355,681 results match your criteria probability survival

Hydrothermal aging affects the three-dimensional fit and fatigue lifetime of zirconia abutments.

J Mech Behav Biomed Mater 2021 Sep 8;124:104832. Epub 2021 Sep 8.

Department of Prosthodontics and Periodontology, Bauru School of Dentistry - University of Sao Paulo, 9-75 Octavio Pinheiro Brizolla, 17012-901, Bauru, SP, Brazil.

Objective: Evaluate the effect of aging using two different methods on the three-dimensional fit of zirconia abutments at the implant-abutment connection and estimate the probability of survival of anterior crowns supported by straight and 17-degree angled abutments.

Materials And Methods: Two different zirconia abutment designs, straight and 17-degree angled abutments (n = 63/group), were evaluated in the current study. The abutments were randomly allocated into three experimental groups according to laboratory aging condition (134°C, 2. Read More

View Article and Full-Text PDF
September 2021

Comparing cancer and cardiovascular disease trends in 20 middle- or high-income countries 2000-19: A pointer to national trajectories towards achieving Sustainable Development goal target 3.4.

Cancer Treat Rev 2021 Sep 9;100:102290. Epub 2021 Sep 9.

Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.

With the 2030 Sustainable Development Goals (SDG) target of a one-third reduction in noncommunicable diseases (NCDs) less than a decade away, it is timely to assess national progress in reducing premature deaths from the two leading causes of mortality worldwide. We examine trends in the probability of dying ages 30-70 from cardiovascular disease (CVD) and cancer 2000-19 in 10 middle-income (MICs) and 10 high-income (HICs) countries with high quality data. We then predict whether the SDG target will be met in each country for CVD, cancer and for the four main NCDs combined. Read More

View Article and Full-Text PDF
September 2021

Basal cortisol concentrations related to maternal behavior during puppy development predict post-growth resilience in dogs.

Horm Behav 2021 Sep 15;136:105055. Epub 2021 Sep 15.

Department of Animal Science and Biotechnology Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara 252-5201, Kanagawa, Japan. Electronic address:

A prolonged stress hyporesponsive period (SHRP) due to the mother's presence may delay the timing of glucocorticoid (GC) elevation in infants, thereby reducing the excessive stress response that would affect post-growth temperament. In dogs, the SHRP has been suggested to persist until postnatal week (PW) 4; therefore, PW 5, which SHRP may be prolonged by the mother dog, may be a critical point in the developmental stage of dogs to establish stress responsiveness. We conducted a long-term survey on the development of dogs to investigate i) whether the degree of the stress response at PW 5 is determined by maternal behavior and ii) whether it can predict post-growth stress responses and temperament in dogs. Read More

View Article and Full-Text PDF
September 2021

Pulmonary hypertension among children with in-hospital cardiac arrest: a multicenter study.

Resuscitation 2021 Sep 15. Epub 2021 Sep 15.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Aims: To determine the prevalence of pulmonary hypertension (PH) among children with in-hospital cardiac arrest (IHCA) and its association with survival.

Methods: Children (<18 years) admitted to ICUs participating in the Virtual Pediatric Systems multicenter registry between January 2011 and December 2017 who had an IHCA during their hospitalization were included. Patients were classified by whether they had a documented diagnosis of PH at the time of IHCA. Read More

View Article and Full-Text PDF
September 2021

The fairness of ventilator allocation during the COVID-19 pandemic.

Xueshi Wang

Bioethics 2021 Sep 18. Epub 2021 Sep 18.

Department of Philosophy, Harvard University, Cambridge, Massachusetts, USA.

There is ongoing debate on how to fairly allocate scarce critical care resources to patients with COVID-19. The debate revolves around two views: those who believe that priority for scarce resources should primarily aim at saving the most lives (SML) or at saving the most life-years, and those who believe that public health should focus on health equity to address health disparities and social determinants of health. I argue that maximizing medical outcomes by saving the greatest number of patients is not a plausible strategy for combating COVID-19. Read More

View Article and Full-Text PDF
September 2021

The management of moderate acute malnutrition in children aged 6-59 mo in low- and middle-income countries: a systematic review and meta-analysis.

Trans R Soc Trop Med Hyg 2021 Sep 17. Epub 2021 Sep 17.

Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.

Background: Malnutrition is a leading cause of morbidity and mortality in children aged <5 y, especially in low- and middle-income countries (LMICs). Unlike severe acute malnutrition, moderate acute malnutrition (MAM) affects greater numbers globally, and guidelines lack a robust evidence base. This systematic review and meta-analysis assessed the evidence for lipid-based nutrient supplements (LNSs), fortified blended flours (FBFs) and nutrition counselling, in the treatment of MAM. Read More

View Article and Full-Text PDF
September 2021

The Effectiveness of Stroke Riskometer™ in Improving Stroke Risk Awareness in Malaysia: A Study Protocol of a Cluster-Randomized Controlled Trial.

Neuroepidemiology 2021 Sep 15:1-11. Epub 2021 Sep 15.

National Institute for Stroke and Applied Neurosciences, Auckland University of Technology (AUT), Auckland City, New Zealand.

Background: Stroke is considered the second leading cause of mortality and disability worldwide. The increasing burden of stroke is strong evidence that currently used primary prevention strategies are not sufficiently effective. The Stroke Riskometer™ application (app) represents a new stroke prevention strategy distinctly different from the conventional high-cardiovascular disease risk approach. Read More

View Article and Full-Text PDF
September 2021

Overall Survival of Patients Receiving Cisplatin or Carboplatin for Primary Metastatic Urothelial Carcinoma of the Bladder: A Contemporary Dutch Nationwide Cohort Study.

Eur Urol Focus 2021 Sep 14. Epub 2021 Sep 14.

Department of Research and Development, The Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Cisplatin is preferred to carboplatin when treating metastatic urothelial carcinoma of the bladder (mUCB), despite its greater toxicity. Randomised studies underpinning this have been performed in noncontemporary populations with limitations in sample sizes and analyses, affecting their validity in current clinical practice.

Objective: To estimate overall survival (OS) and assess the benefit of cisplatin-based regimens over carboplatin-based regimens in a contemporary cohort of patients with mUCB. Read More

View Article and Full-Text PDF
September 2021

Can I Send This Syncope Patient Home From the Emergency Department?

J Emerg Med 2021 Sep 14. Epub 2021 Sep 14.

Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Syncope is a common presentation to the emergency department (ED). A significant minority of these patients have potentially life-threatening pathology. Reliably identifying that patients require hospital admission for further workup and intervention is imperative. Read More

View Article and Full-Text PDF
September 2021

The role of postoperative radiotherapy in pN1 oral cavity cancer without extranodal extension.

World J Surg Oncol 2021 Sep 17;19(1):279. Epub 2021 Sep 17.

Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan.

Background: The administration of postoperative radiotherapy remains controversial in pN1 oral cavity cancer patients without extranodal extension. The aim is to determine whether postoperative radiotherapy reduces the neck recurrence rate and improves the survival outcomes of pN1 patients.

Methods: This study consecutively enrolled 1056 patients with newly diagnosed oral squamous cell carcinoma who underwent tumor wide excision and neck dissection from September 2002 to November 2019. Read More

View Article and Full-Text PDF
September 2021

Racial disparities in the SOFA score among patients hospitalized with COVID-19.

PLoS One 2021 17;16(9):e0257608. Epub 2021 Sep 17.

Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.

Background: Sequential Organ Failure Assessment (SOFA) score predicts probability of in-hospital mortality. Many crisis standards of care suggest the use of SOFA scores to allocate medical resources during the COVID-19 pandemic.

Research Question: Are SOFA scores elevated among Non-Hispanic Black and Hispanic patients hospitalized with COVID-19, compared to Non-Hispanic White patients?

Study Design And Methods: Retrospective cohort study conducted in Yale New Haven Health System, including 5 hospitals with total of 2681 beds. Read More

View Article and Full-Text PDF
September 2021

Noninvasive ventilation at home reduces mortality in COPD with CRF.

Am J Manag Care 2021 Sep 1;27(9):e308-e315. Epub 2021 Sep 1.

PRECISIONheor, 11100 Santa Monica Blvd, Ste 500, Los Angeles, CA 90034. Email:

Objectives: Patients with chronic respiratory failure resulting from chronic obstructive pulmonary disease (COPD-CRF) have limited treatment options and poor health outcomes. We examined the effect of noninvasive ventilation at home (NIVH) treatment on all-cause mortality, hospitalizations, and emergency department (ED) visits.

Study Design: Retrospective cohort study. Read More

View Article and Full-Text PDF
September 2021

New-Onset Postoperative Atrial Fibrillation After Total Arch Repair Is Associated With Increased In-Hospital Mortality.

J Am Heart Assoc 2021 Sep 17:e021980. Epub 2021 Sep 17.

Department of Vascular Surgery Fuwai HospitalState Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Beijing China.

Background It is well established that postoperative atrial fibrillation (POAF) is associated with adverse postoperative outcomes after major cardiac operations. The purpose of this study was to investigate the incidence of new-onset POAF after successful total arch repair surgery and the association between POAF and in-hospital mortality. Methods and Results All consecutive patients undergoing total arch repair from September 2012 to December 2019 in Fuwai hospital were enrolled (n=1280). Read More

View Article and Full-Text PDF
September 2021

Prognostic significance of chromosomal abnormalities at relapse in children with relapsed acute myeloid leukemia: A retrospective cohort study of the Relapsed AML 2001/01 Study.

Pediatr Blood Cancer 2021 Sep 17:e29341. Epub 2021 Sep 17.

Pediatric Oncology, Cancer Center Amsterdam, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Background: In addition to treatment response, cytogenetic and molecular aberrations are the most important prognostic factors in children with de novo acute myeloid leukemia (AML). However, little is known about cytogenetics at the time of relapse.

Methods: This international study analyzed the prognostic value of cytogenetic profiles and karyotypic changes in pediatric relapsed AML in relation to the probability of event-free (pEFS) and overall survival (pOS). Read More

View Article and Full-Text PDF
September 2021

Clinical diagnosis and treatment of breast cancer with brain metastases and establishment of a prognostic model: a 10-year, single-center, real-world study of 559 cases.

Ann Transl Med 2021 Aug;9(16):1331

Department of Breast Disease, Henan Breast Cancer Center, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.

Background: This study involved a retrospective analysis of 559 metastatic breast cancer (MBC) patients with brain metastasis (BM). We aimed to establish the effectiveness of different preferred treatment methods and factors affecting overall survival following BM diagnosis (BMOS) and explore the feasibility of systemic treatment for MBC patients with BM.

Methods: Univariate and multivariate analyses were used to assess the efficacy of different preferred treatments and other factors associated with BMOS, and a nomogram was then established based on the results of the univariate analysis. Read More

View Article and Full-Text PDF

Long-term outcome of stereotactic aspiration, endoscopic evacuation, and open craniotomy for the treatment of spontaneous basal ganglia hemorrhage: a propensity score study of 703 cases.

Ann Transl Med 2021 Aug;9(16):1289

Department of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.

Background: To compare the long-term therapeutic effects of stereotactic aspiration (SA), endoscopic evacuation (EE), and open craniotomy (OC) in the surgical treatment of spontaneous basal ganglia hemorrhage and explore the appropriate clinical indications for each technique.

Methods: Multiple-treatment inverse probability of treatment weighting (IPTW)-adjusted logistic regression analysis was performed to evaluate the therapeutic effects of these techniques. The primary and secondary outcomes were 6-month modified Rankin Scale (mRS) and mortality rates, respectively. Read More

View Article and Full-Text PDF

Cost-effectiveness analysis of camrelizumab in the second-line treatment for advanced or metastatic esophageal squamous cell carcinoma in China.

Ann Transl Med 2021 Aug;9(15):1226

Boston Scientific, Marlborough, MA, USA.

Background: This study aimed to evaluate the cost-effectiveness of camrelizumab versus chemotherapy as second-line treatment for patients with advanced/metastatic esophageal squamous cell carcinoma (ESCC) from the perspective of the Chinese healthcare system.

Methods: A trial-based Markov model was constructed using Excel to integrate clinical and economic data in a hypothetical cohort of advanced/metastatic ESCC patients with a 5-year time horizon. Clinical inputs were derived directly from the ESCORT trial (NCT03099382). Read More

View Article and Full-Text PDF

Baseline Neutrophil-to-Lymphocyte Ratio Is Independently Associated With 90-Day Transplant-Free Mortality in Patients With Cirrhosis.

Front Med (Lausanne) 2021 31;8:726950. Epub 2021 Aug 31.

Department of Infectious Diseases, Institute of Infection and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Patients with cirrhosis have an increased risk of short-term mortality, however, few studies quantify the association between neutrophil-to-lymphocyte ratio (NLR) and 90-day transplant-free mortality in cirrhotic patients. We prospectively analyzed 3,970 patients with chronic liver diseases from two multicenter cohorts in China (January 2015 to December 2016 and July 2018 to January 2019). Restricted cubic splines (RCS) were used to analyze the relation of NLR and all-causes 90-day transplant-free mortality in cirrhosis. Read More

View Article and Full-Text PDF

Bioinformatics analysis based on immune-autophagy-related lncRNAs combined with immune infiltration in bladder cancer.

Transl Androl Urol 2021 Aug;10(8):3440-3455

Department of Urology, Maoming People's Hospital, Maoming, China.

Background: To construct a prognostic model based on immune-autophagy-related long noncoding RNA (IArlncRNAs), mainly to predict the overall survival rate (OS) of bladder cancer patients and investigate its possible mechanisms.

Methods: Transcriptome and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. We identified the IArlncRNA by co-expression analysis, differential expression analysis, and Venn analysis. Read More

View Article and Full-Text PDF

High turn-over rates at the upper range limit and elevational source-sink dynamics in a widespread songbird.

Sci Rep 2021 Sep 16;11(1):18470. Epub 2021 Sep 16.

Swiss Ornithological Institute, Seerose 1, 6204, Sempach, Switzerland.

The formation of an upper distributional range limit for species breeding along mountain slopes is often based on environmental gradients resulting in changing demographic rates towards high elevations. However, we still lack an empirical understanding of how the interplay of demographic parameters forms the upper range limit in highly mobile species. Here, we study apparent survival and within-study area dispersal over a 700 m elevational gradient in barn swallows (Hirundo rustica) by using 15 years of capture-mark-recapture data. Read More

View Article and Full-Text PDF
September 2021

A nomogram to predict stricture-free survival in patients with ureteral stricture after balloon dilation.

BMC Urol 2021 Sep 16;21(1):129. Epub 2021 Sep 16.

Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 West Yanjiang Road, Guangzhou, 510210, China.

Background: Balloon dilation is a commonly used minimally invasive endourological treatment of ureteral stricture, but the postoperative recurrence rate is relatively high. And factors contributing to recurrence after treatment are poorly understood. Herein, we sought to develop a novel clinical nomogram to predict ureteral stricture-free survival in patients suffering from ureter stricture and performed balloon dilation. Read More

View Article and Full-Text PDF
September 2021

Prevalence and Population Attributable Risk for Early COPD in US Hispanics/Latinos.

Ann Am Thorac Soc 2021 Sep 17. Epub 2021 Sep 17.

Brigham and Women's Hospital, 1861, Medicine, Boston, Massachusetts, United States;

Rationale: In predominantly white populations, early COPD (i.e., COPD in people under 50 years of age) has been linked to higher hospitalization rates and mortality; however, the prevalence, risk factors, and population attributable risk (PAR) of early COPD remain to be determined in non-white populations. Read More

View Article and Full-Text PDF
September 2021

ASXL1 and STAG2 are Common Mutations in GATA2 Deficiency Patients with Bone Marrow Disease and Myelodysplastic Syndrome.

Blood Adv 2021 Sep 16. Epub 2021 Sep 16.

National Insitutes of Health, Bethesda, Maryland, United States.

GATA2 Deficiency patients harbor de novo or inherited germline mutations in the GATA2 transcription factor gene, predisposing them to myeloid malignancies. There is considerable variation in disease progression, even among family members with the same mutation in GATA2. We investigated somatic mutations in 106 patients with GATA2 Deficiency to identify acquired mutations that are associated with myeloid malignancies. Read More

View Article and Full-Text PDF
September 2021

Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial.

JAMA Oncol 2021 Sep 16. Epub 2021 Sep 16.

Medical Oncology, Swedish Cancer Institute, Seattle, Washington.

Importance: Residual cancer burden (RCB) distributions may improve the interpretation of efficacy in neoadjuvant breast cancer trials.

Objective: To compare RCB distributions between randomized control and investigational treatments within subtypes of breast cancer and explore the relationship with survival.

Design, Setting, And Participants: The I-SPY2 is a multicenter, platform adaptive, randomized clinical trial in the US that compares, by subtype, investigational agents in combination with chemotherapy vs chemotherapy alone in adult women with stage 2/3 breast cancer at high risk of early recurrence. Read More

View Article and Full-Text PDF
September 2021

Models Predicting Hospital Admission of Adult Patients Utilizing Prehospital Data: Systematic Review Using PROBAST and CHARMS.

JMIR Med Inform 2021 Sep 16;9(9):e30022. Epub 2021 Sep 16.

Department of Health Services Administration, University of Alabama at Birmingham, Birmingham, AL, United States.

Background: Emergency department boarding and hospital exit block are primary causes of emergency department crowding and have been conclusively associated with poor patient outcomes and major threats to patient safety. Boarding occurs when a patient is delayed or blocked from transitioning out of the emergency department because of dysfunctional transition or bed assignment processes. Predictive models for estimating the probability of an occurrence of this type could be useful in reducing or preventing emergency department boarding and hospital exit block, to reduce emergency department crowding. Read More

View Article and Full-Text PDF
September 2021

[Preoperative stress testing in patients prior to vascular surgery].

Angiol Sosud Khir 2021 ;27(3):159-164

Department of Faculty Surgery, Samara State Medical University of the RF Ministry of Public Health, Samara, Russia.

Myocardial infarction is the leading cause of mortality during peripheral artery surgery. The review summarizes the data on cardiac event risk stratification in angiosurgical patients by preoperative stress testing. The prognostic value of positive and negative results is described. Read More

View Article and Full-Text PDF
September 2021

Endovascular repair of the aorti arch.

Angiol Sosud Khir 2021 ;27(3):34-45

Department of Cardiovascular Surgery, National Medical Research Center of Cardiology of the RF Ministry of Public Health, Moscow, Russia.

Aim: The study was aimed at assessing the in-hospital results of aortic arch endoprosthetic repair using different variants of endovascular supraaortic debranching.

Patients And Methods: The analysis included 27 patients subjected within the framework of aortic arch endoprosthetic repair to various types of supraaortic endobranching, including the technique of parallel prostheses and implantation of fenestrated stent grafts. We analysed the clinical and morphological status of patients prior to operation, peculiarities of the intervention (type of debranching and Ishimaru's classification zones in which the reconstruction was performed) and in-hospital results of treatment. Read More

View Article and Full-Text PDF
September 2021

[Hypertension after kidney transplantation].

Rev Med Suisse 2021 Sep;17(750):1571-1574

Centre de transplantation d'organes, Département de médecine, CHUV et Université de Lausanne, 1011 Lausanne.

Kidney transplantation is the treatment of choice for end-stage renal disease. While graft survival has considerably improved with current immunosuppressive strategies, long-term prognosis is dependent on cardiovascular complications. There is a high prevalence of arterial hypertension after kidney transplantation. Read More

View Article and Full-Text PDF
September 2021

A single-center analysis of outcomes, risk factors, and new valves in Asian patients treated with early transcatheter aortic valve implantation.

Cardiovasc Diagn Ther 2021 Aug;11(4):967-979

Department of Extracorporeal Circulation, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Transcatheter aortic valve implantation (TAVI) continues to expand as an optimal treatment in Western countries; however, Asian countries have been slower to adopt this procedure. This research aimed to explore the outcomes and status of early TAVI performed at a single center in Asia, and provide comparative outcomes of the newly designed Chinese valves.

Methods: We enrolled 175 consecutive patients who successfully underwent TAVI from September 2012 to January 2018 at Fuwai Hospital (Beijing, China). Read More

View Article and Full-Text PDF

Incidence of Venous Thromboembolism and Effect of Anticoagulant Dosing in Hospitalized COVID-19 Patients.

J Hematol 2020 Aug 28;10(4):162-170. Epub 2021 Jul 28.

Division of Hematology/Oncology, Georgia Cancer Center, Augusta University, Augusta, GA 30909, USA.

Background: Coronavirus disease 2019 (COVID-19) is characterized by coagulopathy and thrombotic events. We examined factors associated with development of venous thromboembolism (VTE) in COVID-19 and to discern if higher dose of anticoagulation was beneficial in these patients.

Methods: This study involves an observational study of prospectively collected data in the setting of a large community hospital in a rural setting in Northeast Georgia with COVID-19 between March 1, 2020 and February 5, 2021. Read More

View Article and Full-Text PDF