43,021 results match your criteria priorities

The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers.

Eur J Cancer 2021 Sep 21;157:308-347. Epub 2021 Sep 21.

European Commission, Joint Research Centre (JRC), Ispra, Italy.

Introduction: Europe is an important focus for compiling accurate and up-to-date world cancer statistics owing to its large share of the world's total cancer burden. This article presents incidence and mortality estimates for 25 major cancers across 40 individual countries within European areas and the European Union (EU-27) for the year 2020.

Methods: The estimated national incidence and mortality rates are based on statistical methodology previously applied and verified using the most recently collected incidence data from 151 population-based cancer registries, mortality data and 2020 population estimates. Read More

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September 2021

Global research priorities for COVID-19 in maternal, reproductive and child health: Results of an international survey.

PLoS One 2021 24;16(9):e0257516. Epub 2021 Sep 24.

Institute for Infection and Immunity, St George's, University of London, London, United Kingdom.

Background: The World Health Organization's "Coordinated Global Research Roadmap: 2019 Novel Coronavirus" outlined the need for research that focuses on the impact of COVID-19 on pregnant women and children. More than one year after the first reported case significant knowledge gaps remain, highlighting the need for a coordinated approach. To address this need, the Maternal, Newborn and Child Health Working Group (MNCH WG) of the COVID-19 Clinical Research Coalition conducted an international survey to identify global research priorities for COVID-19 in maternal, reproductive and child health. Read More

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September 2021

Developing State Health Improvement Plans: Exploring States' Use of Healthy People.

J Public Health Manag Pract 2021 Nov-Dec 01;27(Suppl 6):S274-S279

NORC at the University of Chicago, Bethesda, MD.

Background: While Healthy People outlines a national framework for improving the health of the nation, many states develop State Health Improvement Plans (SHIPs) to set priorities to improve the health of their residents. The purpose of this study was to understand the processes that states use to develop their SHIPs, how states align their SHIPs with Healthy People, and challenges that states face using Healthy People.

Methods: NORC conducted semistructured interviews with 9 state health department representatives who were responsible for SHIPs. Read More

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September 2021

Orthopaedic Trauma Research Priorities in Latin America: Developing Consensus Through a Modified Delphi Approach.

J Bone Joint Surg Am 2021 Sep 24. Epub 2021 Sep 24.

University of California San Francisco, San Francisco, California.

Background: Despite a substantial burden of musculoskeletal injury, orthopaedic trauma studies in Latin America are lacking. The purpose of the present study was to identify research priorities among orthopaedic trauma surgeons in Latin America.

Methods: Research questions were solicited from members of the Asociación de Cirujanos Traumatólogos de las Américas. Read More

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September 2021

Negotiating Safety and Wellbeing: The Collaboration Between Faith-Based Communities and Public Health During the COVID-19 Pandemic.

J Relig Health 2021 Sep 24. Epub 2021 Sep 24.

Division of Social and Cultural Psychiatry, McGill University, Montreal, QC, Canada.

The COVID-19 pandemic led to lockdown measures where congregational faith-based activities were prohibited. With time, the collateral impacts of confinement emerged as priorities, and impositions had to be balanced with the collaboration of the population. In this process, faith-based organizations played a key role in encouraging their congregations to adhere to lockdown measures while fostering their mental wellbeing and resilience. Read More

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September 2021

Decrease in new diagnosis of HIV/AIDS in the two years period 2019-2020: impact of COVID-19 pandemic.

J Public Health Res 2021 Sep 24. Epub 2021 Sep 24.

Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili General Hospital, Brescia.

The emergence SARS-CoV-2 in late 2019 and early 2020 has caused a pandemic of unprecedented proportions. Management of COVID-19 became emergent public health priorities, and the impact on other public health initiatives, such as expanded HIV screening and linkage to care, remain largely unknown. In this Single-Center retrospective observational study, we describe the characteristics and circumstance of the new HIV cases during 2020 compared to 2019. Read More

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September 2021

Optimising antimicrobial use in humans - review of current evidence and an interdisciplinary consensus on key priorities for research.

Lancet Reg Health Eur 2021 Aug 29;7:100161. Epub 2021 Jun 29.

National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, UK.

Addressing the silent pandemic of antimicrobial resistance (AMR) is a focus of the 2021 G7 meeting. A major driver of AMR and poor clinical outcomes is suboptimal antimicrobial use. Current research in AMR is inequitably focused on new drug development. Read More

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A new qualitative RT-PCR assay detecting SARS-CoV-2.

Sci Rep 2021 Sep 23;11(1):18955. Epub 2021 Sep 23.

Department of Experimental Medicine, "Tor Vergata" University, Via Montpellier 1, 00133, Rome, Italy.

The world is facing an exceptional pandemic caused by SARS-CoV-2. To allow the diagnosis of COVID-19 infections, several assays based on the real-time PCR technique have been proposed. The requests for diagnosis are such that it was immediately clear that the choice of the most suitable method for each microbiology laboratory had to be based, on the one hand, on the availability of materials, and on the other hand, on the personnel and training priorities for this activity. Read More

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September 2021

Multimorbidity and clinical reasoning through the eyes of GPs: a qualitative study.

Fam Med Community Health 2021 Sep;9(4)

Faculty of Medicine (IuMFE), University of Geneva, Geneva, Switzerland

Objectives: Despite the high prevalence of patients suffering from multimorbidity, the clinical reasoning processes involved during the longitudinal management are still sparse.This study aimed to investigate what are the different characteristics of the clinical reasoning process clinicians use with patients suffering from multimorbidity, and to what extent this clinical reasoning differs from diagnostic reasoning.

Design: Given the exploratory nature of this study and the difficulty general practitioners (GPs) have in expressing their reasoning, a qualitative methodology was therefore, chosen. Read More

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September 2021

Are we asking the right questions? Working with the LGBTQ+ community to prioritise healthcare research themes.

Res Involv Engagem 2021 Sep 24;7(1):64. Epub 2021 Sep 24.

Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, East Forvie Building, Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.

Background: Conversations about research priorities with members of the public are rarely designed specifically to include people who identify as Lesbian, Gay, Bisexual, Transgender and Queer (LGBTQ+) and are not researchers.

Methods: Generally, to address this gap, and specifically, to inform future research for CLS, we carried out a rapid review of published research priority sets covering LGBTQ+ topics, and an online workshop to prioritise identified themes.

Results: Rapid review: results. Read More

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September 2021

Priorities for addressing substance use disorder in humanitarian settings.

Confl Health 2021 Sep 23;15(1):71. Epub 2021 Sep 23.

Department of Epidemiology, Columbia University Mailman School of Public Health, 722 W 168th Street, New York, NY, USA.

Background: Populations affected by humanitarian emergencies are vulnerable to substance (alcohol and other drug) use disorders, yet treatment and prevention services are scarce. Delivering substance use disorder treatment services in humanitarian settings is hampered by limited guidance around the preparation, implementation, and evaluation of substance use disorder treatment programs. This study aims to identify and prioritize key gaps and opportunities for addressing substance use disorder in humanitarian settings. Read More

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September 2021

Valuing child and adolescent health: a qualitative study on different perspectives and priorities taken by the adult general public.

Health Qual Life Outcomes 2021 Sep 23;19(1):222. Epub 2021 Sep 23.

School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK.

Background: Quantitative health preference research has shown that different "perspectives", defined here as who is imagined to be experiencing particular health states, impact stated preferences. This qualitative project aimed to elucidate this phenomenon, within the context of adults' valuation of child and adolescent health states.

Methods: Six focus groups with 30 members of the UK adult public were conducted between December 2019 and February 2020 and analysed using framework analysis. Read More

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September 2021

Understanding abortion seeking care outside of formal health care settings in Cape Town, South Africa: a qualitative study.

Reprod Health 2021 Sep 23;18(1):190. Epub 2021 Sep 23.

Ibis Reproductive Health, 1736 Franklin St, Oakland, CA, USA.

Background: Although abortion was legalized in South Africa in 1996, barriers to safe, legal abortion services remain, and women continue to seek abortions outside of the formal healthcare sector. This study explored the decision-making processes that women undertake when faced with an unintended pregnancy, the sources of information used to make their decisions and the factors that contribute to their seeking of informal sector abortion in Cape Town, South Africa.

Methods: We conducted 15 semi-structured in-depth interviews in English with women who had accessed an abortion outside of the formal health care sector. Read More

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September 2021

Priorities for global access to life-saving interventions during public health emergencies: Crisis nationalism, solidarity or charity?

Glob Public Health 2021 Sep 23:1-10. Epub 2021 Sep 23.

London School of Hygiene & Tropical Medicine, London, UK.

Access to COVID-19-vaccines by the global poor has unveiled the impact of global health and scientific inequities on access to life saving interventions during public health emergencies (PHE). Despite calls for global solidarity to ensure equitable global access to COVID-19 vaccines, wealthy countries both in the north and southern hemisphere may find a charity-based approach more appealing and are using the opportunity to forge neo-colonial cooperation ties with some African countries. Solidarity is undoubtedly an ideal equity-based principle of public health emergency of international concern (PHEIC). Read More

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September 2021

Time to publish? Turnaround times, acceptance rates, and impact factors of journals in fisheries science.

Brendan J Runde

PLoS One 2021 23;16(9):e0257841. Epub 2021 Sep 23.

Department of Applied Ecology, North Carolina State University, Morehead City, North Carolina, United States of America.

Selecting a target journal is a universal decision faced by authors of scientific papers. Components of the decision, including expected turnaround time, journal acceptance rate, and journal impact factor, vary in terms of accessibility. In this study, I collated recent turnaround times and impact factors for 82 journals that publish papers in the field of fisheries sciences. Read More

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September 2021

Understanding Emerging Environmental Health Concerns and Environmental Public Health-Tracking Priorities Among State and Local Professionals in Colorado.

J Public Health Manag Pract 2021 Nov-Dec 01;27(6):598-606

Environmental and Occupational Health Department, Colorado School of Public Health, Aurora, Colorado (Drs Murphy and McKenzie); Department of Environmental and Radiological Sciences, Colorado School of Public Health, Colorado State University, Fort Collins, Colorado (Dr Peel); Environmental Health Division; Tri-County Health Department, Greenwood Village, Colorado (Mr Butts); and Environmental Studies Department, University of Colorado-Boulder, Boulder, Colorado (Dr Litt).

Context: Colorado is experiencing dramatic changes related to population growth, climate change, and expanded industrial activity. Local and state public health professionals are trying to address a growing array of unique public health issues with stagnant or limited resources.

Objectives: To understand, through perspectives from local and state public health professionals, the alignment of contemporary environmental and community health issues with state and local capacity and state environmental public health-tracking priorities. Read More

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September 2021

Managing Human Subjects Research During a Global Pandemic at an Academic Center: Lessons Learned from COVID-19.

Acad Med 2021 Sep 21. Epub 2021 Sep 21.

D.F. Stiles is vice president, Research Operations, and policy and chief operating officer, Office of the Executive Vice President for Research, Columbia University, New York, New York; ORCID: https://orcid.org/0000-0001-9845-6804. B.L. Ruotolo is associate vice president, Human Research Protection, Columbia University, New York, New York. H. Kim is associate vice president, Clinical Trials, Columbia University, New York, New York. J. Cho is associate director, Regulatory Science, Clinical Trials Office, Columbia University, New York, New York. P.S. Appelbaum is Elizabeth K. Dollard Professor of psychiatry, medicine, and law, Department of Psychiatry, Columbia University Irving Medical Center, New York, New York; ORCID: https://orcid.org/0000-0002-1940-0042. N.S. Green is professor, Department of Pediatrics, and associate dean, Faculty Operations, Columbia University Irving Medical Center, New York, New York; ORCID: https://orcid.org/0000-0002-9877-1561.

By March 2020, New York City became the early epicenter of the COVID-19 pandemic in the United States. Consequently, Columbia University, with its large portfolio of human subjects research, had to address the challenges of protecting thousands of research participants and research staff from potential exposure to COVID-19 while facilitating essential biomedical research, especially pandemic-related studies. The authors describe, from the perspective of Columbia's research administration leadership, how the university and its primary teaching hospital ramped down-and later ramped up-human subjects research, and reflect on the lessons learned. Read More

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September 2021

The moral imperative of money: what investments in science say about a nation's priorities and ethical compass.

Biol Futur 2021 Jun 22;72(2):139-154. Epub 2020 Oct 22.

The World Academy of Sciences (TWAS), Trieste, Italy.

The era dominated by the liberal world order, dating back to the end of World War II in 1945 and gaining unchallenged dominance with the fall of the Berlin Wall in 1989, is now coming to an end. Yet the universal principles that the era personified in its rhetoric, and in the best of its actions, lives on. The global community has a moral obligation to continue on its journey to build a more equitable, secure and prosperous world for all of its citizens and must devise investment strategies that enable progress to both endure and accelerate. Read More

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Pharmaceutical drug development: high drug prices and the hidden role of public funding.

Stephanie Annett

Biol Futur 2021 Jun 22;72(2):129-138. Epub 2020 Jun 22.

School of Pharmacy and Biomolecular Science, RCSI University of Medicine and Health Sciences, Dublin, Ireland.

In 2019, the record for the most expensive drug was broken at US$2.1 million per patient. The high costs of new drugs are justified by the pharmaceutical industry as the expense required for maintaining research and development (R&D) pipelines. Read More

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Participation de l’équipage à la construction d’actions de santé dans la marine nationale.

Sante Publique 2021 March-April;33(2):245-253

Introduction: Prevention is one of the main priorities for the « Santé de Défense 2019-2022 » strategy. In the current climate where the application of preventive measures is a daily challenge, it is necessary, in conjunction with the target cohort, to develop and agree occupational health policies.

Objective: Having analyzed several papers outlining techniques to generate a co-developed strategy, we created a participation-based process which could be applied to the crew of a French Navy vessel. Read More

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September 2021

Mean blood pressure according to the hypertension care cascade: Analysis of six national health surveys in Peru.

Lancet Reg Health Am 2021 Sep;1:None

CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.

Background: While we have good evidence about the hypertension care cascade, we do not know the mean blood pressure (BP) in these groups. We described the mean BP in four groups based on the hypertension care cascade at the national and sub-national levels in Peru.

Methods: Descriptive analysis of six national health surveys. Read More

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September 2021

Optimal Method of Electrical Stimulation for the Treatment of Upper Limb Dysfunction After Stroke: A Systematic Review and Bayesian Network Meta-Analysis of Randomized Controlled Trials.

Neuropsychiatr Dis Treat 2021 15;17:2937-2954. Epub 2021 Sep 15.

Department of Neurology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, People's Republic of China.

Background: The obstacle of limb motor caused by stroke, especially the decline of motor function of upper limbs, can directly affect the activities of daily living of stroke patients with hemiplegia. Based on long-term clinical practice, the treatment effect of electrical stimulation methods for stroke limb dysfunction has been widely recognized and supported by authoritative guidelines and systematic reviews. However, which electrical stimulation method is the optimum in the treatment of stroke limb dysfunction is still a controversial issue. Read More

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September 2021

Transition to clinical practice during the COVID-19 pandemic: a qualitative study of young doctors' experiences in Brazil and Ireland.

BMJ Open 2021 Sep 22;11(9):e053423. Epub 2021 Sep 22.

School of Medicine, University College Cork, Cork, Ireland

Objectives: To explore and compare the perspectives of junior doctors in Brazil and Ireland regarding transition and professional socialisation during the COVID-19 pandemic, with the purpose of identifying better ways to support doctors as they assume their new professional role.

Design: 27 semistructured interviews. Transcripts were analysed using qualitative thematic analysis. Read More

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September 2021

Same, same, but different? A longitudinal, mixed-methods study of stability in values and preferences for future end-of-life care among community-dwelling, older adults.

BMC Palliat Care 2021 Sep 22;20(1):148. Epub 2021 Sep 22.

Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, 171 77, Stockholm, Sweden.

Background: End-of-life preferences may change over time, e.g. due to illness progression or life events. Read More

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September 2021

Genome Dynamics and Evolution of Multiple Drug-Resistant Bacteria: Implications for Global Infection Control Priorities.

J Infect Dis 2021 Sep 22. Epub 2021 Sep 22.

Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India.

Genomics-driven molecular epidemiology of pathogenic bacteria has largely been carried out through functionally neutral/inert sequences mostly entailing polymorphic gene loci or repetitive tracts. However, it is very important to harness phenotypically relevant markers to assign a valid functional epidemiological context to tracking of pathogens. These should include microbial acumen to acquire multiple drug resistance (MDR), their physiological co-ordinates with reference to clinical or community level dynamics of incidence/transmission and their response or refractoriness to the activated immune system. Read More

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September 2021

Understanding the Potential Impact of Different Drug Properties On SARS-CoV-2 Transmission and Disease Burden: A Modelling Analysis.

Clin Infect Dis 2021 Sep 21. Epub 2021 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.

Background: The public health impact of the COVID-19 pandemic has motivated a rapid search for potential therapeutics, with some key successes. However, the potential impact of different treatments, and consequently research and procurement priorities, have not been clear.

Methods: Using a mathematical model of SARS-CoV-2 transmission, COVID-19 disease and clinical care, we explore the public-health impact of different potential therapeutics, under a range of scenarios varying healthcare capacity, epidemic trajectories; and drug efficacy in the absence of supportive care. Read More

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September 2021

Healthy Aging Biomarkers: The INSPIRE's Contribution.

J Frailty Aging 2021 ;10(4):313-319

Louis Casteilla, RESTORE, UMR 1301-Inserm 5070 Etablissement Français du Sang-Occitanie (EFS), Inserm 1031, University of Toulouse III, National Veterinary School of Toulouse (ENVT), CNRS, Toulouse, France;

The find solutions for optimizing healthy aging and increase health span is one of the main challenges for our society. A novel healthcare model based on integration and a shift on research and care towards the maintenance of optimal functional levels are now seen as priorities by the WHO. To address this issue, an integrative global strategy mixing longitudinal and experimental cohorts with an innovative transverse understanding of physiological functioning is missing. Read More

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September 2021

The impact of COVID-19 on business perspectives of sustainable development and corporate social responsibility in China.

Environ Dev Sustain 2021 Sep 16:1-24. Epub 2021 Sep 16.

College of Information and Management Science, Henan Agricultural University, 15 Longzi Lake Campus, Zhengzhou East New District, Zhengzhou, 450046 China.

The new coronavirus (COVID-19) has generated an unprecedented degree of social and economic impact on the planet, but few researchers have explored the repercussion of COVID-19 for sustainable development (SD) and corporate social responsibility (CSR), especially from the perspective of Chinese businesses. This paper is the first to outline the priority changes of both SD and CSR over the period of COVID-19 incidence in China. An online questionnaire survey of 1161 owners and managers of Chinese companies was conducted, and respondents were asked to score the priorities of their company over the pre, during and post COVID-19 periods. Read More

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September 2021

Cohort profile: a national, community-based prospective cohort study of SARS-CoV-2 pandemic outcomes in the USA-the CHASING COVID Cohort study.

BMJ Open 2021 Sep 21;11(9):e048778. Epub 2021 Sep 21.

City University of New York (CUNY) Institute for Implementation Science in Population Health, New York, New York, USA

Purpose: The Communities, Households and SARS-CoV-2 Epidemiology (CHASING) COVID Cohort Study is a community-based prospective cohort study launched during the upswing of the USA COVID-19 epidemic. The objectives of the cohort study are to: (1) estimate and evaluate determinants of the incidence of SARS-CoV-2 infection, disease and deaths; (2) assess the impact of the pandemic on psychosocial and economic outcomes and (3) assess the uptake of pandemic mitigation strategies.

Participants: We began enrolling participants from 28 March 2020 using internet-based strategies. Read More

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September 2021

Status of Palliative Oncology Care for Children and Young People in Sub-Saharan Africa: A Perspective Paper on Priorities for New Frontiers.

JCO Glob Oncol 2021 Aug;7:1395-1405

Division of Quality of Life and Palliative Care, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.

Purpose: The burden of cancer disproportionately affects low- and middle-income countries. Low 5-year survival figures for children with cancer in low-income countries are due to late presentation at diagnosis, treatment abandonment, absence of sophisticated multidisciplinary care, and lack of adequate resources. The reasons for late presentation are partly due to limited awareness of cancer symptoms, high treatment costs, and facility-level barriers to timely access to treatment. Read More

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