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A highly durable CoOx/N-doped Graphitized- Nano-Diamond electrocatalyst for oxygen reduction reaction.

Nanotechnology 2021 May 13. Epub 2021 May 13.

Henan Functional Diamond Material Innovation Center, Zhengzhou, CHINA.

Oxygen reduction reaction (ORR) occupies a pivotal position in fuel cell applications, and it is a challenge to obtain highly durable ORR catalysts. Herein, porous cobalt oxide microsphere growing at the surface of on nitrogen-doped graphitized-nano-diamond (CoOx/N-GND) was prepared using hydrothermal and subsequent heat treatment process. Porous cobalt oxide of high specific surface area could expose more surface Co2+ that act as active sites than bulk one does. Read More

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In situ fabrication of BiMoO/BiMoO homojunction photocatalyst for simultaneous photocatalytic phenol degradation and Cr(VI) reduction.

J Colloid Interface Sci 2021 Apr 28;599:741-751. Epub 2021 Apr 28.

Shaanxi Key Laboratory of Chemical Reaction Engineering, College of Chemistry and Chemical Engineering, Yan'an University, Yan'an 716000, PR China; Key Laboratory for Green Chemical Process of Ministry of Education, School of Xingfa Mining Engineering, Wuhan Institute of Technology, Wuhan 430073, PR China. Electronic address:

In this work, we designed a novel BiMoO/BiMoO homojunction photocatalyst and successfully fabricated by a facile solvothermal-calcination approach. Experimental characterizations indicated that the formation of BiMoO/BiMoO homojunction was caused by controlling oxygen vacancies formation. Such BiMoO/BiMoO homojunction exhibits about 240 times higher photocatalytic activity towards phenol degradation as compared with pure BiMoO under visible light irradiation. Read More

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Epigenetic Regulation of Melanogenesis.

Ageing Res Rev 2021 May 10:101349. Epub 2021 May 10.

Department of Dermatology, Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, Hunan, 410013, PR China. Electronic address:

Melanogenesis is a complex process in which melanin is synthesized in melanocytes and transported to keratinocytes, which involves multiple genes and signaling pathways. Epigenetics refers to the potential genetic changes that affect gene expression without involving changes in the original sequence of DNA nucleotides. DNA methylation regulates the expression of key genes such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), dopachrome tautomerase (DCT) and microphthalmia-associated transcription factor (MITF), as well as paracrine factors such as stem cell factor (SCF) and endothelin-1 (ET-1) in melanogenesis. Read More

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Network pharmacology integrated with experimental validation reveals the regulatory mechanism of plastrum testudinis in treating senile osteoporosis.

J Ethnopharmacol 2021 May 10:114198. Epub 2021 May 10.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Lingnan Medical Research Center of Guangzhou Univercity of Chinese Medicine, Guangzhou, 510405, China. Electronic address:

Ethnopharmacological Relevance: Plastrum testudinis (PT) has been used in traditional Chinese medicine to treat bone diseases such as senile osteoporosis (SOP) for thousands of years. However, the underlying mechanisms remain largely unknown.

Aim Of The Study: This study aims to investigate the possible molecular mechanism of PT in the treatment of SOP using an integrated strategy of network pharmacology and experimental validation. Read More

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Evaluating the Impact of Summer Drought on Vegetation Growth Using Space-Based Solar-Induced Chlorophyll Fluorescence Across Extensive Spatial Measures.

Big Data 2021 May 13. Epub 2021 May 13.

Key Laboratory of Advanced Process Control for Light Industry, Ministry of Education, Jiangnan University, Wuxi, China.

Drought is the primary and dominant natural cause of stress on vegetation, and thus, it needs our full attention. Current understanding of drought across extensive spatial measures, around the world, is considerably limited. As case studies to evaluate the feasibility of utilizing space-based solar-induced chlorophyll fluorescence (SIF) across extensive spatial measures, here, we have used data from 2007 to 2017 in Heilongjiang and Jiangsu provinces of China. Read More

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Cancer Stem Cells in the Immune Microenvironment.

Adv Exp Med Biol 2021 ;1187:245-266

SillaJen, Inc., Seoul, Republic of Korea.

Cancer stem cells are a subpopulation of cancer cells responsible for the most demanding and aggressive cancer cell phenotypes: therapy resistance, a self-protective feature of stem cells; distant metastasis, requiring anchorage independence for survival in the circulation; and recurrence, which is related to the dormant-active cycling of stem cells. Normal tissues are composed of parenchymal cells, supportive connective components, and cellular disposal systems for removing the products of physiological wear and tear. Cancer stem cells develop from normal counterparts and progressively interact with their microenvironments, modifying and conditioning the cancer microenvironment. Read More

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January 2021

Evaluation of Categorical Matrix Completion Algorithms: Towards Improved Active Learning for Drug Discovery.

Bioinformatics 2021 May 13. Epub 2021 May 13.

Computational Biology Department, Carnegie Mellon University, Pittsburgh, 15213, USA.

Motivation: High throughput and high content screening are extensively used to determine the effect of small molecule compounds and other potential therapeutics upon particular targets as part of the early drug development process. However, screening is typically used to find compounds that have a desired effect but not to identify potential undesirable side effects. This is because the size of the search space precludes measuring the potential effect of all compounds on all targets. Read More

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[Study on drug-target binding kinetics profiles of flavonoids in Chrysanthemum morifolium and xanthine oxidase].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1822-1831

Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.

Based on the target occupancy mathematical model, the binding kinetic process of potential active ingredients of lowering uric acid in Chrysanthemum morifolium with xanthine oxidase(XOD) was evaluated. The potential active ingredients of lowering uric acid in Ch. morifolium were screened by UPLC-Q-Exactivems MS technology, reference substance identification and in vitro enzymatic kinetics experiments. Read More

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[Screening of key genes and pathways of ischemic stroke and prediction of traditional Chinese medicines based on bioinformatics].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1803-1812

Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China Institute for Brain Disorders, Beijing University of Chinese Medicine Bejing 100700, China.

The aim of this paper was to explore the key genes and pathogenesis of ischemic stroke(IS) by bioinformatics, and predict the potential traditional Chinese medicines for IS. Based on the gene-chip raw data set of GSE22255 from National Center of Biotechnology Information(NCBI), the article enrolled in 20 patients with ischemic stroke and 20 sex-and age-matched controls, and differentially expressed genes(DEGs) were screened based on R language software. The DAVID tool and R language software were used to perform gene ontology(GO) biological process enrichment analysis and Kyoto encyclopedia of genes and gnomes(KEGG) pathway enrichment analysis. Read More

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Regulation of Dynamic Protein S-Acylation.

Front Mol Biosci 2021 26;8:656440. Epub 2021 Apr 26.

Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, United States.

Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target proteins. It regulates multiple aspects of protein function, including the localization to membranes, intracellular trafficking, protein interactions, protein stability, and protein conformation. This process is regulated by palmitoyl acyltransferases that have the conserved amino acid sequence DHHC at their active site. Read More

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Possibility of inducing tumor cell senescence during therapy.

Oncol Lett 2021 Jul 27;22(1):496. Epub 2021 Apr 27.

School of Pharmaceutical Sciences and Yunnan Provincial Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.

The treatment options for cancer include surgery, radiotherapy and chemotherapy. However, the traditional approach of high-dose chemotherapy brings tremendous toxic side effects to patients, as well as potentially causing drug resistance. Drug resistance affects cell proliferation, cell senescence and apoptosis. Read More

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Gesture Recognition Using Surface Electromyography and Deep Learning for Prostheses Hand: State-of-the-Art, Challenges, and Future.

Front Neurosci 2021 26;15:621885. Epub 2021 Apr 26.

Institute of Rehabilitation Engineering and Technology, University of Shanghai for Science and Technology, Shanghai, China.

Amputation of the upper limb brings heavy burden to amputees, reduces their quality of life, and limits their performance in activities of daily life. The realization of natural control for prosthetic hands is crucial to improving the quality of life of amputees. Surface electromyography (sEMG) signal is one of the most widely used biological signals for the prediction of upper limb motor intention, which is an essential element of the control systems of prosthetic hands. Read More

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Health literacy in people with venous leg ulcers: a protocol for scoping review.

BMJ Open 2021 May 11;11(5):e044604. Epub 2021 May 11.

School of Psychology, University of Birmingham Edgbaston Campus, Birmingham, UK.

Introduction: Chronic venous leg ulcer (VLU) healing is a complex clinical problem. It requires intervention from skilled, costly, multidisciplinary wound-care teams, working with patients to manage their care. Compression therapy has been shown to help heal venous ulcers and to reduce recurrence, with some evidence suggesting the value of exercise as well. Read More

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Synthesis of Oxygen-Rich Bismuth Oxybromide (BiOBr) Photocatalyst for High Efficiency Degradation of Sulfadiazine Under Simulated Sunlight.

J Nanosci Nanotechnol 2021 Nov;21(11):5477-5485

School of Materials Science and Engineering, Hebei University of Engineering, Handan 056038, p. R. China.

At present, compared with other antibiotic degradation systems, there are few literatures on pho- tocatalytic degradation of sulfadiazine (SDZ). In this research, it was firstly discovered that the oxygen-rich bismuth oxybromide (BiO Br) photocatalyst can efficiently degrade SDZ under simulated sunlight. In this paper, the prepared BiOBr photocatalyst by mixed solvothermal method represented outstanding photocatalytic performance. Read More

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November 2021

Photo-assisted electrochemical advanced oxidation processes for the disinfection of aqueous solutions: A review.

Chemosphere 2021 Jul 12;274:129957. Epub 2021 Feb 12.

Centro de Investigación y Desarrollo Tecnológico en Electroquímica, Parque Tecnológico Querétaro Sanfandila, 76703, Pedro Escobedo, Querétaro, Mexico. Electronic address:

Disinfection is usually the final step in water treatment and its effectiveness is of paramount importance in ensuring public health. Chlorination, ultraviolet (UV) irradiation and ozone (O) are currently the most common methods for water disinfection; however, the generation of toxic by-products and the non-remnant effect of UV and O still constitute major drawbacks. Photo-assisted electrochemical advanced oxidation processes (EAOPs) on the other hand, appear as a potentially effective option for water disinfection. Read More

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Development of a highly sensitive sensor chip using optical diagnostic based on functionalized plasmonically active AuNPs.

Nanotechnology 2021 May 12. Epub 2021 May 12.

Faculty of Materials Science and Technology, University of Science, Vietnam National University Ho Chi Minh City University of Science, Ho Chi Minh City, VIET NAM.

Measuring solution concentration plays an important role in chemical, biochemical, clinical diagnosis, environmental monitoring, and biological analyses. In this work, we develop a transmission-mode localized surface plasmon resonance (LSPR) sensor chip system and convenient method which is highly efficient, highly sensitive for detection sensing using multimode fiber. The plasmonically active sensor's surface AuNPs with high-density NPs were decorated onto 1 cm sensing length of various clad-free fiber in the form of homogeneous monolayer utilizing a self-assembly process for immobilization of the target molecule. Read More

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Design, synthesis and anti-influenza virus activity of furan-substituted spirothiazolidinones.

Bioorg Chem 2021 Apr 30;112:104958. Epub 2021 Apr 30.

Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul University, Istanbul, Turkey.

A new series of N-(3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)carboxamides have been designed, synthesized and evaluated as antiviral agents. The compounds were prepared by condensation of 2-methylfuran-3-carbohydrazide, appropriate carbonyl compounds and sulfanyl acids. Read More

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The Immunity Clock.

J Gerontol A Biol Sci Med Sci 2021 May 12. Epub 2021 May 12.

Department of Genetics, Physiology and Microbiology (Unity of Animal Physiology), Faculty of Biology, Complutense University of Madrid (UCM), Madrid, Spain.

The immune system has been for long considered a marker of health. The age-related decline in its function results in a greater incidence of infections, autoimmune diseases and cancer. Nevertheless, it is still not known if immune function can be used to accurately estimate the rate of aging of an individual. Read More

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A Generalized Asymmetric Dual-front Model for Active Contours and Image Segmentation.

IEEE Trans Image Process 2021 May 12;PP. Epub 2021 May 12.

The Voronoi diagram-based dual-front scheme is known as a powerful and efficient technique for addressing the image segmentation and domain partitioning problems. In the basic formulation of existing dual-front approaches, the evolving contour can be considered as the interfaces of adjacent Voronoi regions. Among these dual-front models, a crucial ingredient is regarded as the geodesic metrics by which the geodesic distances and the corresponding Voronoi diagram can be estimated. Read More

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Recent perspectives of nanotechnology in burn wounds management: a review.

Ruan Na Tian Wei

J Wound Care 2021 May;30(5):350-370

Department of Biomedical Engineering.

Objective: The burden of the management of problematic skin wounds characterised by a compromised skin barrier is growing rapidly. Almost six million patients are affected in the US alone, with an estimated market of $25 billion annually. There is an urgent requirement for efficient mechanism-based treatments and more efficacious drug delivery systems. Read More

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Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.

Transl Stroke Res 2021 May 12. Epub 2021 May 12.

Neurovascular Biology Laboratory, Neurovascular Unit Research Group, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.

Post-stroke vascular remodeling, including angiogenesis, facilitates functional recovery. Proper vascular repair is important for efficient post-stroke recovery; however, the underlying mechanisms coordinating the diverse signaling pathways involved in vascular remodeling remain largely unknown. Recently, axon guidance molecules were revealed as key players in injured vessel remodeling. Read More

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Supported Cu(II)-Schiff base: novel heterogeneous catalyst with extremely high activity for eco-friendly, one-pot and multi-component C-S bond-forming reaction toward a wide range of thioethers as biologically active cores.

Mol Divers 2021 May 12. Epub 2021 May 12.

Department of Chemistry, College of Sciences, Shiraz University, 71454, Shiraz, Iran.

An effective and proficient process for the synthesis of a variety of thioethers via the one-step reaction of benzyl halides, aryl halides, and thiourea is presented. This strategy is a one-pot procedure to achieve a variety of thioethers without the requirement to thiols as starting compounds. A range of thioethers containing electron donating/electron-withdrawing functional groups were obtained with good to excellent yields under mild conditions. Read More

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Theranostic Near-Infrared-Active Conjugated Polymer Nanoparticles.

ACS Nano 2021 May 12. Epub 2021 May 12.

Physics Department, King's College London, Strand Building, London, WC2R 2LS, U.K.

Conjugated polymer nanoparticles (CPNs) based on a common solar cell material (PTB7) have been prepared, and their potential in theranostic applications based on bioimaging and photosensitizing capabilities has been evaluated. The main absorption and emission bands of the prepared CPNs both fell within the NIR-I (650-950 nm) transparency window, allowing facile and efficient implementation of our CPNs as bioimaging agents, as demonstrated in this work for A549 human lung cancer cell cultures. The prepared CPN samples were also shown to produce reactive oxygen species (ROS) upon photoexcitation in the near-infrared or ultraviolet spectral regions, both in aqueous solutions and in HaCaT keratinocyte cell cultures. Read More

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Photochemical processes in flavo-enzymes as a probe for active site dynamics: TrmFO of Thermus thermophilus.

Photochem Photobiol Sci 2021 May 11. Epub 2021 May 11.

LOB, CNRS, INSERM, Ecole Polytechnique, Institut Polytechnique de Paris, 91128, Palaiseau Cedex, France.

Quenching of flavin fluorescence by electron transfer from neighboring aromatic residues is ubiquitous in flavoproteins. Apart from constituting a functional process in specific light-active systems, time-resolved spectral characterization of the process can more generally be employed as a probe for the active site configuration and dynamics. In the C51A variant of the bacterial RNA-transforming flavoenzyme TrmFO from the bacterium Thermus thermophilus, fluorescence is very short-lived (~ 1 ps), and close-by Tyr343 is known to act as the main quencher, as confirmed here by the very similar dynamics observed in protein variants with modified other potential quenchers, Trp283 and Trp214. Read More

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Denominational Differences in US Synagogues' Promotion of Youth Physical Activity Programming.

J Relig Health 2021 May 11. Epub 2021 May 11.

School of Exercise and Nutritional Sciences, San Diego State University, 5500 Campanile Drive, ENS Building 315, San Diego, CA, 92182-7251, USA.

Less than 25% of US children 6-17 years of age are sufficiently active. Faith-based settings are one of the nine societal sectors tasked with promoting physical activity (PA). Religious organizations frequently use diverse media, including websites, bulletins/newsletters, and calendars to inform current/potential members of events. Read More

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Irrelevant features of distractors in intervening visual search tasks cause active visual working memory interference - the more difficult the search task, the more interference it causes.

Atten Percept Psychophys 2021 May 11. Epub 2021 May 11.

Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, 61820, USA.

Visual working memory (VWM) content disrupts visual search performance when there is a singleton in the search array that is similar to the content in VWM, even when this singleton is task irrelevant. Typically, the memory-similar singleton captures attention, which results in slower search performance for memory-similar conditions compared to conditions where memory-similar content is absent. Recently, it has also been shown that VWM content may be affected when memory-similar stimuli are processed. Read More

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De-implementing low-value care in endocrinology.

Endocrine 2021 May 11. Epub 2021 May 11.

Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Knowledge and Evaluation Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Low-value care exposes patients to ineffective, costly, and potentially harmful care. In endocrinology, low-value care practices are common in the care of patients with highly prevalent conditions. There is an urgent need to move past the identification of these practices to an active process of de-implementation. Read More

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Active triggering control of pneumatic rehabilitation gloves based on surface electromyography sensors.

PeerJ Comput Sci 2021 19;7:e448. Epub 2021 Apr 19.

Robotics and Mechatronics Department, Institute of Solid Mechanics of the Romanian Academy, Bucharest, Bucharest, Romania.

The portable and inexpensive hand rehabilitation robot has become a practical rehabilitation device for patients with hand dysfunction. A pneumatic rehabilitation glove with an active trigger control system is proposed, which is based on surface electromyography (sEMG) signals. It can trigger the hand movement based on the patient's hand movement trend, which may improve the enthusiasm and efficiency of patient training. Read More

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The influence of active carbon contaminants on the ozonation mechanism interpretation.

Sci Rep 2021 May 11;11(1):9934. Epub 2021 May 11.

Department of Analytical and Environmental Chemistry, Faculty of Chemistry, Adam Mickiewicz University Poznan, Uniwersytetu Poznańskiego 8, 61-614, Poznań, Poland.

In water treatment technology, activated carbons are used primarily as sorbents to remove organic impurities, mainly natural organic matter, but also as catalysts in the ozonation process. Commercially available activated carbons are usually contaminated with mineral substances, classified into two main groups: alkali metals (Ca, Na, K, Li, Mg) and multivalent metals (Al, Fe, Ti, Si). The presence of impurities on the carbon surface significantly affects the pH values determined for raw and ozonated carbon as well as their acidity and alkalinity. Read More

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Controls on Interspecies Electron Transport and Size Limitation of Anaerobically Methane-Oxidizing Microbial Consortia.

mBio 2021 May 11;12(3). Epub 2021 May 11.

Department of Marine Sciences, University of Georgia, Athens, Georgia, USA.

About 382 Tg yr of methane rising through the seafloor is oxidized anaerobically (W. S. Reeburgh, Chem Rev 107:486-513, 2007, https://doi. Read More

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