768,004 results match your criteria procedure developed

System understanding as a scientific foundation in radioactive waste disposal, legacy site and decommissioning programmes.

J Radiol Prot 2021 Apr 20. Epub 2021 Apr 20.


Ongoing national programmes and International forums have in recent decades developed and enhanced methods and strategies in how to address the characterisation of potentially suitable sites for radioactive waste repositories. Siting processes, site selection and site investigation programmes have been conducted for near surface and geological repositories and plans for construction are in progress or have already been implemented. Lessons learned from these national and international programmes are available and results are published. Read More

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Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors.

J Natl Compr Canc Netw 2021 Apr 20:1-7. Epub 2021 Apr 20.

3Division of Medical Oncology, and.

Background: Bone metastases and skeletal-related events (SREs) are a frequent cause of morbidity in patients with metastatic non-small cell lung cancer (mNSCLC). Data are limited on bone metastases and SREs in patients with mNSCLC treated using immune checkpoint inhibitors (ICIs), and on the efficacy of bone-modifying agents (BMAs) in this setting. Here we report the incidence, impact on survival, risk factors for bone metastases and SREs, and impact of BMAs in patients with mNSCLC treated with ICIs in a multi-institutional cohort. Read More

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A procedure for method development and protein binding ratio as the indicator of sensitivity with anticancer agents on MALDI mass spectrometry imaging.

Drug Metab Pharmacokinet 2021 Jan 30;38:100385. Epub 2021 Jan 30.

Division of Molecular Pharmacology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Department of Medical Oncology and Translational Research, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address:

The concentration and distribution of a drug and its metabolites in tissues are key factors for elucidating both drug efficacy and toxicity in drug development. In this study we developed a pharamaco-imaging procedure for 12 agents and investigated the relationship between the properties of target compounds and the sensitivities of detection in matrix-assisted laser desorption/ionization-mass spectrometer imaging (MALDI-MSI). We prepared mock samples with mouse liver homogenates diluted with gelatin solution, limit of detection concentrations of each compound was confirmed. Read More

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January 2021

Adverse childhood experiences in New Zealand and subsequent victimization in adulthood: Findings from a population-based study.

Child Abuse Negl 2021 Apr 17;117:105067. Epub 2021 Apr 17.

School of Māori Studies and School of Pacific Studies, Faculty of Arts, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

Background: Adverse childhood experiences (ACEs) are widespread and are associated with adverse outcomes in later life, yet few studies have explored their prevalence and consequences in New Zealand.

Objectives: To provide prevalence estimates of ACEs in New Zealand using a large sample of adults, and to explore the associations between ACEs and experience of violence by intimate partners and non-partners in adulthood.

Participants And Setting: 2,887 participants (1464 female, 1423 male) from the 2019 New Zealand Family Violence Survey, a population based study conducted in New Zealand between March 2017-March 2019. Read More

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Quantitative evaluation of the sacroiliac joint fixation in stress reduction on both sacroiliac joint cartilage and ligaments: A finite element analysis.

Clin Biomech (Bristol, Avon) 2021 Apr 17;85:105350. Epub 2021 Apr 17.

Division of Mechanical and Aerospace Engineering, Faculty of Engineering, Hokkaido University, Sapporo, Japan. Electronic address:

Background: The sacroiliac joint fixation is the last resort for patients with prolonged and severe joint pain. Although the clinical results of anterior fixations are conclusive, there exist several inevitable drawbacks with the surgical method such as the difficulty performing the surgery due to the presence of many organs. The posterior fixation technique has thus been developed to overcome those inconveniences. Read More

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Preventing sepsis; how can artificial intelligence inform the clinical decision-making process? A systematic review.

Int J Med Inform 2021 Apr 10;150:104457. Epub 2021 Apr 10.

School of Pharmacy, Newcastle University, King George VI Building, Newcastle upon Tyne, NE1 7RU, UK. Electronic address:

Background And Objectives: Sepsis is a life-threatening condition that is associated with increased mortality. Artificial intelligence tools can inform clinical decision making by flagging patients at risk of developing infection and subsequent sepsis. This systematic review aims to identify the optimal set of predictors used to train machine learning algorithms to predict the likelihood of an infection and subsequent sepsis. Read More

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A "Co-CREATES" framework to foster a positive learning environment for nursing students' professional development in Rwanda.

Nurse Educ Pract 2021 Apr 7;53:103053. Epub 2021 Apr 7.

Western University, Arthur Labatt Family School of Nursing, Faculty of Health Sciences, Western University, London, ON N6A 5B9, Canada. Electronic address:

Aim: The future of the nursing profession in Rwanda in large part depends on the students who join the workforce and the education they have received. Preparing students with the necessary knowledge, values and judgement requires practice settings to be learner-centered. This study aimed at exploring strategies that might improve the current practice-based learning environment. Read More

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Early Clinical and Patient-Reported Outcomes of a New Hybrid Mesh for Incisional Hernia Repair.

J Surg Res 2021 Apr 17;265:49-59. Epub 2021 Apr 17.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Introduction: Consensus on the safety and efficacy of various types of mesh in reconstructing the abdomen has yet to be reached. Hybrid mesh products have been designed to address the need for a cost-effective mesh leveraging the tensile strength of a synthetic mesh while minimizing the prosthetic footprint within the abdominal wall through resorbable materials. In this study we evaluate early clinical outcomes and health related quality of life (HR-QOL) of a new Hybrid mesh, Synecor, for Ventral Hernia Repair (VHR). Read More

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Alberta Stroke Program Early CT Score Calculation Using the Deep Learning-Based Brain Hemisphere Comparison Algorithm.

J Stroke Cerebrovasc Dis 2021 Apr 17;30(7):105791. Epub 2021 Apr 17.

Department of Neurology, Saiseikai Kumamoto Hospital, Chikami 5-3-1, Minami-ku, Kumamoto, Japan. Electronic address:

Objectives: The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is a promising tool for the evaluation of stroke expansion to determine suitability for reperfusion therapy. The aim of this study was to validate deep learning-based ASPECTS calculation software that utilizes a three-dimensional fully convolutional network-based brain hemisphere comparison algorithm (3D-BHCA).

Materials And Methods: We retrospectively collected head non-contrast computed tomography (CT) data from 71 patients with acute ischemic stroke and 80 non-stroke patients. Read More

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A simple and easy-to-perform liquid chromatography-mass spectrometry method for the quantification of tacrolimus and its metabolites in human whole blood. Application to the determination of metabolic ratios in kidney transplant patients.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 8;1173:122698. Epub 2021 Apr 8.

Laboratory of Pharmacology-pharmacogenetics and Toxicology- Grenoble-Alpes University Hospital, F-38043 Grenoble, France; Univ. Grenoble Alpes, F-38041 Grenoble, France; INSERM U1300, HP2, F-38041 Grenoble, France. Electronic address:

Tacrolimus is the cornerstone of immunosuppressive therapy in solid organ transplantation and its blood concentrations are routinely monitored. Tacrolimus is extensively metabolized into metabolites that are supposed to be nephrotoxic. Yet, few analytical methods have been described to simultaneously quantify tacrolimus and its main metabolites. Read More

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Strain-specific alterations in the skeletal response to adenine-induced chronic kidney disease are associated with differences in parathyroid hormone levels.

Bone 2021 Apr 17:115963. Epub 2021 Apr 17.

Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Medicine - Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Biomedical Engineering, Indiana University Purdue University of Indianapolis, Indianapolis, IN, United States; Roudebush Veterans Administration Medical Center, Indianapolis, IN, United States. Electronic address:

Chronic kidney disease (CKD) leads to loss of cortical bone through cortical thinning and the development of cortical porosity. The goal of this current study was to assess cortical bone alterations to adenine-induced chronic kidney disease (CKD) in two strains of mice with known genetic differences in cortical thickness. We hypothesized that C3H mice with thicker cortices and baseline levels of intracortical remodeling would have greater cortical porosity in response to adenine-induced CKD compared to B6 animals. Read More

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Adverse associations of sedentary behavior with cancer incidence and all-cause mortality: A prospective cohort study: Sedentary behavior, cancer and mortality.

J Sport Health Sci 2021 Apr 17. Epub 2021 Apr 17.

Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Background: Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality, but evidence from the Chinese population is scarce. This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity (MVPA) on these relationships.

Methods: We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire. Read More

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Natural immunoglobulin M-based delivery of a complement alternative pathway inhibitor in mouse models of retinal degeneration.

Exp Eye Res 2021 Apr 17:108583. Epub 2021 Apr 17.

Departments of Ophthalmology, USA; Ralph H. Johnson VA Medical Center, Division of Research, Charleston, SC, USA; Neurosciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

Purpose: Age-related macular degeneration is a slowly progressing disease. Studies have tied disease risk to an overactive complement system. We have previously demonstrated that pathology in two mouse models, the choroidal neovascularization (CNV) model and the smoke-induced ocular pathology (SIOP) model, can be reduced by specifically inhibiting the alternative complement pathway (AP). Read More

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Tailoring Disorder and Quality of Photonic Glass Templates for Structural Coloration by Particle Charge Interactions.

ACS Appl Mater Interfaces 2021 Apr 20. Epub 2021 Apr 20.

Institute of Advanced Ceramics, Hamburg University of Technology, Denickestraße 15, 21073 Hamburg, Germany.

To obtain high-quality homogeneous photonic glass-based structural color films over large areas, it is essential to precisely control the degree of disorder of the spherical particles used and reduce the crack density within the films as much as possible. To tailor the disorder and quality of photonic glasses, a heteroaggregation-based process was developed by employing two oppositely charged equal-sized polystyrene (PS) particle types. The influence of the particle size ratio on the extent of heteroaggregation in the suspension mixes is investigated and correlated with both the morphology and the resultant optical properties of the films. Read More

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The Fate of Proximal Junctional Vertebral Fractures after Long-Segment Spinal Fixation : Are There Predictable Radiologic Characteristics for Revision surgery?

J Korean Neurosurg Soc 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurosurgery, Gangnam Severance Hospital, Spine and Spinal Cord Institute, Yonsei University College of Medicine, Seoul, Korea.

Objective: To investigate the radiographic characteristics of the uppermost instrumented vertebrae (UIV) and UIV+1 compression fractures that are predictive of revision surgery following long-segment spinal fixation.

Methods: A total 27 patients who presented newly developed compression fracture at UIV, UIV+1 after long segment spinal fixation (minimum 5 vertebral bodies, lowest instrumented vertebra of L5 or distal) were reviewed retrospectively. Patients were divided into two groups according to following management : revisional surgery (group A, n=13) and conservative care (group B, n=14). Read More

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Compression stockings for preventing deep vein thrombosis in airline passengers.

Cochrane Database Syst Rev 2021 Apr 20;4:CD004002. Epub 2021 Apr 20.

UK Cochrane Centre, Oxford, UK.

Background: Air travel might increase the risk of deep vein thrombosis (DVT). It has been suggested that wearing compression stockings might reduce this risk. This is an update of the review first published in 2006. Read More

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Intra-Operative Vascular Injury and Control During Laparoscopic and Robotic Mesh Explantation for Chronic Post Herniorrhaphy Inguinal Pain (CPIP).

Surg Technol Int 2021 Apr 20;38. Epub 2021 Apr 20.

Department of Surgery, David Geffen School of Medicine, Lichtenstein Amid Hernia Institute at UCLA Santa Monica, CA, USA.

Introduction: Chronic postherniorrhaphy inguinal pain (CPIP) is common following inguinal hernia repair. As even primary minimally-invasive inguinal hernia repairs carry a risk of significant intra-operative bleeding, it is unsurprising that reoperative groin exploration and mesh explantation for chronic post-inguinal herniorrhaphy pain confers an even higher risk of arteriotomy or venotomy due to a distorted anatomy and the presence of adhesions. In this report, we present a single institution's experience with the management of intra-operative vascular injury encountered during minimally invasive groin exploration and mesh explantation for CPIP. Read More

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Extracellular histones are a target in myocardial ischaemia reperfusion injury.

Cardiovasc Res 2021 Apr 20. Epub 2021 Apr 20.

The Hatter Cardiovascular Institute, University College London, WC1E 6HX, United Kingdom.

Acute myocardial infarction causes lethal cardiomyocyte injury during ischaemia and reperfusion (I/R). Histones have been described as important Danger Associated Molecular Proteins (DAMPs) in sepsis. Aims The objective of this study was to establish whether extracellular histone release contributes to myocardial infarction. Read More

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Thyroid immune-related adverse events following immune checkpoint inhibitor treatment.

J Clin Endocrinol Metab 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Background: Thyroid dysfunction occurs commonly following immune checkpoint inhibition. The etiology of thyroid immune-related adverse events (irAEs) remains unclear and clinical presentation can be variable. This study sought to define thyroid irAEs following immune checkpoint inhibitor (ICI) treatment and describe their clinical and biochemical associations. Read More

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Development of an integrated, holistic care package for people with lymphoedema for use at the level of the Primary Health Care Unit in Ethiopia.

PLoS Negl Trop Dis 2021 Apr 20;15(4):e0009332. Epub 2021 Apr 20.

Brighton and Sussex Centre for Global Health Research, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom.

Background: Neglected Tropical Diseases (NTDs) are a group of several communicable and non-communicable diseases prevalent in tropical and subtropical areas. The co-endemicity of these diseases, the similarity of their clinical signs, and the need to maximize limited financial and human resources suggest the importance of adoptingan integratedapproach to their prevention and treatment.

Aims: This study describes the development of a comprehensive package of physical, mental health and psychosocial care for people with lower-limb lymphoedema caused bypodoconiosis, lymphatic filariasis (LF)or leprosy as part of the EnDPoINT program in Ethiopia. Read More

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Vessel network extraction and analysis of mouse pulmonary vasculature via X-ray micro-computed tomographic imaging.

PLoS Comput Biol 2021 Apr 20;17(4):e1008930. Epub 2021 Apr 20.

Thermofluids for Energy and Advanced Material Laboratory, Department of Mechanical and Industrial Engineering, Faculty of Applied Science and Engineering, University of Toronto, Toronto, Ontario, Canada.

In this work, non-invasive high-spatial resolution three-dimensional (3D) X-ray micro-computed tomography (μCT) of healthy mouse lung vasculature is performed. Methodologies are presented for filtering, segmenting, and skeletonizing the collected 3D images. Novel methods for the removal of spurious branch artefacts from the skeletonized 3D image are introduced, and these novel methods involve a combination of distance transform gradients, diameter-length ratios, and the fast marching method (FMM). Read More

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Analysis of the sources of COVID-19 transmission in France by Self-assessment Web-application before and after the partial autumnal lockdown: Observational Study.

J Med Internet Res 2021 Apr 16. Epub 2021 Apr 16.

APHP, Bichat-Claude Bernard University Hospital, Infectious and Tropical Diseases Department, Paris, FR.

Background: We developed a questionnaire on a web-application for COVID-19 circumstances of contamination analysis in France during the 2nd wave of pandemic.

Objective: OBJECTIVE To analyze the impact on contaminations characteristics before and after the second partial lockdown in France to adapt health public restrictions to further pandemic surges.

Methods: Between 12/15/2020 and 12/24/2020, after a national media campaign, users of sourcecovid. Read More

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Characterization and Comparison of Public, Medical Professionals and Technical Communities Utilization of Facebook Groups to Facilitate Idea Sharing and Crowdsourcing During the COVID-19 Pandemic: A Cross-Sectional Observational Study.

JMIR Form Res 2021 Apr 13. Epub 2021 Apr 13.

Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, US.

Background: Strict social distancing measures resulting from the COVID-19 pandemic have led people to rely more heavily on social media, such as Facebook Groups, as a means of communication and information sharing. Multiple Facebook Groups have been developed by medical professionals, lay people, and engineering or technical groups to discuss current issues and possible solutions to the medical crisis.

Objective: To characterize Facebook groups created by laypersons, medical professionals, and technical professionals, with specific focus on information dissemination and requests for crowdsourcing. Read More

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Robust Estimation of Upscaling Factor on Double JPEG Compressed Images.

IEEE Trans Cybern 2021 Apr 20;PP. Epub 2021 Apr 20.

As one of the most important topics in image forensics, resampling detection has developed rapidly in recent years. However, the robustness to JPEG compression is still challenging for most classical spectrum-based methods, since JPEG compression severely degrades the image contents and introduces block artifacts in the boundary of the compression grid. In this article, we propose a method to estimate the upscaling factors on double JPEG compressed images in the presence of image upscaling between the two compressions. Read More

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Learning Methodologies to Generate Kernel-learning-based Image Downscaler for Arbitrary Scaling Factors.

IEEE Trans Image Process 2021 Apr 20;PP. Epub 2021 Apr 20.

Displays and content have various resolutions and aspect ratios, requiring an image downscaler to adaptively reduce the image resolution. However, research on downscaling has garnered less attention than upscaling, including super-resolution. In practical display systems, simple interpolation, such as a bicubic filter that cannot preserve image details well, is still widely used for image downscaling rather than frame optimization-based or learning-based methods because of following reasons: frame optimization-based methods can effectively preserve image details after downscaling but are difficult to implement due to hardware costs. Read More

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Integrating theory-based and data-driven methods to case conceptualization: A functional analysis approach with ecological momentary assessment.

Psychother Res 2021 Apr 20:1-13. Epub 2021 Apr 20.

Pain and Psychotherapy Research Lab, Universität Koblenz-Landau, Landau in der Pfalz, Germany.

Ecological momentary assessment (EMA) and network analysis are promising empirical developments for psychotherapy research and practice, but they lack a therapeutic rationale that could guide case conceptualization and treatment planning. We developed an assessment strategy that aims to assess functional analysis with EMA. The assessment strategy was applied to a series of three N-of-1 assessments in a proof-of-concept study. Read More

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Insurance Status and Ethnicity Impact Health Disparities in Rates of Advance Directives in Trauma.

Am Surg 2021 Apr 20:31348211011115. Epub 2021 Apr 20.

Division of Trauma and Critical Care and Acute Care Surgery, Department of Surgery, 22957Duke University Medical Center, Durham, NC, USA.

Introduction: Advanced directives (ADs) provide a framework from which families may understand patient's wishes. However, end-of-life planning may not be prioritized by everyone. This analysis aimed to determine what populations have ADs and how they affected trauma outcomes. Read More

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Design and Retrospective Application of a Spine Trauma DVT Prophylaxis Protocol on Level 1 Trauma Center Patient Database.

Global Spine J 2021 Apr 20:2192568220979139. Epub 2021 Apr 20.

22683Baylor University Medical Center, Dallas, TX, USA.

Study Design: Systematic literature review.

Objectives: The impact of thromboembolic disease on the morbidity and mortality of patients with acute spinal cord injury is well documented, with rates as high as 67%-100% among untreated patients. The efficacy of mechanical prophylaxis as a stand-alone measure has been questioned, so we sought to determine a safe perioperative window for chemical anticoagulation use after spine surgery. Read More

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Chemotherapy and Abdominal Wall Closure Technique Increase the Probability of Postoperative Ventral Incisional Hernia in Patients With Colon Cancer.

Am Surg 2021 Apr 20:31348211011149. Epub 2021 Apr 20.

Department of Surgical Oncology, 4002The University of Texas MD Anderson Cancer Center, Texas, USA.

Background: Chemotherapy is associated with postoperative ventral incisional hernia (PVIH) after right hemicolectomy (RHC) for colon cancer, and abdominal wall closure technique may affect PVIH. We sought to identify clinical predictors of PVIH.

Methods: We retrospectively analyzed patients who underwent RHC for colon cancer from 2008-2018 and later developed PVIH. Read More

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Dried Blood Spot Screening System for Spinal Muscular Atrophy with Allele-Specific Polymerase Chain Reaction and Melting Peak Analysis.

Genet Test Mol Biomarkers 2021 Apr;25(4):293-301

Department of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, Kobe, Japan.

Spinal muscular atrophy (SMA) is a lower motor neuron disease with autosomal recessive inheritance caused by homozygous deletions. Although SMA has been considered as incurable, newly developed drugs improve life prognoses and motor functions of patients. To maximize the efficacy of the drugs, SMA patients should be treated before symptoms become apparent. Read More

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