1,576 results match your criteria prior tbi


Neuroimaging Correlates of Syndromal Anxiety Following Traumatic Brain Injury: A Systematic Review of the Literature.

J Acad Consult Liaison Psychiatry 2021 Sep 14. Epub 2021 Sep 14.

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences. Electronic address:

Background: Traumatic brain injury (TBI) can precipitate new-onset psychiatric symptoms or worsen existing psychiatric conditions. To elucidate specific mechanisms for this interaction, neuroimaging is often used to study both psychiatric conditions and TBI. This systematic review aims to synthesize the existing literature of neuroimaging findings among patients with anxiety after TBI. Read More

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September 2021

Effect of parental education and household poverty on recovery after traumatic brain injury in school-aged children.

Brain Inj 2021 Sep 16:1-11. Epub 2021 Sep 16.

The Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington, USA.

Objective: While prior studies have found parental socioeconomic status (SES) affects the outcomes of pediatric traumatic brain injury (TBI), the longitudinal trajectory of this effect is not well understood.

Methods: This prospective cohort study included children 8-18 years of age admitted to six sites with a complicated mild (n = 123) or moderate-severe TBI (n = 47). We used caregiver education and household poverty level as predictors, and multiple quality of life and health behavior domains as outcomes. Read More

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September 2021

Refining understanding of life satisfaction in elderly persons with traumatic brain injury using age-defined cohorts: a TBI model systems study.

Brain Inj 2021 Sep 13:1-8. Epub 2021 Sep 13.

University of Alabama, Birmingham, Alabama, United States.

Objective: Examine effects of age cohort on post-injury life satisfaction in elderly persons with TBIDesign: Retrospective cohortSetting: TBI Model Systems centers.

Participants: 5,109 elderly participants with TBI in the TBI Model Systems National DatabaseInterventions: Not applicableMain Outcome Measures: Demographics, injury characteristics and cause, outcomes, age at time of analysis, time to follow commands, maximum follow-up period, and scores on the Satisfaction With Life Scale (SWLS) and Participation Assessment with Recombined Tools-Objective (PART-O) scores at 1, 2, 5, or 10 years post-injury.

Results: Life satisfaction post-TBI across groups increased with age. Read More

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September 2021

Ecological momentary assessment of affect in context after traumatic brain injury.

Rehabil Psychol 2021 Sep 13. Epub 2021 Sep 13.

Moss Rehabilitation Research Institute.

Purpose: To describe where, with whom, and how time was spent daily, and to characterize positive and negative affect, boredom, enjoyment, and perceived accomplishment as a function of time, activity, location, and social context, in people with chronic moderate-severe traumatic brain injury and depression/anxiety.

Research Method: Participants (N = 23) responded to a smartphone app five times daily for approximately 2 weeks prior to treatment in a trial of Behavioral Activation. The app queried activity and physical/social context; concurrent positive and negative affect; and perceived boredom, enjoyment, and accomplishment. Read More

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September 2021

Passive Elaborative Cueing of Retrieval ProcessesFollowing Traumatic Brain Injury.

Brain Inj 2021 Sep 12:1-16. Epub 2021 Sep 12.

Department of Speech, Language, and Hearing Sciences, University of Connecticut, Storrs, Connecticut, United States.

: Semantic elaboration is a process in which target information is analyzed in relation to content associated in meaning. The goal of the present study was to examine the use of phrasal cues intended to engage elaborative processes theorized to bolster cognitive performance. Twenty-two individuals with a history of traumatic brain injury (TBI) and twenty-six neurotypical (NT) individuals were studied. Read More

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September 2021

Improved Pressure Equalization Ratio Following Mannitol Administration in Patients With Severe TBI: A Preliminary Study of a Potential Bedside Marker for Response to Therapy.

Neurocrit Care 2021 Sep 8. Epub 2021 Sep 8.

Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: Performing a cerebrospinal fluid (CSF) drainage challenge can be used to measure the pressure equalization (PE) ratio, which describes the extent to which CSF drainage can equalize pressure to the height of the external ventricular drain and may serve as a correlate of cerebral edema. We sought to assess whether treatment with mannitol improves PE ratio in patients with severe traumatic brain injury (TBI) with elevated intracranial pressure (ICP).

Methods: We studied consecutive patients with TBI and brain edema on computed tomography scan and an external ventricular drain (EVD), admitted to the neurointensive care unit. Read More

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September 2021

Effects of Prescription Opioid Use on Traumatic Brain Injury Risk in Older Adults.

J Head Trauma Rehabil 2021 Sep-Oct 01;36(5):388-395

Departments of Epidemiology and Public Health (Mr Herrera and Drs Brown, Chen, and Albrecht) and Medicine (Dr Gambert), School of Medicine, and Department of Pharmaceutical Health Services Research, School of Pharmacy (Dr Wastila), University of Maryland, Baltimore.

Objective: The objective of this study was to estimate the risk of traumatic brain injury (TBI) associated with opioid use among older adult Medicare beneficiaries.

Setting: Five percent sample of Medicare administrative claims obtained for years 2011-2015.

Participants: A total of 50 873 community-dwelling beneficiaries 65 years and older who sustained TBI. Read More

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January 2022

Scoping Review of Opioid Use After Traumatic Brain Injury.

J Head Trauma Rehabil 2021 Sep-Oct 01;36(5):310-327

Division of Rehabilitation Psychology, Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle (Drs Starosta and Hoffman); Institute for Behavioral Health at the Heller School for Social Policy & Management, Brandeis University, Waltham, Massachusetts (Dr Adams); Rocky Mountain Mental Illness Research Education and Clinical Center, Veterans Health Administration, Aurora, Colorado (Dr Adams); Division of Rehabilitation Psychology and Neuropsychology (Dr Kreutzer), Department of Physical Medicine and Rehabilitation (Ms Marwitz), Department of Rehabilitation Medicine, University of Minnesota, Minneapolis (Dr Monden); Brain Injury Research Center of Mount Sinai, Departments of Rehabilitation Medicine and Neurology, Icahn School of Medicine at Mount Sinai, New York City, New York (Dr Dams O'Connor).

Objective: To summarize the current literature to identify what research has been conducted, examine the approaches used, and determine what is presently known about prescription and nonprescription opioid receipts and use among individuals with traumatic brain injury (TBI).

Data Sources: The search strategy included the following: opioid; opiate; analgesics, opioid; opiate alkaloids; or opioid-related disorders; AND brain injury; brain injuries; brain injuries, traumatic; head injury; head injuries; head injuries, closed; head injuries, penetrating; brain concussion; diffuse axonal injury; diffuse axonal injuries; brain trauma/s; head trauma/s; concussion; craniocerebral trauma/s; or TBI. Filters included English and Adults (19+ years). Read More

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January 2022

You only get one brain. Adult reflections on acute and ongoing symptom experiences after traumatic brain injury in adolescence.

Brain Inj 2021 Sep 6:1-8. Epub 2021 Sep 6.

National Institute for Stroke and Applied Neurorehabilitation, Auckland University of Technology, Auckland, New Zealand.

Background: This research adds to the scarce literature regarding adolescent experiences of traumatic brain injury (TBI). It uses a qualitative methodology to explore the symptoms experienced after sustaining a TBI at this unique stage of development including their persistence into adulthood.

Methods: Thirteen adults (aged 20-25 years; mean 23 years) who sustained a mild-moderate TBI during adolescence (aged 13-17 years at injury), approximately 7. Read More

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September 2021

Massed cognitive processing therapy for posttraumatic stress disorder in women survivors of intimate partner violence.

Psychol Trauma 2021 Sep 2. Epub 2021 Sep 2.

Women's Health Sciences Division.

Objective: Survivors of intimate partner violence (IPV) report significant trauma histories, high rates of posttraumatic stress disorder (PTSD), head injuries and comorbid disorders, and multiple barriers to treatment that often preclude the regular attendance and engagement required in typical therapy protocols. The significant challenges faced by IPV survivors needing treatment may be ameliorated by condensing effective treatments for PTSD, such as cognitive processing therapy (CPT), in an accelerated delivery timeline.

Method: Using a multiple subject, single case design of six matched pairs of 12 female IPV survivors, we preliminarily tested the relative effectiveness of individual massed CPT delivered over 5 days (mCPT) as compared with standard CPT (sCPT) delivery in women IPV survivors. Read More

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September 2021

Neuroradiologic Evaluation of MRI in High-Contact Sports.

Front Neurol 2021 11;12:701948. Epub 2021 Aug 11.

Department of Radiology, Stanford School of Medicine, Stanford, CA, United States.

Athletes participating in high-contact sports experience repeated head trauma. Anatomical findings, such as a cavum septum pellucidum, prominent CSF spaces, and hippocampal volume reductions, have been observed in cases of mild traumatic brain injury. The extent to which these neuroanatomical findings are associated with high-contact sports is unknown. Read More

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Factors influencing clinicians' referral or admission decisions for post-acute stroke or traumatic brain injury rehabilitation: A Scoping Review.

PM R 2021 Aug 13. Epub 2021 Aug 13.

School of rehabilitation, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.

Demand for post-acute stroke and traumatic brain injury (TBI) rehabilitation outweighs resource availability. Every day, clinicians face the challenging task of deciding which patient will benefit or not from rehabilitation. The objectives of this scoping review were to map and compare factors reported by clinicians as influencing referral or admission decisions to post-acute rehabilitation for stroke and TBI patients, to identify most frequently reported factors and those perceived as most influential. Read More

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Epidemiology of traumatic brain injury based on clinical symptoms amongst inhabitants of the Southwest Region of Cameroon: a community-based study.

Brain Inj 2021 Aug 12:1-8. Epub 2021 Aug 12.

Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Background: The majority of studies investigating the epidemiology of traumatic brain injury (TBI) in sub-Saharan Africa are primarily hospital-based, missing fatal, mild, and other cases of TBI that do not present to formal care settings. This study aims to bridge this gap in data by describing the epidemiology of TBI in the Southwest Region of Cameroon.

Methods: This was a cross-sectional community-based study. Read More

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Ability to regulate immunity of mesenchymal stem cells in the treatment of traumatic brain injury.

Neurol Sci 2021 Aug 10. Epub 2021 Aug 10.

Biology Department, Hue University, 03 Le Loi St, Hue City, Vietnam.

Traumatic brain injury (TBI) is characterized by broad clinical symptoms in brain insult by external damages to the skull. TBI potentially leads to severe physical, cognitive, and emotional impairment. The complex biochemical reactions of inflammatory processes in TBI significantly influence brain function and clinical sequelae's overall severity. Read More

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Caloric restriction alleviates radiation injuries in a sex-dependent fashion.

FASEB J 2021 08;35(8):e21787

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Safe and effective regimens are still needed given the risk of radiation toxicity from iatrogenic irradiation. The gut microbiota plays an important role in radiation damage. Diet has emerged as a key determinant of the intestinal microbiome signature and function. Read More

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A randomized, double-blind, placebo-controlled trial of hydrocortisone augmentation of Prolonged Exposure for PTSD in U.S. combat veterans.

Behav Res Ther 2021 Sep 1;144:103924. Epub 2021 Jul 1.

Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objective: Cognitive behavioral therapies such as Prolonged Exposure (PE) are considered first line treatments for posttraumatic stress disorder (PTSD). Nonetheless, many continue to experience significant symptoms following treatment and there is interest in enhancing treatment effectiveness. Glucocorticoid alterations in PTSD are well documented, and these steroids have been shown to enhance extinction learning. Read More

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September 2021

As Time Goes by: Understanding Child and Family Factors Shaping Behavioral Outcomes After Traumatic Brain Injury.

Front Neurol 2021 5;12:687740. Epub 2021 Jul 5.

Department of Pediatrics, Division of Critical Care, School of Medicine, University of Utah, Salt Lake City, UT, United States.

To model pre-injury child and family factors associated with the trajectory of internalizing and externalizing behavior problems across the first 3 years in children with pediatric traumatic brain injury (TBI) relative to children with orthopedic injuries (OI). Parent-reported emotional symptoms and conduct problems were expected to have unique and shared predictors. We hypothesized that TBI, female sex, greater pre-injury executive dysfunction, adjustment problems, lower income, and family dysfunction would be associated with less favorable outcomes. Read More

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Total body irradiation as part of conditioning regimens in childhood leukemia-long-term outcome, toxicity, and secondary malignancies.

Strahlenther Onkol 2021 Jul 19. Epub 2021 Jul 19.

Department for Radiation Oncology and Radiotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Virchow-Clinic, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: Total body irradiation (TBI) is an established part of conditioning regimens prior to stem cell transplantation in childhood leukemia but is associated with long-term toxicity. We retrospectively analyzed survival, long-term toxicity, and secondary malignancies in a pooled cohort of pediatric patients (pts.) treated with the same TBI regimen. Read More

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Surgical Site Infection After Autologous Cranioplasty for Decompressive Craniectomy in Traumatic Brain Injury: A Retrospective Review of Two Level 1 Trauma Centers.

J Craniofac Surg 2021 Jul 12. Epub 2021 Jul 12.

University of Texas Southwestern Department of Neurological Surgery, Dallas, TX St. Louis University Department of Neurological Surgery, St. Louis, MO Baylor University Medical Center, Division of Trauma, Department of Surgery, Dallas, TX.

Object: Surgical site infection (SSI) after cranioplasty can result in unnecessary morbidity. This analysis was designed to determine the risk factors of SSI after cranioplasty in patients who received a decompressive craniectomy with the autologous bone for traumatic brain injury (TBI).

Methods: A retrospective review was performed at two level 1 academic trauma centers for adult patients who underwent autologous cranioplasty after prior decompressive craniectomy for TBI. Read More

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Prebiotic Mannan Oligosaccharide Pretreatment Improves Mice Survival Against Lethal Effects of Gamma Radiation by Protecting GI Tract and Hematopoietic Systems.

Front Oncol 2021 24;11:677781. Epub 2021 Jun 24.

Division of Metabolic Cell Signaling Research, Institute of Nuclear Medicine & Allied Sciences, Delhi, India.

Total body irradiation (TBI) results in critical injuries in a dose dependent manner that primarily damages highly proliferating tissues including hematopoietic stem cells (HSCs) and intestinal crypt stem cells This may result in hematopoietic syndrome leading to bone marrow failure and gastrointestinal syndrome leading to chronic intestinal functional alterations. Death results from the gastrointestinal syndrome due to sepsis, bleeding, dehydration, and multi-system organ failure. We demonstrate that the prebiotic mannan oligosaccharide (MOS) pretreatment substantially prolongs survival in both male and female mice when administered 2 h prior to radiation either through oral or intraperitoneal route. Read More

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Outcomes of severe traumatic brain injury at time of discharge from tertiary academic hospitals in Bloemfontein.

Afr J Thorac Crit Care Med 2020 15;26(2). Epub 2020 Jun 15.

Intensive Care Unit, Pelonomi Tertiary Hospital, Bloemfontein, South Africa.

Background: Despite the condition being a major public health concern, limited data are available regarding survival rates and the requirement for post-hospitalisation support of patients with traumatic brain injury (TBI) in South Africa (SA).

Objectives: To describe the clinical profile and in-hospital outcomes of patients with TBI at intensive care units (ICUs) of tertiary referral hospitals in the Free State Province, SA, between 2013 and 2017.

Methods: This retrospective descriptive study of patients with TBI was conducted at Pelonomi Tertiary and Universitas Academic Hospitals. Read More

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Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response.

J Neuroinflammation 2021 Jul 5;18(1):151. Epub 2021 Jul 5.

Department of Pediatrics, University of Iowa, Iowa City, IA, USA.

Background: Traumatic brain injury (TBI) is a leading cause of death and disability that lacks neuroprotective therapies. Following a TBI, secondary injury response pathways are activated and contribute to ongoing neurodegeneration. Microglia and astrocytes are critical neuroimmune modulators with early and persistent reactivity following a TBI. Read More

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Home-based light therapy for fatigue following acquired brain injury: a pilot randomized controlled trial.

BMC Neurol 2021 Jul 5;21(1):262. Epub 2021 Jul 5.

Monash Epworth Rehabilitation Research Centre, Epworth Healthcare, Melbourne, Australia.

Background And Objectives: Fatigue and sleep disturbance are debilitating problems following brain injury and there are no established treatments. Building on demonstrated efficacy of blue light delivered via a lightbox in reducing fatigue and daytime sleepiness after TBI, this study evaluated the efficacy of a novel in-home light intervention in alleviating fatigue, sleep disturbance, daytime sleepiness and depressive symptoms, and in improving psychomotor vigilance and participation in daily productive activity, following injury METHODS: The impact of exposure to a dynamic light intervention (Treatment) was compared to usual lighting (Control) in a randomized within-subject, crossover trial. Outcomes were fatigue (primary outcome), daytime sleepiness, sleep disturbance, insomnia symptoms, psychomotor vigilance, mood and activity levels. Read More

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White Matter Hyperintensities Are Not Related to Symptomatology or Cognitive Functioning in Service Members with a Remote History of Traumatic Brain Injury.

Neurotrauma Rep 2021 9;2(1):245-254. Epub 2021 Jun 9.

National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

This study aimed to determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMHs) are associated with symptom reporting and/or cognitive performance in 1202 active-duty service members with prior single or multiple mild traumatic brain injury (mTBI). Patients with mTBI evaluated at the National Intrepid Center of Excellence (NICoE) at Walter Reed National Military Medical Center (WRNMMC) were divided into those with ( 632) and without ( 570) WMHs. The groups were compared on several self-report scales including the Neurobehavioral Symptom Inventory (NSI), Post-Traumatic Stress Disorder (PTSD) Checklist-Civilian Version (PCL-C), Satisfaction with Life Scale (SWLS), and Short Form-36 Health Survey (SF-36). Read More

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Pulmonary Toxicity after Total Body Irradiation-An Underrated Complication? Estimation of Risk via Normal Tissue Complication Probability Calculations and Correlation with Clinical Data.

Cancers (Basel) 2021 Jun 12;13(12). Epub 2021 Jun 12.

Department of Radiation Oncology, University Hospital Muenster, 48149 Muenster, Germany.

Total body irradiation (TBI) is an essential part of various conditioning regimens prior to allogeneic stem cell transplantation, but is accompanied by relevant (long-term) toxicities. In the lungs, a complex mechanism induces initial inflammation (pneumonitis) followed by chronic fibrosis. The hereby presented analysis investigates the occurrence of pulmonary toxicity in a large patient collective and correlates it with data derived from normal tissue complication probability (NTCP) calculations. Read More

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Marital Stability Over 10 Years Following Traumatic Brain Injury.

J Head Trauma Rehabil 2021 Jul-Aug 01;36(4):E199-E208

Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis (Drs Hammond, Neumann, Katta-Charles, and Backhaus); Rehabilitation Hospital of Indiana, Indianapolis, Indiana (Drs Hammond, Neumann, Katta-Charles, and Backhaus); Traumatic Brain Injury Model Systems National Data and Statistical Center, Englewood, Colorado (Mss Sevigny and Gazett); Research Department, Craig Hospital, Englewood, Colorado (Mr Sevigny and Ms Gazett); and The Ohio State University, Columbus (Dr Corrigan).

Objective: To examine the stability of marriage from the time of traumatic brain injury (TBI) to 10 years postinjury.

Design: Retrospective cohort.

Setting: TBI Model Systems centers. Read More

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Head Injury Exposure in Veterans Presenting to Memory Disorders Clinic: An Observational Study of Clinical Characteristics and Relationship of Event-Related Potentials and Imaging Markers.

Front Neurol 2021 14;12:626767. Epub 2021 Jun 14.

Center for Translational Cognitive Neuroscience, VA Boston Healthcare System, Boston, MA, United States.

Traumatic brain injury (TBI) and repetitive head impacts (RHI) related to blasts or contact sports are commonly reported among military service members. However, the clinical implications of remote TBI and RHI in veterans remains a challenge when evaluating older veterans at risk of neurodegenerative conditions including Alzheimer's disease (AD) and Chronic Traumatic Encephalopathy (CTE). This study aimed to test the hypothesis that veterans in a memory disorders clinic with remote head injury would be more likely to have neurodegenerative clinical diagnoses, increased rates of amyloid PET positivity, higher prevalence of cavum septum pellucidi/vergae, and alterations in event-related potential (ERP) middle latency auditory evoked potentials (MLAEPs) and long latency ERP responses compared to those without head injuries. Read More

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Prevalence of depression and anxiety disorders following mild traumatic brain injury.

PM R 2021 Jun 22. Epub 2021 Jun 22.

Kaiser Foundation Rehabilitation Center, Kaiser Permanente Vallejo Medical Center, Vallejo, California, USA.

Background: Previous studies have identified an association between traumatic brain injuries and the development of psychiatric disorders in general. However, these studies were subject to limitations that demonstrate the need for a study of a large, clearly defined mild traumatic brain injury (mTBI) population within an integrated healthcare system.

Objective: To determine the prevalence and relative risk of postinjury affective disorders over 4 years following mTBI. Read More

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Preinjury Health Status of Adults With Traumatic Brain Injury: A Preliminary Matched Case-Control Study.

J Head Trauma Rehabil 2021 Jun 15. Epub 2021 Jun 15.

Departments of Rehabilitation & Human Performance (Ms Bulas, Drs Kumar, and Dams-O'Connor), Institute for Healthcare Delivery Science, Population Health Science and Policy (Drs Li and Mazumdar), and Neurology (Dr Dams-O'Connor), Icahn School of Medicine at Mount Sinai, New York; and Departments of Epidemiology (Dr Rosso), Biostatistics (Dr Youk), University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.

Objective: To discern whether there is evidence that individuals who sustained a traumatic brain injury (TBI) had the greater odds of preexisting health conditions and/or poorer health behaviors than matched controls without TBI.

Setting: Brain Injury Inpatient Rehabilitation Unit at Mount Sinai Hospital. Midlife in the United States (MIDUS) control data were collected via random-digit-dialing phone survey. Read More

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Unemployment Status Is Associated With Greater Cognitive Intraindividual Variability in Veterans With a History of Remote Mild TBI.

J Head Trauma Rehabil 2021 Jun 15. Epub 2021 Jun 15.

Research & Psychology Services (Ms Sakamoto and Drs Delano-Wood, Sorg, Schiehser, and Merritt) and Center of Excellence for Stress and Mental Health (Drs Delano-Wood, Schiehser, and Merritt), VA San Diego Healthcare System (VASDHS), San Diego, California; and Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla (Drs Delano-Wood, Sorg, Schiehser, and Merritt).

Objective: To examine the association between employment status and neuropsychological functioning in veterans with a history of remote mild traumatic brain injury (mTBI) using 2 approaches to assess cognitive performance: (a) standard, traditional mean cognitive performance; and (b) across-test intraindividual variability (IIV).

Setting: Outpatient Veterans Affairs (VA) hospital.

Participants: Eligibility criteria included veterans with a history of mTBI who performed adequately on performance validity tests. Read More

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