16,789 results match your criteria procurement surgery


Building a Utility-based Liver Allocation Model in Preparation for Continuous Distribution.

Transplant Direct 2022 Feb 13;8(2):e1282. Epub 2022 Jan 13.

Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA.

Background: The current model for end-stage liver disease-based liver allocation system in the United States prioritizes sickest patients first at the expense of long-term graft survival. In a continuous distribution model, a measure of posttransplant survival will also be included. We aimed to use mathematical optimization to match donors and recipients based on quality to examine the potential impact of an allocation system designed to maximize long-term graft survival. Read More

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February 2022

Technological Advancements in Uterus Transplantation.

Clin Obstet Gynecol 2022 Mar;65(1):44-51

Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center.

Uterus transplantation is barely a decade old and in a young, evolving field it is hard to identify "technological advances" since it is, in of itself, a technological advance. Nonetheless, one can still identify advances in diagnostic imaging that have improved donor screening to avoid graft losses, highlight the adoption of robotic surgery to make the living donor uterus procurement more minimally invasive, and look to a future of biotechnology like perfusion pumps and bioengineering such as synthetic uterus to increase donor supply. Additional technologies are on the horizon and promise to shape the field further. Read More

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Center-Level Variation in Transplant Rates Following the Heart Allocation Policy Change.

JAMA Cardiol 2022 Jan 19. Epub 2022 Jan 19.

Cardiovascular Outcomes Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles.

Importance: Wide state-level variability in waiting list outcomes have been noted for patients listed for heart transplant in the US, but little is known regarding center-level transplant rates since the heart allocation policy change.

Objective: To evaluate center-level transplant rates following the recent allocation policy change for heart transplant.

Design, Setting, And Participants: This cohort study used data from the United Network for Organ Sharing database from October 18, 2015, to March 1, 2020, for a nationwide analysis of transplant centers in the US. Read More

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January 2022

Invited commentary on: "Utilization and effectiveness of the organ procurement and transplantation network 'safety-net' policy".

Surgery 2022 Jan 15. Epub 2022 Jan 15.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:

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January 2022

Usefulness of Thiel-Embalmed Cadavers for Training in Organ Procurement.

Transplant Proc 2022 Jan 11. Epub 2022 Jan 11.

Department of Surgery, Tohoku University, Sendai, Japan.

Background: The number of brain-dead donors has been increasing; however, the opportunity for young surgeons to experience deceased donor surgeries is extremely limited, especially in many Asian countries including Japan. Deceased donor surgeries require unique surgical skills and knowledge; however, it is difficult to provide on-the-job guidance and education. Therefore, cadaver training is meaningful and suitable for the training of deceased donor surgeries. Read More

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January 2022

Organ transplant and Covid-19 vaccination: Considering the ethics of denying transplant to unvaccinated patients.

Clin Transplant 2022 Jan 14:e14589. Epub 2022 Jan 14.

Department of Surgery, Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

Recently, a number of organ transplant centers in the United States have proposed to only allow patients who have received the Covid-19 vaccination to be active on their transplant waiting list. This raises numerous ethical issues. This analysis utilizes current empirical data and the guidelines on the ethics of organ allocation published by the Organ Procurement and Transplant Network to guide our ethical reasoning. Read More

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January 2022

Machine learning to predict waitlist dropout among liver transplant candidates with hepatocellular carcinoma.

Cancer Med 2022 Jan 14. Epub 2022 Jan 14.

Division of Gastroenterology, University of California, San Francisco, California, USA.

Background: Accurate prediction of outcome among liver transplant candidates with hepatocellular carcinoma (HCC) remains challenging. We developed a prediction model for waitlist dropout among liver transplant candidates with HCC.

Methods: The study included 18,920 adult liver transplant candidates in the United States listed with a diagnosis of HCC, with data provided by the Organ Procurement and Transplantation Network. Read More

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January 2022

Intraoperative Verapamil Fails to Reduce Delayed Graft Function in Donation After Circulatory Death Renal Allografts.

Transplant Direct 2022 Feb 5;8(2):e1250. Epub 2022 Jan 5.

Transplant Institute, New York University Langone Health, New York, NY.

Background: The shortage of transplantable organs has led to increased utilization of kidneys that may be particularly vulnerable to ischemia-reperfusion injury (IRI) and delayed graft function (DGF). Kidneys from donation after circulatory death (DCD) donors have additional IRI from donor procurement that results in increased risk of DGF. Verapamil may reduce IRI in kidney allografts when given at the time of organ reperfusion. Read More

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February 2022

Biocompatible Composite Microspheres of Chitin/Ordered Mesoporous Carbon CMK3 for Bilirubin Adsorption and Cell Microcarrier Culture.

Macromol Biosci 2022 Jan 10:e2100412. Epub 2022 Jan 10.

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, Wuhan, 430071, China.

Extra bilirubin in the blood can provoke serious illness in patients with severe liver disease. Hemoperfusion is an effective method to remove the extra bilirubin, but its application is limited by the low adsorption efficiency and poor biocompatibility of available adsorbent materials. In this study, chitin/ordered mesoporous carbon CMK3 (Ch/CMK3) microspheres were successfully prepared. Read More

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January 2022

The Impact of Machine Perfusion of the Heart on Warm Ischemia Time and Organ Yield in Donation After Circulatory Death.

Am J Transplant 2022 Jan 10. Epub 2022 Jan 10.

TransMedics, Inc, Andover, MA, USA.

Successful normothermic machine perfusion of heart allografts (MPH) has led to rapid growth in transplantation of donation after circulatory death (DCD) heart allografts but has introduced complexity in the procurement process. This study examines the impact of MPH use in DCD procurements on warm ischemia time (WIT) and organ yield. DCD procurements from 2019-2020 were identified using the OPTN database. Read More

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January 2022

Outcomes of simultaneous liver-kidney transplant using kidneys of deceased donors with acute kidney injury.

Liver Transpl 2022 Jan 10. Epub 2022 Jan 10.

Division of Nephrology, College of Medicine, University of Arizona, Tucson, Arizona, USA.

To our knowledge, outcomes from simultaneous liver-kidney transplant (SLKT) when using kidneys from donors with acute kidney injury (AKI) have not been studied. We studied 5344 SLKTs between May 1, 2007, and December 31, 2019, by using Organ Procurement and Transplantation Network registry data supplemented with United Network for Organ Sharing-DonorNet data. Designating a donor as having AKI required by definition that the following criteria were met: (1) the donor's condition aligned with the Kidney Disease: Improving Global Outcomes (KDIGO) international consensus guidelines, and the terminal serum creatinine (Scr) level was greater than or equal to 1. Read More

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January 2022

Deceased donor kidneys allocated out of sequence by organ procurement organizations.

Am J Transplant 2022 Jan 9. Epub 2022 Jan 9.

Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA.

Deceased donor kidney allocation follows a ranked match-run of potential recipients. Organ procurement organizations (OPOs) are permitted to deviate from the mandated match-run in exceptional circumstances. Using match-run data for all deceased donor kidney transplants (Ktx) in the US between 2015 and 2019, we identified 1544 kidneys transplanted from 933 donors with an OPO-initiated allocation exception. Read More

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January 2022

Impact of ex vivo lung perfusion on brain-dead donor lung utilization: The French experience.

Am J Transplant 2022 Jan 9. Epub 2022 Jan 9.

Agence de la Biomedecine, Saint-Denis, France.

Ex vivo lung perfusion (EVLP) is a valuable method for expanding the lung donor pool. Its indications currently differ across centers. This national retrospective cohort study aimed to describe the profile of donors with lungs transplanted after EVLP and determine the effectiveness of EVLP on lung utilization. Read More

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January 2022

Advanced considerations in organ donors.

J Thorac Dis 2021 Nov;13(11):6528-6535

Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.

The rising need for lung transplantation over recent years has not paralleled the availability of suitable lung allografts. The number of lung transplantations performed each year in the United States remains limited by an inadequate supply of suitable donors as well as low donor utilization rates. While several methods have been proposed for increasing the donor pool, there is considerable disparity between acceptance and utilization of these practices among transplant centers. Read More

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November 2021

Long-Term Risk of Heart Failure-Related Death and Heart Transplant After Congenital Heart Surgery in Childhood (from the Pediatric Cardiac Care Consortium).

Am J Cardiol 2022 Jan 3. Epub 2022 Jan 3.

Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, New York.

We aimed to describe the longitudinal risk of advanced heart failure (HF) leading to death, heart transplantation, or ventricular assist device (VAD) placement after congenital heart surgery (CHS) and how it varies across the spectrum of congenital heart disease. We linked the records of patients who underwent first CHS in the Pediatric Cardiac Care Consortium between 1982 and 2003 with the United States National Death Index and Organ Procurement and Transplantation Network databases. Primary outcome was time from CHS discharge to HF-related death, heart transplant, or VAD placement, analyzed with proportional hazards models accounting for competing mortality. Read More

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January 2022

The fastest national COVID vaccination in Europe - Malta's strategies.

Health Sci Rev (Oxf) 2021 4;1:100001. Epub 2021 Oct 4.

Department of Paediatric, Mater Dei Hospital, Msida, Malta.

Background: COVID-19 vaccines reduce morbidity and mortality, but mass vaccination faces multiple challenges leading to different vaccination rates in different countries. Malta, a small European country, has achieved a very rapid vaccination rollout. This paper presents a narrative review of Malta's vaccination strategy and its impact on the country's COVID-19 situation. Read More

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October 2021

The history of organ transplantation.

Proc (Bayl Univ Med Cent) 2022 19;35(1):124-128. Epub 2021 Oct 19.

Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Since ancient times, mythology has included tales of creatures made of an amalgamation of others, transferring body parts and skin. In the 1950s, with no other medical options for then incurable diseases, including nephritis, teams of scientists, surgeons, and generous patients started the field of organ transplant with the first successful kidney transplant in a human. The scientific discoveries and innovations since that first successful transplant in 1954 have turned the mythical concept of transplant into reality. Read More

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October 2021

Pure Laparoscopic Living Donor Hepatectomy With/Without Fluorescence-Assisted Technology and Conventional Open Procedure: A Retrospective Study in Mainland China.

Front Surg 2021 13;8:771250. Epub 2021 Dec 13.

Department of Liver Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The application of laparoscopy in donor liver acquisition for living donor liver transplantation (LDLT) has become increasingly popular in the past decade. Indole cyanide green (ICG) fluorescence technique is a new adjuvant method in surgery. The purpose was to compare the safety and efficacy of laparoscopic and open surgery in living donor left lateral hepatectomy, and to evaluate the application of ICG in laparoscopy. Read More

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December 2021

COVID-19 in Low- and Middle-Income Countries (LMICs): A Narrative Review from Prevention to Vaccination Strategy.

Vaccines (Basel) 2021 Dec 14;9(12). Epub 2021 Dec 14.

Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Napoli, Italy.

The management of the COVID-19 pandemic represents a challenging process, especially for low- and middle-income countries (LMICs) due to the serious economic and health resource problems it generates. In this article, we assess COVID-19 situation in LMICs and outline emerging problems and possible solutions. The prevention and control of COVID-19 would be based on focused tests exploiting those systems (e. Read More

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December 2021

Not everything that counts can be counted: Tracking long-term outcomes in pediatric liver transplant recipients.

Am J Transplant 2021 Dec 24. Epub 2021 Dec 24.

Department of Pediatrics, University of California San Francisco, San Francisco, California.

For pediatric liver transplant (LT) recipients, an ideal outcome is to survive and thrive into adulthood. However, outcomes reporting for all LT recipients typically rely on much shorter-term outcomes, 1-5 years post-LT. Using Organ Procurement and Transplantation Network (OPTN) registry data from 1990 to 2018, this analysis seeks to determine if long-term follow-up and outcome data are complete for pediatric LT recipients age 0 to 12 years who survive at least 1 year post-LT without graft loss (n = 9309). Read More

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December 2021

Prescriptive Analytics Determining Which Patients Undergoing Simultaneous Liver-Kidney Transplant May Benefit From High-Risk Organs.

Exp Clin Transplant 2021 Dec;19(12):1303-1312

From the Department of Surgery, UW Medicine Kidney and Pancreas Transplantation Program, University of Washington, Seattle, Washington, USA.

Objectives: Simultaneous liver-kidney transplant is a treatment option for patients with end-stage liver disease and concomitant irreversible kidney injury. We developed a decision toolto aid transplant programs to advise their candidates for simultaneous liver-kidney transplant on accepting high-risk grafts versus waiting for lower-risk grafts.

Materials And Methods: To find the critical decision factors, we used the prescriptive analytic technique of microsimulation. Read More

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December 2021

Portal Perfusion Through the Splenic Vein During Liver Procurement.

Exp Clin Transplant 2021 Dec;19(12):1286-1290

From the Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA.

Objectives: Livers procured via donation after cardiac death have produced good outcomes. Some centers use only aortic perfusion; others add portal perfusion.

Materials And Methods: We report a series of organ procurements in which portal perfusion was performed via cannulation of the splenic vein instead of the inferior mesenteric vein in 4 donors after cardiac death and 2 donors after brain death. Read More

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December 2021

Kidney transplant program specific reporting and transplant metrics.

Curr Opin Organ Transplant 2022 Feb;27(1):70-74

University Hospitals Cleveland Medical Center, Case Western Reserve University, Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, Cleveland, Ohio, USA.

Purpose Of Review: Kidney transplantation is a heavily regulated medical procedure with the Secretary of HHS ultimately responsible for oversight and authority derived from the NOTA and the Final Rule. Transplant Programs undergo publicly reported evaluations every 6 months based on outcomes from a 2-and-a-half-year period. The current Bayesian metrics for kidney transplant programs were created such that over ten percentage of programs are deemed underperformers, or 'flag', every 6 months. Read More

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February 2022

Descemet's detachment in glycerol grafts used in pandemic corneal tissue shortage.

Indian J Ophthalmol 2022 Jan;70(1):299-300

Department of Cornea and Refractive Surgery, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.

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January 2022

Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest.

Transplant Direct 2022 Jan 16;8(1):e1265. Epub 2021 Dec 16.

Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Heart transplantation with donation after circulatory death (DCD) has become a real option to increase graft availability. However, given that DCD organs are exposed to the potentially damaging conditions of warm ischemia before procurement, new strategies for graft evaluation are of particular value for the safe expansion of DCD heart transplantation. Mitochondria-related parameters are very attractive as biomarkers because of their intimate association with cardiac ischemia-reperfusion injury. Read More

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January 2022

Assessment of the Impact of COVID-19 on Drug Store Management in a Tertiary Care Teaching Hospital of Central India.

Cureus 2021 Nov 18;13(11):e19723. Epub 2021 Nov 18.

Paediatrics Surgery, All India Institute of Medical Sciences, Raipur, IND.

Introduction: One-third of the annual hospital budget is spent on the purchase of medicines, materials, and supplies. Drug store management is a complex but critical process within the healthcare delivery system. Health supply chains, the import of active pharmaceutical ingredients, transportation, procurement, finished products have been disrupted by COVID-19. Read More

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November 2021

Procurement Liver Biopsies: More Scrutiny May Yield More Opportunities.

Authors:
David D Lee

Liver Transpl 2021 Dec 21. Epub 2021 Dec 21.

Department of Surgery, Division of Abdominal Transplantation, Loyola University Medical Center, Maywood, IL.

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December 2021

Procurement liver biopsies: More scrutiny may yield more opportunities.

Authors:
David D Lee

Liver Transpl 2021 Dec 20. Epub 2021 Dec 20.

Department of Surgery, Division of Abdominal Transplantation, Loyola University Medical Center, Maywood, IL, USA.

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December 2021

Feasibility and Potential Impact of Heart Transplantation From Adult Donors After Circulatory Death.

J Am Coll Cardiol 2022 Jan 15;79(2):148-162. Epub 2021 Dec 15.

Division of Cardiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA.

Background: A shortage of donation after brain death (DBD) donors for heart transplantation (HT) persists. Recent improvements in organ procurement from donation after circulatory death (DCD) donors and promising early results of DCD-HTs from Europe and Australia have renewed interest in DCD-HT.

Objectives: The current study evaluated donor and recipient characteristics, early outcomes, and potential impact of adult DCD-HT in the United States. Read More

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January 2022

A scoping review of the perceptions of death in the context of organ donation and transplantation.

BMC Med Ethics 2021 12 18;22(1):167. Epub 2021 Dec 18.

Sydney Health Ethics, University of Sydney, Sydney, Australia.

Background: Socio-cultural perceptions surrounding death have profoundly changed since the 1950s with development of modern intensive care and progress in solid organ transplantation. Despite broad support for organ transplantation, many fundamental concepts and practices including brain death, organ donation after circulatory death, and some antemortem interventions to prepare for transplantation continue to be challenged. Attitudes toward the ethical issues surrounding death and organ donation may influence support for and participation in organ donation but differences between and among diverse populations have not been studied. Read More

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December 2021