43,799 results match your criteria procedures guangdong


Diverse risk-avoidance behaviors in DISC1 mice are associated with different neuronal firing patterns in BLA neurons.

Biochem Biophys Res Commun 2021 Nov 29;587:107-112. Epub 2021 Nov 29.

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China; University of Chinese of Academy of Sciences, Beijing, 100049, China. Electronic address:

It is very important to maintain normal levels of risk avoidance in daily life. We found that DISC1-N mice, which are a model for mental disorders, had a phenotype marked by a risk-avoidance impairment as measured in an open-field test (OFT). We used optogenetic methods to modulate glutamatergic neurons in the basolateral amygdala (BLA) in an attempt to rescue this risk-avoidance impairment. Read More

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November 2021

Optimal time-points for detecting expression levels of BAALC, EVI1, and WT1 genes in patients with acute myeloid leukemia: a meta-analysis.

Hematology 2021 Dec;26(1):995-1006

Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Objectives: This meta-analysis examined the prognostic role of brain and acute leukemia, cytoplasmic (BAALC), Ecotropic virus integration site-1 (EVI1) and Wilms' tumor 1 (WT1) genes at different time-points during conventional chemotherapy.

Methods: A systematic search of publications indexed in the electronic databases from January 1988 to October 2020 was performed. Over 7525 cases of AML from 25 studies were involved. Read More

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December 2021

Developing metabolic gene signatures to predict intrahepatic cholangiocarcinoma prognosis and mining a miRNA regulatory network.

J Clin Lab Anal 2021 Dec 6:e24107. Epub 2021 Dec 6.

Hepatopancreatobiliary surgery, Zhongnan hospital of Wuhan university, Wuhan, Hubei, China.

Background: Metabolic disturbance is closely correlated with intrahepatic cholangiocarcinoma (IHCC), and we aimed to identify metabolic gene marker for the prognosis of IHCC.

Methods: We obtained expression and clinical data from 141 patients with IHCC from public databases. Prognostic metabolic genes were selected using univariate Cox regression analysis. Read More

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December 2021

Identification of Hemoglobin Variants Prevalent in China and Their Effects on Hemoglobin A1c Measurements.

Am J Clin Pathol 2021 Dec 6. Epub 2021 Dec 6.

Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Objectives: We aimed to evaluate the effects of hemoglobin (Hb) variants prevalent in China on HbA1c measurements and to identify them during HbA1c measurements.

Methods: We evaluated a cation-exchange high-performance liquid chromatography (HPLC) method (Bio-Rad D-100), a capillary electrophoresis (CE) method (Capillarys 3 TERA), an immunoassay (Cobas c501), and a boronate affinity method (Premier Hb9210, as a comparative method) for HbA1c measurements in the presence of Hb variants prevalent in China.

Results: The Bio-Rad D-100 and Capillarys 3 TERA gave specific retention times and numeric migration positions for each Hb variant, respectively, showing excellent interindividual reproducibility. Read More

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December 2021

The efficacy of Chinese herbal medicine Buyang Huanwu Decoction combined with acupuncture to treat sequela of apoplexy: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Nov;100(44):e27679

Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangdong, China.

Background: Stroke is a common disease in neurology, patients often have different degrees of sequelae, which affect the patient's quality of life. We conducted a protocol for systematic review and meta-analysis to assess the efficacy of Buyang Huanwu Decoction combined with acupuncture for the treatment of stroke sequelae.

Methods: The current protocol is prepared in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols statement guideline. Read More

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November 2021

Efficacy and safety of combination therapy with pramipexole and levodopa vs levodopa monotherapy in patients with Parkinson disease: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Nov;100(44):e27511

Department of Biology and Pharmacy, Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, Yulin Normal University, Yulin, China.

Background: Pramipexole (P) or levodopa (L) treatment has been suggested as a therapeutic method for Parkinson disease (PD) in many clinical studies. Nonetheless, the combined effects of 2 drugs for PD patients are not completely understood.The aim of this research was to evaluate the clinical efficacy and safety of P plus L (P+L) combination therapy in the treatment of PD compared to that of L monotherapy, in order to confer a reference for clinical practice. Read More

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November 2021

The Pediatric Cancer Survivors' User Experiences With Digital Health Interventions: A Systematic Review of Qualitative Data.

Cancer Nurs 2022 Jan-Feb 01;45(1):E68-E82

Author Affiliations: School of Nursing, Fudan University (Drs Cheng and Yuan); and Children's Hospital of Fudan University (Mss Liu and Wang), Shanghai; Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital (Dr Mao); and West China Second Hospital of Sichuan University (Dr Peng), Chengdu; Guangzhou Women and Children's Medical Center (Ms Huang), Guangdong; Anhui Provincial Children's Hospital (Ms Duan); and The Children's Hospital of Zhejiang University School of Medicine (Ms Wang), Hangzhou, China.

Background: Evidence suggests that digital health interventions are feasible and acceptable in pediatric cancer survivors. Efforts to synthesize user experiences, however, are limited.

Objective: The aim of this study was to systematically identify, appraise, and synthesize qualitative evidence on the user experiences of pediatric cancer survivors participating in digital health interventions. Read More

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December 2021

System analysis of in renal cell carcinoma: The expression, prognosis, gene regulation network and regulation targets.

Int J Biol Markers 2021 Dec 6:17246008211063501. Epub 2021 Dec 6.

Department of Parasitology, 12453Guangdong Medical University, Zhanjiang, China.

Background: VEGFA is one of the most important regulators of angiogenesis and plays a crucial role in cancer angiogenesis and progression. Recent studies have highlighted a relationship between expression and renal cell carcinoma occurrence. However, the expression level, gene regulation network, prognostic value, and target prediction of in renal cell carcinoma remain unclear. Read More

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December 2021

Knee Scores of Patients with Non-Lateral Compartmental Knee Osteoarthritis Undergoing Mobile, Fixed-Bearing Unicompartmental Knee and Total Knee Arthroplasties: A Randomized Controlled Trial.

Orthop Surg 2021 Dec 6. Epub 2021 Dec 6.

Department of Orthopedic Surgery, Jiangmen Central Hospital (Affiliated Jiangmen Hospital of Sun Yat-Sen University), Jiangmen, China.

Objective: To evaluate knee scores and clinical efficacies of patients with non-lateral unicompartmental knee osteoarthritis (OA) who randomly underwent mobile-bearing (MB) unicompartmental knee arthroplasty (UKA), fixed-bearing (FB) UKA, and total knee arthroplasty (TKA).

Methods: From September 2015 to February 2017, a prospective, randomized, parallel, single-center trial of 180 patients (78 males and 102 females; 63.3 ± 6. Read More

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December 2021

Methoxy polyethylene glycol modification promotes adipogenesis by inducing the production of regulatory T cells in xenogeneic acellular adipose matrix.

Mater Today Bio 2021 Sep 19;12:100161. Epub 2021 Nov 19.

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

Acellular adipose matrix (AAM) has emerged as an important biomaterial for adipose tissue regeneration. Current decellularization methods damage the bioactive components of the extracellular matrix (ECM), and the residual immunogenic antigens may induce adverse immune responses. Here, we adopted a modified decellularization method which can protect more bioactive components with less immune reaction by methoxy polyethylene glycol (mPEG). Read More

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September 2021

Rapid Naked-Eye Detection of a Liver Disease Biomarker by Discovering Its Monoclonal Antibody to Functionalize Engineered Red-Colored Bacteria Probes.

ACS Omega 2021 Nov 18;6(47):32005-32010. Epub 2021 Nov 18.

Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, Oklahoma 73019-5300, United States.

Glycocholic acid (GCA) is a biomarker for liver diseases, but few facile naked-eye detection methods have been reported to detect it till now. To tackle this challenge, we first prepared a novel monoclonal mouse antibody (mAb) of GCA by a hybridoma technique. The anti-GCA mAb exhibited high specificity, making its cross-reactivity with seven structurally and functionally related GCA analogs negligible. Read More

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November 2021

The Outcomes of Total Anomalous Pulmonary Venous Connection in Neonates-10-Year Experience at a Single Center.

Front Cardiovasc Med 2021 12;8:775578. Epub 2021 Nov 12.

Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Recent developments in surgical techniques and hospital care have led to improved outcomes following repair of total anomalous pulmonary venous connection (TAPVC). However, surgical repair of neonatal TAPVC remains associated with a high risk of postoperative mortality and pulmonary venous obstruction (PVO). We conducted this retrospective study to identify risk factors associated with surgical outcomes in the neonatal population. Read More

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November 2021

Association of Lipoprotein(a)-Associated Mortality and the Estimated Glomerular Filtration Rate Level in Patients Undergoing Coronary Angiography: A 51,500 Cohort Study.

Front Cardiovasc Med 2021 17;8:747120. Epub 2021 Nov 17.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

High lipoprotein(a) is associated with poor prognosis in patients at high risk for cardiovascular disease. Renal function based on the estimated glomerular filtration rate (eGFR) is a potential risk factor for the change of lipoprotein(a). However, the regulatory effect of eGFR stratification on lipoprotein(a)-associated mortality has not been adequately addressed. Read More

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November 2021

Use of the Thrombolysis in Myocardial Infarction Risk Index for Elderly Patients With ST-Segment Elevation Myocardial Infarction.

Front Cardiovasc Med 2021 19;8:743678. Epub 2021 Nov 19.

Division of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Thrombolysis in Myocardial Infarction (TIMI) Risk Index (TRI) is a simple risk assessment tool for patients with ST-segment elevation myocardial infarction (STEMI). However, its applicability to elderly patients with STEMI undergoing percutaneous coronary intervention (PCI) is uncertain. This was a retrospective analysis of elderly (≥60 years) patients who underwent PCI for STEMI from January 2010 to April 2016. Read More

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November 2021

Restrictive vs. Liberal Red Blood Cell Transfusion Strategy in Patients With Acute Myocardial Infarction and Anemia: A Systematic Review and Meta-Analysis.

Front Cardiovasc Med 2021 16;8:736163. Epub 2021 Nov 16.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Anemia is frequent in patients with acute myocardial infarction (AMI), and the optimal red blood cell transfusion strategy for AMI patients with anemia is still controversial. We aimed to compare the efficacy of restrictive and liberal red cell transfusion strategies in AMI patients with anemia. We systematically searched PubMed, EMBASE, Web of Science, Cochrane Library, and Clinicaltrials. Read More

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November 2021

Body Roundness Index Is a Superior Obesity Index in Predicting Diabetes Risk Among Hypertensive Patients: A Prospective Cohort Study in China.

Front Cardiovasc Med 2021 18;8:736073. Epub 2021 Nov 18.

Department of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Individuals with both hypertension and diabetes have been confirmed to significantly increase the risk of cardiovascular disease morbidity and mortality compared with those with only hypertension or diabetes. This study aimed to evaluate the potential of different anthropometric indices for predicting diabetes risk among hypertensive patients. The study group consisted of 6,990 hypertensive adults without diabetes who were recruited in China. Read More

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November 2021

Acute Hemodynamic Responses to Enhanced External Counterpulsation in Patients With Coronary Artery Disease.

Front Cardiovasc Med 2021 12;8:721140. Epub 2021 Nov 12.

Department of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Enhanced external counterpulsation is a non-invasive treatment that increases coronary flow in patients with coronary artery disease (CAD). However, the acute responses of vascular and blood flow characteristics in the conduit arteries during and immediately after enhanced external counterpulsation (EECP) need to be verified. Forty-two patients with CAD and 21 healthy controls were recruited into this study to receive 45 min-EECP. Read More

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November 2021

Administration of Adenosine Triphosphate Provides Additional Value Over Programmed Electrophysiologic Study in Confirmation of Successful Ablation of Atrioventricular Accessory Pathways.

Front Cardiovasc Med 2021 16;8:716400. Epub 2021 Nov 16.

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

To study the benefit of adenosine triphosphate (ATP) in evaluating ablation endpoints of accessory pathways (AP) and subsequent long-term prognosis. We reviewed consecutive patients with supraventricular tachycardias due to APs that underwent radiofrequency catheter ablation (RFCA) from January 2016 to September 2018 in our center. The patients were divided into two groups: the ATP group (who had passed both the ATP test and PES after ablation as the endpoint) and the non-ATP group (who had passed PES only after ablation as the endpoint). Read More

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November 2021

Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD.

Front Surg 2021 19;8:753056. Epub 2021 Nov 19.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Early allograft dysfunction (EAD) is correlated with poor patient or graft survival in liver transplantation. However, the power of distinct definitions of EAD in prediction of graft survival is unclear. This retrospective, single-center study reviewed data of 677 recipients undergoing orthotopic liver transplant between July 2015 and June 2020. Read More

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November 2021

Distribution of White-to-White Corneal Diameter and Anterior Chamber Depth in Chinese Myopic Patients.

Front Med (Lausanne) 2021 18;8:732719. Epub 2021 Nov 18.

Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

To investigate the distribution of white-to-white (WTW) corneal diameter and anterior chamber depth (ACD) in Chinese myopia patients. This was a cross-sectional observational study conducted at five ophthalmic centers. Anterior segment biometry was performed in 7,893 eyes of the 7,893 myopic patients using Pentacam, and the WTW and ACD were recorded. Read More

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November 2021

Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer.

Front Cell Dev Biol 2021 19;9:719613. Epub 2021 Nov 19.

Center of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Gastric cancer (GC) is one of the most common and poor prognosis malignancy in the world. The Family with sequence similarity 83 (FAM83) comprises of eight members of A-H. Accumulating evidence confirmed important roles for FAM83 family in tumorigenesis and progression. Read More

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November 2021

Structural Characterization of Sulfated Polysaccharide Isolated From Red Algae () and Antioxidant and Anti-Inflammatory Effects in Macrophage Cells.

Front Bioeng Biotechnol 2021 18;9:794818. Epub 2021 Nov 18.

College of Food Science and Technology, School of Chemistry and Environment, Shenzhen Institute of Guangdong Ocean University, Zhanjiang, China.

, the red algae belonging to Geliaceae , is a traditional edible and industrial alga in China. A sulfated polysaccharide (GNP) is successfully separated from by acid extraction and two-step column chromatography. Chemical analysis showed that the molecular weight of GNP was 25. Read More

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November 2021

Clinical Characteristics and Outcomes of Severe Pneumonia in Children Under 5 Years Old With and Without Adenovirus Infection in Guangzhou.

Front Pediatr 2021 15;9:599500. Epub 2021 Nov 15.

Clinical Data Center, The Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

To identify the differences of clinical characteristics and outcomes of severe pneumonia in children under 5 years old with and without adenovirus infection. A retrospective cohort study was conducted in three pediatric hospitals in Guangzhou, China. In total, 1,595 children under the age of 5 with WHO-defined severe pneumonia had adenovirus testing performed between January 1, 2009 and December 31, 2019. Read More

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November 2021

Circulating Tumor DNA and Minimal Residual Disease (MRD) in Solid Tumors: Current Horizons and Future Perspectives.

Front Oncol 2021 18;11:763790. Epub 2021 Nov 18.

Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, China.

Circulating tumor DNA (ctDNA) is cell-free DNA (cfDNA) fragment in the bloodstream that originates from malignant tumors or circulating tumor cells. Recently, ctDNA has emerged as a promising non-invasive biomarker in clinical oncology. Analysis of ctDNA opens up new avenues for individualized cancer diagnosis and therapy in various types of tumors. Read More

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November 2021

Transcriptome-Wide Map of N-Methyladenosine Methylome Profiling in Human Bladder Cancer.

Front Oncol 2021 15;11:717622. Epub 2021 Nov 15.

Department of Urology, Peking University First Hospital, Beijing, China.

N-Methyladenosine (mA) is the most widespread internal RNA modification in several species. In spite of latest advances in researching the biological roles of mA, its function in the development and progression of bladder cancer remains unclear. In this study, we used MeRIPty -55-seq and RNA-seq methods to obtain a comprehensive transcriptome-wide mA profiling and gene expression pattern in bladder cancer and paired normal adjacent tissues. Read More

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November 2021

Reactive Oxygen Species Are Essential for Vasoconstriction upon Cold Exposure.

Oxid Med Cell Longev 2021 24;2021:8578452. Epub 2021 Nov 24.

College of Traditional Chinese Medicine, Jinan University, Guangzhou, China.

Purpose: We explored the role of ROS in cold-induced vasoconstriction and corresponding mechanism.

Methods: Three experiments were performed. First, we measured blood flow in human hands before and after cold exposure. Read More

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November 2021

Identification of a Novel Ferroptosis-Related Gene Prediction Model for Clinical Prognosis and Immunotherapy of Colorectal Cancer.

Dis Markers 2021 24;2021:4846683. Epub 2021 Nov 24.

Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.

Background: Colorectal cancer (CRC) is the third most common malignancies worldwide. Ferroptosis is a programmed, iron-dependent cell death observed in cancer cells. However, the prognostic potential and immunotherapy biomarker potential of ferroptosis-related genes (FRGs) in CRC patients remains to be clarified. Read More

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November 2021

A Novel Ferroptosis-Related Gene Risk Signature for Predicting Prognosis and Immunotherapy Response in Gastric Cancer.

Dis Markers 2021 26;2021:2385406. Epub 2021 Nov 26.

Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.

Background: Gastric cancer (GC) is the third leading cause of cancer death worldwide with complicated molecular and cellular heterogeneity. Iron metabolism and ferroptosis play crucial roles in the pathogenesis of GC. However, the prognostic role and immunotherapy biomarker potential of ferroptosis-related genes (FRGs) in GC still remains to be clarified. Read More

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November 2021

A Coordinated and Optimized Mechanism of Artificial Intelligence for Student Management by College Counselors Based on Big Data.

Comput Math Methods Med 2021 25;2021:1725490. Epub 2021 Nov 25.

Department of Computer Science, Superior University Lahore, Pakistan.

The purpose of this article is to perform in-depth research and analysis on the artificial intelligence coordination and optimization mechanism of college counseling student management using big data technology. This study places the collaborative ideological and political work of colleges and universities in the context of big data, and by analyzing its basic connotation and changes in the real situation, it explores the development progression of colleges and universities making full use of big data resources to cultivate a collaborative education model, which is conducive to promoting colleges and universities to cultivate a whole staff, whole process, and all-round accurate ideological education and value-led services and to shape excellent young college students with comprehensive growth. The first is to scientifically build a multilevel linked big data management platform for counselor professionalization construction, plan the technical architecture of the organizational platform, build a cloud database of counselor career files, and extract valuable information and data from the organizational activities at the macrolevel and personal activities at the microlevel with counselor professionalization construction activities; the second is to realize the integrated application of information resources for counselor team construction. Read More

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November 2021

Identification of the Upregulation of MRPL13 as a Novel Prognostic Marker Associated with Overall Survival Time and Immunotherapy Response in Breast Cancer.

Comput Math Methods Med 2021 25;2021:1498924. Epub 2021 Nov 25.

Department of Vascular Surgery, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, China.

Mitochondrial ribosomal protein (MRPL) genes have been reported to participate in many cellular processes, such as cell proliferation, apoptosis, and cell cycle. Meanwhile, the occurrence rate of breast cancer (BRCA) in China steadily increased. Exploring the prognostic value of MRPL genes in BRCA could provide novel biomarkers for BRCA. Read More

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November 2021