7,222 results match your criteria produced improvements


A Smartphone App (TRIANGLE) to Change Cardiometabolic Risk Behaviors in Women Following Gestational Diabetes Mellitus: Intervention Mapping Approach.

JMIR Mhealth Uhealth 2021 May 11;9(5):e26163. Epub 2021 May 11.

Diabetes Research Group, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.

Background: Gestational diabetes mellitus (GDM) is the most common complication during pregnancy and is associated with an increased risk for the development of cardiometabolic diseases. Behavioral interventions can reduce this risk, but current solutions insufficiently address the requirements for such a program. The systematic development of a scalable mobile health (mHealth) promotion program for mothers during the first years post-GDM may contribute to solving this problem. Read More

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Functional Magnetic Resonance Imaging of Language Following Constraint-Induced Aphasia Therapy Primed with Intermittent Theta Burst Stimulation in 13 Patients with Post-Stroke Aphasia.

Med Sci Monit 2021 May 10;27:e930100. Epub 2021 May 10.

Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.

BACKGROUND Aphasia is a debilitating consequence of stroke. This study aimed to investigate the role of functional magnetic resonance imaging (fMRI) activation changes during overt language tasks in promoting language improvements following constraint-induced aphasia therapy (CIAT) primed with intermittent theta burst stimulation (iTBS) in 13 patients with aphasia following ischemic stroke. MATERIAL AND METHODS Participants with post-stroke aphasia participated in CIAT primed with iTBS on 10 consecutive weekdays. Read More

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A Quest for a Universal Plasma-Derived Antivenom Against All Elapid Neurotoxic Snake Venoms.

Front Immunol 2021 23;12:668328. Epub 2021 Apr 23.

Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

This review describes the research aimed at the development of universal antivenom against elapid neurotoxic snake venoms. The antivenoms produced in Thailand in the 1980s were of low potency, especially against the elapid venoms. This was thought to be due to the low immunogenicity of the α-neurotoxins, which are the most lethal toxins in these venoms. Read More

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A milk transportation problem with milk collection centers and vehicle routing.

ISA Trans 2021 Apr 24. Epub 2021 Apr 24.

Industrial Engineering Program, Universidad Andres Bello, Chile. Electronic address:

In this work, we study, model, and propose two approaches to solve a raw milk transportation problem inspired by a real case of a milk company in Chile. The milk is produced by a set of farms scattered in a large rural area. The company must collect all the production daily using a truck fleet. Read More

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Medial displacement calcaneal osteotomy versus lateral column lengthening to treat stage II tibialis posterior tendon dysfunction, a prospective randomized controlled study.

Foot (Edinb) 2021 Apr 7;47:101798. Epub 2021 Apr 7.

Orthopedic Department, Assiut University Hospital, Assiut, Egypt. Electronic address:

Purpose: Adult-acquired flatfoot deformity (AAFD) requires optimum planning that often requires several procedures for deformity correction. The objective of this study was to detect the difference between MDCO versus LCL in the management of AAFD with stage II tibialis posterior tendon dysfunction regarding functional, radiographic outcomes, efficacy in correction maintenance, and the incidence of complications.

Patient And Methods: 42 Patients (21 males and 21 females) with a mean age of 49. Read More

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Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model: a randomized controlled trial.

J Orthop Surg Res 2021 May 3;16(1):290. Epub 2021 May 3.

Faculty of Veterinary Medicine, University of Lisbon (FMV/ULisboa), Lisbon, Portugal.

Background: Osteoarthritis (OA) is a complex joint disease and chronic pain source, affecting a patient's quality of life and posing a financial burden. As the dog is considered a nearly ideal species for translation research of human OA and the most used model for research, exploring spontaneous dog OA under the One Health/One Medicine concept can improve both humans and dogs' health and well-being.

Methods: In a clinical treatment experiment, forty (N=40) joints were selected and randomly assigned to a control group (CG), which received 0. Read More

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A highly accurate method for quantifying LVNC cardiomyophaty.

AMIA Annu Symp Proc 2020 25;2020:223-232. Epub 2021 Jan 25.

Computer Engineering, University of Murcia, Spain.

Left ventricular non-compaction (LVNC) is defined by an increase of trabeculations in left ventricular endo-myocardium. Although LVNC can be in isolation, an increase in hypertrabeculation often accompanies genetic cardiomyopthies. Several enhancements are proposed and implemented to improve a software tool for the automatic quantification of the exact hyper-trabeculation degree in the left ventricular myocardium for a population of patients with LVNC cardiomyopathy (QLVTHC-NC). Read More

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January 2021

Periodized Resistance Training With and Without Functional Training Improves Functional Capacity, Balance, and Strength in Parkinson's Disease.

J Strength Cond Res 2021 Apr 22. Epub 2021 Apr 22.

Department of Kinesiology and Sports Sciences, Laboratory of Neuromuscular Research and Active Aging, University of Miami, Coral Gables, Florida; and Miller School of Medicine, Center on Aging, University of Miami, Miami, Florida.

Abstract: Strand, KL, Cherup, NP, Totillo, MC, Castillo, DC, Gabor, NJ, and Signorile, JF. Periodized resistance training with and without functional training improves functional capacity, balance, and strength in Parkinson's disease. J Strength Cond Res XX(X): 000-000, 2021-Periodized progressive resistance training (PRT) is a common method used to improve strength in persons with Parkinson's disease (PD). Read More

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Mechanical and Fracture Parameters of Ultra-High Performance Fiber Reinforcement Concrete Cured via Steam and Water: Optimization of Binder Content.

Materials (Basel) 2021 Apr 16;14(8). Epub 2021 Apr 16.

Faculty of Civil Engineering, Technische Universität Dresden, 01069 Dresden, Germany.

An investigational study is conducted to examine the effects of different amounts of binders and curing methods on the mechanical behavior and ductility of Ultra-High Performance Fiber Reinforced Concretes (UHPFRCs) that contain 2% of Micro Steel Fiber (MSF). The aim is to find an optimum binder content for the UHPFRC mixes. The same water-to-binder ratio (w/b) of 0. Read More

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Changes in Amino Acid Profiles and Bioactive Compounds of Thai Silk Cocoons as Affected by Water Extraction.

Molecules 2021 Apr 2;26(7). Epub 2021 Apr 2.

Research Unit of Process and Product Development of Functional Foods, Department of Food Technology and Nutrition, Faculty of Technology, Mahasarakham University, Kantarawichai, Mahasarakham 44150, Thailand.

Silk proteins have many advantageous components including proteins and pigments. The proteins-sericin and fibroin-have been widely studied for medical applications due to their good physiochemical properties and biological activities. Various strains of cocoon display different compositions such as amino-acid profiles and levels of antioxidant activity. Read More

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A Dose-Ranging Study of the Novel Inhaled Dual PDE 3 and 4 Inhibitor Ensifentrine in Patients with COPD Receiving Maintenance Tiotropium Therapy.

Int J Chron Obstruct Pulmon Dis 2021 22;16:1137-1148. Epub 2021 Apr 22.

Verona Pharma, Plc, Raleigh, NC, USA.

Purpose: Ensifentrine is an inhaled dual inhibitor of phosphodiesterase (PDE) 3 and 4 that has shown bronchodilatory effects and symptom improvement in clinical studies in patients with chronic obstructive pulmonary disease (COPD), and anti-inflammatory effects in healthy volunteers in a model of COPD-like inflammation. This manuscript reports on the results of the clinical study examining if ensifentrine provides meaningful improvements in lung function when added on to tiotropium over 4 weeks in patients with COPD who have impaired lung function and symptoms despite treatment with tiotropium.

Patients And Methods: This randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study recruited patients with moderate-to-severe COPD. Read More

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Effects of Plyometric Jump Training on Repeated Sprint Ability in Athletes: A Systematic Review and Meta-Analysis.

Sports Med 2021 Apr 28. Epub 2021 Apr 28.

School of Human Sciences (Exercise and Sport Science), The University of Western Australia, Crawley, WA, Australia.

Background: There is a growing body of research examining the effects of plyometric jump training (PJT) on repeated sprint ability (RSA) in athletes. However, available studies produced conflicting findings and the literature has not yet been systematically reviewed. Therefore, the effects of PJT on RSA indices remain unclear. Read More

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Improved methods for estimating mean radiant temperature in hot and sunny outdoor settings.

Int J Biometeorol 2021 Apr 28. Epub 2021 Apr 28.

School of Environmental Sciences, University of Guelph, Guelph, Ontario, Canada.

Thermal comfort research has utilized various sensors and models to estimate the mean radiant temperature (MRT) experienced by a human, including the standard black globe thermometer (SGT), acrylic globe thermometers (AGT), and cylindrical radiation thermometers (CRT). Rather than directly measuring radiation, a temperature is measured in the center of these low-cost sensors that can be related to MRT after theoretically accounting for convection. However, these sensors have not been systematically tested under long-term hot and clear conditions. Read More

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omparison of nanofibrillar and macroporous-spongious composite tissue scaffolds for periodontal tissue engineering.

Connect Tissue Res 2021 Apr 26:1-15. Epub 2021 Apr 26.

Department of Periodontology, Hacettepe University, Ankara, Turkey.

: The ultimate goal of periodontal treatment is to regenerate the lost periodontal tissues. The interest in nanomaterials in dentistry is growing rapidly and has focused on improvements in various biomedical applications, such as periodontal regeneration and periodontal tissue engineering. To enhance periodontal tissue regeneration, hydroxyapatite (HA) was used in conjunction with other scaffold materials, such as Poly lactic-co-glycolic-acid (PLGA) and collagen (C). Read More

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Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS: The Effects of Bioprocessing Conditions on Productivity and Product Quality.

Front Bioeng Biotechnol 2021 9;9:569045. Epub 2021 Apr 9.

School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland.

The biopharmaceutical market is dominated by monoclonal antibodies, the majority of which are produced in Chinese hamster ovary (CHO) cell lines. Intense cell engineering, in combination with optimization of various process parameters results in increasing product titers. To enable further improvements in manufacturing processes, detailed information about how certain parameters affect cellular mechanisms in the production cells, and thereby also the expressed drug substance, is required. Read More

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Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial.

J Psychosom Res 2021 Apr 2;146:110484. Epub 2021 Apr 2.

Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Bart's and the London School of Medicine and Dentistry, Queen Mary University, London, UK.

Objective: The GETSET trial found that guided graded exercise self-help (GES) improved fatigue and physical functioning more than specialist medical care (SMC) alone in adults with chronic fatigue syndrome (CFS) 12 weeks after randomisation. In this paper, we assess the longer-term clinical and health economic outcomes.

Methods: GETSET was a randomised controlled trial of 211 UK secondary care patients with CFS. Read More

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In-planta production of the biodegradable polyester precursor 2-pyrone-4,6-dicarboxylic acid (PDC): Stacking reduced biomass recalcitrance with value-added co-product.

Metab Eng 2021 Apr 22;66:148-156. Epub 2021 Apr 22.

Joint BioEnergy Institute, EmeryStation East, 5885 Hollis St, 4th Floor, Emeryville, CA, 94608, USA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, 94720, USA. Electronic address:

2-Pyrone-4,6-dicarboxylic acid (PDC), a chemically stable intermediate that naturally occurs during microbial degradation of lignin by bacteria, represents a promising building block for diverse biomaterials and polyesters such as biodegradable plastics. The lack of a chemical synthesis method has hindered large-scale utilization of PDC and metabolic engineering approaches for its biosynthesis have recently emerged. In this study, we demonstrate a strategy for the production of PDC via manipulation of the shikimate pathway using plants as green factories. Read More

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Miscanthus biochar value chain - A review.

J Environ Manage 2021 Apr 20;290:112611. Epub 2021 Apr 20.

Department of the Environmental Chemistry & Technology, Faculty of the Environment, Jan Evangelista Purkyně University, Pasteurova 15, Ústí nad Labem, 400 96, Czech Republic; Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Al-Farabi 71, Almaty, 05 00 40, Kazakhstan. Electronic address:

To complete a loop of the Miscanthus value chain including production, phytomanagement, conversion to energy, and bioproducts, the wastes accumulated from these processes have to be returned to the production cycle to provide sustainable use of the feedstock, to reduce costs, and to ensure a zero-waste approach. This can be achieved by converting Miscanthus feedstock into biogas and biochar using pyrolysis and then returning biochar to the production cycle of Miscanthus crop applications in the phytotechnology of trace elements (TEs)-contaminated/marginal lands. These processes are subjects of the current review, which focused on the peculiarities of biochar received from Miscanthus by pyrolysis, its properties, the impact on soil characteristics, the phytoremediation process, biomass yield, and the abundance of soil biodiversity. Read More

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Arrabidaea chica Verlot fractions reduce MIA-induced osteoarthritis progression in rat knees.

Inflammopharmacology 2021 Apr 21. Epub 2021 Apr 21.

Biological and Health Sciences Center, Federal University of Maranhão, Av. dos Portugueses 1966, São Luís, MA, 65085-580, Brazil.

This study aims to investigate the activity of n-hexane, ethyl acetate and butanol fractions obtained from Arrabidaea chica Verlot against MIA-induced osteoarthritis (OA). The antinociceptive potentials of each fraction were evaluated through a cyclooxygenase (COX) 1 and 2 inhibition test and an in vivo OA-model. In addition, toxicity assessments in the liver, spleen and kidney, as well as radiographic and histopathological knee analyses, were performed. Read More

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Evaluation of a urology specialist therapeutic radiographer implemented radiotherapy pathway for prostate cancer patients.

Radiography (Lond) 2021 05 24;27(2):430-436. Epub 2020 Oct 24.

The Royal Marsden NHS Foundation Trust, UK; The Institute of Cancer Research, UK. Electronic address:

Introduction: The role of the Urology Specialist Therapeutic Radiographer (USTR) was introduced to support a busy NHS uro-oncology practice. Key objectives were to improve patient preparedness for and experience of radiotherapy, focussed on prostate cancer. Pre-radiotherapy information seminars were developed, and on-treatment patient review managed by the USTRs. Read More

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Life cycle assessment of a long-term multifunctional winter wheat-summer maize rotation system on the North China Plain under sustainable P management.

Sci Total Environ 2021 Apr 16;783:147039. Epub 2021 Apr 16.

College of Resources and Environmental Science, National Academy of Agriculture Green Development, Key Laboratory of Plant-Soil Interactions, Ministry of Education, China Agricultural University, Beijing 100193, China. Electronic address:

In sustainable agriculture, sufficient crop yields and nutrients must be produced while maintaining environmental protection. Considering the role of phosphorus (P) fertilizer in influencing crops yield and environmental security, life cycle assessment was used to examine the environmental impacts of long-term P application on the grain yield and nutritional quality of winter wheat and summer maize. Thus, a long-term field experiment with six P application rates for winter wheat (0, 25, 50, 100, 200, and 400 kg P ha) and summer maize (0, 12. Read More

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Flavonoids: structure-function and mechanisms of action and opportunities for drug development.

Toxicol Res 2021 Apr 20;37(2):147-162. Epub 2021 Jan 20.

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843 USA.

Flavonoids are polyphenolic phytochemicals produced in fruits, nuts and vegetables and dietary consumption of these structurally diverse compounds is associated with multiple health benefits including increased lifespan, decreased cardiovascular problems and low rates of metabolic diseases. Preclinical studies with individual flavonoids demonstrate that these compounds exhibit anti-inflammatory and anticancer activities and they enhance the immune system. Their effectiveness in both chemoprevention and chemotherapy is associated with their targeting of multiple genes/pathways including nuclear receptors, the aryl hydrocarbon receptor (AhR), kinases, receptor tyrosine kinases and G protein-coupled receptors. Read More

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Reno-pancreas protective effects of Spirulina platensis in alloxan induced diabetic rats.

Pak J Pharm Sci 2020 Nov;33(6):2511-2519

Department of Pharmacology, Bangladesh Agricultural University, Mymensingh, Bangladesh.

A large variety of herbal elements are employed in the treatment of diabetes for their better efficacy and safety compare to synthetic drugs. In this experiment Spirulina platensis was used to evaluate the antidiabetic, kidney & pancreas injury protective potential in alloxan induced diabetic rats. Male Long Evans rats having six weeks of age were used for the experiment. Read More

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November 2020

Zirconia-Reinforced Lithium Silicate (ZLS) mechanical and biological properties: a literature review.

J Dent 2021 Apr 14:103661. Epub 2021 Apr 14.

Department of Neurosciences, Reproductive and Odontostomatological Sciences, Division of Prosthodontics and Digital Dentistry, University "Federico II" of Naples, Via Pansini 5, 80131, Naples, Italy. Electronic address:

Objectives: This paper aimed to provide a literature review of the mechanical and biological properties of zirconia-reinforced lithium silicate glass-ceramics (ZLS) in Computer-aided design / Computer-aided manufacturing (CAD/CAM) systems.

Data/sources: An extensive search of the literature for papers related to ZLS was made on the databases of PubMed/Medline, Scopus, Embase, Google Scholar, Dynamed, and Open Grey. The papers were selected by 3 independent calibrated reviewers. Read More

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Long-term outcomes of dual innervation in functional muscle transfers for facial palsy.

J Plast Reconstr Aesthet Surg 2021 Mar 22. Epub 2021 Mar 22.

 St Andrews' Centre of Plastic and Reconstructive Surgery, Broomfield Hospital, Chelmsford, CM1 7ET, United Kingdom.

Background: This study describes a different approach with a 2-stage facial reanimation in patients with long-standing unilateral facial paralysis using free gracilis muscle transfer, innervated by both cross-facial nerve graft and masseteric nerve. The authors present their rationale, surgical technique, and long-term outcomes.

Methods: Between August 2012 and March 2016, 11 patients (6 female and 5 male patients) underwent a 2-staged dually innervated gracilis muscle transfer. Read More

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Proof of concept efficacy study of intranasal stabilized isoamyl nitrite (SIAN) in rhesus monkeys against acute cyanide poisoning.

Regul Toxicol Pharmacol 2021 Apr 14;123:104927. Epub 2021 Apr 14.

Emergent BioSolutions, Inc., 300 Professional Drive, Gaithersburg, MD, 20879, USA.

Cyanide is a fast-acting toxicant that inhibits aerobic cellular respiration in mitochondria. Historically, amyl nitrite has been used to treat cyanide poisoning. The objective of this study was to demonstrate the effectiveness of intranasal (IN) administration of stabilized isoamyl nitrite (SIAN) against lethal potassium cyanide (KCN) intravenous (IV) challenge in a conscious nonhuman primate (NHP) model. Read More

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Effectiveness of a Community-based Group Mindfulness Program tailored for Arabic and Bangla-speaking Migrants.

Int J Ment Health Syst 2021 Apr 13;15(1):32. Epub 2021 Apr 13.

Translational Health Research Institute, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.

Background: Migrant communities are often underserved by mainstream mental health services resulting in high rates of untreated psychological distress. This collaborative study built on evidence that mindfulness-based interventions delivered in-language and culturally tailored were acceptable and clinically effective for Arabic speakers in Australia. It aimed to establish whether a group mindfulness program produced expected outcomes under normal operational conditions, and to test its scalability and its transferability to Bangla speakers. Read More

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Modified MAX Phase Synthesis for Environmentally Stable and Highly Conductive TiC MXene.

ACS Nano 2021 Apr 13;15(4):6420-6429. Epub 2021 Apr 13.

A.J. Drexel Nanomaterials Institute and Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19143, United States.

One of the primary factors limiting further research and commercial use of the two-dimensional (2D) titanium carbide MXene TiC, as well as MXenes in general, is the rate at which freshly made samples oxidize and degrade when stored as aqueous suspensions. Here, we show that including excess aluminum during synthesis of the TiAlC MAX phase precursor leads to TiAlC grains with improved crystallinity and carbon stoichiometry (termed Al-TiAlC). MXene nanosheets (Al-TiC) produced from this precursor are of higher quality, as evidenced by their increased resistance to oxidation and an increase in their electronic conductivity up to 20 000 S/cm. Read More

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