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The state of adolescent medicine as a specific field: an international exploratory survey.

Int J Adolesc Med Health 2021 Jun 24. Epub 2021 Jun 24.

Faculty of Biology & Medicine, University of Lausanne, Lausanne, Switzerland.

Objectives: The emergence of adolescent medicine (AM) as a specific area of training and health care delivery is progressing at various pace around the world. The objective of this exploratory survey was to inquire about the existence of official bodies and institutions offering recognition of the discipline as a specific field and on the status of related training initiatives.

Methods: A questionnaire was spread among a convenience sample of 21 colleagues involved in adolescent health care around the world, and answers were collected and analysed manually. Read More

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Dinoprostone vaginal insert (DVI) versus adjunctive sweeping of membranes and DVI for term induction of labor.

J Obstet Gynaecol Res 2021 Jun 23. Epub 2021 Jun 23.

Department of Obstetrics & Gynaecology, St George's University of London, London, UK.

Aim: To compare the efficacy and safety of dinoprostone vaginal insert (DVI) alone versus DVI with adjunctive sweeping of membranes (ASM) for induction of labor (IOL).

Methods: Single-center, prospective, randomized controlled trial; women with singleton term pregnancies, cervical dilation ≥1 and <3 cm, intact membranes allocated to either DVI or DVI with ASM. The primary outcome was vaginal delivery within 24 h of insertion. Read More

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Lessons Learned for Identifying and Annotating Permissions in Clinical Consent Forms.

Appl Clin Inform 2021 May 23;12(3):429-435. Epub 2021 Jun 23.

Department of Systems, Populations and Leadership, University of Michigan School of Nursing, Ann Arbor, Michigan, United States.

Background:  The lack of machine-interpretable representations of consent permissions precludes development of tools that act upon permissions across information ecosystems, at scale.

Objectives:  To report the process, results, and lessons learned while annotating permissions in clinical consent forms.

Methods:  We conducted a retrospective analysis of clinical consent forms. Read More

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Implementing the Pediatric Family Satisfaction in the Intensive Care Unit (ICU) Survey in a Pediatric Cardiac ICU.

John Manna

Am J Crit Care 2021 May;30(3):230-236

John Manna is a family nurse practitioner, Lexington Medical Center, Lexington, South Carolina.

Background: Few responses to the Child Hospital Consumer Assessment of Healthcare Providers and Systems and no use of family satisfaction scores indicated the need to implement a program to collect and use family satisfaction data at a pediatric cardiac intensive care unit (ICU) at a southeastern academic medical center.

Objectives: To improve response rates for family satisfaction surveys, to identify future quality improvement initiatives, to receive qualitative feedback from key stakeholders, and to better understand nursing staff's satisfaction with the project implementation process.

Methods: A quality improvement program using the Pediatric Family Satisfaction in the Intensive Care Unit (pFS-ICU) survey was implemented to evaluate family satisfaction data from a pediatric cardiac ICU. Read More

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The microscopic transition process from high-density to low-density amorphous state of SnI.

J Phys Condens Matter 2021 Jun 23. Epub 2021 Jun 23.

Physics, Ehime University, 2-5 Bunkyo-cho, Matsuyama, Ehime, 790-8577, JAPAN.

A molecular crystalline SnIundergoes pressure-induced solid-state amorphization via molecular dissociation to the high-density amorphous (HDA) state, which we call Am-I. In the present study, we examine the reverse transition process from Am-I to the low-density amorphous (LDA) state, called Am-II. We first measure the structure factor on decompression from 30 GPa down to 1. Read More

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Dendritic growth of ice crystals: a test of theory with experiments.

J Phys Condens Matter 2021 Jun 23. Epub 2021 Jun 23.

GPM, Universite de Rouen - Site du Madrillet, technopole du Madrillet, Saint Etienne du Rouvray, 76800, FRANCE.

Motivated by an important application of dendritic crystals in the form of an elliptical paraboloid, which widely spread in nature (ice crystals), we develop here the selection theory of their stable growth mode. This theory enables us to separately define the tip velocity of dendrites and their tip diameter as functions of the melt undercooling. This, in turn, makes it possible to judge the microstructure of the material obtained as a result of the crystallization process. Read More

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Fabrication of cerium doped carbon dots with highly radical scavenging activity alleviates ferroptosis-induced oxidative damage.

Nanotechnology 2021 Jun 23. Epub 2021 Jun 23.

School of medicine, Jiangsu University, Zhangjiagang Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, 215600, China., Zhenjinag, Jiangsu, 215600, CHINA.

Ferroptosis as an iron-dependent lipid peroxidation process causes sevely oxidative damage of cell, but lack of highly efficient and recycable antioxidant agents. To this end, cerium doped carbon dots (Ce-doped CDs) with radical scavenging activity were synthesized using a simple microwave-assisted hydrothermal carbonization. The resultant Ce-doped CDs exhibited an ultra-small size of only approximately 2. Read More

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Current efficiency and selectivity reduction caused by co-ion leakage in electromembrane processes.

Water Res 2021 Jun 10;201:117351. Epub 2021 Jun 10.

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

In electromembrane processes such as electrodialysis (ED) and ion concentration polarization (ICP), the diffusion layers on both diluate and concentrate sides influence permselectivity of the ion-exchange membrane and current utilization. The diffusion layer in the diluate stream, due to lower salinity and higher resistivity, has been regarded as the primary source of energy loss. In contrast, very few studies have focused on the diffusion layer in the concentrate stream. Read More

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Self-assembled caseinate-laponite® nanocomposites for curcumin delivery.

Food Chem 2021 Jun 9;363:130338. Epub 2021 Jun 9.

Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. Electronic address:

In this study, novel self-assembled protein-clay nanocomposites were developed for curcumin delivery. Experimentally, curcumin was dissolved and deprotonated in sodium caseinate-laponite® (NaCas-LAP) dispersion at pH 12.0 for 30 min followed by neutralization to pH = 7. Read More

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The effect of water on the large-scale supercritical fluid chromatography purification of two factor XIa active pharmaceutical ingredients.

J Chromatogr A 2021 Jun 4;1651:462318. Epub 2021 Jun 4.

Department of Discovery Synthesis, Bristol Myers Squibb Research and Early Development, Route 206 & Province Line Rd, Princeton, NJ 08543-4000, United States.

BMS-962212, a parenteral Factor XIa inhibitor, was scaled-up for toxicity studies. Two steps of supercritical fluid chromatography (SFC) were developed for the chiral resolution of the penultimate and achiral purification of final active pharmaceutical ingredient (API), BMS-962212. A robust SFC process using Chiralcel OD-H with methanol-acetonitrile as modifier in CO was established to achieve a stable and uninterrupted operation with reduced mobile phase viscosity and system pressure drop. Read More

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Advances in Automated Piston Liquid-Liquid Microextraction Technique.

J Chromatogr A 2021 Jun 9;1651:462330. Epub 2021 Jun 9.

Dow Canada ULC, PO Bag 16, Hwy 15, Fort Saskatchewan, AB, T8L 2P4, Canada; Australian Centre for Research on Separation Science (ACROSS), University of Tasmania, Private Bag 75 Hobart, 7001 SA. Electronic address:

A new automated micro liquid-liquid extraction technique was successfully developed. This novel syringe-based technique capitalizes on the advantages of vigorous fluid agitation and the shearing effect of two fluids with different properties to achieve high extraction efficiency. The technique is at least 20 times faster than mechanical shaking or sonication in achieving a similar recovery even with a hydrophilic probe molecule such as 1,4-dioxane in an aqueous medium. Read More

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Changes in structural, digestive, and rheological properties of corn, potato, and pea starches as influenced by different ultrasonic treatments.

Int J Biol Macromol 2021 Jun 20. Epub 2021 Jun 20.

National Engineering Laboratory for Rice and By-product Deep Processing, Hunan Key Laboratory of Processed Food For Special Medical Purpose, Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China. Electronic address:

Ultrasound was widely used in starch modification, whereas there was no review focusing on the effects of different ultrasonic treatments on A-, B- and C-type starches. In this study, the effects of ultrasonic power (UP, 100-600 W) and ultrasonic time (UT, 5-35 min) on structural, digestibility and rheology of corn starch (CS), potato starch (PtS), and pea starch (PS) were investigated. As a result, UP and UT decreased the apparent amylose content of CS and PS, while increased the apparent amylose content of PtS. Read More

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Informing the Evidence to Decision Process with Health Equity Considerations: Demonstration from the Canadian Rheumatoid Arthritis Care Context.

J Clin Epidemiol 2021 Jun 20. Epub 2021 Jun 20.

Department of Medicine, Cumming School of Medicine, University of Calgary; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary; Arthritis Research Canada.

Objective: Health equity is a priority for clinical and public health practice and promoted in GRADE's Evidence to Decision (EtD) Framework, yet there is still limited integration of specific equity considerations in chronic disease guideline development and implementation. Our objective was to embed equity considerations for upcoming Canadian Rheumatoid Arthritis treatment guidelines.

Study Design And Setting: In parallel with the Guidelines Committee process, considerations for six population groups (rural and remote residents, Indigenous Peoples, elderly persons with frailty, minority populations of first-generation immigrants and refugees, persons with low socioeconomic status or who are vulnerably housed, and sex and gender populations) based on literature reviews and key informant interviews were identified and contextualized to each step in the GRADE EtD framework. Read More

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Audit of empirical antibiotic therapy for sepsis and the impact of early multidisciplinary consultation on patient outcomes.

Int J Antimicrob Agents 2021 Jun 20:106379. Epub 2021 Jun 20.

Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Objectives: To perform an audit of empirical antibiotic therapy (EAT) of sepsis at the emergency department and to analyse the impact of an antimicrobial stewardship (AMS) programme on process and patient outcomes.

Patients And Methods: A prospective single centre cohort study including patients with SOFA score ≥2 from whom blood cultures were taken, was conducted between February 2019 and April 2020. EAT assessment was done using eight applicable quality indicators for responsible antibiotic use in inpatients (IQIs). Read More

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Attractor competition enriches cortical dynamics during awakening from anesthesia.

Cell Rep 2021 Jun;35(12):109270

Natl. Center for Radioprotection and Computational Physics, Istituto Superiore di Sanità, Rome, Italy.

Slow oscillations (≲ 1 Hz), a hallmark of slow-wave sleep and deep anesthesia across species, arise from spatiotemporal patterns of activity whose complexity increases as wakefulness is approached and cognitive functions emerge. The arousal process constitutes an open window to the unknown mechanisms underlying the emergence of such dynamical richness in awake cortical networks. Here, we investigate the changes in network dynamics as anesthesia fades out in the rat visual cortex. Read More

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Innovative preclinic triage system to guide Australians to the right mental health care first time.

Aust Health Rev 2021 Jun 24. Epub 2021 Jun 24.

This paper presents a case study of an innovative direct-to-consumer preclinic triage system designed to reduce predicted peak demand for Australian mental health services as a result of COVID-19 and its associated socioeconomic consequences by guiding Australians to the right mental health care first time. Our innovative, digital health solution comprises two components: (1) a highly personalised and measurement-based model of care (Brain and Mind Centre model of care) that considers both the heterogeneity of mental disorders and other underlying comorbidities, as well as clinical staging; and (2) a health information technology (i.e. Read More

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What Is the Failure Rate After Arthroscopic Repair of Bucket-Handle Meniscal Tears? A Systematic Review and Meta-analysis.

Am J Sports Med 2021 Jun 23:3635465211015425. Epub 2021 Jun 23.

Orthopaedic and Traumatologic Unit, Umberto I Hospital, Azienda Sanitaria Provinciale di Enna, Enna, Italy.

Background: Meniscal repair has become the treatment of choice for meniscal tears, especially in the subset of bucket-handle meniscal tears (BHMTs). However, a comprehensive estimate of the corresponding failure rate is not available, thus maintaining doubts about the healing potential of these tears. Furthermore, a wide range of factors to predict high failure rates have been reported but with conflicting evidence. Read More

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Design of Neuraminidase-Targeted Imaging and Therapeutic Agents for the Diagnosis and Treatment of Influenza Virus Infections.

Bioconjug Chem 2021 Jun 23. Epub 2021 Jun 23.

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

The last step in influenza virus replication involves the assembly of viral components on the infected cell's plasma membrane followed by budding of intact virus from the host cell surface. Because viral neuraminidase and hemagglutinin are both inserted into the host cell's membrane during this process, influenza virus-infected cells are distinguished from uninfected cells by the presence of viral neuraminidase and hemagglutinin on their cell surfaces. In an effort to exploit this difference in cell surface markers for development of diagnostic and therapeutic agents, we have modified an influenza neuraminidase inhibitor, zanamivir, for targeting of attached imaging and therapeutic agents selectively to influenza viruses and virus-infected cells. Read More

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Compositional Dependence of Li-Ion Conductivity in Garnet-Rich Composite Electrolytes for All-Solid-State Lithium-Ion Batteries-Toward Understanding the Drawbacks of Ceramic-Rich Composites.

ACS Appl Mater Interfaces 2021 Jun 23. Epub 2021 Jun 23.

Materials Synthesis Group, Institute of Material Science, University of Stuttgart, Heisenbergstraße 3, 70569 Stuttgart, Germany.

Composite electrolytes comprising a polymer plus Li salt matrix and embedded fillers have the potential of realizing high lithium-ion conductivity, good mechanical properties, wide electrochemical operational window, and stability against metallic lithium, all of which are essential for the development of high-energy-density all-solid-state lithium-ion batteries. In this study, a solvent-free approach has been used to prepare composite electrolytes with tetragonal and cubic phase garnets synthesized nebulized spray pyrolysis with polyethylene oxide (PEO) being the polymer component. Electrochemical impedance spectroscopy (EIS) is used to examine a series of composites with different garnets and weight fractions. Read More

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Short-term Cost Comparison of Systemic Heparin Therapy vs. Catheter Directed Thrombolysis for the Treatment of Massive and Submassive Pulmonary Embolism with Long-Term Chronic Pulmonary Hypertension Cost Model.

S D Med 2021 Feb;74(2):70-74

Sanford Health Vascular Surgery, Sioux Falls, South Dakota.

Introduction: Pulmonary embolism (PE) is a significant disease process that affects an estimated 117 cases per 100,000 person-years. Chronic pulmonary hypertension (CPH) is a long-term complication associated with acute PE which has a significant cost to treat, ranging from $98,000-117,000.

Methods: A retrospective chart review of 341 patients from January 2011 to November 2018 who presented with massive or submassive PE and were treated with either systemic heparin therapy or catheter directed thrombolysis (CDT). Read More

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February 2021

Potential of Live Spirogyra sp. in the Bioaccumulation of Copper and Nickel ions: A Study for Suitability and Sustainability.

J Appl Microbiol 2021 Jun 23. Epub 2021 Jun 23.

Madhav University, Rajasthan-307026, India.

Aim: Various industrial and municipal wastes are the major source of heavy metal contamination in water and hence thoughtful environmental worries. Bioremediation is an effective and affordable solution for removal of metals and metal pollutants from industrial wastewater. The current study aims to assess the efficacy of live and dead Spirogyra sp. Read More

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The cardioprotective effects of hydrogen sulfide by targeting endoplasmic reticulum stress and the Nrf2 signaling pathway: A review.

Biofactors 2021 Jun 23. Epub 2021 Jun 23.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Cardiac diseases are emerging due to lifestyle, urbanization, and the accelerated aging process. Oxidative stress has been associated with cardiac injury progression through interference with antioxidant strategies and endoplasmic reticulum (ER) function. Hydrogen sulfide (H S) is generated endogenously from l-cysteine in various tissues including heart tissue. Read More

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Quality of life in patients with Chagas disease and the instrument used: an integrative review.

Rev Inst Med Trop Sao Paulo 2021 18;63:e46. Epub 2021 Jun 18.

Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil.

Chagas disease (CD) is a neglected tropical highly morbid disease that can have a negative impact on the quality of life (QoL). The purpose of this study was to conduct an integrative review to analyze the QoL of patients with CD in the chronic phase of the disease, as well as the instruments used and the effect of different interventions. The review was carried out based on the criteria and recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guideline (PRISMA) using the PubMed, Scopus, Web of Science and Science Direct databases. Read More

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The professional autonomy of nursing in pandemic times.

Rev Gaucha Enferm 2021 18;42(spe):e20200404. Epub 2021 Jun 18.

Universidade Federal de Alagoas (UFAL), Escola de Enfermagem, Programa de Pós-Graduação em Enfermagem. Maceió, Alagoas, Brasil.

Objective: To reflect on the exercise of Nursing's professional autonomy in times of pandemic.

Method: Theoretical reflection in the light of the Sociology of Professions proposed by Eliot Freidson. Using the author's main concepts, it was sought to understand the professional practice of Nursing in times when its protagonism in the care process becomes even more challenging. Read More

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Family interview for organ and tissue donation: good practice assumptions.

Rev Bras Enferm 2021 16;74(2):e20190206. Epub 2021 Jun 16.

Universidade Federal de Santa Catarina. Florianópolis, Santa Catarina, Brazil.

Objectives: to identify information that can support creating good practice assumptions to develop family interview for organ and tissue donation.

Methods: this scoping study, conducted in two Brazilian hospitals in the southern, between April and December 2017, included integrative review and consultation with 15 families who experienced interview for organ donation. For data analysis, thematic content analysis was used. Read More

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Vulnerabilities of nurses in an intensive care unit: an integrative review.

Rev Bras Enferm 2021 18;74(3):e20200724. Epub 2021 Jun 18.

Universidade Estadual Paulista. Botucatu, São Paulo, Brazil.

Objectives: to identify vulnerabilities of nurses who work in an intensive care unit.

Methods: an integrative review was held from 2006 to 2019, with searches on the platforms/databases LILACS, BDENF, SciELO, MEDLINE, Scopus, CINAHL, and Web of Science. The theoretical framework of ergology, by Schwartz, was used and the guiding question "What are the main vulnerabilities of nurses who work in an intensive care unit"?

Results: eleven articles were included. Read More

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Reflections on elderly autonomy and its meaning for the practice of nursing care.

Rev Bras Enferm 2021 18;74(3):e20200723. Epub 2021 Jun 18.

Universidade Federal de São Paulo. São Paulo, São Paulo, Brazil.

Objective: To reflect on autonomy in health care, its perspective on the lives of the elderly, and its meaning for the practice of nursing care.

Methods: Theoretical essay on the practice of nursing care to promote autonomy and self-care for the elderly.

Results: It is necessary to qualify the practice of nursing care to consider the aging process and maintain the autonomy of the elderly. Read More

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Training and practice of nurses in Primary Care management: perspectives of Schön's Theory.

Rev Bras Enferm 2021 18;74(3):e20200461. Epub 2021 Jun 18.

Universidade Federal Fluminense. Niterói, Rio de Janeiro, Brazil.

Objectives: to analyze the process of permanent professional training of Primary Health Care nurse managers from the perspective of reflective practice theory, built by Donald Schön.

Methods: this is a theoretical-reflective study.

Results: the findings apply to nurse managers' practice to deal with the dilemmas that present themselves in the professional routine according to their knowledge, skills and attitudes, anchored in the reflection-in-action movement, which unites the process of permanent and practical training reflective, favoring the development of skills relevant to management. Read More

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Medium reach theory for nursing in cardiovascular rehabilitation.

Rev Bras Enferm 2021 18;74(3):e20190718. Epub 2021 Jun 18.

Universidade Federal do Rio de Janeiro. Rio de Janeiro, Rio de Janeiro, Brazil.

Objectives: to describe a medium-range nursing theory for the cardiovascular rehabilitation process.

Methods: theoretical development study, addressing the elaboration of medium-range theory, based on Roy's Adaptation Model, which combined theoretical deduction with induction strategies, based on literature review and concept analysis.

Results: the Medium-Range Theory for Nursing in Cardiovascular Rehabilitation presents eleven concepts and respective definitions, organized in relationships that represent elements, through modeling and image representation. Read More

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Premature birth: topics in physiology and pharmacological characteristics.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):150-155

Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia - Vitória da Conquista (BA), Brasil.

Objective: To review the main physiological and pharmacological changes related to prematurity, to promote the evidence-based clinical practice.

Methods: This is a narrative review whose research was carried out in the ScienceDirect and Medline databases via PubMed, searching for articles in any language from January 2000 to February 2020.

Results: Premature newborns are born before completing the maturation process that prepares them for extrauterine life, which occurs especially in the last weeks of pregnancy. Read More

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January 2021