10,198 results match your criteria procedures pumps

Predictors of the effectiveness of insulin pumps in patients with type 1 diabetes mellitus.

Endocrine 2021 Aug 2. Epub 2021 Aug 2.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal.

Purpose: Insulin pump therapy has become the preferential treatment for type 1 diabetes (T1D) as it mimics the physiological secretion of insulin better than multiple daily injections. However, not all patients improve with insulin pump therapy. This study aims to determine the predictors of the effectiveness of insulin pumps in T1D. Read More

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Investigation of the , , , , and efflux pump genes expression among multidrug-resistant clinical isolates.

Heliyon 2021 Jul 12;7(7):e07566. Epub 2021 Jul 12.

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Different resistance mechanisms for multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) have been reported. Although mutations in target genes are the main cause of drug resistance, efflux pumps (Eps) also play an important role in this process. Here, we investigated the overexpression of five putative EP genes plus gene mutations in MDR-TB clinical isolates. Read More

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Inkk Trial - Intraoperative ketamine for perioperative pain management following total knee endoprosthetic replacement in oncology: a double-blinded randomized trial.

Braz J Anesthesiol 2021 Jul 28. Epub 2021 Jul 28.

Tata Memorial Hospital and Homi Bhabha National Institute, Department of Physiotherapy, Mumbai, India.

Background: There has been a growing interest in the use of ketamine following orthopedic surgeries. We hypothesized that low dose intravenous ketamine during surgery would help in mobilization following total knee replacement (TKR) in oncology patients as assessed by the timed to up and go (TUG) test at 72 hours post-surgery. Our secondary objectives were to compare the opioid requirement at end of 72 hours, pain scores, satisfaction with pain management, adverse effects, range of joint movement achieved in the post-operative period and the functional recovery at the end of 1 month. Read More

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Type 1 diabetes glycemic management: Insulin therapy, glucose monitoring, and automation.

Science 2021 07;373(6554):522-527

Department of Endocrinology, UZ Gasthuisberg, Katholieke Universiteit Leuven (KULeuven), Leuven, Belgium.

Despite innovations in insulin therapy since its discovery, most patients living with type 1 diabetes do not achieve sufficient glycemic control to prevent complications, and they experience hypoglycemia, weight gain, and major self-care burden. Promising pharmacological advances in insulin therapy include the refinement of extremely rapid insulin analogs, alternate insulin-delivery routes, liver-selective insulins, add-on drugs that enhance insulin effect, and glucose-responsive insulin molecules. The greatest future impact will come from combining these pharmacological solutions with existing automated insulin delivery methods that integrate insulin pumps and glucose sensors. Read More

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Oral Misoprostol alone versus oral misoprostol followed by oxytocin for labour induction in women with hypertension in pregnancy (MOLI): protocol for a randomised controlled trial.

BMC Pregnancy Childbirth 2021 Jul 29;21(1):537. Epub 2021 Jul 29.

Department of Women's and Children's Health, Liverpool Women's Hospital, University of Liverpool, Crown Street, Liverpool, L8 7SS, UK.

Background: Every year approximately 30,000 women die from hypertensive disease in pregnancy. Magnesium sulphate and anti-hypertensives reduce morbidity, but delivery is the only cure. Low dose oral misoprostol, a prostaglandin E1 analogue, is a highly effective method for labour induction. Read More

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Unexpectedly Poor Growth in Pediatric Patients on Food-Based Enteral Therapy: Case Series and Suggested Practice Changes.

J Pediatr Gastroenterol Nutr 2021 Jul 27. Epub 2021 Jul 27.

Nationwide Children's Hospital Dartmouth-Hitchcock Medical Center.

Introduction: Enteral feeding pumps at times may deliver different volumes than are prescribed, which can negatively impact growth, nutrition, and well-being. This study sought to assess whether challenges with pump accuracy for patients on food-based formulas contributed to challenges with weight gain.

Methods: Chart review identified complex feeding patients receiving food-based enteral nutrition via feeding pump with unexpected weight loss. Read More

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Leaf infiltration in plant science: old method, new possibilities.

Plant Methods 2021 Jul 28;17(1):83. Epub 2021 Jul 28.

Department of Plant Physiology and Biotechnology, Faculty of Biology, University of Gdańsk, ul. Wita Stwosza 59, 80-308, Gdańsk, Poland.

The penetration of substances from the surface to deep inside plant tissues is called infiltration. Although various plant tissues may be effectively saturated with externally applied fluid, most described infiltration strategies have been developed for leaves. The infiltration process can be spontaneous (under normal atmospheric pressure) or forced by a pressure difference generated between the lamina surface and the inside of the leaf. Read More

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Examination of Adult Spinal Deformity Patients Undergoing Surgery with Implanted Spinal Cord Stimulators and Intrathecal Pumps.

Spine (Phila Pa 1976) 2021 Jul 23. Epub 2021 Jul 23.

Department of Orthopaedics, Warren Alpert Medical School, Brown University, Providence, RI Warren Alpert Medical School, Brown University, Providence, RI Brown University, Providence, RI Hospital for Special Surgery, New York, NY University of Pittsburgh Medical Center, Pittsburgh, PA Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY University of Virginia Health System, Charlottesville, VA Duke University, Durham, NC Washington University, St. Louis, MO University of California-Davis, Sacramento, CA Norton Leatherman Spine Center, Louisville, KY Scripp's Clinic, La Jolla, CA Johns Hopkins University, Baltimore, MD University of Calgary Spine Program, University of Calgary, Alberta Department of Orthopaedic Surgery, Baylor Scoliosis Center, Dallas, TX University of Kansas Hospital, Kansas City, KS Denver International Spine Center, Denver, CO University of California-San Francisco, CA Swedish Neuroscience Institute, Seattle, WA.

Study Design: Retrospective cohort study of a prospectively collected multi-center database of adult spinal deformity (ASD) patients.

Objective: We hypothesized that patients undergoing ASD surgery with and without previous SCS/ITP would exhibit increased complication rates but comparable improvement in HRQOL.

Summary Of Background Data: ASD patients sometimes seek pain management with spinal cord stimulators (SCS) or intrathecal medication pumps (ITP) prior to spinal deformity correction. Read More

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Diabetes distress and glycaemic control in young adults with type 1 diabetes: associations by use of insulin pumps and continuous glucose monitors.

Diabet Med 2021 Jul 26:e14660. Epub 2021 Jul 26.

Columbia-Bassett Program, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Aims: We determined whether high diabetes distress (DD) in young adults with type 1 diabetes was associated with higher glycated haemoglobin (HbA ) levels and whether this association was similar among those who were and were not using diabetes devices (insulin pumps and/or continuous glucose monitors [CGMs]).

Methods: In 2017 an online survey was completed by 423 of 743 (57%) young adults (19-31 years) with type 1 diabetes receiving care at a specialty clinic in New York City. HbA level was the primary outcome measure, and high DD (Diabetes Distress Scale score ≥3) was the primary exposure. Read More

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Complete Revascularisation in Impella-Supported Infarct-Related Cardiogenic Shock Patients Is Associated With Improved Mortality.

Front Cardiovasc Med 2021 9;8:678748. Epub 2021 Jul 9.

Department of Cardiology, University Heart Center, Bonn, Germany.

Acute myocardial infarction-related cardiogenic shock (AMI-CS) still has high likelihood of in-hospital mortality. The only trial evidence currently available for the intra-aortic balloon pump showed no benefit of its routine use in AMI-CS. While a potential benefit of complete revascularisation has been suggested in urgent revascularisation, the CULPRIT-SHOCK trial demonstrated no benefit of multivessel compared to culprit-lesion only revascularisation in AMI-CS. Read More

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Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.

Phytomedicine 2021 Jul 9:153626. Epub 2021 Jul 9.

Instituto de Biología Molecular y Celular (IBMC) and Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (UMH), 03202 Elche, Spain; CIBER: CB12/03/30038, Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.

Background: Antibiotic-resistant bacteria pose a global health threat. Traditional antibiotics can lose their effectiveness, and the development of novel effective antimicrobials has become a priority in recent years. In this area, plants represent an invaluable source of antimicrobial compounds with vast therapeutic potential. Read More

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The Future of Bacteriophage Therapy Will Promote Antimicrobial Susceptibility.

mSystems 2021 Jul 20:e0021821. Epub 2021 Jul 20.

Department of Civil and Environmental Engineering, Northwestern Universitygrid.16753.36, Evanston, Illinois, USA.

Rising antimicrobial resistance severely limits efforts to treat infections and is a cause for critical concern. Renewed interest in bacteriophage therapy has advanced understanding of the breadth of species capable of targeting bacterial antimicrobial resistance mechanisms, but many questions concerning ideal application remain unanswered. The following minireview examines bacterial resistance mechanisms, the current state of bacteriophage therapy, and how bacteriophage therapy can augment strategies to combat resistance with a focus on the clinically relevant bacterium Pseudomonas aeruginosa, as well as the role of efflux pumps in antimicrobial resistance. Read More

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Mechanisms Underlying Poststimulation Block Induced by High-Frequency Biphasic Stimulation.

Neuromodulation 2021 Jul 19. Epub 2021 Jul 19.

Department of Urology, University of Pittsburgh, Pittsburgh, PA, USA.

Objective: To reveal the possible mechanisms underlying poststimulation block induced by high-frequency biphasic stimulation (HFBS).

Materials And Methods: A new axonal conduction model is developed for unmyelinated axons. This new model is different from the classical axonal conduction model by including both ion concentrations and membrane ion pumps to allow analysis of axonal responses to long-duration stimulation. Read More

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Interchangeability of periplasmic adaptor proteins AcrA and AcrE in forming functional efflux pumps with AcrD in Salmonella enterica serovar Typhimurium.

J Antimicrob Chemother 2021 Jul 19. Epub 2021 Jul 19.

Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Background: Resistance-nodulation-division (RND) efflux pumps are important mediators of antibiotic resistance. RND pumps, including the principal multidrug efflux pump AcrAB-TolC in Salmonella, are tripartite systems with an inner membrane RND transporter, a periplasmic adaptor protein (PAP) and an outer membrane factor (OMF). We previously identified the residues required for binding between the PAP AcrA and the RND transporter AcrB and have demonstrated that PAPs can function with non-cognate transporters. Read More

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Genomic characterization of multidrug-resistant Bacillus toyonensis strain 4HC1 isolated from marine plastic in Norway.

J Glob Antimicrob Resist 2021 Jul 14. Epub 2021 Jul 14.

Institute of Marine Research, 5005 Bergen, Norway. Electronic address:

Objectives: Bacillus toyonensis is widespread in nature. Multidrug-resistant B. toyonensis strain 4HC1 was isolated from polyethylene submerged in the water column near a beach in Øygarden, Norway. Read More

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Longitudinal Observation of Insulin use and glucose Sensor metrics in Pregnant women with type 1 diabetes using continuous glucose monitors and insulin pumps: The LOIS-P Study.

Diabetes Technol Ther 2021 Jul 16. Epub 2021 Jul 16.

Harvard University, 29 Oxford St., Cambridge, Massachusetts, United States, 02138.

Background: Suboptimal glycemic control is associated with maternal and neonatal morbidity and mortality in pregnancy complicated by type 1 diabetes (T1D). Prospective analysis of continuous glucose monitor (CGM) metrics, insulin pump settings, and insulin delivery can better characterize the changes in glycemic levels and insulin use throughout pregnancy with T1D.

Materials And Methods: Prescribed parameters, insulin delivery, carbohydrate intake, and CGM data for 25 pregnant women with T1D from three US sites were collected biweekly. Read More

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[Establishment of a Needle-Removal Method Considering Anticancer Drug Exposure after Continuous Administration of Fluorouracil Using an Infusion Pump].

Gan To Kagaku Ryoho 2021 Jul;48(7):939-943

Dept. of Pharmacy, Nitobe Memorial Nakano General Hospital.

In recent years, attention has been focused on environmental exposure of anticancer drugs, and guidelines for occupational exposure measures in cancer drug therapy have been created in Japan. Exposure measures related to the preparation and administration of anticancer drugs are being standardized. Although exposure measures have been implemented for the preparation and administration of the infusion pump(IP)used for continuous fluorouracil administration for 46-hour in FOLFOX and FOLFIRI therapies, which are standard chemotherapies for colorectal cancer, needle-removal procedures after the end of administration have not been investigated. Read More

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Expect the Unexpected: Adolescent and Pre-teens' Experience of Diabetes Technology Self-Management.

Pediatr Diabetes 2021 Jul 15. Epub 2021 Jul 15.

The Ohio State University College of Nursing, Columbus, OH.

Objective: Only 17% of adolescents with type 1 diabetes (T1D) are currently meeting their glycemic targets despite advances in diabetes technologies. Self-management behaviors and challenges specific to use of diabetes technologies are insufficiently studied in adolescents. We aimed to describe the experience of diabetes technology self-management, including facilitators and barriers, among preteens/adolescents with low and high A1C. Read More

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Combined extracorporeal membrane oxygenation and microaxial pump-when left ventricular preload is too low to unload in cardiogenic shock.

Health Sci Rep 2021 Sep 9;4(3):e321. Epub 2021 Jul 9.

Intensive Care Unit, Medizinische Klinik und Poliklinik I Klinikum der Universität München Munich Germany.

Purpose: Severe cardiogenic shock is the major driver of mortality on cardiologic intensive care units. Novel therapeutic options like extracorporeal membrane oxygenation (ECMO) or the combination of ECMO and a percutaneous microaxial pump like Impella CP (ECMELLA) are promising Options. Here we want to focus on the question what happens when left ventricular preload is too low to unload in cardiogenic shock in patients with ECMELLA and this aspect is illustrated by transesophageal echocardiography. Read More

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September 2021

Small-Angle Neutron Scattering Characterization of SrCl-ENG Composites for Thermochemical Heat Storage.

ACS Appl Mater Interfaces 2021 Jul 14;13(29):34213-34226. Epub 2021 Jul 14.

Department of Energy Conversion and Storage, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.

This work presents an in situ nanoscale structural characterization of a SrCl-expanded natural graphite (ENG) composite during ammonia absorption and desorption using small-angle neutron scattering (SANS) together with X-ray powder diffraction and sorption measurements. For the processing of the composite material SANS patterns, we developed and implemented two methods, which showed comparable results. The study allowed following the evolution of the SrCl particles and the nanopores inside the particles during five sorption cycles. Read More

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Impact of smart pump-electronic health record interoperability on patient safety and finances at a community hospital.

Am J Health Syst Pharm 2021 Jul 14. Epub 2021 Jul 14.

Department of Pharmacy, Houston Methodist Hospital System, Houston, TX, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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Genome Features and Activity against Influenza A and SARS-CoV-2 Viruses of Six Probiotic Strains.

Biomed Res Int 2021 18;2021:6662027. Epub 2021 Jun 18.

Vector State Research Centre of Virology and Biotechnology, Koltsovo, Novosibirsk Region 630559, Russia.

Purpose: The aim of this work was to analyze the complete genome of probiotic bacteria 8 RA 3, 90 TC-4, 39, 791, 1, and 379 and to test their activity against influenza A and SARS-CoV-2 viruses.

Methods: To confirm the taxonomic affiliation of the bacterial strains, MALDI TOF mass spectrometry and biochemical test systems were used. Whole genome sequencing was performed on the Illumina Inc. Read More

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Short-Term Outcomes of a High-Volume, Low-Concentration Bolus Starting Dose Technique With Ziconotide: A Case Series.

David Lindley

Neuromodulation 2021 Jul 12. Epub 2021 Jul 12.

Dozier Pain Management, Abilene, TX, USA.

Background And Objectives: There have been numerous recommendations for a starting dose of intrathecal ziconotide. The therapy remains underutilized partially due to reports of inefficacy and/or intolerance. This study describes short-term outcomes of a high-volume, low-concentration bolus (HVLC-B) ziconotide starting dose technique for patients with chronic spine pain. Read More

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Effect of Food on the Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of Tegoprazan.

Clin Ther 2021 Jul 7. Epub 2021 Jul 7.

Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan, Seoul, Korea. Electronic address:

Purpose: Tegoprazan is a potassium-competitive acid blocker (P-CAB) that is designed to treat acid-related diseases through a fundamentally different mechanism than that of proton pump inhibitors (PPIs). Because PPIs inhibit only activated parietal cell H/K adenosine triphosphatase, stimulation of parietal cells by a meal is necessary for optimal results. In contrast, P-CABs can inactivate proton pumps without acid activation and bind to both activated and inactivated adenosine triphosphatase. Read More

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Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea.

J Antimicrob Chemother 2021 Jul 10. Epub 2021 Jul 10.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Background: Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections has proven particularly challenging, with most reported treatment failures of the first-line drug ceftriaxone occurring at this site and lower cure rates in recent trials of new antibiotics reported for oropharyngeal infections compared with other sites of infection. Read More

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Epidemiology of skin event rates among users of pumps for the subcutaneous administration of drugs for chronic conditions.

Curr Med Res Opin 2021 Jul 20:1-9. Epub 2021 Jul 20.

Clinical Development, AbbVie, Inc., North Chicago, IL, USA.

Objective: To provide the epidemiology of skin events occurring during long-term administration of medications delivered by continuous subcutaneous infusion pump (CSIP) systems as background rates for the development of novel CSIP treatments to use in community-based settings.

Methods: Using a United Kingdom general practice database, we conducted a study to assess the rates of skin events among new users of apomorphine and insulin delivered by CSIP in patients with Parkinson's disease or diabetes, respectively. Skin events included skin infections, skin nodules/localized swelling, dermatitis/eczema, urticaria/erythema, and rash/other non-specific skin eruptions. Read More

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Measuring Efflux and Permeability in Mycobacteria.

Methods Mol Biol 2021 ;2314:231-245

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisbon, Portugal.

Mycobacteria are intrinsically resistant to most antimicrobials, which is generally attributed to the impermeability of their cell wall that considerably limits drug uptake. Moreover, like in other pathogenic bacteria, active efflux systems have been widely characterized from diverse mycobacterial species in laboratory conditions, showing that they can promote resistance by extruding noxious compounds prior to their reaching their intended targets. Therefore, the intracellular concentration of a given compound is determined by the balance between permeability, influx, and efflux. Read More

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January 2021

Genetic Characterisation of Colistin Resistant Clinical Isolates From North India.

Front Cell Infect Microbiol 2021 21;11:666030. Epub 2021 Jun 21.

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Background: Increasing use of colistin has led to the world-wide emergence of mobile colistin resistant gene (). The present study aimed to identify and characterise mcr and other drug-resistant genes in colistin resistant clinical isolates.

Methods: Twenty-two colistin resistant were analysed for mcr and other drug-resistant genes, efflux pumps, and virulence genes, and for their biofilm forming ability. Read More

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[Research progress on analytical methods for the determination of hexachlorobutadiene].

Se Pu 2021 Jan;39(1):46-56

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Hexachlorobutadiene (HCBD) is one of persistent organic pollutants (POPs) listed in Annex A and Annex C of the Stockholm Convention in 2015 and 2017, respectively. Research on the sources, environmental occurrences, and biological effects of HCBD has a great significance in controlling this newly added POPs. Sensitive and credible methods for the determination of HCBD are preconditions and form the basis for related research work. Read More

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January 2021