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Periocular Presentation of Solitary Plasmacytomas and Multiple Myeloma.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Orbital Service, Moorfields Eye Hospital, London, United Kingdon.

Aims: To describe patients with periocular solitary extramedullary plasmacytoma (SEMP) and multiple myeloma (MM), together with an estimate of the risk of progression from SEMP to MM.

Patients And Methods: A retrospective case-note review for patients seen between 1978 and 2020, examining demographics, presentation, imaging, pathology, management, and outcome.

Results: Twenty patients (10 male; 50%) presented at a mean age of 60. Read More

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Effect of Sustained Interventions from Infancy to Toddlerhood in Children with Cleft Lip and Palate for Preventing Early Childhood Caries.

Caries Res 2021 Jul 22:1-9. Epub 2021 Jul 22.

Department of Pediatric and Preventive Dentistry, Pushpagiri College of Dental Sciences, Thiruvalla, India.

The study aimed to evaluate the effectiveness of sustained interventions in children with cleft lip and palate (CLP) for preventing early childhood caries (ECC). This prospective, nonrandomized interventional cohort study was conducted in infants aged 0-12 months with congenital CLP. Interventions were given to parents/primary caregivers in the form of combined oral health-care measures (sterile wet gauze piece, finger brush, toothbrush, and toothpaste) by a motivational interviewing approach. Read More

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Factors influencing under-five mortality in rural- urban Ghana: An applied survival analysis.

Soc Sci Med 2021 Jul 7;284:114185. Epub 2021 Jul 7.

Department of Economics, University of Ghana, Ghana. Electronic address:

Objectives: This paper uses a survival analysis technique to examine socio-economic and demographic factors that influence under-five mortality for rural and urban Ghana.

Method: The paper employs the Breslow Method for Ties for survival probability and uses data for the 2014 Ghana Demographic and Health Survey (GDHS). Data on some 5884 children was also generated through the interview of 4086 women aged 15-49. Read More

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Safranin T- SDS- GO ternary system: A fluorescent pH sensor.

Colloids Surf B Biointerfaces 2021 Jul 15;206:111977. Epub 2021 Jul 15.

Department of Chemistry, Atatürk University, Erzurum, 25100, Turkey.

Graphene oxide (GO), one of the popular materials in recent years, has been synthesized according to the modified Hummers' method. Stable dispersions of different amounts of negatively charged GO were prepared in aqueous media. The GO/dye composites were prepared in deionized water by a simple method with the positively charged Safranin T compound (SfT), which is known to have strong fluorescence properties. Read More

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A distributed optimisation framework combining natural gradient with Hessian-free for discriminative sequence training.

Neural Netw 2021 May 29;143:537-549. Epub 2021 May 29.

Cambridge University Engineering Department, Trumpington Street, Cambridge, CB2 1PZ, UK. Electronic address:

This paper presents a novel natural gradient and Hessian-free (NGHF) optimisation framework for neural network training that can operate efficiently in a distributed manner. It relies on the linear conjugate gradient (CG) algorithm to combine the natural gradient (NG) method with local curvature information from Hessian-free (HF). A solution to a numerical issue in CG allows effective parameter updates to be generated with far fewer CG iterations than usually used (e. Read More

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Durability of rilpivirine- versus integrase inhibitor-based regimens in a large cohort of naïve HIV-infected patients starting antiretroviral therapy.

Int J Antimicrob Agents 2021 Jul 19:106406. Epub 2021 Jul 19.

Clinic of Infectious Diseases, S. Paolo Hospital, University of Milan, Milano, Italy.

Objective: Comparisons between rilpivirine (RPV) and integrase strand transfer inhibitors (INSTIs) in antiretroviral therapy (ART)-naïve HIV-infected individuals are currently lacking. Aim of the study was to compare, in an observational cohort setting, the durability of treatment of RPV- and INSTI-based first-line regimens.

Methods: Patients who started first-line ARTs based on RPV or on INSTIs, with HIV-RNA <100,000 copies/mL, CD4 cells count >200 cells/μL, were included. Read More

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Association between bariatric surgery with long-term analgesic prescription and all-cause mortality among patients with osteoarthritis: a general population-based cohort study.

Osteoarthritis Cartilage 2021 Jul 19. Epub 2021 Jul 19.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA;; The Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, USA. Electronic address:

Objectives: There is still a large unmet need for novel osteoarthritis (OA) treatments that could provide clinically important effects on long-term pain relief (≥12 months). We examined the relation of bariatric surgery along with weight loss to analgesic prescription and all-cause mortality among individuals with OA.

Methods: We conducted a cohort study among individuals with OA using The Health Improvement Network. Read More

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Seminal vesicle intrafraction motion during the delivery of radiotherapy sessions on a 1.5 T MR-Linac.

Radiother Oncol 2021 Jul 19. Epub 2021 Jul 19.

University Medical Center Utrecht, Department of Radiotherapy, Utrecht 3508 GA, The Netherlands.

PurposeTo evaluate seminal vesicle (SV) intrafraction motion using cinematic magnetic resonance imaging (cine-MR) during the delivery of online adaptive MR-Linac radiotherapy fractions, in preparation of MR-guided extremely hypofractionated radiotherapy for intermediate to high-risk prostate cancer patients.Material and MethodsFifty prostate cancer patients were treated with 5 x 7.25 Gy on a 1. Read More

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Factors associated with the use and composition of two-drug regimens in a large single-centre HIV cohort.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain.

Objectives: We aimed to assess the clinical characteristics associated with the use of two-drug regimens (2DRs) and the factors associated with specific antiretrovirals in 2DRs in a large single-centre HIV cohort.

Methods: Retrospective analysis of demographics, HIV characteristics and AIDS events, antiretroviral prescription, virological failure and genotypic resistance testing, and laboratory results from all adult people with HIV (PWH) prospectively followed at the Hospital Clinic of Barcelona who were receiving a 3DR or a 2DR in January 2020. We assessed factors associated with the probability of receiving 2DRs relative to three-drug regimens (3DRs) using a logistic regression model, controlling for age, sex and year of HIV diagnosis. Read More

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Body weight and premature retirement: population-based evidence from Finland.

Eur J Public Health 2021 Jul 19. Epub 2021 Jul 19.

Department of Mathematics and Statistics, University of Jyväskylä, Jyväskylä, Finland.

Background: Health status is a principal determinant of labour market participation. In this study, we examined whether excess weight is associated with withdrawal from the labour market owing to premature retirement.

Methods: The analyses were based on nationally representative data from Finland over the period 2001-15 (N ∼ 2500). Read More

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Male microchimerism in females: a quantitative study of twin pedigrees to investigate mechanisms.

Hum Reprod 2021 Jul 19. Epub 2021 Jul 19.

Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.

Study Question: Does having a male co-twin, older brothers, or sons lead to an increased probability of persistent male microchimerism in female members of twin pedigrees?

Summary Answer: The presence of a male co-twin did not increase risk of male microchimerism and the prevalence of male microchimerism was not explained by having male offspring or by having an older brother.

What Is Known Already: Microchimerism describes the presence of cells within an organism that originate from another zygote and is commonly described as resulting from pregnancy in placental mammals. It is associated with diseases with a female predilection including autoimmune diseases and pregnancy-related complications. Read More

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Non-native plant removal and high rainfall years promote post-fire recovery of Artemisia californica in southern California sage scrub.

PLoS One 2021 22;16(7):e0254398. Epub 2021 Jul 22.

W.M. Keck Science Department, Claremont, California, United States of America.

Non-native plant invasions, changes in fire regime, and increasing drought stress all pose important threats to biodiverse mediterranean-climate shrublands. These factors can also interact, with fire and drought potentially creating opportunities for non-native species to establish dominance before native shrubs recover. We carried out post-fire demographic monitoring of the common native shrub Artemisia californica in a southern California sage scrub fragment for 7 years, including several with very low rainfall. Read More

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Protein-Peptide Binding Site Detection Using 3D Convolutional Neural Networks.

J Chem Inf Model 2021 Jul 22. Epub 2021 Jul 22.

iMolecule, Center for Computational and Data-Intensive Science and Engineering, Skolkovo Institute of Science and Technology, Moscow 121205, Russia.

Peptides and peptide-based molecules represent a promising therapeutic modality targeting intracellular protein-protein interactions, potentially combining the beneficial properties of biologics and small-molecule drugs. Protein-peptide complexes occupy a unique niche of interaction interfaces with respect to protein-protein and protein-small molecule complexes. Protein-peptide binding site identification resembles image object detection, a field that had been revolutionalized with computer vision techniques. Read More

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Method Used to Identify Adenomyosis and Potentially Undiagnosed Adenomyosis in a Large, U.S. Electronic Health Record Database.

Pharmacoepidemiol Drug Saf 2021 Jul 22. Epub 2021 Jul 22.

Optum, Boston, MA.

Background: The prevalence of adenomyosis is underestimated due to lack of a specific diagnostic code and diagnostic delays given most diagnoses occur at hysterectomy.

Objectives: To identify women with adenomyosis using indicators derived from natural language processing (NLP) of clinical notes in the Optum Electronic Health Record database (2014-2018), and to estimate the prevalence of potentially undiagnosed adenomyosis.

Methods: An NLP algorithm identified mentions of adenomyosis in clinical notes that were highly likely to represent a diagnosis. Read More

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Urinary exosomal circular RNAs of sex chromosome origin are associated with gender-related risk differences of clinicopathological features in patients with IgA nephropathy.

J Nephrol 2021 Jul 22. Epub 2021 Jul 22.

Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, Jilin, China.

Background: There are arguments for individualized treatments and the necessity of non-invasive biomarkers for patients with IgA nephropathy (IgAN) according to gender, but the rationale remains unclear. We aimed to investigate the relationship between urine exosomal circular RNA (circRNA) levels, related genes, clinical features, and renal pathological features in IgA nephropathy patients of different genders.

Methods: Clinicopathological data from patients of different genders from a multicenter cohort were retrospectively analyzed. Read More

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Genetic portrait of 23 Y-STR loci in the Naga tribes of Nagaland, India.

Int J Legal Med 2021 Jul 22. Epub 2021 Jul 22.

DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Govt. of MP, Sagar, 470001, India.

To explore the genomic diversity and forensic characterization of Naga tribes, Nagaland, haplotypes for 23 Y-STR markers have been analyzed. In this study, 203 unrelated male individuals residing in the Northeast Indian state of Nagaland were selected. A total of 203 unique haplotypes were observed. Read More

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The similarity-updating model of probability judgment and belief revision.

Psychol Rev 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychology.

People often take nondiagnostic information into account when revising their beliefs. A probability judgment decreases due to nondiagnostic information represents the well-established "dilution effect" observed in many domains. Surprisingly, the opposite of the dilution effect called the "confirmation effect" has also been observed frequently. Read More

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Effect of brief nicotine corrective messaging on nicotine beliefs in persons who use opioids.

Exp Clin Psychopharmacol 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychiatry.

This pilot study tested the effect of a brief nicotine education messaging exposure on beliefs about nicotine, nicotine-replacement therapy (NRT), and e-cigarettes. Participants ages 18 and older were recruited via Amazon Mechanical Turk to complete a 20-min online survey in April/May 2020 to assess relationships between opioid use, smoking, and other behaviors. Participants with past-month extra-medical opioid use completed questions on background characteristics and literacy and then were randomized in a 2:1 ratio of two conditions: nicotine education ( = 362) or no message control ( = 181). Read More

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Developmental Trajectories in the Understanding of Everyday Uncertainty Terms.

Top Cogn Sci 2021 Jul 22. Epub 2021 Jul 22.

MPRG iSearch, Max Planck Institute for Human Development.

Dealing with uncertainty and different degrees of frequency and probability is critical in many everyday activities. However, relevant information does not always come in the form of numerical estimates or direct experiences, but is instead obtained through qualitative, rather vague verbal terms (e.g. Read More

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COVID-19: Fear and Anxiety among Healthcare Workers in Saudi Arabia. A Cross-Sectional Study.

Inquiry 2021 Jan-Dec;58:469580211025225

Unaizah College of Medicine, Qassim University, Unaizah, Qassim, Saudi Arabia.

The novel coronavirus (COVID-19) is an extremely contagious respiratory disease. It poses a serious threat to healthcare workers which may cause substantial degree of psychological distress. This study aimed to evaluate the level of fear and anxiety among healthcare workers. Read More

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Nurses competence in the reporting of medication-related incidents: An intervention study.

Nurs Open 2021 Jul 22. Epub 2021 Jul 22.

School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Objectives: Less than 5% of all harmful medicine-related incidents (MIs) or adverse drug reactions received by the Spanish Pharmacovigilance system are notified by Registered Nurses (RNs). The main objective of this study was to determine the impact of a multifaceted institutional intervention (MII) in patient safety on the reporting competence of medication incidents of hospital RNs.

Design: One-group pre-test-posttest design. Read More

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Why proper understanding of confidence intervals and statistical significance is important.

James C Hurley

Med J Aust 2021 Jul 21. Epub 2021 Jul 21.

Ballarat Health Services, Ballarat, VIC.

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Endoscopic third ventriculostomy before surgery of third ventricle and posterior fossa tumours decreases the risk of secondary hydrocephalus and early postoperative complications.

Neurosurg Rev 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurosurgery, Wroclaw Medical University, Borowska str. 213, 50-556, Wroclaw, Poland.

Endoscopic third ventriculostomy (ETV) is an effective treatment for obstructive hydrocephalus (HCP) at the level of third or fourth ventricle. To date, there is no consensus regarding its role as intervention preceding the operation of tumour removal. The aim of this prospective open-label controlled study is to assess if ETV prevents secondary HCP after tumour removal and if ETV influences the early results of tumour surgery. Read More

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Association of preoperative cone biopsy with recurrences after radical hysterectomy.

Arch Gynecol Obstet 2021 Jul 21. Epub 2021 Jul 21.

Department of Gynecology and Obstetrics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hanover, Germany.

Objective: To evaluate association of preoperative cone biopsy with the probability of recurrent disease after radical hysterectomy for cervical cancer.

Methods: This is a retrospective single-center study. Patients with cervical cancer stage IA1 with LVSI to IIA2 and squamous, adenosquamous and adenocarcinoma subtype were included. Read More

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Hospital variation in sphincter-preservation rates in rectal cancer treatment: results of a population-based study in the Netherlands.

BJS Open 2021 Jul;5(4)

Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: This study aimed to examine the sphincter-preservation rate variations in rectal cancer surgery. The influence of hospital volume on sphincter-preservation rates and short-term outcomes (anastomotic leakage (AL), positive circumferential resection margin (CRM), 30- and 90-day mortality rates) were also analysed.

Methods: Non-metastasized rectal cancer patients treated between 2009 and 2016 were selected from the Netherlands Cancer Registry. Read More

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Impact of the Mayo Adhesive Probability Score on Donor and Recipient Outcomes After Living-donor Kidney Transplantation: A Retrospective, Single-center Study of 782 Transplants.

Transplant Direct 2021 Aug 16;7(8):e728. Epub 2021 Jul 16.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: This study was performed to assess the impact of the Mayo Adhesive Probability (MAP) score on donor and recipient outcomes after living-donor kidney transplantation (LDKT).

Methods: We retrospectively analyzed 782 transplants involving LDKT between February 2008 and October 2019 to assess the correlation between the MAP score and outcome after LDKT. We divided the transplants into 2 groups according to the donor MAP score: 0 (MAP) and 1-5 (MAP). Read More

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Independent Versus Transtibial Drilling in Anterior Cruciate Ligament Reconstruction: A Meta-analysis With Meta-regression.

Orthop J Sports Med 2021 Jul 12;9(7):23259671211015616. Epub 2021 Jul 12.

Clinica Ortopedica e Traumatologica II, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background: Anterior cruciate ligament (ACL) reconstruction can be performed with different techniques for independent and transtibial (TT) drilling of femoral tunnels, but there is still no consensus on which approach leads to the best outcome.

Purpose: To assess whether the independent or TT drilling approach for ACL reconstruction leads to the best functional outcomes.

Study Design: Systematic review; Level of evidence, 2. Read More

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Multi-State Analysis of the Impact of Childhood Starvation on the Healthy Life Expectancy of the Elderly in China.

Front Public Health 2021 5;9:690645. Epub 2021 Jul 5.

Department of Health Management, Harbin Medical University, Harbin, China.

Child malnutrition is not only common in developing countries but also an important issue faced by developed countries. This study aimed to explore the influence and degree of childhood starvation on the health of the elderly, which provides a reference for formulating health-related policies under the concept of full lifecycle health. Based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2008, 2011, and 2014, this study took a total of 13,185 elderly people aged 65-99 years as the target population. Read More

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Counting single cells and computing their heterogeneity: from phenotypic frequencies to mean value of a quantitative biomarker.

Quant Biol 2020 Jul 20;8(2):172-176. Epub 2020 Apr 20.

Department of Applied Mathematics, University of Washington, Seattle, WA 98195-3925, USA.

This tutorial presents a mathematical theory that relates the probability of sample frequencies, of phenotypes in an isogenic population of cells, to the probability distribution of the sample mean of a quantitative biomarker, when the is very large. An analogue to the statistical mechanics of canonical ensemble is discussed. Read More

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Perioperative Outcomes Following Kidney-Pancreas Transplantation in Alberta, Canada: Research Letter.

Can J Kidney Health Dis 2021 9;8:20543581211029389. Epub 2021 Jul 9.

Department of Community Health Sciences, University of Calgary, AB, Canada.

Background: Simultaneous kidney-pancreas transplantation (SPK) has benefits for patients with kidney failure and type I diabetes mellitus, but is associated with greater perioperative risk compared with kidney-alone transplantation. Postoperative care settings for SPK recipients vary across Canada and may have implications for patient outcomes and hospital resource use.

Objective: To compare outcomes following SPK transplantation between patients receiving postoperative care in the intensive care unit (ICU) compared with the ward. Read More

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