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Prognostic value of ferroptosis-related genes in patients with lung adenocarcinoma.

Thorac Cancer 2021 May 12. Epub 2021 May 12.

Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China.

Background: The prevalence of lung adenocarcinomas (LUADs) has dramatically increased in recent decades. Ferroptosis is a process of iron-dependent regulatory cell death. It is still unclear whether the expression of ferroptosis-related genes (FRGs) is involved in the pathogenesis and survival of patients with LUAD. Read More

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'If relevant, yes; if not, no': General practitioner (GP) users and GP perceptions about asking ethnicity questions in Irish general practice: A qualitative analysis using Normalization Process Theory.

PLoS One 2021 12;16(5):e0251192. Epub 2021 May 12.

School of Medicine & Health Research Institute, University of Limerick, Limerick, Ireland.

Context: The use of ethnic identifiers in health systems is recommended in several European countries as a means to identify and address heath inequities. There are barriers to implementation that have not been researched.

Objective: This study examines whether and how ethnicity data can be collected in Irish general practices in a meaningful and acceptable way. Read More

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General practice responses to opioid prescribing feedback: a qualitative process evaluation.

Br J Gen Pract 2021 May 11. Epub 2021 May 11.

University of Leeds, Academic Unit of Primary Care, Leeds, United Kingdom.

Background: The rise in opioid prescribing in primary care represents a significant public health challenge, associated with increased psychosocial problems, hospitalisations and mortality. We developed and implemented an evidence-based bi-monthly feedback intervention to reduce opioid prescribing targeting 316 general practices in West Yorkshire over one year.

Aim: To understand how general practice staff received and responded to the feedback intervention. Read More

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Bacteriome depiction and the trophic status of the largest Northern highland lake from Andes system: Lago de Tota, Boyacá, Colombia.

Arch Microbiol 2021 May 12. Epub 2021 May 12.

Escuela de Ciencias Biológicas, Laboratorio de Investigación en Genética Evolutiva - LIGE, L-214, Universidad Pedagógica Y Tecnológica de Colombia, Avenida Central del Norte 39-115, Tunja, Boyacá, Colombia.

Lago de Tota is the largest highland lake in Colombia and one of the most remarkable of Northern Andean Mountain range. This lake is under an anthropogenic-based eutrophication process as a consequence of non-sustainable agriculture practices developing nearby. Notable relationship between the trophic status and Bacteriome loop dynamics has been increasingly disclosed in lakes worldwide. Read More

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Full-length de novo protein structure determination from cryo-EM maps using deep learning.

Bioinformatics 2021 May 12. Epub 2021 May 12.

School of Physics, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P. R. China.

Motivation: Advances in microscopy instruments and image processing algorithms have led to an increasing number of cryo-EM maps. However, building accurate models for the EM maps at 3-5 Å resolution remains a challenging and time-consuming process. With the rapid growth of deposited EM maps, there is an increasing gap between the maps and reconstructed/modeled 3-dimensional (3D) structures. Read More

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Successful emergency evacuation from a hospital within a 5-km radius of Fukushima Daiichi Nuclear Power Plant: the importance of cooperation with an external body.

J Radiat Res 2021 May;62(Supplement_1):i122-i128

Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Japan.

Emergency evacuation during a disaster may have serious health implications in vulnerable populations. After the accident at the Fukushima Daiichi Nuclear Power Plant (FDNPP) in March 2011, the Japanese central government immediately issued an evacuation order for residents living near the plant. There is limited information on the process of evacuation from medical institutions within the evacuation zone and the challenges faced. Read More

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Laboratory Test Ordering Patterns in Pediatrics From Naturopaths and General Practitioners.

Am J Clin Pathol 2021 May 12. Epub 2021 May 12.

Department of Laboratory Medicine, University of Washington, and Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA.

Objectives: Naturopathic medicine emphasizes prevention and the self-healing process through natural therapies. Naturopathic doctors (NDs) use clinical laboratories as frequently as traditionally trained physicians. Here we evaluated the test-ordering patterns of NDs and general practitioners (GPs). Read More

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Exploring Race Differences in Satisfaction with Rehabilitation Following Total Knee Arthroplasty: a Qualitative Study.

J Gerontol A Biol Sci Med Sci 2021 May 11. Epub 2021 May 11.

Department of Physical Therapy, University of Pittsburgh School of Health and Rehabilitation Sciences; Pittsburgh, PA, USA.

Background: The purpose of this qualitative focus group study was to explore race differences in the rehabilitation experience and satisfaction with rehabilitation following total knee arthroplasty (TKA).

Methods: We conducted a series of qualitative focus group discussions with groups of Non-Hispanic White and Non-Hispanic Black older adults who recently underwent TKA. We used grounded theory approach, which asks the researcher to develop theory from the data that are collected. Read More

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What's novel in the new Eurachem guide on uncertainty from sampling?

Anal Methods 2020 May;12(17):2295-2297

A second edition of the Eurachem guide, Measurement uncertainty arising from sampling (UfS),1 has recently been published (Fig. 1), in collaboration with CITAC, Eurolab, Nordtest and the Royal Society of Chemistry's Analytical Methods Committee. This Technical Brief aims to explain how this new second edition differs significantly from the first edition that was published in 2007. Read More

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Screening Fermentation and Extract Generation.

Methods Mol Biol 2021 ;2296:209-216

Bacteriology Department, Biomar Microbial Technologies S.A., León, Spain.

This chapter describes the process of fermenting actinomycetes in flask and the generation of extracts from these broths. A medium for secondary metabolite production and a general procedure for flask fermentation are specified. Directions are given to reproduce aeration when using different flasks. Read More

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January 2021

Delivery of systemic anti-cancer therapy during the COVID-19 pandemic.

Ir J Med Sci 2021 May 12. Epub 2021 May 12.

Medical Oncology Department, Beaumont Hospital, Dublin, Ireland.

Background: The first confirmed case of COVID-19 in Ireland was on February 29th 2020. From March until late April, the number of cases increased exponentially. The delivery of anti-cancer therapy during the COVID-19 pandemic was extremely challenging. Read More

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Modern perioperative medicine - past, present, and future.

Innov Surg Sci 2019 Dec 5;4(4):123-131. Epub 2019 Dec 5.

Department of General Surgery, Yeovil District Hospital, Higher Kingston, Yeovil BA21 4AT, UK.

Modern perioperative medicine has dramatically altered the care for patients undergoing major surgery. Anaesthetic and surgical practice has been directed at mitigating the surgical stress response and reducing physiological insult. The development of standardised enhanced recovery programmes combined with minimally invasive surgical techniques has lead to reduction in length of stay, morbidity, costs, and improved outcomes. Read More

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December 2019

Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?

Drug Des Devel Ther 2021 3;15:1851-1860. Epub 2021 May 3.

Blood Purification Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People's Republic of China.

Forkhead box protein O1 (FoXO1) is a transcription factor involved in the regulation of a wide variety of physiological process including glucose metabolism, lipogenesis, bone mass, apoptosis, and autophagy. FoXO1 dysfunction is involved in the pathophysiology of various diseases including metabolic diseases, atherosclerosis, and tumors. FoXO1 activity is regulated in response to different physiological or pathogenic conditions by changes in protein expression and post-translational modifications. Read More

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2021 Advocacy Statements for the Role of Tc-Pyrophosphate Scintigraphy in the Diagnosis of Transthyretin Cardiac Amyloidosis: A Report of the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China.

Acta Cardiol Sin 2021 May;37(3):221-231

Department of Nuclear Medicine, National Taiwan University Hospital.

Transthyretin cardiac amyloidosis (ATTR-CM) is an increasingly recognized cause of heart failure with preserved ejection fraction. Favorable prognosis depends on early diagnosis and correct treatment strategy. Among patients for whom there is a high clinical suspicion of cardiac amyloidosis, Tc-labeled bone avid scintigraphy including Tc-pyrophosphate (PYP) scintigraphy may be of diagnostic and prognostic importance. Read More

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Linking functional traits and demography to model species-rich communities.

Nat Commun 2021 May 11;12(1):2724. Epub 2021 May 11.

Landscape Ecology, Institute of Terrestrial Ecosystems, ETH Zurich, Zürich, Switzerland.

It has long been anticipated that relating functional traits to species demography would be a cornerstone for achieving large-scale predictability of ecological systems. If such a relationship existed, species demography could be modeled only by measuring functional traits, transforming our ability to predict states and dynamics of species-rich communities with process-based community models. Here, we introduce a new method that links empirical functional traits with the demographic parameters of a process-based model by calibrating a transfer function through inverse modeling. Read More

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The effectiveness of handout assisted versus verbal consent on post-operative recall and understanding - A randomized control study.

Surgeon 2021 May 8. Epub 2021 May 8.

Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. Electronic address:

Background: Consent is an important component of surgical care. Poorly attempted consent bears significant ethical and legal implications. We assessed the effectiveness of handouts in improving postoperative consent understanding and recall compared to standard verbal consent during laparoscopic cholecystectomy as a tool that may improve information retention and leads to better treatment satisfaction. Read More

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"A coalition of the willing": experiences of co-designing an online pain management programme (iSelf-help) for people with persistent pain.

Res Involv Engagem 2021 May 11;7(1):28. Epub 2021 May 11.

Centre for Health, Activity and Rehabilitation Research (CHARR), School of Physiotherapy, Dunedin, New Zealand.

Background: Participatory approaches to developing health interventions with end-users are recommended to improve uptake and use. We aimed to explore the experiences of co-designing an online-delivered pain management programme (iSelf-help) for people with persistent pain.

Methods: A modified participatory action research (PAR) framework was used to co-design contents and delivery of iSelf-help. Read More

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How therapists and patients need to develop a clinical feedback system after 18 months of use in a practice-research network: a qualitative study.

Int J Ment Health Syst 2021 May 11;15(1):43. Epub 2021 May 11.

Department of Psychiatry, District General Hospital of Førde, Førde, Norway.

Background: A personalized computer-adaptive system for clinical feedback and routine outcome monitoring in mental health, Norse Feedback aims to bridge the needs for standardized and idiographic measures in ordinary practice.

Methods: Item response theory analyses of completed treatment processes (n = 800) informed a qualitative study comprising individual in-depth interviews and focus groups with patients (n = 9) and clinicians (n = 10). The research question was: How do clinicians and patients contribute to developing a clinical feedback system in a continuous process aimed at refining its clinical usefulness?

Results: We conducted thematic analyses and found five themes: 1. Read More

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Combining genetic algorithm with machine learning strategies for designing potent antimicrobial peptides.

BMC Bioinformatics 2021 May 11;22(1):239. Epub 2021 May 11.

Mechanical Engineering Department, University of Kansas, 1530 W 15th St, Learned Hall, Room 3135A, Lawrence, KS, 66045, USA.

Background: Current methods in machine learning provide approaches for solving challenging, multiple constraint design problems. While deep learning and related neural networking methods have state-of-the-art performance, their vulnerability in decision making processes leading to irrational outcomes is a major concern for their implementation. With the rising antibiotic resistance, antimicrobial peptides (AMPs) have increasingly gained attention as novel therapeutic agents. Read More

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Organizational Readiness for Intimate Partner Violence Response among Supportive Housing Providers: A Capacity Assessment in Maryland.

J Interpers Violence 2021 May 11:8862605211015223. Epub 2021 May 11.

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Intimate partner violence (IPV) frequently leads to housing instability and homelessness among survivors. While the client populations of many housing support programs are likely to include IPV survivors who have unique safety needs, the organizational readiness of these housing providers to identify and support IPV survivors is not clear. This study assessed organizational readiness for IPV response among Rapid Re-Housing (RRH) and Transitional Housing (TH) providers in Maryland, whose client populations include women ( = 32). Read More

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Bioproduction process of natural products and biopharmaceuticals: Biotechnological aspects.

Biotechnol Adv 2021 May 8:107768. Epub 2021 May 8.

Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, United Kingdom.

Decades of research have been put in place for developing sustainable routes of bioproduction of high commercial value natural products (NPs) on the global market. In the last few years alone, we have witnessed significant advances in the biotechnological production of NPs. The development of new methodologies has resulted in a better understanding of the metabolic flux within the organisms, which have driven manipulations to improve production of the target product. Read More

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More than half of systematic reviews have relevant core outcome sets.

J Clin Epidemiol 2021 May 8. Epub 2021 May 8.

MRC/NIHR Trials Methodology Research Partnership, Department of Health Data Science, University of Liverpool (a member of Liverpool Health Partners), Liverpool, UK. Electronic address:

Objectives: Using recent systematic reviews (SRs), our objectives were to: (1) develop a framework to assess whether a given COS is relevant to the scope of a SR; (2) examine the proportion of SRs for which relevant COS exist; and (3) for SRs for which COS exist, examine the extent to which outcomes in the COS and outcomes in the SR match.

Study Design And Setting: We included a sample of SRs published by the Agency for Healthcare Research and Quality Evidence-based Practice Center Program between January 1, 2018 and October 12, 2020. We searched for potentially relevant COS from the Core Outcome Measures for Effectiveness Trials (COMET) database. Read More

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Epithelial-mesenchymal transition: When tumor cells meet myeloid-derived suppressor cells.

Biochim Biophys Acta Rev Cancer 2021 May 8:188564. Epub 2021 May 8.

Department of Laboratory Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang, China; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China. Electronic address:

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous myeloid cell population characterized by protumoral functions in the tumor immune network. An increasing number of studies have focused on the biological functions of MDSCs in tumor immunity. Epithelial-mesenchymal transition (EMT) is a cellular plasticity process accompanied by a loss of epithelial phenotypes and an acquisition of mesenchymal phenotypes. Read More

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Named Entity Aware Transfer Learning for Biomedical Factoid Question Answering.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 11;PP. Epub 2021 May 11.

Biomedical factoid question answering is an important task in biomedical question answering application. It has attracted much attention because of its reliability of the answer. In question answering system, better representation of word is of much importance and a proper word embedding usually can improve the performance of system significantly. Read More

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Are we prepared for the future? A mixed-method study on quality management in decentralized family medicine teaching.

Med Educ Online 2021 Dec;26(1):1923114

Institute for General Practice and Interprofessional Health Care, Tübingen University Hospital, Tübingen, Germany.

In Germany, two-week clinical clerkships in university-associated general practices have existed since 2002. Approximately 10,000 medical students participate in these decentral clerkships each year. Empirical information on quality management strategies in decentral learning environments is sparse. Read More

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December 2021

Electronic Health Records As a Platform for Audiological Research: Data Validity, Patient Characteristics, and Hearing-Aid Use Persistence Among 731,213 U.S. Veterans.

Ear Hear 2020 Dec 16. Epub 2020 Dec 16.

1Manchester Centre for Audiology and Deafness, School of Health Sciences, University of Manchester, Manchester, United Kingdom; 2VA Rehabilitation R&D, National Center for Rehabilitative Auditory Research, Portland, Oregon, USA; 3Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA 4Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Objectives: This article presents a summary of audiological, general health, and hearing aid (HA) outcome data in a large sample of U.S. Veterans receiving HAs. Read More

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December 2020

A core outcome set for genitourinary symptoms associated with menopause: the COMMA (Core Outcomes in Menopause) global initiative.

Menopause 2021 May 10. Epub 2021 May 10.

Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University. Melbourne, Australia School of Nursing, Indiana University, Indianapolis, IN Department of Obstetrics and Gynaecology, University of Chicago, Chicago, IL Red Hot Mamas North America, Inc., New York, NY Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY Department of Obstetrics and Gynaecology, University Hospitals Dorset NHS Trust, Poole, Dorset, UK Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK Centre for Women's Health, Institute of Population Health Sciences, Queen Mary University London, UK Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Department of Obstetrics and Gynaecology, Fortis Escort Hospital, Jaipur, India Department of Gynaecology and Obstetrics, University of Muenster, Muenster, Germany Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia Department of Reproductive and Maternal Medicine, School of Medicine, University of Glasgow, Glasgow, UK Departments of Psychiatry, Psychology and Obstetrics and Gynecology, University of Illinois at Chicago, Chicago IL Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS San Matteo Foundation, University of Pavia, Pavia, Italy Department of Urology, UIC College of Medicine, Chicago IL Queen Charlotte's and Chelsea and Westminster Hospitals, Imperial College London, London, UK Auckland District Health Board, Auckland, New Zealand Department of Obstetrics and Gynecology, Midlife Women's Health Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Obstetrics and Gynecology, George Washington University, Washington, DC Department of Obstetrics and Gynecology, University Clinic Inselspital Bern, Bern, Switzerland Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada.

Objective: Genitourinary symptoms, such as vaginal dryness and pain with sex, are commonly experienced by postmenopausal women. Comparing treatments for these genitourinary symptoms are restricted by the use of different outcome measures in clinical trials and the omission of outcomes, which may be relevant to women. The aim of this project was to develop a Core Outcome Set (COS) to be reported in clinical trials of treatments for genitourinary symptoms associated with menopause. Read More

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Identifying potential classification criteria for calcium pyrophosphate deposition disease (CPPD): Item generation and item reduction.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Division of Rheumatology, University of Alabama at Birmingham, Birmingham Veterans Affairs Medical Center, Birmingham, United States.

Objective: Classification criteria for calcium pyrophosphate deposition disease (CPPD) will facilitate clinical research on this common crystalline arthritis. We report on the first two phases of a four-phase process for developing CPPD classification criteria.

Methods: CPPD classification criteria development is overseen by a 12-member Steering Committee. Read More

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Improving Transfer of Care Between Psychiatrists and Residents: Participants' Perspective on the Implementation of a Handover Protocol in a Psychiatric Emergency.

Acad Psychiatry 2021 May 10. Epub 2021 May 10.

Douglas Mental Health University Institute, Montreal, Quebec, Canada.

Objectives: Handover refers to the transfer of information from one professional to another during transitions of care. I-PASS is a mnemonic tool which stands for Illness severity; Patient summary; Action list; Situation awareness and contingency planning; and Synthesis by receiver. It was developed to standardize the handover process. Read More

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Application of interval-valued Pythagorean fuzzy VIKOR approach for petroleum sludge treatment technology evaluation and selection.

Environ Sci Pollut Res Int 2021 May 10. Epub 2021 May 10.

School of Management Engineering, Shandong Jianzhu University, Jinan, 250000, China.

Petroleum sludge is produced during oilfield development and production and can negatively impact the production area and surrounding environment. With increasing attention to the environmental protection of oilfields, finding an energy-efficient, environmentally sound, cost-effective and socially acceptable sludge treatment method is crucial to the sustainable development of oil companies. However, there are several problems in the selection process: ① there is no effective index system for the evaluation of treatment technologies; ② there is data uncertainty and loss of information; ③ experts in the field often make one-sided decisions; and ④ the common decision models fail to balance the general effect and local dominance of a treatment technology. Read More

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