Food Res Int 2021 Jul 12;145:110403. Epub 2021 May 12.

Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Instituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), Zaragoza, Spain. Electronic address:

Due to their excellent antimicrobial properties, essential oils (EO) have been proposed as potential preservatives for certain kinds of foods, such as dairy products. However, the occurrence of pathogenic populations that are resistant to EOs could pose a health risk. This report seeks to assess the emergence of resistant populations in Listeria monocytogenes EGD-e growth at 37 °C under selective pressure of Thymbra capitata EO (TCO), to characterise their resistance in laboratory media, and to identify their genotypic changes, as well as to evaluate the resistance in skimmed milk. Read More

View Article and Full-Text PDF

Sulfated modification enhances the modulatory effect of yam polysaccharide on gut microbiota in cyclophosphamide-treated mice.

Food Res Int 2021 Jul 14;145:110393. Epub 2021 May 14.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. Electronic address:

Our previous study has demonstrated that sulfated yam polysaccharide (SCYP) had a stronger immunomodulatory activity than yam polysaccharide (CYP). In order to investigate how the sulfated modification influence the immunological activity of CYP, this research was mainly focused on the study of gut microbiotal. The results showed that SCYP treatment could increase the digestive enzyme activities of colon contents and restore the production of short-chain fatty acids (SCFAs) in mice that were decreased by cyclophosphamide (Cy) treatment. Read More

View Article and Full-Text PDF

Intracellular quercetin accumulation and its impact on mitochondrial dysfunction in intestinal Caco-2 cells.

Food Res Int 2021 Jul 20;145:110430. Epub 2021 May 20.

Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent 9000, Belgium. Electronic address:

Purpose: Flavonoid bioavailability and bioactivity is associated with interindividual variability, which is partially due to differences in health status. Previously, it was demonstrated that cellular stress, especially mitochondrial stress, increases intracellular quercetin uptake and this is associated with beneficial health effects. Here, the impact of quercetin on mitochondrial dysfunction, induced by stressors targeting different sites of the electron transport chain, is investigated. Read More

View Article and Full-Text PDF

The emerging role of phosphorus in human health.

Adv Food Nutr Res 2021 15;96:27-88. Epub 2021 Apr 15.

Department of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, MB, Canada.

Phosphorus, an essential nutrient, performs vital functions in skeletal and non-skeletal tissues and is pivotal for energy production. The last two decades of research on the physiological importance of phosphorus have provided several novel insights about its dynamic nature as a nutrient performing functions as a phosphate ion. Phosphorous also acts as a signaling molecule and induces complex physiological responses. Read More

View Article and Full-Text PDF

Current Classification of the Bacillus pumilus Group Species, the Rubber-Pathogenic Bacteria Causing Trunk Bulges Disease in Malaysia as Assessed by MLSA and Multi rep-PCR Approaches.

Plant Pathol J 2021 Jun 1;37(3):243-257. Epub 2021 Jun 1.

Department of Plant Protection, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Bacillus pumilus is the causal agent of trunk bulges disease affecting rubber and rubberwood quality and yield production. In this study, B. pumilus and other closely related species were included in B. Read More

View Article and Full-Text PDF

Legacy and emerging per- and polyfluoroalkyl substances (PFAS) in sediments from the East China Sea and the Yellow Sea: Occurrence, source apportionment and environmental risk assessment.

Chemosphere 2021 Jun 3;282:131042. Epub 2021 Jun 3.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

The Yellow Sea (YS), the East China Sea (ECS) and their coastal areas have undergone rapid urbanization and industrialization. These areas are important sinks for many persistent organic pollutants. In this study, the concentration of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in marine sediments from the YS and ECS were investigated. Read More

View Article and Full-Text PDF

Different Proportions of Branched-Chain Amino Acids Modulate Lipid Metabolism in a Finishing Pig Model.

J Agric Food Chem 2021 Jun 10. Epub 2021 Jun 10.

Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process; Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha 410125, China.

This study aimed to investigate the effect of the supplementation of branched-chain amino acids (BCAAs) at different ratios in protein restriction diets on lipid metabolism in a finishing pig model. The BCAA supplementation (leucine/isoleucine/valine = 2:1:1 and 2:1:2) ameliorated the poor growth performance and carcass characteristics, particularly high fat mass caused by a protein-restricted diet. Serum adiponectin increased while leptin decreased in BCAA diets in comparison to the 12% CP group. Read More

View Article and Full-Text PDF

Expression Liabilities in a Four-Chain Bispecific Molecule.

Biotechnol Bioeng 2021 Jun 10. Epub 2021 Jun 10.

Department of Therapeutic Discovery, Amgen Research, Amgen Inc., Thousand Oaks, CA, USA.

Multispecific antibodies, often composed of three to five polypeptide chains, have become increasingly relevant in the development of biotherapeutics. These molecules have mechanisms of action that include redirecting T cells to tumors and blocking multiple pathogenic mediators simultaneously. One of the major challenges for asymmetric multispecific antibodies is generating a high proportion of the correctly paired antibody during production. Read More

View Article and Full-Text PDF

strains derived from human gut ameliorate metabolic disorders via modulation of gut microbiota composition and short-chain fatty acids metabolism.

Benef Microbes 2021 Jun 10;12(3):267-281. Epub 2021 Jun 10.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China P.R.

Regulation on gut microbiota and short-chain fatty acids (SCFAs) are believed to be a pathway to suppress the development of metabolic syndrome. In this study, three strains derived from the human gut were investigated for their effects on alleviation of metabolic disorders. These strains were individually administered to metabolic disorder rats induced by high-fat-high-sucrose (HFHS) diet. Read More

View Article and Full-Text PDF

Vitamin K Vitamers Differently Affect Energy Metabolism in IPEC-J2 Cells.

Front Mol Biosci 2021 24;8:682191. Epub 2021 May 24.

Department of Veterinary Medical Science, University of Bologna, Ozzano Emilia, Italy.

The fat-soluble vitamin K (VK) has long been known as a requirement for blood coagulation, but like other vitamins, has been recently recognized to play further physiological roles, particularly in cell development and homeostasis. Vertebrates cannot synthesize VK, which is essential, and it can only be obtained from the diet or by the activity of the gut microbiota. The IPEC-J2 cell line, obtained from porcine small intestine, which shows strong similarities to the human one, represents an excellent functional model to study the effect of compounds at the intestinal level. Read More

View Article and Full-Text PDF

Intramuscular Expression of Plasmid-Encoded FVII-Fc Immunoconjugate for Tumor Immunotherapy by Targeting Tumoral Blood Vessels and Cells.

Front Oncol 2021 24;11:638591. Epub 2021 May 24.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.

Tissue factor (TF) has been confirmed to be specifically expressed by vascular endothelial cells (VECs) in solid tumors and certain types of malignant tumor cells. Coagulation factor VII (FVII) can specifically bind to TF with high affinity, so the FVII-TF interaction provides an ideal target for tumor therapy. Expression of proteins in skeletal muscles is a simple and economical avenue for continuous production of therapeutic molecules. Read More

View Article and Full-Text PDF

Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins.

Front Physiol 2021 24;12:650313. Epub 2021 May 24.

Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, Chile.

Short-chain fatty acids (SCFAs) are carboxylic acids produced as a result of gut microbial anaerobic fermentation. They activate signaling cascades, acting as ligands of G-protein-coupled receptors, such as GPR41, GPR43, and GPR109A, that can modulate the inflammatory response and increase the intestinal barrier integrity by enhancing the tight junction proteins functions. These junctions, located in the most apical zone of epithelial cells, control the diffusion of ions, macromolecules, and the entry of microorganisms from the intestinal lumen into the tissues. Read More

View Article and Full-Text PDF

Application of Single-Domain Antibodies ("Nanobodies") to Laboratory Diagnosis.

Ann Lab Med 2021 Nov;41(6):549-558

Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.

Antibodies have proven to be central in the development of diagnostic methods over decades, moving from polyclonal antibodies to the milestone development of monoclonal antibodies. Although monoclonal antibodies play a valuable role in diagnosis, their production is technically demanding and can be expensive. The large size of monoclonal antibodies (150 kDa) makes their re-engineering using recombinant methods a challenge. Read More

View Article and Full-Text PDF
November 2021

Coordination of a fresh agricultural product supply chain with option contract under cost and loss disruptions.

PLoS One 2021 9;16(6):e0252960. Epub 2021 Jun 9.

School of Marketing and Logistics Management, Nanjing University of Finance & Economics, Nanjing, PR China.

This paper analyzes the option coordination problem of a fresh agricultural product supply chain under two supply chain structures, when the production cost and the loss rate are disrupted simultaneously. This paper provides the explicit option coordination conditions for the disrupted supply chain under two supply chain structures, and then explores the effects of the disruptions and supply chain structure on the option coordination conditions. The results suggest that it is unfavorable to apply the original coordinating contracts without disruptions to coordinate the disrupted supply chain. Read More

View Article and Full-Text PDF