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Evaluating a standardized protocol for the management of diabetes insipidus in pediatric neurosurgical patients.

J Pediatr Endocrinol Metab 2021 Sep 27. Epub 2021 Sep 27.

Department of Pediatrics, Division of Endocrinology, University of Tennessee Health Sciences Center, Memphis, TN, USA.

Objectives: Central diabetes insipidus (DI) is a known complication following surgical resection of a suprasellar mass. There are limited data analyzing the outcomes of a standardized protocol for the management of postoperative DI in the pediatric population. We sought to fill this gap and hypothesized that utilizing a standardized protocol for fluid management (3-bag system) would reduce serum sodium fluctuations in the postoperative period after suprasellar surgery. Read More

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September 2021

Regulation of Immunity in Clear Cell Renal Carcinoma: Role of PD-1, PD-L1, and PD-L2.

Curr Issues Mol Biol 2021 Sep 6;43(2):1072-1080. Epub 2021 Sep 6.

Cancer Research Institute, Tomsk National Research Medical Center, 634050 Tomsk, Russia.

Regulation of immunity is a unique oncogenic mechanism that differs in different cancers. VHL deficient clear cell renal cell carcinomas (ccRCC) trigger the immune response resulting in cancer progression. This study aimed to investigate PD-1, PD-L1, and PD-L2 expression in ccRCC primary cancers and metastatic tissues associated with the p-VHL content, transcriptional, and growth factors expression. Read More

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September 2021

Post-COVID-19 Necrotizing Pneumonia in Patients on Invasive Mechanical Ventilation.

Infect Dis Rep 2021 Sep 8;13(3):835-842. Epub 2021 Sep 8.

Department of Medicine, Division of Infectious Diseases, Universidad Pontificia Bolivariana, Medellín, Colombia.

(1) Background: Few reports of necrotizing pneumonia in patients with COVID-19 have been published. We have observed an elevated incidence at two hospitals in our city, suggesting this complication is not uncommon, and may have been overlooked. (2) Methods: This article presents a retrospective, descriptive cohort study that was undertaken from 22 March 2020 to 15 June 2021 in two tertiary care hospitals in Medellín, Colombia. Read More

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September 2021

Stereoscopic Visual Perceptual Learning in Seniors.

Geriatrics (Basel) 2021 Sep 18;6(3). Epub 2021 Sep 18.

Interdisciplinary Center of Ophthalmic Preventive Medicine and Imaging, Department of Ophthalmology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.

Background: We showed that seniors can improve their stereoscopic ability (stereoacuity) and corresponding reaction time with repetitive training and, furthermore, that these improvements through training are still present even after a longer period of time without training.

Methods: Eleven seniors (average age: 85.90 years) trained twice a week for six weeks with dynamic stereoscopic perception training using a vision training apparatus (c-Digital Vision Trainer). Read More

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September 2021

The Mini-Cog, Clock Drawing Test, and Three-Item Recall Test: Rapid Cognitive Screening Tools with Comparable Performance in Detecting Mild NCD in Older Patients.

Geriatrics (Basel) 2021 Sep 16;6(3). Epub 2021 Sep 16.

Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Background: Early mild neurocognitive disorder (mild NCD) detection can allow for appropriate planning and delay disease progression. There have been few studies examining validated mild NCD detection tools. One such tool that may be of use is the Mini-Cog, which consists of the clock drawing test (CDT) and three-item recall. Read More

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September 2021

Argon Bioactivation of Implants Installed Simultaneously to Maxillary Sinus Lifting without Graft. An Experimental Study in Rabbits.

Dent J (Basel) 2021 Sep 6;9(9). Epub 2021 Sep 6.

Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, Brazil.

Background: The treatment of the surface of titanium implants with argon plasma improved its hydrophilicity and cell adhesion, resulting in higher bone apposition on implant and graft surfaces. The spontaneous perforation over time of the sinus mucosa after sinus augmentation has been documented in experimental studies at both implants and graft particles. The aim of the present study was to evaluate the influence of plasma argon treatment of the implant surface on bone apposition and on the rate of sinus mucosa perforations. Read More

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September 2021

Improved Repopulation Efficacy of Decellularized Small Diameter Vascular Grafts Utilizing the Cord Blood Platelet Lysate.

Bioengineering (Basel) 2021 Aug 27;8(9). Epub 2021 Aug 27.

Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou Street, 115 27 Athens, Greece.

Background: The development of functional bioengineered small-diameter vascular grafts (SDVGs), represents a major challenge of tissue engineering. This study aimed to evaluate the repopulation efficacy of biological vessels, utilizing the cord blood platelet lysate (CBPL).

Methods: Human umbilical arteries (hUAs, = 10) were submitted to decellularization. Read More

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Advancement in Detection Methods: From Conventional to Electrochemical-Based Sensing Detection.

Biosensors (Basel) 2021 Sep 18;11(9). Epub 2021 Sep 18.

Collaborative Microelectronic Design Excellence Centre (CEDEC), [email protected], Universiti Sains Malaysia, Level 1, Block C, No. 10 Persiaran Bukit Jambul, Bayan Lepas 11900, Malaysia.

Large-scale food-borne outbreaks caused by are rarely seen nowadays, thanks to the advanced nature of the medical system. However, small, localised outbreaks in certain regions still exist and could possess a huge threat to the public health if eradication measure is not initiated. This review discusses the progress of detection approaches covering their basic principles, characteristics, applications, and performances. Read More

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September 2021

Objectively Measured Physical Activity in Patients with Coronary Artery Disease: A Cross-Validation Study.

Biosensors (Basel) 2021 Sep 6;11(9). Epub 2021 Sep 6.

Division of Cardiology, General Hospital Murska Sobota, 9000 Murska Sobota, Slovenia.

Physical activity (PA) and sedentary behavior (SB) levels in healthy adults are predominately based on self-reporting measures, which generally overestimate PA but underestimate SB. Patients with coronary artery disease (CAD) eligible for cardiac rehabilitation (CR) follow an individualized program; thus, objective assessment of physical performance and regular daily activity is required. This study aimed to compare self-reported and objectively measured PA and SB in patients with CAD prior to out-patient CR. Read More

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September 2021

Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011-2016).

Diabetes Metab Syndr 2021 Sep 11;15(6):102280. Epub 2021 Sep 11.

Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background And Aims: Reproductive-aged women are prone to type 2 diabetes mellitus. This study aims to evaluate the optimal cut off point of Triglyceride/Glucose Index for predicting glucose status conversion among women of reproductive age.

Methods: This study involved normoglycemic and prediabetes women aged 20-49 years from the Bogor Non-Communicable Diseases Cohort Study (West Java, Indonesia) conducted from 2011 to 2016. Read More

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September 2021

Evaluation of the safety and efficacy of Advax as an adjuvant: A systematic review and meta-analysis.

Adv Med Sci 2021 Sep 22;67(1):10-17. Epub 2021 Sep 22.

Institute of Health Sciences, Interdisciplinary Food, Metabolism and Clinical Nutrition Department, Ankara University Faculty of Medicine, Ankara, Turkey; Department of Pathophysiology, Faculty of Medicine, Ankara University, Ankara, Turkey. Electronic address:

Purpose: Developing a vaccine with improved immunogenicity is still a growing priority for many diseases. Different types of adjuvants may be beneficial to initiate and maintain the long-lasting immunogenicity of vaccines. Evidence has shown that polysaccharide adjuvants are efficient in improving immunological mechanisms with their biocompatibility and biodegradability characteristics. Read More

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September 2021

Effectiveness of technology-assisted cardiac rehabilitation: A systematic review and meta-analysis.

Int J Nurs Stud 2021 Sep 5;124:104087. Epub 2021 Sep 5.

The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.

Objectives: The objectives of this review were to identify different technology-assisted interventions in cardiac rehabilitation, to explore and examine the effectiveness of technology-assisted cardiac rehabilitation.

Design: A systematic review and meta-analysis.

Methods: A systematic search was performed on six electronic databases: CINALH Complete, Cochrane Library, PubMed, MEDLINE via OvidSP, British Nursing Index and PsycINFO to identify randomised controlled trials from 2010 to 2020. Read More

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September 2021

Partial Latissimus Dorsi Muscle Flap With Implant for Immediate Breast Reconstruction.

J Surg Res 2021 Sep 22;269:134-141. Epub 2021 Sep 22.

Department of Breast Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology and Hubei Provincial Clinical Research Center for Breast Cancer, Wuhan, China; Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis and Treatment, Wuhan, China. Electronic address:

Purpose: Latissimus dorsi flap is a widely used technique in breast reconstruction. Here we describe a modified method, the partial latissimus dorsi muscle flap with vertical incision for immediate implant-based breast reconstruction which has been used at our institution since 2014. Our primary objective is to determine the safety, prognostic benefit, and cosmetic outcome of this surgical procedure. Read More

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September 2021

Prognostic role of USP7 expression in cancer patients: A systematic review and meta-analysis.

Pathol Res Pract 2021 Sep 17;227:153621. Epub 2021 Sep 17.

College of Creative Studies, Niigata University, 8050 Ikarashi-nino-cho, Nishi-ku, Niigata 950-2181, Japan. Electronic address:

Background: Numerous studies have examined the prognostic value of ubiquitin-specific protease 7 (USP7) in cancer, but the results remain controversial. Differences in assessment assays (mRNA/protein) used could be a potential confounding factor. Thus, we extracted studies that measured the protein expression and performed a meta-analysis to assess the prognostic role of USP7 expression in cancer and to identify clinicopathological features associated with USP7 expression. Read More

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September 2021

CircPTK2 inhibits the tumorigenesis and metastasis of gastric cancer by sponging miR-134-5p and activating CELF2/PTEN signaling.

Pathol Res Pract 2021 Sep 14;227:153615. Epub 2021 Sep 14.

Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth people's Hospital, Shanghai 200233, PR China. Electronic address:

Background: CircRNAs are a new subset of noncoding RNAs formed by covalent closed loops and play crucial roles in the regulation of cancer gene expression. However, the roles and underlying mechanisms of circRNAs in gastric cancer (GC) remain indistinct. This study aimed to explore the role and mechanism of hsa_circ_0006421 (circPTK2) in GC. Read More

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September 2021

c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma: a systematic review and one-arm meta-analysis.

Eur J Cancer 2021 Sep 22;157:348-357. Epub 2021 Sep 22.

Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany; Comprehensive Cancer Center Erlangen - European Metropolitan Region of Nuremberg, Erlangen, Germany. Electronic address:

Background: Activating genomic alterations of the receptor tyrosine kinase KIT are found preferentially in certain melanoma subtypes such as acral and mucosal melanoma or melanoma arising in chronically sun-damaged skin. However, the therapeutic value of c-Kit inhibitors for these subtypes currently remains unclear.

Objectives: The objective of this study was to summarise the efficacy and safety of c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma. Read More

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September 2021

Association between osteosarcopenia and cognitive frailty in older outpatients visiting a frailty clinic.

Arch Gerontol Geriatr 2021 Sep 17;98:104530. Epub 2021 Sep 17.

Department of Geriatric Medicine, Hospital, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi 474-8511, Japan. Electronic address:

Purpose: Osteosarcopenia and cognitive frailty are both risk factors for falls and fractures. The purpose of this study was to determine the association between osteosarcopenia and cognitive frailty.

Materials And Methods: This was a cross-sectional secondary data analysis of the Frailty Registry Study with outpatients aged ≥65 years who visited a frailty clinic at a geriatric hospital. Read More

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September 2021

Aspirin and growth, rupture of unruptured intracranial aneurysms: A systematic review and meta-analysis.

Clin Neurol Neurosurg 2021 Sep 17;209:106949. Epub 2021 Sep 17.

Department of Neurosurgery, Qinghai Provincial People's Hospital, Xining, Qinghai, China. Electronic address:

Objectives: Aspirin has been suggested as a potential therapeutic strategy to prevent the growth and rupture of unruptured intracranial aneurysms (UIAs), but there is still controversy. The aim of this systematic review and meta-analysis is to determine the association between aspirin use and growth, rupture of UIAs.

Methods: We performed a systematic literature search of electronic databases to identify cohort and case-control studies investigating the relationship between aspirin use and growth or rupture of UIAs. Read More

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September 2021

Bibliometric analysis of mental health during the COVID-19 pandemic.

Asian J Psychiatr 2021 Sep 21;65:102846. Epub 2021 Sep 21.

School of Nursing, Tianjin Medical University, Tianjin, China. Electronic address:

Background: As a global pandemic, coronavirus disease 2019 (COVID-19) has had a profound effect on public mental health.

Methods: Publications related to mental health during the COVID-19 pandemic from December 1, 2019, to November 13, 2020, were extracted from the Web of Science database. Bibliometric indicator analysis was performed using VOSviewer 1. Read More

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September 2021

Alterations of serum trace elements and other biochemical parameters are correlated with the pathogenesis of systemic lupus erythematosus: A preliminary study on Bangladeshi population.

J Trace Elem Med Biol 2021 Sep 20;68:126861. Epub 2021 Sep 20.

Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh. Electronic address:

Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder in which the body's defense system wrongly attacks healthy body tissues. The objective of this current setup was to quantify and compare the serum concentration of ascorbic acid (Vit-C), malondialdehyde (MDA), c-reactive protein (CRP) and trace elements (Cu, Fe, Mn and Zn) in SLE and normal subjects.

Methods: The proposed case-control study was performed with 25 SLE patients and 25 healthy subjects as case and control, respectively. Read More

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September 2021

iR5hmcSC: Identifying RNA 5-hydroxymethylcytosine with multiple features based on stacking learning.

Comput Biol Chem 2021 Sep 20;95:107583. Epub 2021 Sep 20.

School of Mathematics and Statistics, Xidian University, Xi'an 710071, PR China.

RNA 5-hydroxymethylcytosine (5hmC) modification is the basis of the translation of genetic information and the biological evolution. The study of its distribution in transcriptome is fundamentally crucial to reveal the biological significance of 5hmC. Biochemical experiments can use a variety of sequencing-based technologies to achieve high-throughput identification of 5hmC; however, they are labor-intensive, time-consuming, as well as expensive. Read More

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September 2021

Lesions of the cerebello-thalamic tract rather than the ventral intermediate nucleus determine the outcome of focused ultrasound therapy in essential tremor: A 3T and 7T MRI-study.

Parkinsonism Relat Disord 2021 Sep 20;91:105-108. Epub 2021 Sep 20.

Department of Neurology, University Hospital Bonn, Germany; German Centre of Neurodegenerative Diseases (DZNE), Bonn, Germany.

Introduction: The ventral intermediate nucleus of the thalamus (VIM) is an important relay station receiving cerebellar and pallidal fiber tracts. Data on structural visualization of the VIM however is limited and uncertainty prevails to what extent lesional approaches to treat tremor affect the VIM itself or passing tracts. The aim of the study was to analyze the localization of individual lesions with respect to the VIM and the cerebello-thalamic tract (CTT). Read More

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September 2021

Successful continuous positive airway pressure treatment reduces skin sympathetic nerve activity in patients with obstructive sleep apnea.

Heart Rhythm 2021 Sep 22. Epub 2021 Sep 22.

Indiana University Health Physicians, Indianapolis, IN, USA. Electronic address:

Background: Obstructive sleep apnea (OSA) is associated with cardiovascular diseases and increased sympathetic tone. We previously demonstrated that OSA patients have increased skin sympathetic nerve activity (SKNA).

Objectives: To test the hypothesis that continuous positive airway pressure (CPAP) treatment reduces SKNA. Read More

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September 2021

Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet.

Mol Metab 2021 Sep 22:101328. Epub 2021 Sep 22.

First Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. Electronic address:

Objective: Expansion of adipose tissue during obesity through the recruitment of newly-generated adipocytes (hyperplasia) is metabolically healthy, whereas that through the enlargement of pre-existing adipocytes (hypertrophy) leads to metabolic complications. Accumulating evidence from genetic fate mapping studies suggests that in animal models receiving a high-fat diet (HFD), only adipocyte progenitors (APs) in gonadal white adipose tissue (gWAT) have proliferative potential. However, the proliferative potential and differentiating capacity of APs in the inguinal WAT (iWAT) of male mice remains controversial. Read More

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September 2021

Clinical Implications of a Targeted RNA Sequencing Panel in the Detection of Gene Fusions in Solid Tumors.

J Mol Diagn 2021 Sep 22. Epub 2021 Sep 22.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

The detection of recurrent gene fusions can help confirm diagnoses in solid tumors, particularly when the morphology and staining are unusual or nonspecific, and can guide therapeutic decisions. While fluorescence in situ hybridization (FISH) and PCR are often used to identify fusions, the rearrangement must be suspected, with only a few prioritized probes run. We hypothesized that the Illumina TruSight RNA Fusion Panel, which detects fusions of 507 genes and their partners, would uncover fusions with greater sensitivity than other approaches, leading to changes in diagnosis, prognosis, or therapy. Read More

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September 2021

WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.

Biochim Biophys Acta Mol Basis Dis 2021 Sep 22:166271. Epub 2021 Sep 22.

Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China. Electronic address:

Background: Recurrence and metastasis are the major problems of bladder urothelial carcinoma, which mainly attribute to tumor cell stemness, epithelial-mesenchymal transition (EMT) and chemoresistance.

Methods: TCGA database was interrogated for gene mRNA expression in bladder urothelial carcinoma samples. CCLE database was interrogated for gene mRNA expression in bladder cancer cell lines. Read More

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September 2021

The Effect of Race, Socioeconomic Status, and Comorbidity on Patients Afflicted with COVID 19: A Local Perspective.

Ann Epidemiol 2021 Sep 22. Epub 2021 Sep 22.

Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Department of Medicine, Tulane University School of Medicine, New Orleans, LA. Electronic address:

Purpose: The aim of this study is to further examine the associations of race, socioeconomic factors, and comorbidity with COVID-19 health outcomes.

Methods: This is a retrospective cohort study of 309 PCR confirmed COVID-19 positive adults who presented to Tulane Medical Center in New Orleans, LA, from March 9 to May 29, 2020. The primary outcomes investigated were need for invasive mechanical ventilation (IMV) and in-hospital mortality. Read More

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September 2021

Establishing and Maintaining a Remote Vascular Surgery Aortic Program, A Single-Center Five-Year Experience at the Veterans Affairs.

J Vasc Surg 2021 Sep 22. Epub 2021 Sep 22.

Division of Vascular & Endovascular Surgery, Department of Surgery, University of Miami Miller School of Medicine & Miami VAMC. Electronic address:

Objective: To detail the process of establishing a vascular surgery aortic telehealth program and to report the outcomes of a five-year experience.

Methods: A telehealth program was established between two regional Veterans Affairs (VA) hospitals, one of which was without a comprehensive aortic surgical program, until such a program was established at the referring institution. A retrospective review was performed of all patients who underwent aortic surgery between 2014 and 2019. Read More

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September 2021

Evaluating the optimal training paradigm for transcarotid artery revascularization based on worldwide experience.

J Vasc Surg 2021 Sep 22. Epub 2021 Sep 22.

Department of Medicine, Univ of Maryland, Baltimore, MD.

Background: Transcarotid artery revascularization (TCAR) is new a hybrid approach to carotid artery revascularization. Proctored training on live cases is an effort-, time-, and resource-intensive approach to learning new procedures. We analyzed the worldwide experience with TCAR to develop objective performance metrics for the procedure, and compared the effectiveness of training physicians on cadavers or synthetic models to traditional in-person training on live cases. Read More

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September 2021