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Multiple sclerosis is associated with higher comorbidity and healthcare resource use: a population-based, case-control study in a western Mediterranean region.

Eur J Neurol 2021 Jul 22. Epub 2021 Jul 22.

Servei de Neurología-Neuroimmunología, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Hospital Universitari, Barcelona, Spain.

Background: Comorbidities are common in multiple sclerosis (MS), and have been associated with worse outcomes and increased healthcare resource usage. We studied the frequency of comorbidities and adverse health behaviors (AHB) in MS patients in the Mediterranean region of Catalonia.

Methods: Population-based, case-control study using primary healthcare information covering 80% of Catalonia's population. Read More

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Diagnostic accuracy of a novel artificial intelligence system for adenoma detection in daily practice: a prospective non-randomized comparative study.

Endoscopy 2021 Jul 22. Epub 2021 Jul 22.

Department of Gastroenterology and interventional Endoscopy, Krankenhaus Barmherzige Bruder Regensburg, Regensburg, Germany.

Background And Aims: Adenoma detection rate (ADR) varies significantly between endoscopists with up to 26% adenoma miss rate (AMR). Artificial intelligence (AI) systems may improve endoscopic quality and reduce the rate of interval cancer. We evaluated the efficacy of an AI system in real time colonoscopy and its influence on the AMR and the ADR. Read More

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Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Neuroendocrine Tumors in Routine Clinical Practice in Germany and Austria.

Exp Clin Endocrinol Diabetes 2021 Jul 22;129(7):500-509. Epub 2021 Jul 22.

ENDOC Center for Endocrine Tumors, Hamburg, Germany.

Background: The long-acting somatostatin analog lanreotide autogel is effective in the treatment of patients with neuroendocrine tumors.

Objective: To evaluate the long-term treatment response in patients with neuroendocrine tumors receiving lanreotide autogel in routine clinical practice.

Methods: Non-interventional, 24-month study in patients with neuroendocrine tumors treated with lanreotide autogel (NCT01840449). Read More

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Relatively Low Rate of Heterotopic Ossification Following Primary Total Knee Arthroplasty: A Systematic Review and Meta-analysis.

J Am Acad Orthop Surg Glob Res Rev 2021 Jul 22;5(7). Epub 2021 Jul 22.

From the Stavros Niarchos Foundation Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY (Dr. Gkiatas, Mr. Xiang, Mr. Windsor, Dr. Malahias, Dr. Tarity, and Dr. Sculco), and the School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (Mr. Karasavvidis).

Background: Heterotopic ossification (HO) is abnormal growth of ectopic bone and negatively affects the outcomes after total knee arthroplasty (TKA). This systematic review and meta-analysis were performed to characterize the prevalence and severity of HO after primary TKA.

Methods: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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Sequencing of Circulating Microbial Cell-Free DNA Can Identify Pathogens in Periprosthetic Joint Infections.

J Bone Joint Surg Am 2021 Jul 22. Epub 2021 Jul 22.

Hospital for Special Surgery Research Institute, New York, NY.

Background: Over 1 million Americans undergo joint replacement each year, and approximately 1 in 75 will incur a periprosthetic joint infection. Effective treatment necessitates pathogen identification, yet standard-of-care cultures fail to detect organisms in 10% to 20% of cases and require invasive sampling. We hypothesized that cell-free DNA (cfDNA) fragments from microorganisms in a periprosthetic joint infection can be found in the bloodstream and utilized to accurately identify pathogens via next-generation sequencing. Read More

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Metabolic Disorders/Obesity Is a Primary Risk Factor in Hidradenitis Suppurativa: An Immunohistochemical Real-World Approach.

Dermatology 2021 Jul 22:1-9. Epub 2021 Jul 22.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

Background: Hidradenitis suppurativa (HS) is an inflammatory, potentially scarring disease of the hair follicle, affecting the apocrine gland-bearing skin areas. The major comorbid disorders associated with the occurrence or the aggravation of the disease are obesity and smoking. Numerous efforts to dissociate these factors led to controversial results. Read More

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Effect of Sustained Interventions from Infancy to Toddlerhood in Children with Cleft Lip and Palate for Preventing Early Childhood Caries.

Caries Res 2021 Jul 22:1-9. Epub 2021 Jul 22.

Department of Pediatric and Preventive Dentistry, Pushpagiri College of Dental Sciences, Thiruvalla, India.

The study aimed to evaluate the effectiveness of sustained interventions in children with cleft lip and palate (CLP) for preventing early childhood caries (ECC). This prospective, nonrandomized interventional cohort study was conducted in infants aged 0-12 months with congenital CLP. Interventions were given to parents/primary caregivers in the form of combined oral health-care measures (sterile wet gauze piece, finger brush, toothbrush, and toothpaste) by a motivational interviewing approach. Read More

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Ferric Citrate Dosing in Iron Deficiency Anemia in Nondialysis-Dependent Chronic Kidney Disease.

Am J Nephrol 2021 Jul 22:1-10. Epub 2021 Jul 22.

Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.

Introduction: Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). Read More

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Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: A novel clinical entity?

J Autoimmun 2021 Jul 15;123:102706. Epub 2021 Jul 15.

Epatocentro Ticino, Via Soldino 5, 6900, Lugano, Switzerland; King's College London Faculty of Life Sciences & Medicine, Institute of Liver Studies, MowatLabs, London, UK; Faculty of Biomedical Sciences, Università Della Svizzera Italiana, 6900, Lugano, Switzerland. Electronic address:

Autoimmune phenomena and clinically apparent autoimmune diseases, including autoimmune hepatitis, are increasingly been reported not only after natural infection with the SARS-CoV-2 virus, but also after vaccination against it. We report the case of a 63-year old man without a history of autoimmunity or SARS-CoV-2 natural infection who experienced acute severe autoimmune-like hepatitis seven days after the first dose of the mRNA-1273 SARS-CoV-2 vaccine. Liver histology showed inflammatory portal infiltrate with interface hepatitis, lobular and centrilobular inflammation with centrilobular necrosis, in absence of fibrosis and steatosis. Read More

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Identifying optimal virtual water management strategy for Kazakhstan: A factorial ecologically-extended input-output model.

J Environ Manage 2021 Jul 19;297:113303. Epub 2021 Jul 19.

School of Environmental Science and Engineering, Xiamen University of Technology, Xiamen, 361024, China. Electronic address:

Virtual water is an important indicator measuring the amount of water needed from the perspective of consumption, which can help decision makers to identify desired system design and optimal management strategy against water resources shortage. In this study, a novel model named as factorial ecologically-extended input-output model (abbreviated as FEIOM) is developed for virtual water management. FEIOM integrates techniques of input-output model (IOM), ecological network analysis (ENA) and factorial analysis (FA) into a general framework. Read More

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Systemic therapy and prognosis of older patients with stage II/III breast cancer: A large-scale analysis of the Japanese Breast Cancer Registry.

Eur J Cancer 2021 Jul 19;154:157-166. Epub 2021 Jul 19.

Department of Breast Oncology, Aichi Cancer Center, Nagoya, Japan. Electronic address:

Aim: This study aimed at investigating the real-world prognostic impact of systemic treatment in older patients with stage II/III breast cancer (BC).

Methods: This retrospective cohort study included patients with stage II/III primary BC, aged ≥55 years, and registered in the Japanese Breast Cancer Registry from 2004 to 2011. The clinicopathological characteristics, treatments, and prognosis of patients aged ≥75 years (older) were compared to those of younger patients. Read More

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Chondrosarcoma arising in monostotic fibrous dysplasia treated with total femur resection and megaprothesis: A case report.

Int J Surg Case Rep 2021 Jul 9;85:106194. Epub 2021 Jul 9.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia. Electronic address:

Introduction: Fibrous dysplasia is tumor like lesions of bone which develop as substitution of bone by an expansion of fibrous connective tissue mixed with hard trabeculae. Chondrosarcomas is one of common malignant primary bone tumor derived from heterogenous group of neoplasm producing chondroid matrix. Chondrosarcoma arising in fibrous dysplasia, especially in monostotic fibrous dysplasia is a very rare case. Read More

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Efficacy of double antibiotics in hydroxypropyl methylcellulose for bactericidal activity against Enterococcus faecalis and Streptococcus gordonii in biofilm.

Arch Oral Biol 2021 Jul 16;129:105210. Epub 2021 Jul 16.

Center of Excellence in Oral and Maxillofacial Biology, Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Objective: This study aimed to investigate the efficacy of double antibiotics, including ciprofloxacin and metronidazole, in a new vehicle, hydroxypropyl methylcellulose (HPMC), against Enterococcus faecalis and Streptococcus gordonii grown in biofilm.

Design: Human mandibular premolars were prepared and divided into four groups: (i) negative control, (ii) positive control, (iii) infected with E. faecalis and S. Read More

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Higher order aberrations and retinal image quality during short-term accommodation in children.

Vision Res 2021 Jul 19;188:74-84. Epub 2021 Jul 19.

Queensland University of Technology, Contact Lens and Visual Optics Laboratory, School of Optometry and Vision Science, Centre for Vision and Eye Research, Brisbane, Queensland, Australia.

Changes in higher order aberrations (HOA's) and retinal image quality during accommodation have not previously been examined in children. This study measured ocular HOA's in ninety non-myopic, school-aged children during short-term accommodation tasks at 0, 3, 6, and 9 D demands presented via a Badal optometer mounted to a Hartmann-Shack wavefront aberrometer (COAS-HD, Wavefront Sciences). Eighty-four participants who exhibited active accommodation were included in the analyses. Read More

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Leishmania infantum strains from cats are similar in biological properties to canine and human strains.

Vet Parasitol 2021 Jul 15;298:109531. Epub 2021 Jul 15.

Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (NOVA), 1349-008, Lisbon, Portugal; Medical Parasitology Unit, IHMT/NOVA, 1349-008, Lisbon, Portugal. Electronic address:

Zoonotic visceral leishmaniosis is a worldwide severe disease caused by Leishmania infantum, a protozoan that has phlebotomine sand flies as vectors and dogs as primary reservoir hosts. Over the last few decades, cats have been regarded as an indisputable piece within the ecological system in which L. infantum is maintained indefinitely. Read More

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Leveraging unsupervised image registration for discovery of landmark shape descriptor.

Med Image Anal 2021 Jul 9;73:102157. Epub 2021 Jul 9.

Scientific Computing and Imaging Institute, 72 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA; School of Computing, 50 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA.

In current biological and medical research, statistical shape modeling (SSM) provides an essential framework for the characterization of anatomy/morphology. Such analysis is often driven by the identification of a relatively small number of geometrically consistent features found across the samples of a population. These features can subsequently provide information about the population shape variation. Read More

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Hematopoietic Stem Cell Transplantation For Patients With Autosomal Recessive Complete Interferon Gamma Receptor 2 Deficiency: Experience In Oman.

Transplant Cell Ther 2021 Jul 19. Epub 2021 Jul 19.

Department of, Hematology, Sultan Qaboos University Hospital, Muscat, Oman; Apollo Hospital, Muscat, Oman. Electronic address:

Autosomal recessive complete interferon- gamma receptor-2 (IFN-γR2) deficiency is a rare potentially fatal primary immune deficiency that predisposes to disseminated mycobacterial disease.Hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment. Few patients had been reported so far. Read More

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Medicated multi-targeted alginate-based dressings for potential treatment of mixed bacterial-fungal infections in diabetic foot ulcers.

Int J Pharm 2021 Jul 19:120903. Epub 2021 Jul 19.

School of Science, Faculty of Engineering and Science, University of Greenwich, Medway, Central Ave. Chatham Maritime, Kent ME4 4TB, UK. Electronic address:

Recently developed medicated dressings target either bacterial or fungal infection only, which is not effective for the treatment of mixed infections common in diabetic foot ulcers (DFUs). This study aims to develop advanced bioactive alginate-based dressings (films and wafers) to deliver therapeutically relevant doses of ciprofloxacin (CIP) and fluconazole (FLU) to target mixed bacterial and fungal infections in DFUs. The alginate compatibility with the drugs was confirmed by SEM, XRD, FTIR and texture analysis, while the medicated wafers showed better fluid handling properties than the films in the presence of simulated wound fluid. Read More

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Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 Study): an open-label, nonrandomized, multicenter, phase 2 trial.

Ann Oncol 2021 Jul 19. Epub 2021 Jul 19.

Service de Dermatologie et Cancérologie Cutanée, Aix-Marseille University, Marseille, France.

Background: Pembrolizumab demonstrated clinically meaningful and durable antitumor activity with a manageable safety profile in recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (cSCC).

Patients And Methods: KEYNOTE-629 was a global, open-label, nonrandomized, phase 2 trial of patients with locally advanced (LA) or R/M cSCC conducted at 59 centers. Eligible patients received intravenous pembrolizumab 200 mg every three weeks for up to 35 cycles. Read More

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An integrated approach to uncover anti-tumor active materials of Curcumae Rhizoma-Sparganii Rhizoma based on spectrum-effect relationship, molecular docking, and ADME evaluation.

J Ethnopharmacol 2021 Jul 19:114439. Epub 2021 Jul 19.

School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102488, PR China; Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, PR China. Electronic address:

Ethnopharmacological Relevance: Curcumae Rhizoma-Sparganii Rhizoma (CR-SR), an ancient and classical herbal couple, has been extensively used for tumor treatment in clinic of traditional Chinese medicines (TCMs).

Aim Of The Study: The study aimed to uncover the anti-tumor active materials of CR-SR water decoction (CR:SR = 1:1) via an integrated approach of spectrum-effect relationship, molecular docking, and ADME evaluation.

Materials And Methods: The anti-tumor activities toward A549, HepG2, Hela, BGC-823, and MCF-7 cells of the different polar elution fractions (DPEFs) of CR, SR, and CR-SR were determined by Cell Counting Kit-8 (CCK-8) assay. Read More

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Durability of rilpivirine- versus integrase inhibitor-based regimens in a large cohort of naïve HIV-infected patients starting antiretroviral therapy.

Int J Antimicrob Agents 2021 Jul 19:106406. Epub 2021 Jul 19.

Clinic of Infectious Diseases, S. Paolo Hospital, University of Milan, Milano, Italy.

Objective: Comparisons between rilpivirine (RPV) and integrase strand transfer inhibitors (INSTIs) in antiretroviral therapy (ART)-naïve HIV-infected individuals are currently lacking. Aim of the study was to compare, in an observational cohort setting, the durability of treatment of RPV- and INSTI-based first-line regimens.

Methods: Patients who started first-line ARTs based on RPV or on INSTIs, with HIV-RNA <100,000 copies/mL, CD4 cells count >200 cells/μL, were included. Read More

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Revealing new therapeutic opportunities in hypertension through network-driven integrative genetic analysis and drug target prediction approach.

Gene 2021 Jul 19:145856. Epub 2021 Jul 19.

Translational Research Lab, Department of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India. Electronic address:

Epidemiological studies have established that untreated hypertension (HTN) is a major independent risk factor for developing cardiovascular diseases (CVD), stroke, renal failure, and other conditions. Several important studies have been published to prevent and manage HTN; however, antihypertensive agents' optimal choice remains controversial. Therefore, the present study is undertaken to update our knowledge in the primary treatment of HTN, specifically in the setting of other three important diseases. Read More

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Adolescent Primary Genital HSV-1 Infection with Sepsis Secondary to Streptococcus pyogenes Bacteremia.

J Pediatr Adolesc Gynecol 2021 Jul 19. Epub 2021 Jul 19.

Campbell University School of Osteopathic Medicine; Wake Med North Hospital, Raleigh NC.

Background: Adolescents and young adults are responsible for the majority of new genital herpes virus infections. Historically, primary genital herpes infections were thought to be caused by herpes simplex virus-2, however, recent studies suggest that up to 50% of incident episodes of genital herpes are caused by herpes simplex virus-1.

Case: This case discusses an 18-year-old G1P0010 female who presented with a primary genital HSV-1 outbreak that resulted in sepsis secondary to Streptococcus pyogenes bacteremia. Read More

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Association of periodontal disease with breed size, breed, weight, and age in pure-bred client-owned dogs in the United States.

Vet J 2021 Jul 19:105717. Epub 2021 Jul 19.

Waltham Petcare Science Institute, Freeby Lane, Waltham-on-the-Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK.

Despite periodontal disease (PD) being amongst the most common diagnoses in primary-care practice, the disease is generally underdiagnosed. However, the millions of clinical records generated by pet hospitals each year provide unique opportunities to generate insights about disease risk across large numbers of dogs. The objective of this study was to undertake a retrospective analysis of medical records to ascertain which sizes and breeds of dog are most frequently diagnosed with PD. Read More

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Automated read-across workflow for predicting acute oral toxicity: I. The decision scheme in the QSAR Toolbox.

Regul Toxicol Pharmacol 2021 Jul 19:105015. Epub 2021 Jul 19.

Laboratory of Mathematical Chemistry, Prof. As. Zlatarov University, Bourgas, Bulgaria. Electronic address:

A decision-scheme outlining the steps for identifying the appropriate chemical category and subsequently appropriate tested source analog(s) for data gap filling of a target chemical by read-across is described. The primary features used in the grouping of the target chemical with source analogs within a database of 10,039 discrete organic substances include reactivity mechanisms associated with protein interactions and specific-acute-oral-toxicity-related mechanisms (e.g. Read More

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Glenohumeral osteoarthritis with intact rotator cuff treated with reverse shoulder arthroplasty: a systematic review.

J Shoulder Elbow Surg 2021 Jul 19. Epub 2021 Jul 19.

Division of Upper Extremity Surgery, Department of Orthopaedic Surgery, Director of Upper Extremity Surgery Research, Emory University 59 Executive Park South, Atlanta, GA 30329, USA.

Background: While reverse shoulder arthroplasty has shown satisfactory outcomes in rotator cuff deficient shoulders, its performance in shoulders with an intact rotator cuff has not been fully elucidated. Shoulder osteoarthritis can present with alterations in glenoid morphology which have contributed to inconsistent outcomes in anatomic shoulder replacement. A predominance of these arthroplasty complications is due to the glenoid component. Read More

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Pan-cancer analysis reveals that neurotrophin signaling correlates positively with anti-tumor immunity, clinical outcomes, and response to targeted therapies and immunotherapies in cancer.

Life Sci 2021 Jul 19:119848. Epub 2021 Jul 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Aims: The crosstalk between cancer cells and nerves plays an important role in tumor biology. However, the correlation between the neurotrophin signaling (NS) and anti-tumor immunity and immunotherapy response in cancer remains unexplored.

Materials And Methods: We analyzed associations of NS with anti-tumor immune signatures, tumor immunity-related molecular and genomic features, and clinical features in 33 TCGA cancer types. Read More

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Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies.

Neurochem Int 2021 Jul 19:105137. Epub 2021 Jul 19.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, SE-17121, Sweden. Electronic address:

Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma correlated with poor patient survival. There are no curative treatments for GB, and it becomes resistant to chemotherapy, radiation therapy, and immunotherapy. Resistance in GB cells is closely related to their states of redox imbalance, and the role of reactive oxygen species and its impact on cancer cell survival is still far from elucidation. Read More

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Low Rate of Spontaneous Closure in Premature Infants Discharged with a Patent Ductus Arteriosus: A Multicenter Prospective Study.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, FL; Greenville Memorial Hospital, SC.

Objectives: To assess the rate of spontaneous closure and the incidence of adverse events in infants discharged home with a patent ductus arteriosus.

Study Design: In a prospective multicenter study, we enrolled 201 premature infants (gestational age 23-32 weeks at birth) discharged home with a persistently patent ductus arteriosus (PDA) and followed their PDA status at 6-month intervals through 18 months of age. The primary study outcome was the rate and timing of spontaneous ductal closure. Read More

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