Cell Syst 2021 Sep 13. Epub 2021 Sep 13.
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Statistical Sciences, University of Toronto, Toronto, ON M5S 3G3, Canada; Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada; Ontario Institute of Cancer Research, Toronto, ON M5G 1M1, Canada; Vector Institute, Toronto, ON M5G 1M1, Canada. Electronic address:
A major challenge in the analysis of highly multiplexed imaging data is the assignment of cells to a priori known cell types. Existing approaches typically solve this by clustering cells followed by manual annotation. However, these often require several subjective choices and cannot explicitly assign cells to an uncharacterized type. Read More