48,414 results match your criteria produced body

[Development of an ivermectin-containing syrup as an extemporaneous preparation for treatment of scabies in children].

Hautarzt 2021 Apr 13. Epub 2021 Apr 13.

An-Institut für angewandte Dermatopharmazie e. V., Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Deutschland.

Background: Oral ivermectin can be used to treat scabies. Evidence for safe and effective use in young children in individual treatment situations has been developed and published. In order to also ensure a body weight-adapted dosage for children, an ivermectin-containing syrup was developed as an extemporaneous preparation. Read More

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Biomimetic hydroxyapate/polydopamine composites with good biocompatibility and efficiency for uncontrolled bleeding.

J Biomed Mater Res B Appl Biomater 2021 Apr 13. Epub 2021 Apr 13.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, P.R. China.

Uncontrolled bleeding is thought to be the most deadly cause of pre-hospital, traffic, and military accidents death. However, the popular commercial hemostats can only realize the hemostasis of mild bleeding. Therefore, we developed polydopamine (PDA) composite materials (PMs), which applied hydroxyapatite as the parent body. Read More

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CRISPR/Cas9-mediated mutagenesis reveals the roles of Calaxin in gastropod larval cilia.

Gene 2021 Apr 9:145640. Epub 2021 Apr 9.

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 266071, Qingdao, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, 266000, Qingdao, China; University of Chinese Academy of Sciences, 100039, Beijing, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, 7 Nanhai Road, 266071, Qingdao, China. Electronic address:

Obtaining detectable knockout phenotypes in the G0 generation is essential for gene function studies. Although CRISPR/Cas9-mediated gene editing has been employed to knock out molluscan genes, detectable phenotypes in the G0 generation have not been reported in these animals. In this study, we determined the knockout phenotype of a cilium-related gene, calaxin, using CRISPR/Cas9 technology in the gastropod mollusk Lottia goshimai. Read More

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Neuroanatomical Correlates of Macrolinguistic Aspects in Narrative Discourse in Unilateral Left and Right Hemisphere Stroke: A Voxel-Based Morphometry Study.

J Speech Lang Hear Res 2021 Apr 12:1-16. Epub 2021 Apr 12.

Linguistics Department, School of Humanities, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Background A growing body of literature has demonstrated the importance of discourse assessment in patients who suffered from brain injury, both in the left and right hemispheres, as discourse represents a key component of functional communication. However, little is known about the relationship between gray matter density and macrolinguistic processing. Purpose This study aimed to investigate this relationship in a group of participants with middle-low to low socioeconomic status. Read More

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Effects of Tannic Acid on Antioxidant Activity and Ovarian Development in Adolescent and Adult Female Brandt's Voles.

Reprod Sci 2021 Apr 12. Epub 2021 Apr 12.

Department of College of Biological Science and Technology, Yangzhou University, Yangzhou, 225009, China.

It is well known that tannins can influence the reproduction of animals, but there is little research published to elucidate the mechanics of this phenomenon. The purpose of this study was to investigate the role of antioxidation in the influence of tannic acid on the ovarian development of Brandt's voles (Lasiopodomys brandtii), which is a species of prairie animal that feeds on plants containing tannins. Postnatal 4-week-old female Brandt's voles were treated with 0 (control), 0. Read More

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Hero Turned Villain: Identification of Components of the Sex Pheromone of the Tomato Bug, Nesidiocoris tenuis.

J Chem Ecol 2021 Apr 12. Epub 2021 Apr 12.

NIAB EMR, New Road, East Malling, Kent, UK.

Nesidiocoris tenuis (Reuter) (Heteroptera: Miridae) is a tropical mirid bug used as a biocontrol agent in protected crops, including tomatoes. Although N. tenuis predates important insect pests, especially whitefly, it also causes damage by feeding on tomato plants when prey populations decline, resulting in significant economic losses for growers. Read More

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Tuning the Conductivity and Electron Work Function of a Spin-Coated PEDOT:PSS/PEO Nanofilm for Enhanced Interfacial Adhesion.

Langmuir 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, T6G 2H5 Canada.

We report a novel phenomenon of increasing the adherence of a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS/PEO) nanofilm for SiN through cosolvent treatment by DMSO. By varying the w/w% ratio of DMSO, nanofilms with different conductivities were produced. Atomic force microscopy (AFM) analysis showed that the adhesive force between the AFM's SiN probe and the nanofilm increased by 35. Read More

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Effects of long-acting analogues of lamprey GLP-1 and paddlefish glucagon on alpha- to beta-cell transdifferentiation in an insulin-deficient transgenic mouse model.

J Pept Sci 2021 Apr 11:e3328. Epub 2021 Apr 11.

Diabetes Research Group, School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, UK.

The abilities of the long-acting, dual-agonist anti-diabetic peptides [D-Ala ]palmitoyl-lamprey GLP-1 and [D-Ser ]palmitoyl-paddlefish glucagon to induce α-cell to β-cell transdifferentiation were investigated in Glu ;ROSA26-eYFP mice. These animals have been genetically engineered so that yellow fluorescent protein is specifically expressed in glucagon-producing α-cells, thereby allowing cell lineage tracing. Insulin deficiency was produced by treatment of the mice with multiple low doses of streptozotocin. Read More

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Biodegradable Materials for Sustainable Health Monitoring Devices.

ACS Appl Bio Mater 2021 Jan 23;4(1):163-194. Epub 2020 Dec 23.

Bendable Electronics and Sensing Technologies (BEST) Group, James Watt School of Engineering, University of Glasgow, G12 8QQ Glasgow, U.K.

The recent advent of biodegradable materials has offered huge opportunity to transform healthcare technologies by enabling sensors that degrade naturally after use. The implantable electronic systems made from such materials eliminate the need for extraction or reoperation, minimize chronic inflammatory responses, and hence offer attractive propositions for future biomedical technology. The eco-friendly sensor systems developed from degradable materials could also help mitigate some of the major environmental issues by reducing the volume of electronic or medical waste produced and, in turn, the carbon footprint. Read More

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January 2021

A review of machine learning experiments in equity investment decision-making: why most published research findings do not live up to their promise in real life.

Int J Data Sci Anal 2021 Apr 5:1-22. Epub 2021 Apr 5.

University of Cambridge, Cambridge, UK.

The numerical nature of financial markets makes market forecasting and portfolio construction a good use case for machine learning (ML), a branch of artificial intelligence (AI). Over the past two decades, a number of academics worldwide (mostly from the field of computer science) produced a sizeable body of experimental research. Many publications claim highly accurate forecasts or highly profitable investment strategies. Read More

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Targeting Certain Interleukins as Novel Treatment Options for Liver Fibrosis.

Front Pharmacol 2021 24;12:645703. Epub 2021 Mar 24.

Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, United States.

The liver is a major metabolic organ and an immunologically complex organ. It produces and uses many substances such as acute phase proteins, cytokines, chemokines, and complementary components to maintain the balance between immunity and tolerance. Interleukins are important immune control cytokines, that are produced by many body cells. Read More

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Types, norms, and normalisation: Hormone research and treatments in Italy, Argentina, and Brazil, c. 1900-50.

Hist Human Sci 2021 Apr 17;34(2):113-137. Epub 2020 Sep 17.

University of Lincoln, UK.

Displacing the physiological model that had held sway in 19th-century medical thinking, early 20th-century hormone research promoted an understanding of the body and sexual desires in which variations in sex characteristics and non-reproductive sexual behaviours such as homosexuality were attributed to anomalies in the internal secretions produced by the testes or the ovaries. Biotypology, a new brand of medical science conceived and led by the Italian endocrinologist Nicola Pende, employed hormone research to study human types and hormone treatments to normalise individuals who did not conform to accepted medical norms. Latin American medical doctors, eugenicists, and sexologists took up biotypology with enthusiasm. Read More

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Male mice and cows perceive human emotional chemosignals: a preliminary study.

Anim Cogn 2021 Apr 11. Epub 2021 Apr 11.

Centre des Sciences du Goût et de L'Alimentation, UMR6265 CNRS, Université de Bourgogne Franche-Comté, INRAE, Agrosup Dijon, Dijon, France.

Olfactory cues of individuals of the same species or from different species may induce changes in behaviors and physiological reactions in mammals. However, there are few studies on the influence of human odor on animal behavior and welfare, especially those of rodents and farm animals. The present study aimed to investigate whether the odor of a stressed human (in sweat) would modify the behavior of mice and cows. Read More

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Production of natural chitin film from pupal shell of moth: Fabrication of plasmonic surfaces for SERS-based sensing applications.

Carbohydr Polym 2021 Jun 5;262:117909. Epub 2021 Mar 5.

Department of Biotechnology and Molecular Biology, Faculty of Science and Letters, Aksaray University, 68100, Aksaray, Turkey. Electronic address:

Commercially available types of chitin or chitin isolate are usually in powder form and are nanofibrous in microstructure. However, the surface characteristics of natural chitin in the body of insects are currently understudied. Herein, natural chitin film was successfully produced from bio-waste of insect pupae of the Japanese giant silkworm. Read More

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Microbial ACBP/DBI-like genes are rare in the human gut microbiome and show no links with obesity.

Appl Environ Microbiol 2021 Apr 9. Epub 2021 Apr 9.

Department CIBIO, University of Trento, Italy

Acyl coenzyme A (CoA) binding protein (ACBP), also called diazepam-binding inhibitor (DBI) is a phylogenetically conserved protein that is expressed by all eukaryotic species as well as by some bacteria. Since elevated ACBP/DBI levels play a major role in the inhibition of autophagy, increase in appetite and lipoanabolism that accompany obesity, we wondered whether ACBP/DBI produced by the human microbiome might affect host weight. We found that the genomes of bacterial commensals rarely contain ACBP/DBI homologues, which are rather encoded by genomes of some pathogenic or environmental taxa that were not prevalent in human feces. Read More

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Protective effect of selenomethionine on T-2 toxin-induced liver injury in New Zealand rabbits.

BMC Vet Res 2021 Apr 9;17(1):153. Epub 2021 Apr 9.

College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, Henan, China.

Background: T-2 toxin is a mycotoxin produced by Fusarium species that is highly toxic to animals. Recent studies have indicated that Selenomethionine (SeMet) have protective effect against mycotoxins-induced toxicity. The aim of the present study was to investigate the protective effect of SeMet on T-2-toxin-induced liver injury in rabbit and explore its molecular mechanism. Read More

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A 4,565-My-old andesite from an extinct chondritic protoplanet.

Proc Natl Acad Sci U S A 2021 Mar 8;118(11). Epub 2021 Mar 8.

Université de Lorraine, CNRS, CRPG, F-54000 Nancy, France.

The age of iron meteorites implies that accretion of protoplanets began during the first millions of years of the solar system. Due to the heat generated by Al decay, many early protoplanets were fully differentiated with an igneous crust produced during the cooling of a magma ocean and the segregation at depth of a metallic core. The formation and nature of the primordial crust generated during the early stages of melting is poorly understood, due in part to the scarcity of available samples. Read More

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Altered acoustic startle, prepulse facilitation, and object recognition memory produced by corticosterone withdrawal in male rats.

Behav Brain Res 2021 Apr 6:113291. Epub 2021 Apr 6.

Division of Medical Sciences, University of Victoria, Victoria, BC, V8W 2Y2, Canada.

The symptoms of human depression often include cognitive deficits. However, cognition is not frequently included in the behavioral assessments conducted in preclinical models of depression. For example, it is well known that repeated corticosterone (CORT) injections in rodents produce depression-like behavior as measured by the forced swim test, sucrose preference test, and tail suspension test, but the cognitive impairments produced by repeated CORT have not been thoroughly examined. Read More

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Dura promotes metastatic potential in prostate cancer through the CXCR2 pathway.

J Neurooncol 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurosurgery, University of Michigan, 3552 Taubman Center, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.

Purpose: Spinal metastases are common in cancer. This preferential migration/growth in the spine is not fully understood. Dura has been shown to affect the surrounding microenvironment and promote cancer growth. Read More

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Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats.

Environ Sci Pollut Res Int 2021 Apr 9. Epub 2021 Apr 9.

Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Salah Salem St, 62511, Beni-Suef, Egypt.

The study examines the prophylactic action of artichoke leaf hydroethanolic extract (ALE) and artichoke flower head hydroethanolic extract (AFE) against diethylnitrosamine (DEN)/acetylaminofluorene (AAF)-induced lung cancer in Wistar rats. To chemically induce lung cancer, DEN was injected intraperitoneally twice a week for a fortnight at a dose of 150 mg/kg body weight (b.w. Read More

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Evaluation of complete-arch implant scanning with 5 different intraoral scanners in terms of trueness and operator experience.

J Prosthet Dent 2021 Apr 5. Epub 2021 Apr 5.

Associate Professor, Department of Conservative Dentistry, Faculty of Dentistry, Semmelweis University, Budapest, Hungary. Electronic address:

Statement Of Problem: The intraoral scanning of the edentulous arch might be challenging for an inexperienced operator because of the large mucosal area and the use of scan bodies.

Purpose: The purpose of this ex vivo study was to compare the trueness of 5 intraoral scanners in replicating implant scan bodies and soft tissues in an edentulous maxilla and to investigate the effects of operator experience.

Material And Methods: The maxilla was resected from a fresh cadaver, 5 implants placed, and a reference scan made. Read More

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Tailoring the biological response of zirconium implants using zirconia bioceramic coatings: A systematic review.

J Trace Elem Med Biol 2021 Apr 2;66:126756. Epub 2021 Apr 2.

Department of Materials Engineering, Bu-Ali Sina University, Hamedan, 65178-38695, Iran. Electronic address:

Background: The poor biological performance of zirconium implants in the human body resulting from their bio-inertness and vulnerability to corrosion and bacterial activity reflects the need for further studies on substitution or performing the surface modification. The suggestion of employing zirconia (ZrO) bioceramic coatings for surface modification seems beneficial.

Objectives: This systematic review aims to identify and summarize existing documents reporting the biological responses for ZrO coatings produced by the PEO process on zirconium implants. Read More

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Maternal nutrient restriction in late pregnancy programs postnatal metabolism and pituitary development in beef heifers.

PLoS One 2021 8;16(4):e0249924. Epub 2021 Apr 8.

Department of Animal Science, Texas A&M University, College Station, Texas, United States of America.

Maternal undernutrition during pregnancy followed by ad libitum access to nutrients during postnatal life induces postnatal metabolic disruptions in multiple species. Therefore, an experiment was conducted to evaluate postnatal growth, metabolism, and development of beef heifers exposed to late gestation maternal nutrient restriction. Pregnancies were generated via transfer of in vitro embryos produced using X-bearing sperm from a single Angus sire. Read More

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Synthesis and evaluation of antioxidant activity of some novel hydroxypyridinone derivatives: a DFT approach for explanation of their radical scavenging activity.

Res Pharm Sci 2020 Dec 27;15(6):515-528. Epub 2020 Nov 27.

Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.

Background And Purpose: Reactive oxygen species (ROSs) are continuously produced as byproducts of cell metabolism. Free radicals are an unstable form of ROSs with the tendency to react readily with biomolecules such as amino acids, lipids and DNA. These reactions lead to oxidative damages to the cell. Read More

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December 2020

Formulation of Effervescent Granule from Robusta Green Coffee Bean Ethanolic Extract ().

J Pharm Bioallied Sci 2020 Nov 5;12(Suppl 2):S743-S746. Epub 2020 Nov 5.

Department of Pharmacy, Universitas Syiah Kuala, Aceh, Indonesia.

Introduction: Robusta coffee () is one of the many crops cultivated in Aceh, and at present is only being used as a drink. Research has shown the potential of many pharmacological uses for coffee, including its use as a remedy to treat diabetes. Effervescent granules are one of the oral dosage forms that can not only mask the unpleasant taste of bioactive substances, but also have a high aesthetic value and can contain relatively large doses of bioactive substances. Read More

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November 2020

Genomic prediction for growth using a low-density SNP panel in dromedary camels.

Sci Rep 2021 Apr 7;11(1):7675. Epub 2021 Apr 7.

Persian BayanGene Research and Training Center, 7134767617, Shiraz, Iran.

For thousands of years, camels have produced meat, milk, and fiber in harsh desert conditions. For a sustainable development to provide protein resources from desert areas, it is necessary to pay attention to genetic improvement in camel breeding. By using genotyping-by-sequencing (GBS) method we produced over 14,500 genome wide markers to conduct a genome- wide association study (GWAS) for investigating the birth weight, daily gain, and body weight of 96 dromedaries in the Iranian central desert. Read More

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Biocompatibility and degradation of the open-pored magnesium scaffolds LAE442 and La2.

Biomed Mater 2021 Apr 7. Epub 2021 Apr 7.

Clinic of Small Animal Surgery and Reproduction, Ludwig-Maximilians-Universität München Tierärztliche Fakultät, Veterinärstr. 13, München, Bayern, 80539, GERMANY.

Porous magnesium implants are of particular interest for application as resorbable bone substitutes, due to their mechanical strength and a Young's modulus similar to bone. The objective of the present study was to compare the biocompatibility, bone and tissue ingrowth, and the degradation behaviour of scaffolds made from the magnesium alloys LAE442 (n = 40) and Mg-La2 (n = 40) in vivo. For this purpose, cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined, interconnecting pores were produced by investment casting and coated with MgF2. Read More

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Crystalline deposits in the cornea and various areas of the kidney as symptoms of an underlying monoclonal gammopathy: a case report.

BMC Nephrol 2021 Apr 6;22(1):117. Epub 2021 Apr 6.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str 62, D-50937, Cologne, Germany.

Background: Plasma cell dyscrasias (PCD) are characterized by an abnormal production of intact monoclonal immunoglobulins or parts such as heavy or light chains. In most cases, the monoclonal protein (also termed paraprotein) is produced by a clonal plasma cell population. The production of monoclonal proteins can result in deposits of various types and localization depending on the type, amount, and electrochemical properties of the paraprotein. Read More

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Habitat loss, predation pressure and episodic heat-shocks interact to impact arthropods and photosynthetic functioning of microecosystems.

Proc Biol Sci 2021 Apr 7;288(1948):20210032. Epub 2021 Apr 7.

UK Centre for Ecology and Hydrology, Bush Estate, Penicuik, Midlothian EH26 0QB, UK.

Ecosystems face multiple, potentially interacting, anthropogenic pressures that can modify biodiversity and ecosystem functioning. Using a bryophyte-microarthropod microecosystem we tested the combined effects of habitat loss, episodic heat-shocks and an introduced non-native apex predator on ecosystem function (chlorophyll fluorescence as an indicator of photosystem II function) and microarthropod communities (abundance and body size). The photosynthetic function was degraded by the sequence of heat-shock episodes, but unaffected by microecosystem patch size or top-down pressure from the introduced predator. Read More

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Molecular Characterization and Transcriptional Expression Analysis of ABC Transporter H Subfamily Genes in the Oriental Fruit Fly.

J Econ Entomol 2021 Apr 6. Epub 2021 Apr 6.

Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, China.

The oriental fruit fly, Bactrocera dorsalis Hendel (Diptera: Tephretidae), is a serious pest of fruits and vegetables and has developed high levels of insecticide resistance. ATP-binding cassette transporter genes (ABC transporters) are involved in mediating the energy-driven transport of many substances across membranes and are closely associated with development and insecticide detoxification. In this study, three ABC transporters in the H subfamily were identified, and the possible roles of these genes in B. Read More

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