430,145 results match your criteria product


Radiological findings of e-cigarette or vaping product use associated lung injury: A systematic review.

Heart Lung 2021 Jun 12;50(5):736-741. Epub 2021 Jun 12.

Melbourne Medical School, University of Melbourne, Melbourne, VIC, 3010, Australia; Department of Radiology, Royal Melbourne Hospital, Melbourne VIC, 3010, Australia.

Introduction: Chest radiology provides an opportunity to better understand the diagnostic characteristics of e-cigarette or vaping product use associated lung injury (EVALI). This systematic review aimed to summarize the radiological findings associated with EVALI reported in the literature.

Methods: This systematic review was conducted in accordance with PRISMA guidelines. Read More

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Lipolytic enzymes and free fatty acids at the endothelial interface.

Atherosclerosis 2021 May 28;329:1-8. Epub 2021 May 28.

Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address:

Lipids released from circulating lipoproteins by intravascular action of lipoprotein lipase (LpL) reach parenchymal cells in tissues with a non-fenestrated endothelium by transfer through or around endothelial cells. The actions of LpL are controlled at multiple sites, its synthesis and release by myocytes and adipocytes, its transit and association with the endothelial cell luminal surface, and finally its activation and inhibition by a number of proteins and by its product non-esterified fatty acids. Multiple pathways mediate endothelial transit of lipids into muscle and adipose tissues. Read More

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Synthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles.

Bioorg Med Chem 2021 Jun 12;42:116253. Epub 2021 Jun 12.

Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

African trypanosomiasis is a zoonotic protozoan disease affecting the nervous system. Various natural products reportedly exhibit trypanocidal activity. Naturally occurring 2,5-diphenyloxazoles present in Oxytropis lanata, and their derivatives, were synthesized. Read More

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Analytical performance of the Xpert MTB/XDR® assay for tuberculosis and expanded resistance detection.

Diagn Microbiol Infect Dis 2021 Apr 20;101(1):115397. Epub 2021 Apr 20.

FIND, Geneva, Switzerland; Division of Tropical Medicine, Center of Infectious Diseases, University Hospital of Heidelberg, Heidelberg, Germany.

In a manufacturer-independent laboratory validation study, the Xpert MTB/XDR® assay demonstrated equivalent limit of detection to Xpert MTB/RIF®, detected 100% of tested resistance mutations and showed some utility for resistance detection in strain mixtures. The Xpert MTB/XDR assay is a reliable, sensitive assay for tuberculosis and expanded resistance detection. Read More

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Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus.

Biochem Biophys Res Commun 2021 Jun 11;567:1-8. Epub 2021 Jun 11.

Department of Virology II, National Institute of Infectious Diseases, 162-8640, Tokyo, Japan. Electronic address:

Natural product-derived crude drugs are expected to yield an abundance of new drugs to treat infectious diseases. Hepatitis C virus (HCV) is an oncogenic virus that significantly impacts public health. In this study, we sought to identify anti-HCV compounds in extracts of natural products. Read More

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Modification of ordered mesoporous carbon for removal of environmental contaminants from aqueous phase: A review.

J Hazard Mater 2021 May 30;418:126266. Epub 2021 May 30.

College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225127, Jiangsu, China; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, China. Electronic address:

Contamination of water bodies by potentially toxic elements and organic pollutants has aroused extensive concerns worldwide. Thus it is significant to develop effective adsorbents for removing these contaminants. As a new member of carbonaceous material families (activated carbon, biochar, and graphene), ordered mesoporous carbon (OMC) with larger specific surface area, ordered pore structure, and higher pore volume are being evaluated for their use in contaminant removal. Read More

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Determination of hydroxytyrosol and tyrosol in human urine after intake of extra virgin olive oil produced with an ultrasounds-based technology.

J Pharm Biomed Anal 2021 Jun 10;203:114204. Epub 2021 Jun 10.

Department of Chemistry, University of Bari "Aldo Moro", 70126, Bari, Italy.

Extra virgin olive oil (EVOO) is a known source of antioxidants, such as phenolic compounds, useful in the prevention of non-infectious diseases (atherosclerosis, diabetes, cancer, and other diseases). In the present study, EVOO obtained using an innovative ultrasounds-based technology was found richer in total polyphenols, hydroxytyrosol and tyrosol, than EVOO obtained using a conventional mechanical technology. The urinary excretion in humans of hydroxytyrosol and tyrosol, after the administration of ultrasounds and mechanical EVOOs, respectively, was assessed and compared. Read More

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Feature engineering and machine learning for causality assessment in pharmacovigilance: Lessons learned from application to the FDA Adverse Event Reporting System.

Comput Biol Med 2021 Jun 8;135:104517. Epub 2021 Jun 8.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine Baltimore, MD, USA. Electronic address:

Background: Our objective was to support the automated classification of Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) reports for their usefulness in assessing the possibility of a causal relationship between a drug product and an adverse event.

Method: We used a data set of 326 redacted FAERS reports that was previously annotated using a modified version of the World Health Organization-Uppsala Monitoring Centre criteria for drug causality assessment by a group of SEs at the FDA and supported a similar study on the classification of reports using supervised machine learning and text engineering methods. We explored many potential features, including the incorporation of natural language processing on report text and information from external data sources, for supervised learning and developed models for predicting the classification status of reports. Read More

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The use of cleaning products and its relationship with the increasing health risks during the Covid-19 pandemic.

Int J Clin Pract 2021 Jun 15:e14534. Epub 2021 Jun 15.

Mersin University, Nursing Faculty, Department of Public Helath Nursing.

Objective: The present study aimed to determine the factors affecting the use of cleaning products at the home environment and the frequency of problems during the COVID-19 pandemic.

Materials And Methods: This cross-sectional research was performed online between 30.08. Read More

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Pharmacogenetics-guided advances in antipsychotic treatment.

Clin Pharmacol Ther 2021 Jun 15. Epub 2021 Jun 15.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Pharmacogenetics (PGx) research over the past two decades has produced extensive evidence for the influence of genetic factors on the efficacy and tolerability of antipsychotic treatment. However, the application of these findings to optimize treatment outcomes for patients in clinical practice has been limited. This paper presents a meta-review of key PGx findings related to antipsychotic response and common adverse effects, including antipsychotic-induced weight gain (AIWG), tardive dyskinesia (TD) and clozapine-induced agranulocytosis (CIAG), and highlights advances and challenges in clinical implementation. Read More

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Association of cigarette and electronic nicotine delivery systems use with internalizing and externalizing problems among US adults: Findings from wave 3 (2015-2016) of the PATH study.

PLoS One 2021 15;16(6):e0253061. Epub 2021 Jun 15.

Institute for Global Tobacco Control, Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

Aims: Electronic Nicotine Delivery System (ENDS) use is increasing among US adults. While existing research has demonstrated higher cigarette smoking rates among people with mental health conditions, there is sparse information on the association between ENDS use and mental health such as internalizing and externalizing problems. The aim of this study was to evaluate associations between internalizing and externalizing problems for cigarette only, ENDS only, and dual users, as well as changes in mental health among those groups. Read More

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Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study.

PLoS Med 2021 Jun 15;18(6):e1003669. Epub 2021 Jun 15.

Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.

Background: In Phase II/III randomized controlled clinical trials for the treatment of acute uncomplicated malaria, pyronaridine-artesunate demonstrated high efficacy and a safety profile consistent with that of comparators, except that asymptomatic, mainly mild-to-moderate transient increases in liver aminotransferases were reported for some patients. Hepatic safety, tolerability, and effectiveness have not been previously assessed under real-world conditions in Africa.

Methods And Findings: This single-arm, open-label, cohort event monitoring study was conducted at 6 health centers in Cameroon, Democratic Republic of Congo, Gabon, Ivory Coast, and Republic of Congo between June 2017 and April 2019. Read More

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Designing microbial communities to maximize the thermodynamic driving force for the production of chemicals.

PLoS Comput Biol 2021 Jun 15;17(6):e1009093. Epub 2021 Jun 15.

Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.

Microbial communities have become a major research focus due to their importance for biogeochemical cycles, biomedicine and biotechnological applications. While some biotechnological applications, such as anaerobic digestion, make use of naturally arising microbial communities, the rational design of microbial consortia for bio-based production processes has recently gained much interest. One class of synthetic microbial consortia is based on specifically designed strains of one species. Read More

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Folded thin-film lithium niobate modulator based on a poled Mach-Zehnder interferometer structure.

Opt Lett 2021 Jun;46(12):2940-2943

The thin-film lithium niobate structure has been used recently to construct compact and high-performance electro-optical modulators. Due to the moderate electro-optical coefficient of the lithium niobate material, the device length of such a modulator is still long, a few centimeters usually. Here, a folded Mach-Zehnder interferometer based modulator on -cut thin-film lithium niobate is demonstrated. Read More

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40 GHz high-efficiency Michelson interferometer modulator on a silicon-rich nitride and thin-film lithium niobate hybrid platform.

Opt Lett 2021 Jun;46(12):2811-2814

We propose and demonstrate a Michelson interferometer modulator with integrated Bragg reflectors on a silicon-rich nitride-thin-film lithium niobate hybrid platform. High-reflectivity Bragg reflectors are placed at the ends of both arms, which double the electro-optic (E-O) interaction length and reduce the velocity mismatch between the microwave and optical wave. The presented Michelson interferometer modulator achieves a measured half-wave voltage length product as low as 1. Read More

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Time-Driven Activity-Based Costing for Cataract Surgery in Canada: The Case of the Kensington Eye Institute.

Healthc Policy 2021 May;16(4):97-108

Director, Health System Strategy, Medtronic ULC, Brampton, ON.

Time-driven activity-based costing (TDABC) has received considerable attention globally as a way to measure value in healthcare systems. This study aimed to apply TDABC for cataract surgery at the Kensington Eye Institute (KEI). During a field evaluation, a detailed process map was created for cataract surgery at KEI. Read More

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Adverse Childhood Experiences and Past 30-Day Cigarette and E-Cigarette Use Among Sexual and Gender Minority College Students.

LGBT Health 2021 Jun 15. Epub 2021 Jun 15.

Department of Health Sciences, California State University, Northridge, Northridge, California, USA.

Sexual and gender minority (SGM) young adults report disproportionately higher rates of tobacco and nicotine product use. This study assessed the role of adverse childhood experiences (ACEs) in nicotine and tobacco product use among SGM young adults. A cross-sectional survey was administered to 11,694 college students (ages 18-29 years) between 2017 and 2018 in California, Minnesota, and Texas. Read More

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Eyes on New Product Development.

Authors:
Gary D Novack

J Ocul Pharmacol Ther 2021 Jun 15. Epub 2021 Jun 15.

PharmaLogic Development, Inc., San Rafael, California, USA.

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First report of infecting white clover () in Finland.

Plant Dis 2021 Jun 15. Epub 2021 Jun 15.

Finnish Food Authority, Laboratory and Research, Mustialankatu 3, Helsinki, Finland, 00790;

Soybean dwarf virus (SbDV, genus ) is a single-stranded positive-sense RNA virus able to infect several legume species. SbDV was first reported in Japan where it was associated with significant yield losses in soybean (Tamada, 1969). Since then the virus has been detected worldwide. Read More

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Efficacy of Hypochlorite in Disinfesting Non-fungal Plant Pathogens in Agricultural and Horticultural Plant Production: A Meta-analysis.

Plant Dis 2021 Jun 15. Epub 2021 Jun 15.

North Carolina State University, Department of Plant Pathology, 239 Partners III Campus Box 7567, Raleigh, North Carolina, United States, 27695;

Bleach products containing hypochlorite are commonly used as disinfestants to eliminate non-fungal plant pathogens from production surfaces, tools, plant surfaces, irrigation water, and produce dump tanks. While bleach products are useful, their effectiveness has been reported to vary under specific settings. A meta-analysis was conducted using 86 studies to assess the overall efficacy of hypochlorite against plant pathogenic bacteria, oomycetes and viruses and to identify factors that explain differences in product efficacy. Read More

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Supramolecular Click Product Interactions Induce Dynamic Stiffening of Extracellular Matrix-Mimetic Hydrogels.

Biomacromolecules 2021 Jun 15. Epub 2021 Jun 15.

Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843-3120, United States.

Progressive stiffening of the extracellular matrix (ECM) is observed in tissue development as well as in pathologies such as cancer, cardiovascular disease, and fibrotic disease. However, methods to recapitulate this phenomenon face critical limitations. Here, we present a poly(ethylene glycol)-based peptide-functionalized ECM-mimetic hydrogel platform capable of facile, user-controlled dynamic stiffening. Read More

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Synthesis of a Seco -Secologanin Aglycone Analogue of Interest toward Secoiridoids and Monoterpene Indole Alkaloids.

J Org Chem 2021 Jun 15. Epub 2021 Jun 15.

Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Saclay, CNRS, 91405 Orsay, France.

We report the access to an acyclic -secologanin aglycone analogue relevant to secoiridoids and monoterpene indole alkaloids. Its synthesis involved the regioselective allylic alkylation of a linear dienyl carbonate with dimethyl malonate, which was catalyzed by an iridium complex, and an anti-Markovnikov Wacker-type oxidation of the terminal alkene of the branched product that was obtained. The thus-formed aldehyde was engaged in a Pictet-Spengler reaction with tryptamine toward monoterpene indole alkaloids. Read More

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Ionic liquid-based in situ product removal (ISPR) design exemplified for an ABE fermentation.

Biotechnol Prog 2021 Jun 15:e3183. Epub 2021 Jun 15.

Department of Chemical and Biochemical Engineering, Technical University of Denmark, Lyngby, Denmark.

Selecting an appropriate separation technique is essential for the application of in situ product removal (ISPR) technology in biological processes. In this work, a three-stage systematic design method is proposed as a guide to integrate ionic liquid (IL)-based separation techniques into ISPR. This design method combines the selection of a suitable ISPR processing scheme, the optimal design of an IL-based liquid-liquid extraction (LLE) system followed by process simulation and evaluation. Read More

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Counterion Control of t-BuO-Mediated Single Electron Transfer to Nitrostilbenes Constructs N-Hydroxyindoles or Oxindoles.

Angew Chem Int Ed Engl 2021 Jun 15. Epub 2021 Jun 15.

University of Illinois at Chicago, Chemistry, 845 West Taylor Street, 60607, Chicago, UNITED STATES.

tert -Butoxide unlocks new reactivity patterns embedded in nitroarenes. Exposure of nitrostilbenes to sodium tert -butoxide was found to produce N -hydroxyindoles at room temperature without an additive. Changing the counterion to potassium changed the reaction outcome to yield solely oxindoles through an unprecedented dioxygen-transfer reaction followed by a 1,2-phenyl migration. Read More

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Systems-level approaches for understanding and engineering of the oleaginous cell factory Yarrowia lipolytica.

Biotechnol Bioeng 2021 Jun 15. Epub 2021 Jun 15.

Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.

Concerns about climate change and the search for renewable energy sources together with the goal of attaining sustainable product manufacturing have boosted the use of microbial platforms to produce fuels and high-value chemicals. In this regard, Y. lipolytica has been known as a promising yeast with potentials in diverse array of biotechnological applications such as being a host for different oleochemicals, organic acid and recombinant protein production. Read More

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Kidney outcomes using a sustained ≥40% decline in eGFR: A meta-analysis of SGLT2 inhibitor trials.

Clin Cardiol 2021 Jun 15. Epub 2021 Jun 15.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: A recent meta-analysis of sodium-glucose cotransporter 2 (SGLT2) inhibitor outcome trials reported that SGLT2 inhibitors were associated with reduction in the risk of adverse composite kidney outcomes, with moderate heterogeneity across the trials; however, the endpoints were defined differently across the trials.

Hypothesis: The apparent heterogeneity of the meta-analysis of kidney composite outcomes of SGLT2 inhibitor trials will be substantially reduced by using a consistent assessment of sustained ≥40% decline in eGFR/chronic kidney dialysis/transplantation/renal death across trials.

Methods: We performed a meta-analysis of kidney composite outcomes from the four SGLT2 cardiovascular outcome trial programs conducted in general type 2 diabetes mellitus populations, which included, as a surrogate of progression to kidney failure, a sustained ≥40% decline in eGFR along with kidney replacement therapy and kidney death. Read More

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Reverse orientation in the ultrasound-assisted [3 + 2]-cycloaddition reaction of nitrile imines with 3-formylchromone-Meldrum's acid adducts.

Mol Divers 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.

The [3 + 2]-cycloaddition reaction of nitrile imines with 2,2-dimethyl-5-[(4-oxo-4H-chromen-3-yl)methylene]-1,3-dioxane-4,6-dione tends to form the reverse-orientation products under ultrasound irradiation in EtOH in the presence of EtN. Evidence for the structure of product 5b was obtained from single-crystal X-ray analysis. Read More

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Bi-polymeric Spongy Matrices Through Cross-linking Polymerization: Synthesized and Evaluated for Solubility Enhancement of Acyclovir.

AAPS PharmSciTech 2021 Jun 15;22(5):181. Epub 2021 Jun 15.

Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.

In this study, two hydrophilic polymers hydroxypropyl methyl cellulose and beta-cyclodextrin (β-CD) are used to synthesize highly responsive and spongy polymeric matrices. Porous and stimulus-responsive polymeric network was developed to improve the solubility of acyclovir (ACV) at significant level. Grafting was successfully carried out by free radical polymerization technique. Read More

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Atherogenic oxoaldehyde of cholesterol induces innate immune response in monocytes and macrophages.

Cell Biochem Biophys 2021 Jun 15. Epub 2021 Jun 15.

Departments of Environmental Toxicology, College of Sciences and Engineering, Southern University and A & M College, Baton Rouge, LA, 70813, USA.

Cholesterol oxidation product, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (cholesterol 5,6-secosterol, ChSeco or Atheronal-A), formed at inflammatory sites, has been shown to promote monocyte differentiation into macrophages and cause elevated expression of macrophage scavenger receptors. Since inflammation is a key event at all stages of atherosclerotic plaque formation, the pro-inflammatory actions of ChSeco in human THP-1 monocytes and mouse J774 macrophages were investigated in the present study by employing ELISA, qRT-PCR, and functional assays. An increase in the secretion of interleukin-8 and platelet-derived growth factor (PDGF) isoform AA and, to a limited extent, PDGF isoform BB was observed into the culture medium of THP-1 monocytes exposed to ChSeco. Read More

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PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study.

Surg Endosc 2021 Jun 15. Epub 2021 Jun 15.

Campus Benjamin Franklin, Medizinische Klinik mit Schwerpunkt Gastroenterologie, Infektiologie und Rheumatologie, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

Background: A recently developed haemostatic peptide gel for endoscopic application has been introduced to improve the management of gastrointestinal bleeding. The aim of this pilot study was to evaluate the feasibility, safety, efficacy and indication profiles of PuraStat in a clinical setting.

Methods: In this prospective observational multicentre pilot study, patients with acute non-variceal gastrointestinal bleeding (upper and lower) were included. Read More

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