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Psychiatry Investig 2021 Apr 15. Epub 2021 Apr 15.

International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, UK.

Objective: Accumulating empirical research has emphasized that a wide range of online activities-such as using social networking sites-can be performed in order to compensate unattained needs or to cope with negative affect and psychopathological symptoms. Although the correlates of problematic social networking use have been extensively investigated, less is known about problematic YouTube use (PYU), an umbrella term grouping a number of different activities (e.g. Read More

Cancer 2021 Apr 13. Epub 2021 Apr 13.

Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.

With rapid modifications in cancer clinical trial operations necessitated by the global pandemic over the last year, there is now an unprecedented opportunity to reform clinical research permanently and solidify innovative practices that have clearly been effective. On the basis of the authors' experience and recommendations from other institutions, a set of specific proposals for clinical trial reform are identified that can be implemented immediately by sponsors, regulators, and study sites. Improvements in clinical trial processes should include increased leverage of technology to facilitate remote trial activity and electronic documents, more efficient and effective communication of adverse event information, and better study design to optimize inclusion criteria, required research procedures, and data collection. Read More

Nucleic Acids Res 2021 Apr 13. Epub 2021 Apr 13.

School of Medicine and Surgery, BioNanoMedicine Center NANOMIB, University of Milano-Bicocca, 20854 Vedano al Lambro (MB), Italy.

G-quadruplexes (G4s) are tetrahelical DNA structures stabilized by four guanines paired via Hoogsteen hydrogen bonds into quartets. While their presence within eukaryotic DNA is known to play a key role in regulatory processes, their functional mechanisms are still under investigation. In the present work, we analysed the nanomechanical properties of three G4s present within the promoter of the KIT proto-oncogene from a single-molecule point of view through the use of magnetic tweezers (MTs). Read More

Dermatology 2021 Apr 13:1-8. Epub 2021 Apr 13.

Centre of Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Background: Mobile teledermoscopy is an emerging technology that involves imaging and digitally sending dermoscopic images of skin lesions to a clinician for assessment. High-quality, consistent images are required for accurate telediagnoses when monitoring lesions over time. To date there are no tools to assess the quality of sequential images taken by consumers using mobile teledermoscopy. Read More

Sci Total Environ 2021 Apr 5;782:146813. Epub 2021 Apr 5.

Office National des Forêts, 75570 CEDEX 12 Paris, France. Electronic address:

In northern Europe, coastal dune remobilization by restoring natural processes is considered by some to maintain the coastal dune in chronically eroding sectors by migrating landward and to restore dune ecology. In wet climatic contexts, this nature-based solution has been shown to induce an increase in both sand bare areas and vegetation diversity. However, it has never been tested in the coastal dunes of southern Europe with a drier climate and, thus, more stressful conditions, where disturbance may inversely decrease vegetation diversity. Read More

Sci Total Environ 2021 Mar 26;782:146599. Epub 2021 Mar 26.

Faculty of Civil Engineering and Environmental Science, Bialystok University of Technology, 45EWiejska St., Bialystok 15-351, Poland. Electronic address:

The aim of the research was to determine the indicators of electricity consumption in every stage of the dairy sewage treatment process in relation to the sewage flow and the load of removed organics (BOD, COD) and nutrients (TN, TP). The research was conducted in a dairy wastewater treatment plant (WWTP) consisting of mechanical treatment, averaging tank, dissolved air flotation (DAF) and biological treatment with sequence batch reactors (SBRs). Energy consumption was measured with the help of transducers. Read More

J Affect Disord 2021 Apr 3;288:107-113. Epub 2021 Apr 3.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Background: Panic disorder (PD) is an anxiety disorder characterized by recurrent panic attacks whose aetiology might be associated with alterations of the prefrontal-amygdala circuitry. The prefrontal cortex is a key region involved in executive functioning (EF) whose disturbance may imply harsh consequences over personal, social, and working aspects of PD patients. Indeed, defining the real involvement of EF in PD could lead to early assessment, better treatment, and rehabilitation options. Read More

PLoS One 2021 13;16(4):e0249113. Epub 2021 Apr 13.

School of Earth and Ocean Sciences, Cardiff University, Cardiff, United Kingdom.

Planktonic foraminifera are heterotrophic sexually reproducing marine protists with an exceptionally complete fossil record that provides unique insights into long-term patterns and processes of evolution. Populations often exhibit strong biases towards either right (dextral) or left (sinistral) shells. Deep-sea sediment cores spanning millions of years reveal that some species show large and often rapid fluctuations in their dominant coiling direction through time. Read More

Elife 2021 Apr 13;10. Epub 2021 Apr 13.

Department of Genetics, Albert Einstein College of Medicine, Bronx, United States.

Aneuploidy causes birth defects and miscarriages, occurs in nearly all cancers and is a hallmark of aging. Individual aneuploid cells can be eliminated from developing tissues by unknown mechanisms. Cells with ribosomal protein () gene mutations are also eliminated, by cell competition with normal cells. Read More

J Neurosci Res 2021 Apr 12. Epub 2021 Apr 12.

Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA.

Although sex differences in learning behaviors are well documented, sexual dimorphism in the synaptic processes of encoding is only recently appreciated. Studies in male rodents have built upon the discovery of long-term potentiation (LTP), and acceptance of this activity-dependent increase in synaptic strength as a mechanism of encoding, to identify synaptic receptors and signaling activities that coordinate the activity-dependent remodeling of the subsynaptic actin cytoskeleton that is critical for enduring potentiation and memory. These molecular substrates together with other features of LTP, as characterized in males, have provided an explanation for a range of memory phenomena including multiple stages of consolidation, the efficacy of spaced training, and the location of engrams at the level of individual synapses. Read More

Int J Mol Med 2021 Jun 13;47(6). Epub 2021 Apr 13.

Department of Urology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.

Bladder cancer (BC) is among the most common urinary system tumors with a high morbidity and mortality worldwide. Despite advancements being made in the diagnosis and treatment of bladder cancer, targeted therapy remains the most promising treatment, and novel therapeutic targets are urgently required in to improve the outcomes of patients with BC. Kinesin family member 4A (KIF4A) is a plus‑end directed motor protein involved in the regulation of multiple cellular processes, such as mitosis and axon growth. Read More