J Drug Issues 1999 Apr;29(2):203-214
, Ph.D., is an Assistant Professor of Pediatrics at Case Western Reserve University. His research interests indude motor development and prenatal drug exposure. , Ph.D., is a Professor of Pediatrics at Case Western Reserve University, and director of the Center for the Advancement of Mothers and Children at MetroHealth Medical Center. The Center, which serves a predominately underprivileged inner-city population of children at risk for developmental disabilities, provides clinical services and research support for studies in physiological, psychological, and social aspects of prenatal drug exposure. , Ph.D., is the coordinator of Project Newborn, a longitudinal study of prenatally cocaine exposed infants and their mothers, at Case Western Reserve University. Her research emphasizes the psychological and cognitive effects of chronic substance abuse on women. , M.S., is a biostatistician with the Division of Clinical Epidemiology, Department of Pediatrics at Case Western Reserve University. Her research focus is on clinical trials and longitudinal research. Address correspondence and reprint requests to Case Western Reserve University, Department of Pediatrics, 11100 Euclid Ave., Cleveland, OH 44106-6038.
A basic problem encountered by investigations of prenatal cocaine effects has been the valid identification and quantification of exposure. Based on a combination of sources: (a) medical record review, (b) maternal urine toxicology screen, (c) meconium analysis, and (d) maternal postpartum interview, drug exposure status of 415 infants was established. Using this combination as a benchmark, maternal postpartum interview was found most sensitive, while medical record review was slightly less accurate. Read More