93 results match your criteria produced mannosides


Beam pen lithography as a new tool for spatially controlled photochemistry, and its utilization in the synthesis of multivalent glycan arrays.

Chem Sci 2014 May 4;5(5):2023-2030. Epub 2014 Feb 4.

Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA.

Herein, we describe how cantilever-free scanning probes can be used to deposit precursor material and subsequently irradiate the precursor to initiate polymerization, resulting in a 3D lithographic method wherein the position, height and diameter of each feature can be tuned independently. Specifically, acrylate and methacrylate monomers were patterned onto thiol terminated glass and subsequently exposed to UV light produced brush polymers by a photoinduced radical acrylate polymerization reaction. Here, we report the first examples of glycan arrays, comprised of methacrylate brush polymers that are side-chain functionalized with α-glucose, by this new lithographic approach. Read More

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Anomeric Retention of Carbohydrates in Multistage Cyclic Ion Mobility (IMS): De Novo Structural Elucidation of Enzymatically Produced Mannosides.

Anal Chem 2021 04 8;93(15):6254-6261. Epub 2021 Apr 8.

INRAE, UR BIA, F-44316 Nantes, France.

Carbohydrates are complex structures that still challenge analysts today because of their different levels of isomerism, notably the anomerism of the glycosidic bond. It has been shown recently that anomerism is preserved upon gas-phase fragmentation and that high-resolution ion mobility (IMS) can distinguish anomers. However, these concepts have yet to be applied to complex biological products. Read More

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Haloechinothrix aidingensis sp. nov., an actinomycete isolated from salt lake in Xinjiang province, north-west China.

Arch Microbiol 2021 May 23;203(4):1801-1806. Epub 2021 Jan 23.

Yunnan Institute of Microbiology, Key Laboratory for Conservation and Utilization of Bio-Resource, and Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, 650091, P. R. China.

An actinomycete strain, designated YIM 98757, was isolated from the hypersaline sediment of Aiding Lake in Xinjiang province, north-west China. The strain grew well on most media tested and no diffusible pigment was produced. The substrate mycelium was well developed and fragmented. Read More

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steryl 6--acyl-α-D-mannosides agonize signalling through Mincle.

Chem Commun (Camb) 2020 Dec;56(95):15060-15063

School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, 3010, Victoria, Australia.

The C-type lectin receptor Mincle binds Candida albicans and has been implicated in its pathobiology, but the molecular effectors responsible have not been identified. We report the synthesis of cholesteryl and ergosteryl 6-O-acyl-α-d-mannosides, produced by C. albicans mycelium, and demonstrate their ability to signal through human and mouse Mincle. Read More

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December 2020

FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against Uropathogens.

Antibiotics (Basel) 2020 Jul 10;9(7). Epub 2020 Jul 10.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.

Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic strategy has become less effective in the treatment of uropathogen-related UTIs, the anti-adhesive molecules active against fimbrial adhesins, key determinants of urovirulence, are attractive alternatives. The best-characterized bacterial adhesin is FimH, produced by uropathogenic (UPEC). Read More

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sp. nov., an actinomycete isolated from desert soil.

Int J Syst Evol Microbiol 2020 Mar;70(3):1882-1887

The Key Laboratory of Biotechnology for Medicinal Plant of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, PR China.

A Gram-stain-positive, aerobic actinomycete, designated strain BMP B8144, was isolated from desert soil, in Xinjiang province, northwest China. The isolate produced scanty aerial mycelium and fragmented substrate mycelium on most tested media. Cell-wall hydrolysates contained -diaminopimelic acid, galactose and mannose. Read More

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Actinomadura deserti sp. nov., isolated from desert soil.

Int J Syst Evol Microbiol 2018 Sep 9;68(9):2930-2935. Epub 2018 Aug 9.

3​State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.

A Gram-positive, strictly aerobic actinobacterium, designated BMP B8004, was isolated from desert soil collected in Xinjiang Province, Northwest China. It produced an extensively branched non-fragmenting substrate mycelium, and very scanty aerial mycelium that formed a short hooked chain of arthrospores with a smooth surface. Optimum growth occurred at 28 °C, pH 7. Read More

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September 2018

Glycomyces sediminimaris sp. nov., a new species of actinobacteria isolated from marine sediment.

Int J Syst Evol Microbiol 2018 Jul 5;68(7):2357-2363. Epub 2018 Jun 5.

Microbial Strain Collection, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.

A novel Glycomyces strain, designated as MH2460, was isolated from marine sediment collected from 12 m depth in Rostami seaport, Bushehr Province in Iran. On International Streptomyces Project 2 medium it produced branching substrate hyphae that developed into a large number of irregularly shaped spores in 8 days. It showed optimal growth at 25-35 °C, pH 6. Read More

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Streptomyces kalpinensis sp. nov., an actinomycete isolated from a salt water beach.

Int J Syst Evol Microbiol 2017 Dec 16;67(12):4892-4896. Epub 2017 Oct 16.

College of Life Science, Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps; Tarim University, Alar 843300, PR China.

A novel actinobacterium designated TRM 46509 was isolated from a salt water beach at Kalpin, Xinjiang, north-west China. The strain was aerobic and Gram-stain-positive, with an optimum NaCl concentration for growth of 1 % (w/v). The isolate formed sparse aerial mycelium and produced spiral spores at the end of the aerial mycelium on Gauze's No. Read More

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December 2017

Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy.

Int J Pharm 2017 Aug 15;528(1-2):440-451. Epub 2017 Jun 15.

Department of Life Sciences, University of Modena and Reggio Emilia, via G. Campi 103, 41125 Modena, Italy. Electronic address:

This study describes the development of new mannosylated Solid Lipid Nanoparticle assemblies (SLNas) delivering rifampicin for an inhaled treatment of tuberculosis. SLNas were surface engineered with mannose residues to recognize mannose receptors located on infected alveolar macrophages and facilitate cell internalization. Two sets of SLNas were produced by the melt emulsifying technique using biocompatible lipid components, i. Read More

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Nonomuraea rhodomycinica sp. nov., isolated from peat swamp forest soil.

Int J Syst Evol Microbiol 2017 Jun 7;67(6):1683-1687. Epub 2017 Jun 7.

Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

The taxonomic position of an actinomycete, strain NR4-ASC07T, isolated from a soil sample collected from Sirindhorn peat swamp forest, Narathiwat Province, Thailand, was clarified using a polyphasic approach. On the basis of morphological and chemotaxonomic characteristics, it was classified among the members of the genus Nonomuraea. It produced tightly closed spiral spore chains on aerial mycelium as well as forming a pseudosporangium. Read More

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Mannoside recognition and degradation by bacteria.

Biol Rev Camb Philos Soc 2017 Nov 20;92(4):1969-1990. Epub 2016 Dec 20.

LISBP, Université de Toulouse, CNRS, INRA, INSA, 31077, Toulouse, France.

Mannosides constitute a vast group of glycans widely distributed in nature. Produced by almost all organisms, these carbohydrates are involved in numerous cellular processes, such as cell structuration, protein maturation and signalling, mediation of protein-protein interactions and cell recognition. The ubiquitous presence of mannosides in the environment means they are a reliable source of carbon and energy for bacteria, which have developed complex strategies to harvest them. Read More

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November 2017

C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection.

Immunity 2016 12 22;45(6):1245-1257. Epub 2016 Nov 22.

Division of Molecular Immunology, Research Center for Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan; Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan. Electronic address:

Phosphatidyl-inositol mannosides (PIM) are glycolipids unique to mycobacteria and other related bacteria that stimulate host immune responses and are implicated in mycobacteria pathogenicity. Here, we found that the FcRγ-coupled C-type lectin receptor DCAR (dendritic cell immunoactivating receptor; gene symbol Clec4b1) is a direct receptor for PIM. Mycobacteria activated reporter cells expressing DCAR, and delipidation of mycobacteria abolished this activity. Read More

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December 2016

Saccharothrix isguenensis sp. nov., an actinobacterium isolated from desert soil.

Int J Syst Evol Microbiol 2016 Nov 17;66(11):4785-4790. Epub 2016 Aug 17.

Laboratoire de Biologie des Systèmes Microbiens (LBSM), Ecole Normale Supérieure de Kouba, Algiers, Algeria.

A novel actinobacterial strain, designated MB27T, was isolated from a Saharan soil sample collected in Mzab region (Ghardaïa province, South Algeria). Strain MB27T was characterized following a polyphasic taxonomic approach. This strain produced a branched and fragmented substrate mycelium, which was found to have a yellowish orange colour. Read More

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November 2016

A Gene Cluster for Biosynthesis of Mannosylerythritol Lipids Consisted of 4-O-β-D-Mannopyranosyl-(2R,3S)-Erythritol as the Sugar Moiety in a Basidiomycetous Yeast Pseudozyma tsukubaensis.

PLoS One 2016 21;11(6):e0157858. Epub 2016 Jun 21.

Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.

Mannosylerythritol lipids (MELs) belong to the glycolipid biosurfactants and are produced by various fungi. The basidiomycetous yeast Pseudozyma tsukubaensis produces diastereomer type of MEL-B, which contains 4-O-β-D-mannopyranosyl-(2R,3S)-erythritol (R-form) as the sugar moiety. In this respect it differs from conventional type of MELs, which contain 4-O-β-D-mannopyranosyl-(2S,3R)-erythritol (S-form) as the sugar moiety. Read More

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Nocardia donostiensis sp. nov., isolated from human respiratory specimens.

Antonie Van Leeuwenhoek 2016 May 25;109(5):653-60. Epub 2016 Feb 25.

Faculty of Medicine, University of the Basque Country UPV/EHU, San Sebastián, Spain.

Three human clinical isolates (X1654, X1655, and W9944) were recovered from the sputum and bronchial washings of two patients with pulmonary infections. The 16S rRNA gene sequence analysis of the isolates showed that they share 100 % sequence similarity with each other and belong to the genus Nocardia. Close phylogenetic neighbours are Nocardia brevicatena ATCC 15333(T) (98. Read More

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Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.

ChemMedChem 2016 Feb 26;11(4):367-73. Epub 2016 Jan 26.

Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.

Uropathogenic E. coli (UPEC) employ the mannose-binding adhesin FimH to colonize the bladder epithelium during urinary tract infection (UTI). Previously reported FimH antagonists exhibit good potency and efficacy, but low bioavailability and a short half-life in vivo. Read More

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February 2016

sp. nov., an endophytic actinomycete isolated from the rhizome of .

Int J Syst Evol Microbiol 2016 Mar 12;66(3):1377-1382. Epub 2016 Jan 12.

Department of Biology, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang,Bangkok 10520,Thailand.

A novel Gram-stain-positive, non-motile, endophytic actinomycete, designated strain BR3-1, which produced spore chains borne on the tips of short sporophores, was isolated from the rhizome of collected from Udon Thani province, Thailand. This strain was investigated for its taxonomic position using a polyphasic approach. The strain contained 3-hydroxydiaminopimelic acid and -diaminopimelic acid in the cell-wall peptidoglycan. Read More

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Actinoplanes lichenis sp. nov., isolated from lichen.

Int J Syst Evol Microbiol 2016 Jan 6;66(1):468-473. Epub 2015 Nov 6.

Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

A novel species of the genus Actinoplanes, strain LDG1-22T, for which we propose the name Actinoplanes lichenis sp. nov., was isolated from a lichen sample collected from tree bark in Thailand. Read More

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January 2016

Candida albicans β-1,2-mannosyltransferase Bmt3 prompts the elongation of the cell-wall phosphopeptidomannan.

Glycobiology 2016 Feb 1;26(2):203-14. Epub 2015 Nov 1.

Univ. Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F 59000 Lille, France

β-1,2-Linked mannosides are expressed on numerous cell-wall glycoconjugates of the opportunistic pathogen yeast Candida albicans. Several studies evidenced their implication in the host-pathogen interaction and virulence mechanisms. In the present study, we characterized the in vitro activity of CaBmt3, a β-1,2-mannosyltransferase involved in the elongation of β-1,2-oligomannosides oligomers onto the cell-wall polymannosylated N-glycans. Read More

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February 2016

Synthesis of mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic pathogen Pseudomonas aeruginosa.

Carbohydr Res 2015 Aug 5;412:34-42. Epub 2015 May 5.

Department of Chemistry and Graduate School Chemical Biology, University of Konstanz, D-78457 Konstanz, Germany; Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), D-66123 Saarbrücken, Germany; Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Germany. Electronic address:

Biofilm formation and chronic infections with Pseudomonas aeruginosa depend on lectins produced by the bacterium. The bacterial C-type lectin LecB binds to the two monosaccharides l-fucose and d-mannose and conjugates thereof. Previously, d-mannose derivatives with amide and sulfonamide substituents at C6 were reported as potent inhibitors of the bacterial lectin LecB and LecB-mediated bacterial surface adhesion. Read More

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Actinorugispora endophytica gen. nov., sp. nov., an actinomycete isolated from Daucus carota.

Int J Syst Evol Microbiol 2015 Aug 6;65(8):2562-2568. Epub 2015 May 6.

State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, College of Ecology and Evolution, Sun Yat-Sen University, Guangzhou, 510275, PR China.

An actinomycete strain, designated YIM 690008T, was isolated from Daucus carota collected from South Korea and its taxonomic position was investigated by using a polyphasic approach. The strain grew well on most media tested and no diffusible pigment was produced. The aerial mycelium formed wrinkled single spores and short spore chains, some of which were branched. Read More

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Carbohydrate-dependent binding of langerin to SodC, a cell wall glycoprotein of Mycobacterium leprae.

J Bacteriol 2015 Feb 24;197(3):615-25. Epub 2014 Nov 24.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA

Langerhans cells participate in the immune response in leprosy by their ability to activate T cells that recognize the pathogen, Mycobacterium leprae, in a langerin-dependent manner. We hypothesized that langerin, the distinguishing C-type lectin of Langerhans cells, would recognize the highly mannosylated structures in pathogenic Mycobacterium spp. The coding region for the extracellular and neck domain of human langerin was cloned and expressed to produce a recombinant active trimeric form of human langerin (r-langerin). Read More

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February 2015

A single arabinan chain is attached to the phosphatidylinositol mannosyl core of the major immunomodulatory mycobacterial cell envelope glycoconjugate, lipoarabinomannan.

J Biol Chem 2014 Oct 17;289(44):30249-30256. Epub 2014 Sep 17.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 and. Electronic address:

Lipoarabinomannan (LAM) is composed of a phosphatidylinositol anchor followed by a mannan followed by an arabinan that may be capped with various motifs including oligosaccharides of mannose. A related polymer, lipomannan (LM), is composed of only the phosphatidylinositol and mannan core. Both the structure and the biosynthesis of LAM have been studied extensively. Read More

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October 2014

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site.

Glycobiology 2015 Jan 10;25(1):101-14. Epub 2014 Sep 10.

School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, WA 6845, Australia Centre for Biomedical Research, Burnet Institute, Melbourne, VIC 3004, Australia Department of Surgery Austin Health, University of Melbourne, Heidelberg, VIC 3084, Australia Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Melbourne, VIC 3004, Australia

Euonymus europaeus lectin (EEL) is a carbohydrate-binding protein derived from the fruit of the European spindle tree. EEL was first identified for its erythrocyte agglutinating properties and specificity for B and H blood groups. However, a detailed molecular picture of the structural basis of carbohydrate recognition by EEL remains to be developed. Read More

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January 2015

Streptomyces lushanensis sp. nov., a novel actinomycete with anti-cyanobacterial activity.

J Antibiot (Tokyo) 2015 Jan 2;68(1):5-8. Epub 2014 Jul 2.

1] Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming, China [2] State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.

Strain JXJ 0135(T), an anti-cyanobacterial actinomycete, was isolated from a soil sample collected from Lushan Mountain, south China, and identified by using polyphasic approach. Phylogenetic analysis of the near-complete 16S rRNA gene sequence indicated that strain JXJ 0135(T) belongs to the genus Streptomyces and exhibited distinct subclade and also highest similarity (98.6%) to Streptomyces scopuliridis RB72(T). Read More

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January 2015

Sphaerisporangium rufum sp. nov., an endophytic actinomycete from roots of Oryza sativa L.

Int J Syst Evol Microbiol 2014 Apr 20;64(Pt 4):1077-1082. Epub 2013 Dec 20.

Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.

An endophytic actinomycete, strain R10-82(T), isolated from surface-sterilized roots of rice (Oryza sativa L.) was studied using a polyphasic approach. Strain R10-82(T) produced branching substrate mycelia and developed spherical spore vesicles on aerial hyphae containing non-motile spores. Read More

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Selective production of two diastereomers of disaccharide sugar alcohol, mannosylerythritol by Pseudozyma yeasts.

Appl Microbiol Biotechnol 2014 Jan 23;98(2):823-30. Epub 2013 Nov 23.

Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5-2, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Japan.

Mannosylerythritol (ME) is the hydrophilic backbone of mannosylerythritol lipids as the most promising biosurfactants produced by different Pseudozyma yeasts, and has been receiving attention as a new sugar alcohol. Different Pseudozyma yeasts were examined for the sugar alcohol production using glucose as the sole carbon source. P. Read More

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January 2014

Verrucosispora andamanensis sp. nov., isolated from a marine sponge.

Int J Syst Evol Microbiol 2013 Nov 24;63(Pt 11):3970-3974. Epub 2013 May 24.

Actinobacterial Research Unit, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

An actinomycete strain, SP03-05(T), was isolated from a marine sponge sample (Xestospongia sp.) collected from Phuket Province of Thailand. The strain was aerobic, Gram-stain-positive and produced single spores at the tips of the substrate mycelium. Read More

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November 2013

Micromonospora spongicola sp. nov., an actinomycete isolated from a marine sponge in the Gulf of Thailand.

J Antibiot (Tokyo) 2013 Sep 15;66(9):505-9. Epub 2013 May 15.

Department of Biology, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.

An actinomycete strain, S3-1(T), was isolated from marine sponge sample collected from the Gulf of Thailand. The strain is aerobic, Gram-positive and produced single spores at the tip of the substrate mycelium. Strain S3-1(T) contained meso-diaminopimelic acid in the peptidoglycan, whole-cell sugars were arabinose, galactose, glucose, rhamnose, ribose and xylose. Read More

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September 2013