94,945 results match your criteria problem drinking

Successful implementation of managed alcohol programs in the San Francisco Bay Area during the COVID-19 crisis.

Subst Abus 2021 Apr 13:1-8. Epub 2021 Apr 13.

School of Nursing-Department of Social and Behavioral Sciences, University of California, San Francisco, San Francisco, San Francisco, CA.

The COVID-19 crisis presents new challenges and opportunities in managing alcohol use disorders, particularly for people unable to shelter in place due to homelessness or other reasons. Requiring abstinence for shelter engagement is impractical for many with severe alcohol use disorders and poses a modifiable barrier to self-isolation orders. Managed alcohol programs (MAPs) have successfully increased housing adherence for those with physical alcohol dependence in Canada, but to our knowledge, they have not been implemented in the United States. Read More

View Article and Full-Text PDF

Vulnerability to recurrent episodes of acute decompensation/acute-on-chronic liver failure characterizes those triggered by indeterminate precipitants in patients with liver cirrhosis.

PLoS One 2021 13;16(4):e0250062. Epub 2021 Apr 13.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Background: Acute decompensation (AD) of liver cirrhosis (LC) and subsequent acute-on-chronic liver failure (ACLF) are fatal and impair quality of life. Insufficient knowledge of the highly heterogeneous natural history of LC, including decompensation, re-compensation, and possible recurrent decompensation, hinders the development and application of novel therapeutics. Approximately 10%-50% of AD/ACLF is reported to be precipitated by any indeterminate (unidentifiable, cryptogenic, or unknown) acute insults; however, its clinical characteristics are unclear. Read More

View Article and Full-Text PDF

Epidemiological characteristics of 561 cases of intracerebral hemorrhage in Chengdu, China.

Medicine (Baltimore) 2021 Apr;100(15):e24952

Department of Neurosurgery.

Abstract: To explore the epidemiology of patients with spontaneous intracerebral hemorrhage (sICH) in Chengdu, China, we retrieved the data of patients with spontaneous cerebral hemorrhage admitted to the First Affiliated Hospital of Chengdu Medical College from January 2017 to December 2019. We performed a comprehensive analysis of the location of hemorrhage, demographics, factors of hemorrhage, condition of body, severity of disturbance of consciousness, treatment, length of stay (days), inpatient costs, prognosis, and mortality rate in patients with sICH. In total, data of 561 in patients with sICH were included. Read More

View Article and Full-Text PDF

Occupational position and alcohol use disorders in Poland.

Int J Occup Med Environ Health 2021 Apr 6. Epub 2021 Apr 6.

Institute of Psychiatry and Neurology, Warsaw, Poland (Department of Studies on Alcoholism and Drug Dependencies).

Objectives: The following analysis covers the role of the occupational structure in the prevalence of alcohol use disorders (AUDs). The authors investigated whether the occupational position affected the prevalence of AUDs among men and women, and how this relationship varied in lifetime and past year periods.

Material And Methods: Data were taken from the General Population Survey on Mental Health in Poland (EZOP) utilizing the questionnaire (N = 2806). Read More

View Article and Full-Text PDF

"Undisciplined" drinking, multi-sectoralism and political power: Examining problematisations in the Botswana alcohol policy.

Tebogo B Sebeelo

Int J Drug Policy 2021 Apr 9;94:103228. Epub 2021 Apr 9.

Department of Sociology, University of Miami, 5202 University Drive, Miami, Coral Gables, FL 33146, USA. Electronic address:

The Botswana government has recently ramped up efforts to control alcohol consumption through various measures. These include the alcohol tax levy, reduction in trading hours for bars and other licenced premises and increased penalties for alcohol-related road offenses. Whilst these efforts have recently received considerable attention, the processes of alcohol policy development remain unknown and understudied. Read More

View Article and Full-Text PDF

Porous Se@SiO2 nanospheres attenuate cerulein-induced acute pancreatitis in mice via downregulation of oxidative stress.

J Dig Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Objective: Acute pancreatitis (AP) is a common digestive tract disease caused by gall stone obstruction, alcoholism and other factors. Pancreatitis may develop into severe pancreatitis, which has a relatively high mortality rate. Thus, effective methods for treating it need to be developed. Read More

View Article and Full-Text PDF

Assessment of arsenic exposure in the population of Sabalpur village of Saran District of Bihar with mitigation approach.

Environ Sci Pollut Res Int 2021 Apr 11. Epub 2021 Apr 11.

Mahavir Cancer Sansthan and Research Centre, Phulwarisharif, Patna, Bihar, 801505, India.

Arsenic poisoning through groundwater is the world's greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial plains. In Bihar, out of 38 districts, 18 districts are exceptionally influenced with groundwater arsenic defilement. Read More

View Article and Full-Text PDF

Factors associated with phosphatidylethanol (PEth) sensitivity for detecting unhealthy alcohol use: An individual patient data meta-analysis.

Alcohol Clin Exp Res 2021 Apr 10. Epub 2021 Apr 10.

Department of Community Health Sciences, Boston University, School of Public Health, Section of General Internal Medicine, Boston University, School of Medicine and Boston Medical Center, Grayken Center on Addiction, Boston Medical Center, Boston, MA, USA.

Background: Objective measurement of alcohol consumption is important for clinical care and research. Adjusting for self-reported alcohol use, we conducted an individual participant data (IPD) meta-analysis to examine factors associated with the sensitivity of phosphatidylethanol (PEth), an alcohol metabolite, among persons self-reporting unhealthy alcohol consumption.

Methods: We identified 21 eligible studies and obtained 4073 observations from 3085 participants with Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) positive scores (≥3 for women and ≥4 for men) and PEth measurements. Read More

View Article and Full-Text PDF

Hydrochemical characterization and quality assessment of groundwater in the hilly area of the Taihang Mountains in Henan Province, China.

Environ Sci Pollut Res Int 2021 Apr 10. Epub 2021 Apr 10.

Henan Institute of Geological Environment Monitoring, Zhengzhou, 450016, China.

This study evaluated the quality of groundwater and its suitability for drinking and irrigation in the hilly area of the Taihang Mountains in Henan Province, China. Groundwater samples were collected from 43 unconfined and 20 confined wells and analyzed. The pollution index of groundwater (PIG) was estimated based on the physicochemical parameters, and seven indices, including the sodium adsorption ratio (SAR), sodium percentage (%Na), residual sodium carbonate (RSC), permeability index (PI), magnesium ratio (MR), Kelley's ratio (KR), and corrosivity ratio (CR), were calculated to qualify the groundwater within the research area for irrigation activities. Read More

View Article and Full-Text PDF

Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents.

Sci Adv 2021 Apr 9;7(15). Epub 2021 Apr 9.

National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.

Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD ( = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet ( = 14). Read More

View Article and Full-Text PDF

Help-Seeking Patterns and Barriers to Care Among Latino Immigrant Men with Unhealthy Alcohol Use.

J Racial Ethn Health Disparities 2021 Apr 8. Epub 2021 Apr 8.

Department of Health Services, School of Public Health, University of Washington, Seattle, WA, USA.

Latino immigrant men have high rates of unhealthy alcohol use, a wide range of behaviors, from drinking above the recommended limits to severe alcohol use disorder, yet have low levels of treatment-seeking. Little is known about their preferred sources of care and barriers to care. Using survey data from a community-based sample of Latino immigrant men (N=121) with unhealthy alcohol use (AUDIT≥6), we described help-seeking patterns and perceived barriers to care. Read More

View Article and Full-Text PDF

Impact of obesity on influenza compared to pneumonia hospitalization outcomes.

Obes Res Clin Pract 2021 Apr 5. Epub 2021 Apr 5.

Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Objectives: Previous literature has suggested that obesity impacts mortality risk differently in bacterial versus viral infections. This study sought to further elucidate this association in pneumonia versus influenza.

Design: Retrospective cohort study. Read More

View Article and Full-Text PDF

Assessment of aversive effects of methylone in male and female Sprague-Dawley rats: Conditioned taste avoidance, body temperature and activity/stereotypies.

Neurotoxicol Teratol 2021 Apr 5:106977. Epub 2021 Apr 5.

Psychopharmacology Laboratory, Center for Neuroscience and Behavior, Department of Neuroscience, American University, 4400 Massachusetts Ave, NW, Washington, D.C 20016, USA. Electronic address:

Methylone's rewarding effects have been well characterized; however, little is known about its aversive effects and how such effects may be impacted by sex. In this context, the present study investigated the aversive effects of methylone (vehicle, 5.6, 10 or 18 mg/kg, IP) in 35 male and 31 female Sprague-Dawley rats assessed by conditioned taste avoidance and changes in body temperature and activity/stereotypies. Read More

View Article and Full-Text PDF

Case report of recurring pneumonia due to unusual foreign body aspiration in the airway.

Medwave 2021 Mar 25;21(2):e8136. Epub 2021 Mar 25.

Hospital Regional Docente de Trujillo, Trujillo, Perú. ORCID: 0000-0001-5453-8998.

Foreign body aspiration is a rare but life-threatening event. Most accidental aspiration events occur in children. In adults, it can represent up to 25% of cases. Read More

View Article and Full-Text PDF

Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity.

J Nutr 2021 Apr 8. Epub 2021 Apr 8.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China.

Background: Obesity, a major public health problem worldwide, is associated with dysfunction of the intestinal barrier. Glycine (Gly) has been reported to enhance the expression of tight-junction proteins in porcine enterocytes. It is unknown whether Gly can improve intestinal barrier integrity in obese mice. Read More

View Article and Full-Text PDF

Relation between Serum Magnesium Level and Migraine.

Mymensingh Med J 2021 Apr;30(2):301-306

Dr Md Rezaul Karim, Registrar (Neurology), Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail:

Migraine is one of the most disabling types of headache. It affects 4-6% of men and 13-18% of women; more than 80% of them are under 30 years. Many theories to explain mechanism of migraine are present; role of serum magnesium is one of them. Read More

View Article and Full-Text PDF

Usability and Acceptability of a Mobile App for the Self-Management of Alcohol Misuse Among Veterans (Step Away): Pilot Cohort Study.

JMIR Mhealth Uhealth 2021 Apr 8;9(4):e25927. Epub 2021 Apr 8.

Center of Excellence in Substance Addiction Treatment and Education (CESATE), Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States.

Background: Alcohol misuse is common among Operation Enduring Freedom and Operation Iraqi Freedom veterans, yet barriers limit treatment participation. Mobile apps hold promise as means to deliver alcohol interventions to veterans who prefer to remain anonymous, have little time for conventional treatments, or live too far away to attend treatment in person.

Objective: This pilot study evaluated the usability and acceptability of Step Away, a mobile app designed to reduce alcohol-related risks, and explored pre-post changes on alcohol use, psychological distress, and quality of life. Read More

View Article and Full-Text PDF

I am what I am: A meta-analysis of the association between substance user identities and substance use-related outcomes.

Psychol Addict Behav 2021 Apr 8. Epub 2021 Apr 8.

Center on Alcoholism, Substance Use, & Addictions.

Objective: Research indicates that a substance user identity (i.e., drinking, smoking, and marijuana identity) is positively correlated with substance use-related outcomes (e. Read More

View Article and Full-Text PDF

Millimeter-Shaped Metal-Organic Framework/Inorganic Nanoparticle Composite as a New Adsorbent for Home Water-Purification Filters.

ACS Appl Mater Interfaces 2021 Apr 7. Epub 2021 Apr 7.

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and the Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193 Barcelona, Spain.

Heavy-metal contamination of water is a global problem with an especially severe impact in countries with old or poorly maintained infrastructure for potable water. An increasingly popular solution for ensuring clean and safe drinking water in homes is the use of adsorption-based water filters, given their affordability, efficacy, and simplicity. Herein, we report the preparation and functional validation of a new adsorbent for home water filters, based on our metal-organic framework (MOF) composite containing UiO-66 and cerium(IV) oxide (CeO) nanoparticles. Read More

View Article and Full-Text PDF

Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases.

Curr Neurovasc Res 2021 Apr 6. Epub 2021 Apr 6.

Department of Experimental Medicine, Sapienza University of Rome, Rome. Italy.

Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate drinkers have a lower ACVD risk than abstainers because of their higher levels of high-density lipoprotein (HDL) cholesterol, an important protective factor against ACVD. On the contrary, heavy drinking increases ACVD risk. Read More

View Article and Full-Text PDF

Affect-Based Problem Drinking Risk: The Reciprocal Relationship between Affective Lability and Problem Drinking.

Alcohol Alcohol 2021 Apr 5. Epub 2021 Apr 5.

University of Kentucky, Department of Psychology, 106B Kastle Hall, Lexington, KY 40506, USA.

Aims: Negative affect has been implicated in risk for the development of problematic drinking behavior. Furthermore, there is evidence for reciprocal relationships between negative affect and problem drinking, such that engagement in problem drinking also predicts increases in negative affect. However, affective models of risk often fail to consider affective lability-the experience of rapidly changing mood. Read More

View Article and Full-Text PDF

Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression.

World J Biol Psychiatry 2021 Apr 6:1-29. Epub 2021 Apr 6.

Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Objective: Adolescence drinking and subsequent development of alcohol use disorder (AUD) is a worldwide health concern. In particular, mood dysregulation or early alcohol exposure can be the cause of heavy drinking in some individuals or a consequence of heavy drinking in others.

Methods: This study investigated the effects of voluntary alcohol intake during adolescence, i. Read More

View Article and Full-Text PDF

Clinical response in patients treated with once-monthly paliperidone palmitate: analysis of a therapeutic drug monitoring (TDM) database.

Eur Arch Psychiatry Clin Neurosci 2021 Apr 5. Epub 2021 Apr 5.

Alexianer Hospital Aachen, Aachen, Germany.

To investigate pharmacokinetic correlates of clinical response in patients treated with once-monthly paliperidone palmitate (PP1M) injections at steady state. Plasma concentrations and dose-adjusted-plasma concentrations (C/D) of paliperidone from a naturalistic therapeutic drug monitoring (TDM) database were compared between responders and non-responders using the Clinical Global Impressions-Improvement scale (CGI-I) ratings. Analyses were based on the non-parametric Mann-Whitney U test and the Pearson Chi-squared test (χ) with a significance level of 0. Read More

View Article and Full-Text PDF

Risk Perception, Unhealthy Behavior, and Anxiety Due to Viral Epidemic Among Healthcare Workers: The Relationships With Depressive and Insomnia Symptoms During COVID-19.

Front Psychiatry 2021 19;12:615387. Epub 2021 Mar 19.

Department of Psychiatry, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.

We aimed to investigate the relationship between mental health problems and unhealthy behaviors among healthcare workers in response to the COVID-19 pandemic. Using an online survey, we collected data on healthcare workers' perception regarding COVID-19 exposure in a work unit. Workers' depression, insomnia, and anxiety symptoms were assessed using the Patient Health Questionnaire-9, Insomnia Severity Index, and Generalized Anxiety Disorder-7 scale, respectively. Read More

View Article and Full-Text PDF

Malignant Syphilis: A Systematic Review of the Case Reports Published in 2014-2018.

Actas Dermosifiliogr 2021 Mar 31. Epub 2021 Mar 31.

Servicio de Dermatología y Venereología, Facultad de Medicina de la Universidad de Hasanuddin, 90245, Makassar, Indonesia; Hospital Dr. Wahidin Sudirohusodo, 90245, Makassar, Indonesia.

Malignant syphilis (MS) is a rare manifestation of secondary syphilis which mainly occurs in immunocompromised individuals such as those coinfected with human immunodeficiency virus (HIV). However, recent reports have described MS in immunocompetent individuals. To describe the characteristics of individuals with MS and associated risk factors, a review of case reports published from 2014 to 2018 was conducted. Read More

View Article and Full-Text PDF

Pitfalls in the Immunochemical Determination of β-Lactam Antibiotics in Water.

Antibiotics (Basel) 2021 Mar 12;10(3). Epub 2021 Mar 12.

BAM Federal Institute for Materials Research and Testing, 12205 Berlin, Germany.

Contamination of waters with pharmaceuticals is an alarming problem as it may support the evolution of antimicrobial resistance. Therefore, fast and cost-effective analytical methods for potential on-site analysis are desired in order to control the water quality and assure the safety of its use as a source of drinking water. Antibody-based methods, such as the enzyme-linked immunosorbent assay (ELISA), can be helpful in this regard but can also have certain pitfalls in store, depending on the analyte. Read More

View Article and Full-Text PDF