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Impact of PTRIA (Patient Test Result Information Act) on patient follow up management.

Clin Imaging 2021 Mar 22;79:20-23. Epub 2021 Mar 22.

Hospital of the University of Pennsylvania, Department of Radiology, 3400 Spruce Street, 1, Silverstein Ste. 130, Philadelphia, PA 19104, United States of America. Electronic address: https://twitter.com/asset25.

Objective: We aim to study if direct patient notification in accordance with the Patient Test Results Information Act (Act 112) in Pennsylvania leads to decreased loss to follow up and prompt management of actionable imaging findings.

Methods: For this IRB-approved study, radiology reports were randomly identified using the Nuance mPower™ search engine. The actionable finding group (prior to Act-112) contained 300 patients for which a voice notification was sent by radiologists to alert ordering physicians about significant imaging findings. Read More

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Decoding imagined speech and computer control using brain waves.

J Neurosci Methods 2021 Apr 14:109196. Epub 2021 Apr 14.

Department of Computer Science and Engineering, Indian Institute of Technology Bombay, India. Electronic address:

Background: . In this work, we explore the possibility of decoding Imagined Speech (IS) brain waves using machine learning techniques.

Approach: . Read More

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Urinary metabolomic analysis to identify potential markers for the diagnosis of tuberculosis and latent tuberculosis.

Arch Biochem Biophys 2021 Apr 14:108876. Epub 2021 Apr 14.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. Electronic address:

Tuberculosis (TB) is a serious infectious disease with high infection and mortality rates. 5%-10% of the latent tuberculosis infections (LTBI) are likely to develop into active TB, and there are currently no clinical biomarkers that can distinguish between LTBI, active TB and other non-tuberculosis populations. Therefore, it is necessary to develop rapid diagnostic methods for active TB and LTBI. Read More

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[Combined cerebral revascularization for moyamoya disease].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):47-59

Burdenko Neurosurgical Center, Moscow, Russia.

Introduction: Combined cerebral revascularization with direct and indirect components is recognized as the most appropriate method for treating patients with Moyamoya disease all over the world, however, large studies on its effectiveness in Russia have not yet been conducted.

The Aim Of The Study: Was to evaluate the results of combined cerebral revascularization in patients with Moyamoya disease with an analysis of the clinical state and perfusion and angiographic features of neoangiogenesis.

Material And Methods: For the period from 2013 to 2020 in N. Read More

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January 2021

Association of APOE genotype with lipid profiles and type 2 diabetes mellitus in a Korean population.

Genes Genomics 2021 Apr 17. Epub 2021 Apr 17.

Department of Life Science, Sogang University, Seoul, 04107, Republic of Korea.

Background: Type 2 diabetes mellitus (T2DM) is associated with chronic hyperglycemia and lipid metabolism. A previous genome-wide association study revealed the TOMM40-APOE region as novel locus for T2DM susceptibility.

Objective: This association study was conducted to determine the genetic effects of APOE single nucleotide polymorphisms (SNPs) on T2DM susceptibility and lipid profiles in a Korean population. Read More

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Implications of component size and calibration error on digital templating for total hip arthroplasty. A visual matrix from a simple mathematical model.

Int J Comput Assist Radiol Surg 2021 Apr 17. Epub 2021 Apr 17.

Division of Orthopaedics, Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objective: Preoperative digital templating is a standard procedure in total hip arthroplasty. Deviations between template size and final implant size may result from inaccurate calibration, templating as well as intraoperative decisions. So far, the explicit effect of calibration errors on templating has not been addressed adequately. Read More

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The effect of acute low-load resistance exercise with the addition of blood flow occlusion on muscle function in boys and men.

Eur J Appl Physiol 2021 Apr 17. Epub 2021 Apr 17.

Department of Kinesiology, Faculty of Applied Health Sciences, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, ON, L2S 3A1, Canada.

Purpose: In adults, low-load resistance training with blood flow occlusion (BFO) mimics strength increases that occur from high-load training, without the need to experience high mechanical stress. In view of child-adult differences in exercise responses, this study examined whether BFO during exercise elicits differential changes in maximal voluntary contraction (MVC) and electromyographical (EMG) activity in children and adults.

Methods: Sixteen men (24. Read More

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Effectiveness of intranasal steroids on rhinitis symptoms, sleep quality, and quality of life in patients with perennial allergic rhinitis.

Eur Arch Otorhinolaryngol 2021 Apr 17. Epub 2021 Apr 17.

Department of Otorhinolaryngology, Faculty of Medicine, Minia University, Minia, Egypt.

Purpose: Evaluate the impact of perennial allergic rhinitis (PAR) on the health-related quality of life (HRQL) and measure performance issues that are of major concerns for PAR patients, as well as determining the effect of intra-nasal steroids (INS) on PAR and associated congestion, sleep complaints, and daytime sleepiness.

Methods: This study was a cross-sectional study. A total of 78 PAR patients underwent otorhinolaryngological examination and skin test. Read More

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Utility of 18F-AlF-NOTA-octreotide PET/CT in the localization of Tumor-Induced Osteomalacia.

J Clin Endocrinol Metab 2021 Apr 17. Epub 2021 Apr 17.

Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Purpose: Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder, usually caused by benign mesenchymal tumors that produce high levels of the hormone fibroblast-growth-factor 23 (FGF23). The only curative therapy of the disease is resection of the causative tumors. This research was conducted to evaluate the efficacy of 18F-AlF-NOTA-octreotide ( 18F-OC) PET/CT in detecting TIO and its impact on patient management. Read More

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Prognostic Value of C-Reactive Protein to Albumin Ratio in Patients Resuscitated from Out-of-Hospital Cardiac Arrest.

Int J Clin Pract 2021 Apr 17:e14227. Epub 2021 Apr 17.

Department of Anesthesiology and Reanimation, University of Health Sciences, Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.

Background: Despite major advances in basic and advanced life supports, patients who survived from out of hospital cardiac arrest (OHCA) has still poor prognosis. Several inflammatory parameters have been used to determine early and long-term prognosis in patients with OHCA. C-reactive protein-to-albumin ratio (CAR) is also a novel marker of systemic inflammation. Read More

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Should the location of distal tibial plating be influenced by the varus or valgus fracture pattern of tibial pilon fracture?

Arch Orthop Trauma Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Orthopaedic Surgery, National University Hospital, National University Health System, 1E Kent Ridge Road, Singapore, 119228, Singapore.

Introduction: Operative treatment of tibial pilon fracture is challenging. There is a lack of consensus and only one clinical study on the optimal location of distal tibial plating for fixation of pilon fractures based on varus or valgus fracture patterns. We hypothesize that complications rates, specifically mechanical complications, are not influenced by the location of the tibial plating in the fixation of pilon fractures with respect to varus or valgus fracture patterns. Read More

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Incidence of necrotizing enterocolitis in South Korea from 2007 to 2017.

J Perinatol 2021 Apr 16. Epub 2021 Apr 16.

Department of Pediatric Surgery, College of Medicine, Seoul National University, Seoul, Korea.

Objectives: The aim of this study was to investigate the trends of the incidence of and mortality from necrotizing enterocolitis (NEC) in South Korea.

Methods: Claim data were extracted with diagnosis code, including all stage of NEC. Kaplan-Meier curves for cumulative mortality rates are presented by birth weight (Bwt) and gestational age (GA). Read More

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Congolius, a new genus of African reed frog endemic to the central Congo: A potential case of convergent evolution.

Sci Rep 2021 Apr 16;11(1):8338. Epub 2021 Apr 16.

Czech Academy of Sciences, Institute of Vertebrate Biology, Květná 8, 603 65, Brno, Czech Republic.

The reed frog genus Hyperolius (Afrobatrachia, Hyperoliidae) is a speciose genus containing over 140 species of mostly small to medium-sized frogs distributed in sub-Saharan Africa. Its high level of colour polymorphism, together with in anurans relatively rare sexual dichromatism, make systematic studies more difficult. As a result, the knowledge of the diversity and taxonomy of this genus is still limited. Read More

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The effectiveness of maternity waiting homes in reducing perinatal mortality: a case-control study in Ethiopia.

BMJ Glob Health 2021 Apr;6(4)

Hygiene and Public Health Unit, Department of Cardiac Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Background: The 2030 Agenda for Sustainable Development aims to reduce neonatal mortality to at least 12 per 1000 live births. Most of the causes can be prevented or cured. Access to quality healthcare during pregnancy and labour is the key to reduce perinatal deaths, and maternity waiting homes (MWHs) may have an impact, especially for women who live far from the healthcare system. Read More

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Actinic keratoses contiguous with squamous cell carcinomas are mostly non-hyperkeratotic and with severe dysplasia.

J Clin Pathol 2021 Apr 16. Epub 2021 Apr 16.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

Aims: Actinic keratosis (AK) is a precursor of cutaneous squamous cell carcinoma (SCC). No validated parameters can predict which AKs will progress into SCCs, but especially thick AKs are under suspicion. The clinical and histopathological thickness of AKs is strongly correlated. Read More

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Radioguided surgery with iodine-125 seeds in breast cancer patients treated with neoadjuvant chemotherapy.

Rev Esp Med Nucl Imagen Mol 2021 Apr 13. Epub 2021 Apr 13.

Servicio de Radiodiagnóstico. Hospital Universitario Virgen de las Nieves, Granada, España.

Objective: To evaluate the use of radioactive iodine-125 seed (RIS) in breast and/or axillary surgery, in patients with breast cancer treated with neoadjuvant chemotherapy (NAC).

Material And Methods: Prospective study between January 2016 and June 2020. 80 women T1-3,N0-2,M0: 30 RIS marking the breast tumor, 36 both the tumor and the biopsied positive axillary node, and 14 only the axilla. Read More

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The struggle of nurses in initial trauma emergency care in challenging geographic areas of Indonesia: A phenomenology.

Australas Emerg Care 2021 Apr 13. Epub 2021 Apr 13.

Department of Public Health, Faculty of Medicine, Universitas Brawijaya, Malang Indonesia. Electronic address:

Background: East Sumba Regency is dominated by hills, mountains, and damaged road conditions, which increases the prevalence of accidents that result in trauma. The initial management of trauma patients by puskesmas nurses has several obstacles that cause delays in the treatment process; consequently, the safety of patients becomes a serious problem. This study is aimed to explore nurses' experience in managing early trauma emergencies. Read More

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Use of Three-dimensional Titanium Trusses for Arthrodesis Procedures in Foot and Ankle Surgery: A Retrospective Case Series.

J Foot Ankle Surg 2020 Aug 15. Epub 2020 Aug 15.

Program Director, Foot & Ankle Residency Training Program, West Penn Hospital, Allegheny Health Network, Pittsburgh, PA. Electronic address:

Periarticular osseous defects pose a challenge when considering arthrodesis. Failure to restore the cubic content of bone can result in shortening and malalignment, as well as subsequent biomechanical issues. This study reports on 12 patients treated with patient-specific 3-D printed (7) and prefabricated titanium trusses (5). Read More

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Current surgical practice for multi-level degenerative cervical myelopathy: Findings from an international survey of spinal surgeons.

J Clin Neurosci 2021 May 17;87:84-88. Epub 2021 Mar 17.

Division of Neurosurgery, Addenbrooke's Hospital and University of Cambridge, Cambridge, United Kingdom; Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Degenerative cervical myelopathy (DCM) results from compression of the cervical spine cord as a result of age related changes in the cervical spine, and affects up to 2% of adults, leading to progressive disability. Surgical decompression is the mainstay of treatment, but there remains significant variation in surgical approaches used. This survey was conducted in order to define current practice amongst spine surgeons worldwide, as a possible prelude to further studies comparing surgical approaches. Read More

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Differences between proximal and distal M1 occlusions after mechanical thrombectomy.

J Clin Neurosci 2021 May 26;87:1-7. Epub 2021 Feb 26.

Department of Neurosurgery, Inje University Haeundae Paik Hospital, Busan, Republic of Korea. Electronic address:

Purpose: Whether M1 occlusions proximal (pM1) and distal (dM1) to the lenticulostriate perforators result in different clinical outcomes after mechanical thrombectomy (MT) is unknown. We retrospectively compared the clinical outcomes and baseline characteristics of patients with these two types of occlusions.

Methods: From March 2010 to May 2019, we performed MT for 141 M1 occlusions, including pM1 occlusions (n = 58) and dM1 occlusions (n = 83). Read More

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Short-term hot water immersion results in substantial thermal strain and partial heat acclimation; comparisons with heat-exercise exposures.

J Therm Biol 2021 Apr 25;97:102898. Epub 2021 Feb 25.

Department of Kinesiology, California Baptist University, 8432 Magnolia Ave, Riverside, CA, 92504, USA. Electronic address:

Objective: To examine the effectiveness of hot water immersion (HWI) as a heat acclimation strategy in comparison to time and temperature matched, exercise-heat acclimation (EHA).

Methods: 8 males performed heat stress tests (HST) (45 min of cycling at 50% of VO in 40 °C, 40% RH) before and after heat acclimation sessions. Acclimation sessions were either three consecutive bouts of HWI (40 min of submersion at 40 °C) or EHA (40 min of cycling at 50% VO in 40 °C, 40% RH). Read More

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A novel mouse model of heatstroke accounting for ambient temperature and relative humidity.

J Intensive Care 2021 Apr 16;9(1):35. Epub 2021 Apr 16.

Department of Emergency, Critical Care and Disaster Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Background: Heatstroke is associated with exposure to high ambient temperature (AT) and relative humidity (RH), and an increased risk of organ damage or death. Previously proposed animal models of heatstroke disregard the impact of RH. Therefore, we aimed to establish and validate an animal model of heatstroke considering RH. Read More

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Shock and awe or incentive-compatible harm reduction? Graphic health warnings on tobacco packages.

Harm Reduct J 2021 Apr 16;18(1):43. Epub 2021 Apr 16.

School of Pharmacy, Memorial University of Newfoundland, St. John's, Canada.

Background: Graphic Health Warnings (GHWs) on cigarette packages were first introduced in Canada in 2001 and will become mandatory in the US as of January 2022. While previous studies have evaluated the impacts of GHWs, the data used in these studies have several shortcomings. The objective of this paper was to investigate the likely impact of such warnings in the US based upon the experience of Canada using hitherto unexplored monthly cigarette sales data, and to explore if alternative approaches involving risk-reduced products might be more successful in reducing smoking. Read More

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Comparison between two cell collecting methods for liquid-based brush biopsies: a consecutive and retrospective study.

BMC Oral Health 2021 Apr 16;21(1):195. Epub 2021 Apr 16.

Department of Oral, Maxillofacial and Facial Plastic Surgery, Section of Clinical and Experimental Oral Medicine, Leipzig University Hospital, Liebigstraße 10-14, 04103, Leipzig, Germany.

Background: This study compares two different cell collectors, the Orcellex Brush (rigid brush) and the Cytobrush GT (nylon brush), using liquid-based cytology. A comparison of their obtainment procedures was also considered. The aim was to determine the diagnostic accuracy for detection of malignancy in oral brush biopsies. Read More

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Incidence, clinical risk and prognostic factors for liver metastasis in patients with cervical cancer: a population-based retrospective study.

BMC Cancer 2021 Apr 16;21(1):421. Epub 2021 Apr 16.

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, China.

Background: Cervical cancer is one of the most frequent malignancies in women, particularly metastasis resulting in a poor prognosis. However, the clinical characteristics of cervical cancer patients with advanced liver metastasis have not been well investigated. We aimed to evaluate the incidence, clinical risk and prognostic factors for hepatic metastasis in cervical cancer patients. Read More

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Appetite, oral health and weight loss in community-dwelling older men: an observational study from the Concord Health and Ageing in Men Project (CHAMP).

BMC Geriatr 2021 Apr 16;21(1):255. Epub 2021 Apr 16.

Centre for Education and Research on Ageing, Concord Clinical School, The University of Sydney, and the Ageing and Alzheimer's Institute, Concord Repatriation General Hospital, Sydney Local Health District, Concord, NSW, Australia.

Background: Unintended weight loss and the reduction in appetite are common phenomenon among older people. Reduced appetite has been linked to medication related reductions in saliva production, reduced taste ability and poor oral health. Poor appetite can result in reduced nutrient intake ensuing weight loss. Read More

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Individual calculation of perfusion activity based on ventilation efficiency for V/P-SPECT.

Nuklearmedizin 2021 Apr 16. Epub 2021 Apr 16.

Klinik für Radiologie und Neuroradiologie - Abteilung für Nuklearmedizin, Klinikum Dortmund gGmbH, Dortmund, Germany.

Aim:  Implementation of the individual calculation of perfusion activity to ensure the guideline-compliant ratio of perfusion to ventilation (P/V-ratio) of ≥ 3 in the diagnosis of acute pulmonary embolism (PE) using V/P-SPECT.

Material And Methods:  50 consecutive V/P-SPECT examinations, in which a standard activity of 160 MBq was applied for perfusion imaging, are evaluated retrospectively. Based on this patient group an activity factor is determined, which provides a correlation between the applied perfusion activity and the expected perfusion counts of the gamma camera. Read More

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Dual Regeneration of Muscle and Nerve by Intramuscular Infusion of Mitochondria in a Nerve Crush Injury Model.

Neurosurgery 2021 Apr 16. Epub 2021 Apr 16.

Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan.

Background: Peripheral nerve injuries result in muscle denervation and apoptosis of the involved muscle, which subsequently reduces mitochondrial content and causes muscle atrophy. The local injection of mitochondria has been suggested as a useful tool for restoring the function of injured nerves or the brain.

Objective: To determine outcomes following the administration of isolated mitochondria into denervated muscle after nerve injury that have not been investigated. Read More

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Targeting accuracy of robot-assisted deep brain stimulation surgery in childhood-onset dystonia: a single-center prospective cohort analysis of 45 consecutive cases.

J Neurosurg Pediatr 2021 Apr 16:1-11. Epub 2021 Apr 16.

1Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London.

Objective: Deep brain stimulation (DBS) is an established treatment for pediatric dystonia. The accuracy of electrode implantation is multifactorial and remains a challenge in this age group, mainly due to smaller anatomical targets in very young patients compared to adults, and also due to anatomical abnormalities frequently associated with some etiologies of dystonia. Data on the accuracy of robot-assisted DBS surgery in children are limited. Read More

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The effect of platelet-rich fibrin (PRF) on wound healing, adhesion, and hemostasis after endoscopic sinus surgery in patients with nasal polyposis.

Am J Otolaryngol 2021 Mar 29;42(5):103010. Epub 2021 Mar 29.

Prof. Dr. Cemil Tascioglu City Hospital, Otorhinolaryngology Department, Turkey.

Purpose: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases seen worldwide. Endoscopic sinus surgery (ESS) has become a widely accepted procedure for medically refractory chronic rhinosinusitis and nasal polyps. Prevention of revision surgery often depends on good wound healing and less adhesion formation. Read More

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