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Analysis of the mechanism for enhanced pyrene biodegradation based on the interactions between iron-ions and Rhodococcus ruber strain L9.

Ecotoxicol Environ Saf 2021 Sep 21;225:112789. Epub 2021 Sep 21.

School of Civil Engineering, Yulin University, Yulin 719000, China.

A slow degradation rate and low transformation efficiency are the main problems in the biodegradation of polycyclic aromatic hydrocarbons (PAHs). This study selected pyrene as the target PAH to investigate the effect of ferrous ion and ferric ion on pyrene degradation. The driving effect and mechanism, including the interaction between pyrene and iron ions and the bacterial physiological response during the biodegradation process by Rhodococcus ruber strain L9, were investigated. Read More

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September 2021

Adsorption of copper (II) and cadmium (II) ions by in situ doped nano-calcium carbonate high-intensity chitin hydrogels.

J Hazard Mater 2021 Sep 10;423(Pt B):127137. Epub 2021 Sep 10.

Guangxi University for Nationalities, Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Key Laboratory of New Technology for Chemical and Biological Transformation Process of Guangxi Higher Education Institutes, Nanning 530006, China. Electronic address:

Most natural polymers exhibit limited functional groups, which is not favourable for the adsorption of various ions and their utilisation. To overcome this drawback, a novel in-situ-doped nano-calcium carbonate (CaCO) chitin hydrogel was synthesised as an efficient adsorbent for Cu (II) and Cd (II) ions. Scanning electron microscopy and Brunauer-Emmett-Teller results revealed that the synthesised CaCO/chitin hydrogel exhibited loose macropores and mesopores. Read More

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September 2021

Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process.

Placenta 2021 Sep 12;115:60-69. Epub 2021 Sep 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Introduction: Disturbance in placental epigenetic regulation contributes to the pathogenesis of preeclampsia (PE). Although aberrant placental DNA methylation status in PE has been thoroughly studied, the role of histone modifications, including histone methylation, in PE remains unclear. Moreover, no study has ever reported the association between PE and placental histone methylation status by focusing on histone methyltransferases. Read More

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September 2021

ChartStory: Automated Partitioning, Layout, and Captioning of Charts into Comic-Style Narratives.

IEEE Trans Vis Comput Graph 2021 Sep 24;PP. Epub 2021 Sep 24.

Visual data storytelling is gaining importance as a means of presenting data-driven information or analysis results, especially to the general public. This has resulted in design principles being proposed for data-driven storytelling, and new authoring tools being created to aid such storytelling. However, data analysts typically lack sufficient background in design and storytelling to make effective use of these principles and authoring tools. Read More

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September 2021

The role of the cord blood platelet gel in the management of a diabetic foot with tendon exposure.

Regen Med 2021 Sep 24. Epub 2021 Sep 24.

Unit of Vascular & Endovascular Surgery, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, 89124, Italy.

Diabetic foot infection is frequent in diabetic patients and is due to neuropathy, trauma or peripheral arterial disease. The presence of an abscess requires urgent drainage and specific antibiotic therapy. Patients with critical limb ischemia need revascularization and, subsequently the intervention of a plastic surgeon is often required in cases of exposure of tendons and ligaments. Read More

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September 2021

HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation.

Mol Med Rep 2021 Nov 24;24(5). Epub 2021 Sep 24.

Department of Thoracic Surgery, Jilin Province Cancer Hospital, Changchun, Jilin 130000, P.R. China.

Pancreatic cancer (PC) is a malignant tumor disease, whose molecular mechanism is not fully understood. Sodium channel epithelial 1α subunit (SCNN1A) serves an important role in tumor progression. The current study explored the role of homeobox D9 (HOXD9) and SCNN1A in the progression of PC. Read More

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November 2021

Luminescence switching in polymerically confined carbon nanoparticles triggered by UV-light.

Nanoscale 2021 Sep 24. Epub 2021 Sep 24.

Departments of Bioengineering, Materials Science & Engineering, Beckman Institute for Advanced Science & Technology, and Carle Cancer Centre at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Photo-caged carbon nanoparticles (CNPs) that are non-luminescent under typical microscopic illumination but can be activated by UV light have been synthesized in this work. Negatively charged "bare" CNPs with high luminescence can lose their photoluminescence (PL) when they are chemically crosslinked to a monomer and subsequently polymerized to form an intra-particulate "caged" network at the nanoscale surface. These caged particles could regain their PL emission upon UV irradiation for a sustained period (∼24 h) resulting in the photolytic cleavage of the polymer network, thus, freeing the nanoscale surface of CNPs, ultimately resulting in six-fold emission enhancement. Read More

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September 2021

Cross-cultural Adaptation of the Health Sciences Evidence-based Practice Questionnaire into Japanese and Its Test-Retest Reliability in Undergraduate Students.

Prog Rehabil Med 2021 27;6:20210034. Epub 2021 Aug 27.

Balearic Islands Health Research Institute (IdISBa), Palma de Mallorca, Spain.

Objectives: The Health Sciences Evidence-Based Practice (HS-EBP) questionnaire was recently developed for measuring five constructs of evidence-based clinical practice among Spanish health professionals by applying content and construct validity investigation. The current study aims to undertake a cross-cultural adaptation of the HS-EBP into Japanese and to investigate the internal consistency and test-retest reliability of the Japanese HS-EBP among undergraduate students of nursing and physical and occupational therapies.

Methods: Cross-cultural adaptation was undertaken by following Beaton's five-step process. Read More

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De-implementation and substitution of clinical care processes: stakeholder perspectives on the transition to primary human papillomavirus (HPV) testing for cervical cancer screening.

Implement Sci Commun 2021 Sep 23;2(1):108. Epub 2021 Sep 23.

Department of Research and Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Ave, Pasadena, CA, 91101, USA.

Background: New cervical cancer screening guidelines recommend primary human papillomavirus (HPV) testing for women age 30-65 years. Healthcare organizations are preparing to de-implement the previous recommended strategies of Pap testing or co-testing (Pap plus HPV test) and substitute primary HPV testing. However, there may be significant challenges to the replacement of this entrenched clinical practice, even with an evidence-based substitution. Read More

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September 2021

eCross-cultural adaptation of the spine oncology-specific SOSGOQ2.0 questionnaire to German language and the assessment of its validity and reliability in the clinical setting.

BMC Cancer 2021 Sep 23;21(1):1044. Epub 2021 Sep 23.

University Comprehensive Spine Center (UCSC), University Center for Orthopedics, Traumatology and Plastic Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.

Background: The recently developed Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) was proven a valid and reliable instrument measuring health-related quality of life (HRQOL) for patients with spinal malignancies. A German version was not available. Read More

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September 2021

Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients.

Mol Med 2021 Sep 23;27(1):117. Epub 2021 Sep 23.

Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan International Joint Laboratory of Intelligentized Orthopedics Innovation and Transformation, Henan Key Laboratory for Intelligent Precision Orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan, 450003, Zhengzhou, China.

Background: GINS4, an indispensable component of the GINS complex, is vital for a variety of cancer. However, no known empirical research has focused on exploring relationships between GINS4 and glioma. Thus, this study aims to understand and explain the role of GINS4 in glioma. Read More

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September 2021

DFT-Machine Learning Approach for Accurate Prediction of p.

J Phys Chem A 2021 Sep 23. Epub 2021 Sep 23.

School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0245, United States.

In this study, we propose a novel method of p prediction in a diverse set of acids, which combines density functional theory (DFT) method with machine learning (ML) methods. First, the DFT method with B3LYP/6-31++G**/SM8 is used to predict p, yielding a mean absolute error of 1.85 p units. Read More

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September 2021

Twelve new microsatellite loci of Eurasian perch Perca fluviatilis Linnaeus, 1758.

Biol Futur 2021 Sep 24;72(3):385-393. Epub 2021 May 24.

Department of Aquaculture, Institute for Conservation of Natural Resources, Faculty of Agricultural and Environmental Sciences, Szent István University, Páter K. Str. 1, 2100, Gödöllő, Hungary.

The Eurasian perch (Perca fluviatilis Linnaeus, 1758) is native to almost entire Eurasia. For over the last two decades, this species became an important candidate for intensive freshwater aquaculture due to its high consumer's acceptance and overall market value. Hence, the intensive production of Eurasian perch has increased considerably allowing effective domestication; there is still a need for the development of effective selective breeding programmes allowing its further expansion. Read More

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September 2021

Use of ensiled green willow biomass in biogas fermentation.

Biol Futur 2021 Jun 24;72(2):263-271. Epub 2021 Feb 24.

Department of Biotechnology, University of Szeged, Szeged, Hungary.

The biggest challenges of our era include climate change and the global fossil energy problem. Extensive utilization of renewable energy sources should be a part of the solution for both these problems. Biogas is a versatile renewable energy carrier that has the potential to substitute fossil fuels. Read More

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How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways.

Phys Fluids (1994) 2021 Aug 19;33(8):081911. Epub 2021 Aug 19.

School of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane 4000, Australia.

The recent outbreak of the COVID-19 causes significant respirational health problems, including high mortality rates worldwide. The deadly corona virus-containing aerosol enters the atmospheric air through sneezing, exhalation, or talking, assembling with the particulate matter, and subsequently transferring to the respiratory system. This recent outbreak illustrates that the severe acute respiratory syndrome (SARS) coronavirus-2 is deadlier for aged people than for other age groups. Read More

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Boronic acid-functionalized spherical polymer brushes for efficient and selective enrichment of glycoproteins.

J Mater Chem B 2021 Sep 22;9(36):7557-7565. Epub 2021 Sep 22.

State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, People's Republic of China.

Glycoproteins are related to many biological activities and diseases, and thereby their efficient capture and enrichment for diagnostics and proteomics have emerged to exhibit great significance. However, the lack of materials with high binding capacity and selectivity is still a big obstacle for further application. Herein, we reported a facile and eco-friendly approach to fabricate spherical polymer brushes with multiple boronic acid groups. Read More

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September 2021

MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β.

Exp Mol Med 2021 Sep 21. Epub 2021 Sep 21.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.

PD-L1 is abnormally regulated in many cancers and is critical for immune escape. Fully understanding the regulation of PD-L1 expression is vital for improving the clinical efficacy of relevant anticancer agents. TGF-β plays an important role in the low reactivity of PD-1/PD-L1 antibody immunotherapy. Read More

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September 2021

Exploration of the structural requirements of Aurora Kinase B inhibitors by a combined QSAR, modelling and molecular simulation approach.

Sci Rep 2021 Sep 21;11(1):18707. Epub 2021 Sep 21.

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Aurora kinase B plays an important role in the cell cycle to orchestrate the mitotic process. The amplification and overexpression of this kinase have been implicated in several human malignancies. Therefore, Aurora kinase B is a potential drug target for anticancer therapies. Read More

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September 2021

Alternative Splicing and Liver Disease.

Ann Hepatol 2021 Sep 18:100534. Epub 2021 Sep 18.

Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, 34149 Trieste, Italy. Electronic address:

Alternative splicing produces complex and dynamic changes in the protein isoforms that are necessary for the proper biological functioning of the metabolic pathways involved in liver development and hepatocyte homeostasis. Changes in the physiological state of alternatively spliced forms are increasingly linked to liver pathologies. This may occur when the expression or function of the set of proteins controlling the alternative splicing processes are altered by external effectors such as oxidative stress and other environmental variations. Read More

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September 2021

METTL3-mA-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.

Mol Ther 2021 Sep 18. Epub 2021 Sep 18.

Department of Endocrinology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

N-methyladenosine (mA) mRNA modification plays critical roles in various biological events and involves in multiple complex diseases. However, the role of mA modification in autophagy in nonalcoholic fatty liver disease (NAFLD) remains largely unknown. Here, we report that mA modification was increased in livers of NAFLD mouse models and in free fatty acids (FFAs)-treated hepatocytes, and the abnormal mA modification was attributed to the upregulation of methyltransferase like 3 (METTL3) induced by lipotoxicity. Read More

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September 2021

Endoplasmic reticulum stress induces hepatic steatosis by transcriptional upregulating lipid droplet protein perilipin2.

FASEB J 2021 Oct;35(10):e21900

Key laboratory of Aquaculture Nutrition and Feed, Ministry of Agriculture and Rural Affairs, and The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, People's Republic of China.

Previous studies have shown that endoplasmic reticulum (ER) stress contributes to hepatic steatosis in several manners. However, how lipid droplet (LD) proteins participate in this process has rarely been reported. In the present study, ER stress was induced at both in vitro and in vivo levels with tunicamycin in large yellow croaker (Larimichthys crocea). Read More

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October 2021

Feasibility and Accuracy of Artificial Intelligence-Assisted Sponge Cytology for Community-Based Esophageal Squamous Cell Carcinoma Screening in China.

Am J Gastroenterol 2021 Sep 21. Epub 2021 Sep 21.

Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.

Introduction: Screening is the pivotal strategy to relieve the burden of esophageal squamous cell carcinoma (ESCC) in high-risk areas. The cost, invasiveness, and accessibility of esophagogastroduodenoscopy (EGD) necessitate the development of preliminary screening methods.

Methods: Residents aged 40-85 years were recruited in a high-risk area of ESCC. Read More

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September 2021

In silico screening of ssDNA aptamer against Escherichia coli O157:H7: A machine learning and the Pseudo K-tuple nucleotide composition based approach.

Comput Biol Chem 2021 Aug 27;95:107568. Epub 2021 Aug 27.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

This study was planned to in silico screening of ssDNA aptamer against Escherichia coli O157:H7 by combination of machine learning and the PseKNC approach. For this, firstly a total numbers of 47 validated ssDNA aptamers as well as 498 random DNA sequences were considered as positive and negative training data respectively. The sequences then converted to numerical vectors using PseKNC method through Pse-in-one 2. Read More

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How physicians evaluate patients with dementia who present with shortness of breath.

J Am Geriatr Soc 2021 Sep 20. Epub 2021 Sep 20.

Center for the Study of Healthcare Innovation, Implementation, and Policy, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.

Background: Whether the presence of dementia in patients makes it difficult for physicians to assess the risk such patients might have for serious conditions such as pulmonary embolism (PE) is unknown. Our objective was to examine the differential association of four clinical factors (deep venous thrombosis (DVT)/PE, malignancy, recent surgery, and tachycardia) with PE testing for patients with dementia compared to patients without dementia.

Methods: We performed a cross-sectional study of emergency department (ED) visits to 104 Veterans Affairs (VA) hospitals from 2011 to 2018 by patients aged 60 years and over presenting with shortness of breath (SOB). Read More

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September 2021

Thermal-comfort evaluation of and plan for public space of Maling Village, Henan, China.

PLoS One 2021 20;16(9):e0256439. Epub 2021 Sep 20.

School of Architecture, North China University of Water Resources and Electric Power, Zhengzhou, China.

The thermal environment of village public space affects the comfort of people ' s outdoor activities, and then affects the willingness of residents to outdoor activities, which has an important impact on the villagers' quality of life. Previously published studies of thermal comfort mostly focused on the evaluation of thermal comfort index, few studies on the application of thermal comfort planning. The study was carried out in Maling Village, Changdai Town, Mengjin County, Luoyang City, Henan Province, China. Read More

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September 2021

Strain-Induced Ferroelectric Heterostructure Catalysts of Hydrogen Production through Piezophototronic and Piezoelectrocatalytic System.

ACS Nano 2021 Sep 20. Epub 2021 Sep 20.

Department of Materials Science and Engineering, National Tsing Hua University, 101, Section 2 Kuang Fu Road, Hsinchu 300, Taiwan.

In this work, we discover a piezoelectrocatalytic system composed of a ferroelectric heterostructure of BaTiO (BTO)@MoSe nanosheets, which exhibit piezoelectric potential (piezopotential) coupling with electrocatalyzed effects by a strain-induced piezopotential to provide an internal bias to the catalysts' surface; subsequently, the catalytic properties are substantially altered to enable the formation of activity states. The H production rate of [email protected] for the piezoelectrocatalytic H generation is 4533 μmol h g, which is 206% that of [email protected] for piezophototronic (referred to as piezophotocatalytic process) H generation (∼2195.6 μmol h g). Read More

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September 2021

Understanding Preferences for Lifestyle-Focused Visual Text Messages in Patients With Cardiovascular and Chronic Respiratory Disease: Discrete Choice Experiment.

J Med Internet Res 2021 Sep 20;23(9):e26224. Epub 2021 Sep 20.

Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Background: Supporting healthy lifestyle changes is a key aim of cardiovascular and pulmonary rehabilitation programs. SMS text messaging programs have demonstrated effectiveness in cardiovascular disease risk reduction, weight loss, increasing physical activity, and smoking cessation. The optimization of SMS text messaging programs may deliver greater population benefits as mobile phone use becomes ubiquitous. Read More

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September 2021

Effect of training on time efficiency and marginal adaptation of computer-aided design/computer-aided manufacturing crowns among dental students.

Eur J Dent Educ 2021 Sep 19. Epub 2021 Sep 19.

Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

Introduction: The computer-aided design/computer-aided manufacturing (CAD/CAM) technology has revolutionised dentistry at present. An operator's skills can affect the overall clinical duration and marginal accuracy of the prosthesis fabricated through this workflow. The aim of this study was to assess the effect of CAD/CAM hands-on training compared with that of a self-instructional video on the performance of dental students in digital impression and fabrication of a CAD/CAM crown. Read More

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September 2021

Development of a new decellularization protocol for the whole porcine heart.

J Clin Transl Res 2021 Aug 8;7(4):563-574. Epub 2021 Aug 8.

Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.

Background: Cardiovascular diseases are the leading cause of death in many countries. Advances in technology have been promoted in this regard, especially in tissue engineering, to meet the need for tissue or organ grafts. In this way, the porcine model has been used due to its morphophysiological similarity between the human species, mainly regarding the cardiovascular system. Read More

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TANK Promotes Pressure Overload Induced Cardiac Hypertrophy Activating AKT Signaling Pathway.

Front Cardiovasc Med 2021 3;8:687540. Epub 2021 Sep 3.

Division of Cardiology, TongRen Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

TANK (TRAF family member associated NF-κB activator) acts as a member of scaffold proteins participated in the development of multiple diseases. However, its function in process of cardiac hypertrophy is still unknown. In this study, we observed an increased expression of TANK in murine hypertrophic hearts after aortic banding, suggesting that TANK may be involved in the pathogenesis of cardiac hypertrophy. Read More

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September 2021