538,564 results match your criteria primary care


Effect of Oral Anticoagulation and Adenosine Diphosphate Inhibitor Therapies on Short-term Outcome of Traumatic Brain Injury.

Neurology 2022 Jun 28. Epub 2022 Jun 28.

Heart Centre and Center for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland.

Objective: Usage of oral anticoagulants (OAC) or adenosine diphosphate inhibitors (ADPi) is known to increase the risk of bleeding. We aimed to investigate the impact of OAC and ADPi therapies on short-term outcomes after traumatic brain injury (TBI).

Methods: All adult patients hospitalized for TBI in Finland during 2005-2018 were retrospectively studied using a combination of national registries. Read More

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Caregiver Burden Is Associated With the Physical Function of Individuals on Long-Term Oxygen Therapy.

Respir Care 2022 Jun 28. Epub 2022 Jun 28.

Post-Graduate Research Program on Rehabilitation Sciences and Physical Function Performance, Faculty of Physiotherapy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil; and Department of Physiotherapy, Federal University of Juiz de Fora, Governador Valadares, Minas Gerais, Brazil.

Background: The influence of physical function of individuals on long-term oxygen therapy (LTOT) on caregiver burden is underexplored. This study investigated the association of caregiver burden with physical function of individuals on LTOT and the association between caregiver's burden and quality of life.

Methods: This was a cross-sectional study. Read More

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Almost half of people on long term antidepressants can stop without relapsing.

BMJ 2022 Jun 28;377:o1362. Epub 2022 Jun 28.

Division of Psychiatry, University College London, UK.

The studyDuffy L, Clarke CS, Lewis G, et al. Antidepressant medication to prevent depression relapse in primary care: the ANTLER RCT. 2021;25:69. Read More

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The association of race and ethnicity with severe maternal morbidity among individuals diagnosed with hypertensive disorders of pregnancy.

Am J Perinatol 2022 Jun 28. Epub 2022 Jun 28.

Obstetrics & Gynecology, University of Texas Health Sciences Center at Houston, Houston, United States.

Objective: To examine racial disparities in severe maternal morbidity in patients with hypertensive disorder of pregnancy (HDP).

Study Design: Secondary analysis of an observational study of 115,502 patients who had a live birth at ≥ 20 weeks in 25 hospitals in the US, 2008-2011. Only patients with HDP were included in this analysis. Read More

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Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice.

Br J Pharmacol 2022 Jun 28. Epub 2022 Jun 28.

Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Background And Purpose: Pulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructive disease that leads to right heart failure and death. Maresin 1 is an endogenous lipid mediator known to promote inflammation resolution. However, the effect of Maresin 1 on PAH remains unclear. Read More

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Profiles of Pain Acceptance and Values-Based Action in the Assessment and Treatment of Chronic Pain.

J Pain 2022 Jun 25. Epub 2022 Jun 25.

School of Psychology, Queen's University Belfast & the Centre for Chronic Pain Rehabilitation, Belfast Health and Social Care Trust.

Pain acceptance and values-based action are relevant to treatment outcomes in those with chronic pain. It is unclear if patterns of responding in these two behavioral processes can be used to classify patients into distinct classes at treatment onset and used to predict treatment response. This observational cohort study had two distinct goals. Read More

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Considerations for Fostering Palliative Care Awareness in Developing Contexts: Strategies from Locally Initiated Projects in India.

J Pain Symptom Manage 2022 Jun 25. Epub 2022 Jun 25.

Division of Primary Care and Population Health, Stanford University School of Medicine, Palo Alto California, USA; VA HSR&D Center for Innovation to Implementation (Ci2i), Menlo Park, California, USA.

Background: Lack of palliative care (PC) awareness is a barrier to its utilization in developing contexts.

Objectives: To identify and understand strategies that changed awareness of the concepts and value of palliative care in a multi-site quality improvement project in India.

Methods: The Palliative Care - Promoting Assessment and Improvement of the Cancer Experience (PC-PAICE) evaluation team conducted 44 semi-structured interviews with clinician and organization stakeholders at seven geographically dispersed sites. Read More

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Effects of an exercise-based lifestyle intervention on systemic markers of oxidative stress and advanced glycation endproducts in persons with type 2 diabetes: Secondary analysis of a randomised clinical trial.

Free Radic Biol Med 2022 Jun 25. Epub 2022 Jun 25.

Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. Electronic address:

Aims/hypothesis: This secondary analysis aimed to investigate the effects of a 12 months intensive exercise-based lifestyle intervention on systemic markers of oxidative stress in persons with type 2 diabetes. We hypothesized lifestyle intervention to be superior to standard care in decreasing levels of oxidative stress.

Methods: The study was based on the single-centre, assessor-blinded, randomised, controlled U-turn trial (ClinicalTrial. Read More

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Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia.

Pharmacol Ther 2022 Jun 25:108236. Epub 2022 Jun 25.

The Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry and Molecular Medicine, Hempstead, NY, USA; Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany.

Almost fifty years after its first introduction into clinical care, clozapine remains the only evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which affects approximately 30% of patients with schizophrenia. Despite the long-time experience with clozapine, the specific mechanism of action (MOA) responsible for its superior efficacy among antipsychotics is still elusive, both at the receptor and intracellular signaling level. This systematic review is aimed at critically assessing the role and specific relevance of clozapine's multimodal actions, dissecting those mechanisms that under a translational perspective could shed light on molecular targets worth to be considered for further innovative antipsychotic development. Read More

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HBM4EU chromates study - Usefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposure.

Environ Res 2022 Jun 25:113758. Epub 2022 Jun 25.

National Institute of Health Dr. Ricardo Jorge, Department of Health Promotion, Lisbon, Portugal.

Occupational exposures to hexavalent chromium (Cr(VI)) can occur in welding, hot working stainless steel processing, chrome plating, spray painting and coating activities. Recently, within the human biomonitoring for Europe initiative (HBM4EU), a study was performed to assess the suitability of different biomarkers to assess the exposure to Cr(VI) in various job tasks. Blood-based biomarkers may prove useful when more specific information on systemic and intracellular bioavailability is necessary. Read More

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Nurse-led reinforced education by mobile messenger improves the quality of bowel preparation of colonoscopy in a population-based colorectal cancer screening program: A randomized controlled trial.

Int J Nurs Stud 2022 May 30;133:104301. Epub 2022 May 30.

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, Hong Kong; Stanley Ho Big Data Decision Analytics Research Centre, The Chinese University of Hong Kong, Hong Kong, Hong Kong; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Electronic address:

Background: Adequate bowel preparation is an important colonoscopy quality indicator. Reinforced education is effective in improving bowel preparation quality of colonoscopy with mixed indications. However, it remains unclear whether such improvement can be consistently observed in pre- and post-irrigation during colonoscopy in screening population. Read More

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Impact of mean perfusion pressure and vasoactive drugs on occurrence and reversal of cardiac surgery-associate acute kidney injury: A cohort study.

J Crit Care 2022 Jun 25;71:154101. Epub 2022 Jun 25.

Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium; Research Foundation-Flanders (FWO), Brussels, Belgium.

Purpose: Low cardiac output and kidney congestion are associated with acute kidney injury after cardiac surgery (CSA-AKI). This study investigates hemodynamics on CSA-AKI development and reversal.

Materials And Methods: Adult patients undergoing cardiac surgery were retrospectively included. Read More

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Incidence and Trends in the Use of Palliative Care among Patients with Reduced, Middle-Range, and Preserved Ejection Fraction Heart Failure.

J Palliat Med 2022 Jun 28. Epub 2022 Jun 28.

Yale School of Nursing, West Haven, Connecticut, USA.

Clinical practice guidelines recommend integrating palliative care (PC) into the care of patients with heart failure (HF) to address their many palliative needs. However, the incidence rates of PC use among HF subtypes are unknown. We conducted a retrospective cohort study of patients with the following HF subtypes in the Department of Veterans Affairs: reduced ejection fraction (HFrEF), mid-range ejection fraction (HFmEF), and preserved ejection fraction (HFpEF). Read More

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Atezolizumab With Neoadjuvant Anti-Human Epidermal Growth Factor Receptor 2 Therapy and Chemotherapy in Human Epidermal Growth Factor Receptor 2-Positive Early Breast Cancer: Primary Results of the Randomized Phase III IMpassion050 Trial.

J Clin Oncol 2022 Jun 28:JCO2102772. Epub 2022 Jun 28.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Combining standard of care (pertuzumab-trastuzumab [PH], chemotherapy) with cancer immunotherapy may potentiate antitumor immunity, cytotoxic activity, and patient outcomes in high-risk, human epidermal growth factor receptor 2 (HER2)-positive early breast cancer. We report the phase III IMpassion050 primary analysis of neoadjuvant atezolizumab, PH, and chemotherapy in these patients.

Methods: Patients with a primary tumor of > 2 cm and histologically confirmed, positive lymph node status (T2-4, N1-3, M0) were randomly assigned 1:1 to atezolizumab/placebo with dose-dense doxorubicin/cyclophosphamide, followed by paclitaxel, and PH. Read More

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Gender Differences in Smoking Attitude among Saudi Medical Students.

Asian Pac J Cancer Prev 2022 Jun 1;23(6):2089-2093. Epub 2022 Jun 1.

Department of Public Health, College of Health Sciences, Saudi Electronic University, Dammam, Saudi Arabia.

Background: Smoking is a growing public health problem throughout the world. However, the attitude of males and females toward smoking may differ. Therefore, this study examines gender differences in smoking behavior and attitude among Saudi medical students. Read More

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Using Intervention Mapping to Develop a Theory-Based Intervention to Promote Colorectal Cancer Screening in Egypt.

Asian Pac J Cancer Prev 2022 Jun 1;23(6):1975-1981. Epub 2022 Jun 1.

University of Alabama at Birmingham, O'Neal Comprehensive Cancer Center, 1824 6th Ave South, Birmingham, AL 35233 U.S.A.

Background: Colorectal cancer (CRC) incidence and mortality rates are increasing in Egypt. Because no national screening guidelines exist, developing an effective evidence-based screening intervention could lower rates by early detection of pre-cancerous and cancerous lesions and polyps. This paper describes the development of a CRC screening intervention in Alexandria, Egypt using Intervention Mapping (IM). Read More

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Cholangiocarcinoma Attributed to Occupation: A Systematic Reviews.

Asian Pac J Cancer Prev 2022 Jun 1;23(6):1837-1845. Epub 2022 Jun 1.

Department of Preventive and Social Medicine, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.

Background: The occurrence of a cluster of occupational cholangiocarcinoma(CCA) cases among Japanese workers at a small offset printing plant led to the hypotheses that occupational exposure was the root cause of this cancer. Numerous workplace carcinogens can be found at various jobs sites and are integral to various industrial processes. Therefore, a systematic evaluation of potential occupationally-related CCA and likely exposure types is needed. Read More

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Improving screening, treatment, and intervention for unhealthy alcohol use in primary care through clinic, practice-based research network, and health plan partnerships: Protocol of the ANTECEDENT study.

PLoS One 2022 28;17(6):e0269635. Epub 2022 Jun 28.

Oregon Rural Practice-Based Research Network, Oregon Health & Science University, Portland, Oregon, United States of America.

Background: Unhealthy alcohol use (UAU) is a leading cause of morbidity and mortality in the United States, contributing to 95,000 deaths annually. When offered in primary care, screening, brief intervention, referral to treatment (SBIRT), and medication-assisted treatment for alcohol use disorder (MAUD) can effectively address UAU. However, these interventions are not yet routine in primary care clinics. Read More

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The early impacts of COVID-19 on people living with dementia: part I of a mixed-methods systematic review.

Aging Ment Health 2022 Jun 28:1-14. Epub 2022 Jun 28.

Lewy Body Society, Wigan, UK.

The aim of this Part I systematic review was to understand the impact of the COVID-19 pandemic on the lives of people with dementia living in the community or in residential care. Part II focused on unpaid carers. This review was registered on PROSPERO [CRD42021248050]. Read More

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Understanding patients' and significant others' preferences on starting a diagnostic trajectory for dementia: An integrative review.

Aging Ment Health 2022 Jun 28:1-12. Epub 2022 Jun 28.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.

Objective: To explore the preferences of people with memory complaints (PwMC) and their significant others regarding starting a diagnostic trajectory for dementia.

Methods: A systematic literature search was conducted in PubMed, PsycINFO, CINAHL, Web of Science, and Embase. Selection of abstracts and papers was performed independently by two researchers. Read More

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Diagnostic accuracy of the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) within a civilian primary care sample.

J Clin Psychol 2022 Jun 28. Epub 2022 Jun 28.

Department of Psychiatry & Behavioral Sciences, Texas A&M Health Science Center, College of Medicine, Bryan, Texas, USA.

Objective: This study aims to evaluate the diagnostic accuracy of the Primary Care Posttraumatic Stress Disorder (PTSD) Screen for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) (PC-PTSD-5) as a screening tool for the identification of PTSD among a civilian sample receiving behavioral health treatment within a primary care setting. Validation within a civilian sample will increase the generalizability of the PC-PTSD-5 as a brief screening measure to identify PTSD within primary care practices.

Method: The present study is a retrospective review of data (N = 198) collected as part of a patient registry for an integrated behavioral health consultation service within a primary care clinic. Read More

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Systematic Review of Endolymphatic Sac Tumor Treatment and Outcomes.

Otolaryngol Head Neck Surg 2022 Jun 28:1945998221108313. Epub 2022 Jun 28.

University of South Florida Department of Otolaryngology-Head and Neck Surgery, Tampa, Florida, USA.

Objective: Endolymphatic sac tumors are rare neoplasms originating in the endolymphatic sac. Current literature is limited to case reports and small case series. The objective of this study was to systematically review the literature to better describe clinical presentation, treatment options, and outcomes in endolymphatic sac tumors. Read More

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User Perceptions of eHealth and mHealth Services Promoting Physical Activity and Healthy Diets: Systematic Review.

JMIR Hum Factors 2022 Jun 28;9(2):e34278. Epub 2022 Jun 28.

Department of Health Promoting Science, Sophiahemmet University, Stockholm, Sweden.

Background: Physical activity and a diet that follows general recommendations can help to prevent noncommunicable diseases. However, most adults do not meet current recommended guidelines, and support for behavior change needs to be strengthened. There is growing evidence that shows the benefits of eHealth and mobile health (mHealth) services in promoting healthy habits; however, their long-term effectiveness is uncertain because of nonadherence. Read More

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Accuracy of Three Commercial Home-Use HbA1c Tests.

Diabetes Technol Ther 2022 Jun 28. Epub 2022 Jun 28.

Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, Florida, United States, 33647;

Background: The COVID-19 pandemic and the rapid expansion of telemedicine have increased the need for accurate and reliable capillary HbA1c testing. Nevertheless, validation studies of commercially available products suitable for home use have been in short supply.

Methods: Three commercial home-use capillary blood sample HbA1c tests (Home Access, CoreMedica, A1cNow+) were evaluated in 219 participants with type 1 or type 2 diabetes (aged 4-80 years, HbA1c 5. Read More

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Positive Impact of the Bionic Pancreas on Diabetes Control in Youth 6-17 Years Old with Type 1 Diabetes: A Multicenter Randomized Trial.

Diabetes Technol Ther 2022 Jun 28. Epub 2022 Jun 28.

Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, Florida, United States, 33647;

Objective: To evaluate the insulin-only configuration of the iLet® bionic pancreas (BP) in youth 6-17 years old with type 1 diabetes (T1D).

Methods: In this multicenter, randomized, controlled trial, 165 youth with T1D (6-17 years old; baseline HbA1c 5.8-12. Read More

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Long-term Effects of a Social Media-Based Intervention (Run4Love) on Depressive Symptoms of People Living With HIV: 3-Year Follow-up of a Randomized Controlled Trial.

J Med Internet Res 2022 Jun 28;24(6):e36809. Epub 2022 Jun 28.

Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China.

Background: Emerging studies have shown the effectiveness of mobile health (mHealth) interventions in reducing depressive symptoms among people living with HIV. Most of these studies included only short-term follow-up, with limited data on long-term effects.

Objective: The purpose of this study is to assess the long-term effects of a randomized controlled trial called Run4Love on depressive symptoms among people living with HIV at 1-year and 3-year follow-ups. Read More

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Factors influencing parents' willingness to vaccinate their preschool children against COVID-19: Results from the mixed-method study in China.

Hum Vaccin Immunother 2022 Jun 28:2090776. Epub 2022 Jun 28.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

During the COVID-19 pandemic, little is known about parental hesitancy to receive the COVID-19 vaccine for preschool children who are the potential vaccinated population in the future. The purpose of this mixed-method study was to explore the factors influencing Chinese parents' decision to vaccinate their children aged 3-6 years old against COVID-19. In July 2021, we conducted semi-structured interviews (n = 19) and a cross-sectional survey (n = 2605) with parents of kindergarten children in an urban-rural combination pilot area in China. Read More

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Reactogenicity and immunogenicity of BNT162b2 or mRNA-1273 COVID-19 booster vaccinations after two doses of BNT162b2 among healthcare workers in Japan: a prospective observational study.

Expert Rev Vaccines 2022 Jun 28. Epub 2022 Jun 28.

Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

Background: This study evaluates the immunogenicity and reactogenicity of BNT162b2 and mRNA-1273 booster doses after the primary two-dose BNT162b2 series in Japan and is the first report from Western Pacific region.

Research Design And Methods: Healthcare workers receiving the two-dose BNT162b2 series and eligible for booster vaccination were enrolled. Self-reported adverse reactions were recorded for eight days. Read More

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