422,048 results match your criteria primary tumors


Disability-Adjusted Life Years and Mortality Rate Attributed to Brain and Central Nervous System Cancer in the Middle East and North Africa Countries.

Neuroepidemiology 2021 Oct 14:1-13. Epub 2021 Oct 14.

Clinical Research Development Centre, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Primary brain tumors are among the main causes of death. This study aimed to determine the epidemiological features of the brain and central nervous system cancer in the Middle East and North Africa (MENA) region.

Methods: In this study, data of the Global Burden of Disease (GBD) study were used to estimate the incidence, prevalence, deaths, disability-adjusted life years (DALYs), and mortality in 21 countries in the MENA region from 1990 to 2019 based on age and sex. Read More

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October 2021

Deep learning can predict lymph node status directly from histology in colorectal cancer.

Eur J Cancer 2021 Oct 11;157:464-473. Epub 2021 Oct 11.

Digital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Background: Lymph node status is a prognostic marker and strongly influences therapeutic decisions in colorectal cancer (CRC).

Objectives: The objective of the study is to investigate whether image features extracted by a deep learning model from routine histological slides and/or clinical data can be used to predict CRC lymph node metastasis (LNM).

Methods: Using histological whole slide images (WSIs) of primary tumours of 2431 patients in the DACHS cohort, we trained a convolutional neural network to predict LNM. Read More

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October 2021

Carcinoma showing thymus-like differentiation (CASTLE) of the salivary gland: Report of 2 cases of a hitherto under-recognized extrathyroid counterpart.

Pathol Res Pract 2021 Oct 8;227:153646. Epub 2021 Oct 8.

Department of Anatomic Pathology, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan.

Carcinoma showing thymus-like differentiation (CASTLE) outside the thyroid gland is extremely rare. Here we report two cases of CASTLE of the major salivary gland. The tumors occurred in the parotid gland of a 31-year-old female (Case 1) and in the submandibular gland of a 40-year-old female (Case 2). Read More

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October 2021

Predictive Medicine for Salivary gland tumours identification through Deep Learning.

IEEE J Biomed Health Inform 2021 Oct 14;PP. Epub 2021 Oct 14.

Nowadays, predictive medicine begins to become a reality thanks to Artificial Intelligence (AI) which allows, through the processing of huge amounts of data, to identify correlations not perceptible to the human brain. The application of AI in predictive diagnostics is increasingly pervasive; through the use and interpretation of data, the first signs of some diseases (i.e. Read More

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October 2021

Metagenomic analysis of gut microbiome reveals a dynamic change in Alistipes onderdonkii in the preclinical model of pancreatic cancer, suppressing its proliferation.

Appl Microbiol Biotechnol 2021 Oct 14. Epub 2021 Oct 14.

Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 05505, Republic of Korea.

Pancreatic cancer is a lethal cancer with aggressive and invasive characteristics. By the time it is diagnosed, patients already have tumors extended to other organs and show extremely low survival rates. The gut microbiome is known to be associated with many diseases and its imbalance affects the pathogenesis of pancreatic cancer. Read More

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October 2021

Disease-free time stratification in locally recurrent head and neck carcinoma after definitive radiotherapy or chemoradiotherapy.

Eur Arch Otorhinolaryngol 2021 Oct 14. Epub 2021 Oct 14.

Department of Head and Neck Oncology, Gustave Roussy Institute, University Paris-Saclay, 114 Rue Edouard Vaillant, 94800, Villejuif, France.

Purpose: There is no standard definition of disease-free interval before local recurrence after treatment in head and neck carcinoma (HNSCC). We evaluated an easy-to-use stratification and its association with survival in a large cohort of patients.

Methods: We performed a retrospective cohort analysis of prognostic variables in 325 HNSCC patients with a local recurrence after definitive radiotherapy or concurrent chemoradiotherapy. Read More

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October 2021

Preexisting TP53-Variant Clonal Hematopoiesis and Risk of Secondary Myeloid Neoplasms in Patients With High-grade Ovarian Cancer Treated With Rucaparib.

JAMA Oncol 2021 Oct 14. Epub 2021 Oct 14.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle.

Importance: A total of 1% to 3% of patients treated with a poly(adenosine diphosphate-ribose) polymerase inhibitor for high-grade ovarian cancer (HGOC) develop therapy-related myeloid neoplasms (t-MNs), which are rare but often fatal conditions. Although the cause of these t-MNs is unknown, clonal hematopoiesis of indeterminate potential (CHIP) variants can increase the risk of primary myeloid malignant neoplasms and are more frequent among patients with solid tumors.

Objectives: To examine whether preexisting CHIP variants are associated with the development of t-MNs after rucaparib treatment and how these CHIP variants are affected by treatment. Read More

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October 2021

The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms.

Endocr Relat Cancer 2021 Oct 1. Epub 2021 Oct 1.

S Knappskog, Department of Clinical Science, University of Bergen, Bergen, Norway.

High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare but have a very poor prognosis and represent a severely understudied class of tumours. Molecular data for HG GEP-NEN are limited and treatment strategies for the carcinoma subgroup (HG GEP-NEC) are extrapolated from small-cell lung cancer (SCLC). After pathological re-evaluation, we analysed DNA from tumours and matched blood samples from 181 HG GEP-NEN patients; 152 neuroendocrine carcinomas (NEC) and 29 neuroendocrine tumours (NET G3). Read More

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October 2021

Comparison of Tumor Microenvironments Between Primary Tumors and Brain Metastases in Patients With NSCLC.

JTO Clin Res Rep 2021 Oct 20;2(10):100230. Epub 2021 Sep 20.

Division of Medical Oncology, Department of Internal Medicine, James Thoracic Center, The Ohio State University, Columbus, Ohio.

Introduction: This study investigates the immune profile of the primary lung tumors and the corresponding brain metastasis from patients with NSCLC using multiplex fluorescence immunohistochemistry.

Methods: The study evaluated 34 patients who underwent autopsy or surgical resection for brain metastasis and autopsy, surgical resection, or core biopsy for primary lung cancer. We compared the densities of various immune cells in the primary tumors and the brain metastases by multiplex fluorescence immunohistochemical analysis. Read More

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October 2021

Laparoscopic Right Hemicolectomy to Curatively Treat Primary Leiomyosarcoma at the Ileocecal Valve.

ACG Case Rep J 2021 Sep 5;8(9):e00670. Epub 2021 Oct 5.

Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.

Primary leiomyosarcomas of the colon (PLC) are rare tumors, representing 0.12% of all colon malignancies. We report a 59-year-old man with weight loss, mild anemia, and rectal bleeding. Read More

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September 2021

Macrophage-Related SPP1 as a Potential Biomarker for Early Lymph Node Metastasis in Lung Adenocarcinoma.

Front Cell Dev Biol 2021 27;9:739358. Epub 2021 Sep 27.

Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Lymph node metastasis is a major factor that affects prognosis in patients with lung adenocarcinoma (LUAD). In some cases, lymph node metastasis has already occurred when the primary tumors are still small (i.e. Read More

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September 2021

Detection of Metastatic Tumor Cells in the Bone Marrow Aspirate Smears by Artificial Intelligence (AI)-Based System.

Front Oncol 2021 27;11:742395. Epub 2021 Sep 27.

Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Introduction: Metastatic carcinomas of bone marrow (MCBM) are characterized as tumors of non-hematopoietic origin spreading to the bone marrow through blood or lymphatic circulation. The diagnosis is critical for tumor staging, treatment selection and prognostic risk stratification. However, the identification of metastatic carcinoma cells on bone marrow aspiration smears is technically challenging by conventional microscopic screening. Read More

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September 2021

Bone Metastases of Glioblastoma: A Case Report and Review of the Literature.

Front Oncol 2021 27;11:705455. Epub 2021 Sep 27.

Department of Radiation Oncology, Weifang People's Hospital, Weifang, China.

Background: Glioblastoma (GBM) is the most common primary intracranial tumor and originates from the small pool of adult neural stem and progenitor cells (NSPCs). According to the World Health Organization (WHO) classification of brain tumors, gliomas are classified into grades I-IV, and GBM is defined as the highest grade (IV). GBM can be disseminated by cerebrospinal fluid (CSF), but extracranial metastasis is rare. Read More

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September 2021

Multiple Small Intestinal Neuroendocrine Tumors With Findings of Intestinal Obstruction.

Cureus 2021 Sep 1;13(9):e17629. Epub 2021 Sep 1.

Medicine, College of Medicine, King Abdulaziz University Hospital, Jeddah, SAU.

Carcinoid tumors are one of the most common types of small intestinal neuroendocrine tumors (SI-NETs). However, SI-NETs that manifest as subacute intestinal obstruction are extremely rare. The annual occurrence rate of jejuno-ileal NETs is 0. Read More

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September 2021

Primary Esophageal Lymphoma: Clinical Experience in Diagnosis and Treatment.

Cureus 2021 Sep 1;13(9):e17628. Epub 2021 Sep 1.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, CHN.

Primary esophageal lymphoma is a rare malignant tumor, which is often misdiagnosed. To improve the diagnosis and treatment of this disease, we presented one case admitted at our institution and a literature review of primary esophageal lymphoma cases, including the clinical data, features of imaging, endoscopy and pathology, treatment, and prognosis. The symptoms were non-specific. Read More

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September 2021

Pneumoblastoma: A Rare Tumor in Children Revealed by Pyopneumothorax.

Cureus 2021 Aug 29;13(8):e17539. Epub 2021 Aug 29.

Department of Radiology, University Hospital Mohammed VI, Marrakesh, MAR.

Pneumoblastoma is a rare but severely aggressive primary lung tumor. Exceptional at the pediatric age, pneumoblastoma lacks clinical and radiological specificity. It is rarely mentioned as a first-line differential, as radiological images are often confused with those of congenital lung malformation. Read More

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Pure primary non-gestational choriocarcinoma originating in the ovary: A case report and literature review.

Rare Tumors 2021 8;13:20363613211052506. Epub 2021 Oct 8.

Department of Pathology, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin, China.

Non-gestational choriocarcinoma (NGCO) of the ovary is rare, with a prevalence of less than 0.6% of all ovarian germ-cell tumors; and when found with other germ cell tumors, pure NGCO is exceedingly rare. We herein report the case of a 22-year-old woman who complained of menstrual disorders for over 2 months. Read More

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October 2021

Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem.

Theranostics 2021 13;11(19):9470-9491. Epub 2021 Sep 13.

State Key Laboratory of Silkworm Genome Biology, School of Materials and Energy, Southwest University, Chongqing 400715, China.

An imbalance in redox homeostasis consistently inhibits tumor cell proliferation and further causes tumor regression. Thus, synchronous glutaminolysis inhibition and intracellular reactive oxygen (ROS) accumulation cause severe redox dyshomeostasis, which may potentially become a new therapeutic strategy to effectively combat cancer. Mitochondrial-targeting liposomal nanoparticles (abbreviated MLipRIR NPs) are synthesized by the encapsulation of R162 (inhibitor of glutamate dehydrogenase 1 [GDH1]) and IR780 (a hydrophobic sonosensitizer) within the lipid bilayer, which are exploited for ultrasound (US)-activated tumor dyshomeostasis therapy reinforced by immunogenic cell death (ICD). Read More

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September 2021

Precision Oncology in Metastatic Uterine Cancer; Croatian First-Year Experience of the Comprehensive Genomic Profiling in Everyday Clinical Practice.

Pathol Oncol Res 2021 27;27:1609963. Epub 2021 Sep 27.

Department of Oncology, School of Medicine, University Hospital Center Split, University of Split, Split, Croatia.

Comprehensive genomic profiling (CGP) is gradually becoming an inevitable part of the everyday oncology clinical practice. The interpretation and optimal implementation of the results is one of the hot topics of modern-day oncology. According to the recent findings, uterine cancer harbors a high level of gene alterations but is still insufficiently explored. Read More

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September 2021

A new prognostic score for predicting survival in patients treated with robotic stereotactic radiotherapy for brain metastases.

Sci Rep 2021 Oct 13;11(1):20347. Epub 2021 Oct 13.

Radiotherapy Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.

The study aimed to analyze potential prognostic factors in patients treated with robotic radiosurgery for brain metastases irrespective of primary tumor location and create a simple prognostic score that can be used without a full diagnostic workup. A retrospective analysis of 142 patients with 1-9 brain metastases treated with stereotactic radiosurgery (1-4 fractions) was performed. Volumes of all lesions were calculated using linear dimensions of the tumors (CC, LR, AP) and 4/3*π*(CC/2)*(LR/2)*(AP/2) formula. Read More

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October 2021

A Case of Multiple Endocrine Neoplasia Type 1 with Functional Parathyroid Cysts.

Intern Med 2021 Oct 12. Epub 2021 Oct 12.

Department of Metabolism and Endocrinology, Tokyo Medical University Ibaraki Medical Center, Japan.

A 51-year-old woman was admitted because of hypercalcemia. Neck ultrasonography and computed tomography revealed the presence of parathyroid cysts on both sides. After primary hyperparathyroidism was diagnosed by technetium-99 m-methoxyisobutylisonitrile scintigraphy, the patient was successfully treated with total parathyroidectomy and autotransplantation. Read More

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October 2021

Immunological configuration of ovarian carcinoma: features and impact on disease outcome.

J Immunother Cancer 2021 Oct;9(10)

Sotio Biotech, Prague, Czech Republic.

Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival. Read More

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October 2021

Awareness of HPV-associated oropharyngeal cancers among GPs in the netherlands: cross-sectional study.

BJGP Open 2021 Oct 13. Epub 2021 Oct 13.

Department of Pathology, GROW-school for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands

Background: The incidence of human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is increasing in high-income countries. HPV-associated OPC generally presents as an invasive disease, often with lymph node involvement, in relatively young patients with minimal or no history of smoking and alcohol consumption. Knowledge on HPV-associated OPC among primary care professionals is essential for disease recognition and early start of treatment. Read More

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October 2021

Biomarkers of response and resistance to palbociclib plus letrozole in patients with ER+/HER2- breast cancer.

Clin Cancer Res 2021 Oct 13. Epub 2021 Oct 13.

Breast Unit, Royal Marsden Hospital.

To determine (i) the relationship between candidate biomarkers of the antiproliferative (Ki67) response to letrozole and palbociclib alone and combined in ER+/HER2- breast cancer; (ii) the pharmacodynamic effect of the agents on the biomarkers. 307 postmenopausal women with ER+/HER2- primary breast cancer were randomly assigned to neoadjuvant treatment with letrozole for 14 weeks; letrozole for 2 weeks, then letrozole+palbociclib to 14 weeks; palbociclib for 2 weeks, then letrozole+palbociclib to 14 weeks; or letrozole+palbociclib for 14 weeks. Biopsies were taken at baseline, 2 and 14 weeks and surgery at varying times after stopping palbociclib. Read More

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October 2021

Hypoxia drives dihydropyrimidine dehydrogenase expression in macrophages and confers chemoresistance in colorectal cancer.

Cancer Res 2021 Oct 13. Epub 2021 Oct 13.

Institute for Advanced Biosciences

Colorectal adenocarcinoma is a leading cause of death worldwide, and immune infiltration in colorectal tumors has been recognized recently as an important pathophysiological event. In this context, tumor-associated macrophages (TAM) have been related to chemoresistance to 5-fluorouracil (5-FU), the first-line chemotherapeutic agent used in treating colorectal cancers. Nevertheless, the details of this chemoresistance mechanism are still poorly elucidated. Read More

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October 2021

Low-grade intracranial meningioma with bilateral pulmonary metastases incidentally detected postpartum: a case report and review of the literature.

J Med Case Rep 2021 Oct 14;15(1):509. Epub 2021 Oct 14.

Neurosurgery Resident, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Meningiomas are the most commonly encountered intracranial tumors, usually showing indolent behavior. Extra-axial spreading and distant metastases are seldom detected in these tumors, and lung metastasis from a low-grade meningioma is a rare event.

Case Presentation: This case report aimed to present the clinical, imaging, and pathological features of a 37-year-old Caucasian pregnant woman with bilateral lung metastases incidentally detected during preoperative workup ahead of surgery for a primary intracranial meningioma. Read More

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October 2021

Malignant primary pericardial mesothelioma presenting as effusive constrictive pericarditis: a case report study.

J Cardiothorac Surg 2021 Oct 13;16(1):298. Epub 2021 Oct 13.

Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital School of Medicine, Guilan University of Medical Sciences, 15 Khordad Street, District 2, Rasht, Guilan Province, Iran.

Background: Primary pericardial mesothelioma (PPM) is a rare malignancy with a high prevalence of mortality. The diagnosis is usually challenging using a variety of imaging modalities and invasive procedures and is generally performed at the later stages of the disease or in autopsy. This case study points to an unconventional presentation of PPM and the challenges in diagnosing this rare mortal malignancy. Read More

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October 2021

Environmental Factors, Lifestyle Risk Factors, and Host Characteristics Associated With Philadelphia Negative Myeloproliferative Neoplasm: A Systematic Review.

Cancer Control 2021 Jan-Dec;28:10732748211046802

Professor of Social & Administrative Pharmacy, College of Pharmacy, QU Health, 61780Qatar University, Doha, Qatar.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the overproduction of mature myeloid cells and are often associated with an acquired genetic mutation of . Various epidemiological studies have indicated associations between environmental factors, lifestyle factors, and host characteristics with developing MPNs. This review aims to collect and summarize the existing information on these risk factors and establish their association with pathogenesis MPNs. Read More

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October 2021

[Comparative study on prognosis of neoadjuvant chemotherapy followed by hepatic surgery versus upfront surgery in patients with synchronous colorectal liver metastasis].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Mar;24(3):248-255

Department of Hepatopancreatobiliary Surgery Unit I, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China.

To compare the survival outcome in patients with synchronous colorectal cancer liver metastasis receiving neoadjuvant chemotherapy followed by hepatic surgery versus upfront surgery strategies. A retrospective cohort study was carried out. Data of patients undergoing surgery at the Department of Hepatopancreatobiliary Surgery Unit I of Peking University Cancer Hospital from January 2008 to December 2018 for initially resectable synchronous colorectal liver metastasis were retrospectively collected. Read More

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[Efficacy of 1 384 cases of peritoneal carcinomatosis underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Mar;24(3):230-239

Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Peritoneal carcinomatosis refers to a group of heterogeneous (primary or secondary) malignancies in the surface of the peritoneum. Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) is a comprehensive treatment strategy aiming at peritoneal carcinomatosis. This study analyzed the efficacy and safety of CRS+HIPEC in patients with peritoneal carcinomatosis, and explored prognostic factors. Read More

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