Adv Rheumatol 2019 07 24;59(1):30. Epub 2019 Jul 24.
Laboratório de Imunologia Celular (LIM-17) - Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Background: Adaptive immune cells, including CD4CD69 and CD4CD25FoxP3 regulatory T (Treg) cells, are important for maintaining immunological tolerance. In human systemic lupus erythematosus (SLE), CD4CD25FoxP3 Treg cells are reduced, whereas CD69 expression is increased, resulting in a homeostatic immune imbalance that may intensify autoreactive T cell activity. To analyze the mechanisms implicated in autotolerance failure, we evaluated CD4CD69 and CD4CD25FoxP3 T cells and interleukin profiles in a pristane-induced SLE experimental model. Read More