65,741 results match your criteria primary breast


Application of a new serratus anterior plane block in modified radical mastectomy under ultrasound guidance: A prospective, randomized controlled trial.

J Clin Anesth 2021 Jun 9;74:110377. Epub 2021 Jun 9.

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address:

Study Objectives: Post-operative pain is a significant concern following modified radical mastectomy in breast cancer patients. The serratus anterior plane block has recently been described as an effective technique for post-operative analgesia of modified radical mastectomy. The purpose of this study was to evaluate the analgesic efficacy and safety of a new serratus anterior plane (SAP) block for post-operative pain of mastectomy. Read More

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The extracellular matrix proteins type I collagen, type III collagen, fibronectin, and laminin 421 stimulate migration of cancer cells.

FASEB J 2021 Jul;35(7):e21692

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

For metastasis formation, individual cells from a primary tumor must migrate toward other tissues. The aim of this study was to determine if mesenchymal stromal cells (MSCs) from human bone marrow are able to emit signals that induce this migratory activity in cancer cells. We separated the supernatant of MSCs derived from human bone marrow by size-exclusion and ion-exchange chromatography and have subsequently studied the migratory behavior of the prostate cancer cell line PC3 and the breast cancer cell line MDA-MB-231 toward the respective fractions in a transwell migration assay. Read More

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Fuzuloparib: First Approval.

Authors:
Arnold Lee

Drugs 2021 Jun 12. Epub 2021 Jun 12.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Fuzuloparib (AiRuiYi, ; formerly fluzoparib) is a small molecule, orally active PARP inhibitor being developed by Jiangsu Hengrui Pharmaceuticals Co., Ltd. (formerly Jiangsu Hengrui Medicine Co. Read More

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Efficacy and safety of TAS-115, a novel oral multi-kinase inhibitor, in osteosarcoma: an expansion cohort of a phase I study.

Invest New Drugs 2021 Jun 12. Epub 2021 Jun 12.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Background osteosarcoma is a rare, primary malignant bone tumour with limited available treatments for advanced or recurrent disease, resulting in a poor prognosis for patients. TAS-115 is a novel tyrosine kinase inhibitor under investigation in a phase I study in patients with solid tumours. We report data of osteosarcoma patients in the expansion cohort of this ongoing study. Read More

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Nodal status in luminal A invasive breast cancer: relationships with cytotoxic CD8 + and regulatory FOXP3 + cells tumor-associated infiltrate and other prognostic factors.

Virchows Arch 2021 Jun 12. Epub 2021 Jun 12.

Department of Pathomorphology, Jagiellonian University Medical College, Cracow, Poland.

Luminal A breast cancers are generally associated with low metastatic potential and good prognosis. However, there is a proportion of patients, who present with metastases in lymph nodes. The aim of our study was to determine the association between the number of positive lymph nodes and infiltrates of tumor-associated cytotoxic CD8 + (CTLs), regulatory FOXP3 + T cells (Tregs), as well as other prognostic factors. Read More

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Establishment of risk prediction nomogram for ipsilateral axillary lymph node metastasis in T1 breast cancer.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Feb;50(1):81-89

Department of Breast Surgery,Zhejiang University Lishui Hospital,Lishui 323000,Zhejiang Province,China.

:To establish and verify a risk prediction nomogram for ipsilateral axillary lymph node metastasis in breast cancer stage T1 (mass ≤ 2 cm). :The clinicopathological data of 907 patients with T1 breast cancer who underwent surgical treatment from January 2010 to June 2015 were collected,including 573 cases from the Second Affiliated Hospital of Zhejiang University School of Medicine (modeling group) and 334 cases from Zhejiang University Lishui Hospital (verification group). The risk factors of ipsilateral axillary lymph node metastasis were analyzed by univariate and multivariate logistic regression. Read More

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February 2021

Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations.

Sci Rep 2021 Jun 11;11(1):12370. Epub 2021 Jun 11.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Childhood acute lymphoblastic leukemia (ALL) has an origin in the fetal period which may distinguish it from ALL diagnosed later in life. We wanted to test whether familial risks differ in ALL diagnosed in the very early childhood from ALL diagnosed later. The Swedish nation-wide family-cancer data were used until year 2016 to calculate standardized incidence ratios (SIRs) for familial risks in ALL in three diagnostic age-groups: 0-4, 5-34 and 35 + years. Read More

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Circulating tumor cell number and endocrine therapy index in ER positive metastatic breast cancer patients.

NPJ Breast Cancer 2021 Jun 11;7(1):77. Epub 2021 Jun 11.

Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.

Circulating tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). The CTC-endocrine therapy index (CTC-ETI), consisting of CTC-ER (estrogen receptor), BCL2, human epidermal growth factor receptor (HER2), and Ki67 expression, might predict resistance to endocrine therapy (ET) in patients with ER-positive MBC. One hundred twenty-one patients with ER-positive/HER2-negative MBC initiating a new ET after ≥1 lines of ET were enrolled in a prospective, multi-institutional clinical trial. Read More

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Phase II clinical trial using anti-CD3 × anti-HER2 bispecific antibody armed activated T cells (HER2 BATs) consolidation therapy for HER2 negative (0-2+) metastatic breast cancer.

J Immunother Cancer 2021 Jun;9(6)

Medicine, University of Virginia, Charlottesville, Virginia, USA

Background: Metastatic human epidermal growth receptor II (HER2) negative breast cancer remains incurable. Our phase I study showed that anti-CD3 × anti-HER2 bispecific antibody armed activated T cells (HER2 BATs) may be effective against HER2-tumors. This phase II trial evaluates the efficacy and immune responses of HER2 BATs given to patients with metastatic HER2-estrogen and/or progesterone receptor positive (HR+) and triple negative breast cancer (TNBC) as immune consolidation after chemotherapy. Read More

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Association of cardiovascular disease risk factors with late cardiotoxicity and survival in HER2-positive breast cancer survivors.

Clin Cancer Res 2021 Jun 11. Epub 2021 Jun 11.

Emergency Medicine, The University of Texas MD Anderson Cancer Center.

Purpose: Breast cancer and cardiovascular diseases often share the same risk factors. It is increasingly important to identify risk factors for cardiovascular (CV) events in high-risk breast cancer patients and explore optimal treatment regimens.

Patients And Methods: Early HER2-positive breast cancer patients at our institution between January 1998 and October 2009 were reviewed. Read More

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Sacred oak woods increase bird diversity and specialization: Links with the European Biodiversity Strategy for 2030.

J Environ Manage 2021 Jun 8;294:112982. Epub 2021 Jun 8.

Department of Biological Applications and Technology, University of Ioannina, 45110, Ioannina, Greece. Electronic address:

Sacred groves in Greece are usually forest remnants with large trees around chapels, protected through centuries by Orthodox religion. We examined the comparative ecological value of 20 oak-dominated sacred groves vs managed oakwoods, in terms of their habitat characteristics and avian communities (passerines and woodpeckers). Sacred groves have maintained a more pronounced old-growth character than managed oakwoods in terms of average Diameter at Breast Height (DBH) and tree height. Read More

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Evaluation of diagnostic ultrasound use in a breast cancer detection strategy in Northern Peru.

PLoS One 2021 11;16(6):e0252902. Epub 2021 Jun 11.

Department of Radiology, University of Washington, Seattle, Washington, United States of America.

To evaluate the diagnostic impact of point-of-care breast ultrasound by trained primary care physicians (PCPs) as part of a breast cancer detection program using clinical breast exam in an underserved region of Peru. Medical records and breast ultrasound images of symptomatic women presenting to the Breast Cancer Detection Model (BCDM) in Trujillo, Peru were collected from 2017-2018. Performance was measured against final outcomes derived from regional cancer center medical records, fine needle aspiration results, patient follow-up (sensitivity, specificity, positive, and negative predictive values), and by percent agreement with the retrospective, blinded interpretation of images by a fellowship-trained breast radiologist, and a Peruvian breast surgeon. Read More

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PD-L1 Expression in Metaplastic Breast Carcinoma Using the PD-L1 SP142 Assay and Concordance Among PD-L1 Immunohistochemical Assays.

Am J Surg Pathol 2021 Jun 10. Epub 2021 Jun 10.

Departments of Pathology Medicine Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.

Immunotherapy for the treatment of programmed death-ligand 1 (PD-L1) positive locally advanced or metastatic triple negative breast cancer may benefit patients with metaplastic breast cancer (MpBC). Previous study of PD-L1 in MpBC scored tumor cells (TCs), different from Food and Drug Administration-approved scoring methods. We sought to define PD-L1 expression in MpBCs and to evaluate concordance of 3 PD-L1 assays. Read More

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Malpractice Cases in Breast Surgery: An Assessment of Litigation Involving Surgeons.

Ann Surg Oncol 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, Breast Care Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02115, USA.

Introduction: Improving patient safety and quality are priorities in health care. The study of malpractice cases provides an opportunity to identify areas for quality improvement. While the issues surrounding malpractice cases in breast cancer are often multifactorial, there are few studies providing insight into malpractice cases specifically related to common breast cancer surgical procedures. Read More

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Using a Tailored Digital Health Intervention for Family Communication and Cascade Genetic Testing in Swiss and Korean Families With Hereditary Breast and Ovarian Cancer: Protocol for the DIALOGUE Study.

JMIR Res Protoc 2021 Jun 11;10(6):e26264. Epub 2021 Jun 11.

Department of Clinical Research, University of Basel, Basel, Switzerland.

Background: In hereditary breast and ovarian cancer (HBOC), family communication of genetic test results is essential for cascade genetic screening, that is, identifying and testing blood relatives of known mutation carriers to determine whether they also carry the pathogenic variant, and to propose preventive and clinical management options. However, up to 50% of blood relatives are unaware of relevant genetic information, suggesting that potential benefits of genetic testing are not communicated effectively within family networks. Technology can facilitate communication and genetic education within HBOC families. Read More

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A Pan-Cancer Analysis of the Oncogenic Role of Twinfilin Actin Binding Protein 1 in Human Tumors.

Front Oncol 2021 25;11:692136. Epub 2021 May 25.

Department of Thoracic Oncology, Lung Cancer Diagnosis and Treatment Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Background: Understanding common and unique mechanisms driving oncogenic processes in human tumors is indispensable to develop efficient therapies. Recent studies have proposed Twinfilin Actin Binding Protein 1 (TWF1) as a putative driver gene in lung cancer, pancreatic cancer and breast cancer, however a systematic pan-cancer analysis has not been carried out.

Methods: Here, we set out to explore the role of TWF1 in 33 tumor types using TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus) dataset, Human Protein Atlas (HPA), and several bioinformatic tools. Read More

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Cutaneous metastasis as a first sign of breast carcinoma.

Radiol Case Rep 2021 Jul 26;16(7):1899-1901. Epub 2021 May 26.

Radiology department, Military Hospital Mohammed V, Rabat, Morocco.

Unlike visceral, lymphonodal or bone metastases, skin metastases are rare and their identification portends of a bad prognosis. They may appear as the first sign revealing the primary tumour, synchronous or developing late in the course of neglected primary cancer. We report a case of 86 year-old women witch belongs to this rare group of patients in whom cutaneous metastasis were identified before the primary cancer. Read More

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The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant.

Genet Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Purpose: To evaluate the association between a previously published 313 variant-based breast cancer (BC) polygenic risk score (PRS) and contralateral breast cancer (CBC) risk, in BRCA1 and BRCA2 pathogenic variant heterozygotes.

Methods: We included women of European ancestry with a prevalent first primary invasive BC (BRCA1 = 6,591 with 1,402 prevalent CBC cases; BRCA2 = 4,208 with 647 prevalent CBC cases) from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), a large international retrospective series. Cox regression analysis was performed to assess the association between overall and ER-specific PRS and CBC risk. Read More

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Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type.

J Pathol Transl Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST.

Materials And Methods: Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Read More

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A phase I trial of sorafenib with whole brain radiotherapy (WBRT) in breast cancer patients with brain metastases and a correlative study of FLT-PET brain imaging.

Breast Cancer Res Treat 2021 Jun 10. Epub 2021 Jun 10.

Breast Cancer Medicine Service, Evelyn Lauder Breast Center, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY, 10065, USA.

Purpose: Sorafenib has demonstrated anti-tumor efficacy and radiosensitizing activity preclinically and in breast cancer. We examined sorafenib in combination with whole brain radiotherapy (WBRT) and explored the [18F] 3'deoxy-3'-fluorothymidine (FLT)-PET as a novel brain imaging modality in breast cancer brain metastases.

Methods: A phase I trial of WBRT + sorafenib was conducted using a 3 + 3 design with safety-expansion cohort. Read More

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Conceptualizing problems with symptoms, function, health behavior, health-seeking skills, and financial strain in breast cancer survivors using hierarchical clustering.

J Cancer Surviv 2021 Jun 9. Epub 2021 Jun 9.

Professor (Retired) Uniformed Services University, Bethesda, MD, USA.

Purpose: Determine whether a diverse set of problems experienced by breast cancer survivors (BCS) following curative treatment can be formulated into a reduced number of clusters, potentially simplifying the conceptualization of these problems.

Method: Female BCS were recruited from four cancer hospitals in China. The Chinese translation of the Cancer Survivor Profile (CSPro) was used to measure 18 common problem areas, as supported by epidemiological and phenomenological research. Read More

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Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer.

Sci Rep 2021 Jun 9;11(1):12119. Epub 2021 Jun 9.

Department of Breast Surgery, Zibo Central Hospital, Shandong First Medical University, Zibo, Shandong Province, China.

Sentinel lymph node biopsy (SLNB) for axillary lymph node staging in early breast cancer has been widely recognized. The combination of radio-colloids and dye method is the best method recognized. The reagents and equipment required in the process of the combined method are complex and expensive, so there are certain restrictions in the use of primary medical institutions. Read More

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[Gastric metastasis of breast cancer treated as stage IV gastric cancer for 13 years: a case report].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(6):555-561

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital.

A 52-year-old woman had a surgical history of breast cancer. A follow-up blood test showed that the level of carcinoembryonic antigen was elevated. Esophagogastroduodenoscopy revealed a Borrmann type IV tumor in the stomach, and biopsy revealed poorly differentiated adenocarcinoma with signet ring cells. Read More

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[Primary breast diffuse large B-cell lymphoma in an elderly man maintaining long-term complete response].

Rinsho Ketsueki 2021 ;62(5):341-345

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine.

Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin's lymphoma that mostly affects women. Here, we report a case of primary breast DLBCL that affected an older man without any autoimmune disease or drug-related female hormones. The patient was a 65-year-old man whose chief complaints were gradually-increasing lump in the right chest and swelling of the right axillary lymph nodes. Read More

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Clinicopathological Characteristics and Recurrence-Free Survival of Rare Variants of Papillary Thyroid Carcinomas in Korea: A Retrospective Study.

Endocrinol Metab (Seoul) 2021 Jun 10. Epub 2021 Jun 10.

Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Background: We aimed to evaluate the clinicopathological features and biological behaviors of Korean thyroid cancer patients with rare variants of papillary thyroid carcinoma (PTC) to address the ambiguity regarding the prognostic consequences of these variants.

Methods: We retrospectively reviewed the medical records of 5,496 patients who underwent thyroid surgery for PTC, between January and December 2012, in nine tertiary hospitals. Rare PTC variants included tall cell (TCV), columnar cell (CCV), diffuse sclerosing (DSV), cribriform-morular (CMV), solid (SV), hobnail, and Warthin-like variants. Read More

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Characterizing Health-Related Quality of Life by Ambulatory Status in Patients With Spinal Metastases.

Spine (Phila Pa 1976) 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 Department of Orthopaedic Surgery, NYU Langone Medical Center, New York University, Westbury, NY 11590.

Study Design: Retrospective review of prospective longitudinal data.

Objective: To determine health-related quality of life (HRQL) utilities associated with specific ambulatory states in patients with spinal metastases: independent, ambulatory with assistance and non-ambulatory.

Summary Of Background Data: It is assumed that HRQL is aligned with ambulatory ability in patients with spinal metastases. Read More

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PARP Inhibitors and Newly Second Primary Malignancies in Cancer Patients: a Systematic Review and Safety Meta-Analysis of Placebo Randomized Controlled Trials.

Ann Oncol 2021 May 4. Epub 2021 May 4.

Normandie Univ, UNICAEN, CHU de Caen Normandie, Department of Pharmacology, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), Caen, France. Electronic address:

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Is pre-operative axillary ultrasound alone sufficient to determine need for axillary dissection in early breast cancer patients?

Medicine (Baltimore) 2021 May;100(19):e25412

Department of Surgery.

Abstract: Pre-operative status of axillary lymph node (ALN) in early breast cancer is usually initially assessed by pre-operative ultrasound, followed by ultrasound-guided needle biopsy (UNB) confirmation. Patients with positive nodal status will undergo axillary lymph node dissection (ALND), while those with negative nodal status will have sentinel lymph node biopsy. ALND is associated with higher morbidity than Sentinel lymph node biopsy. Read More

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Clinicopathologic and Genomic Landscape of Breast Carcinoma Brain Metastases.

Oncologist 2021 Jun 8. Epub 2021 Jun 8.

Foundation Medicine, Inc., USA.

Background: Among breast carcinoma patients with metastatic disease, 15-30% will eventually develop brain metastases. We examined the genomic landscape of a large cohort of breast carcinoma brain metastases (BCBMs) and compared them to a cohort of primary breast carcinomas (BCs).

Material And Methods: We retrospectively analyzed 733 BCBMs tested with comprehensive genomic profiling (CGP) and compared them to 10,772 primary breast carcinomas (not-paired) specimens. Read More

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Dietary trans-fatty acid intake in relation to cancer risk: a systematic review and meta-analysis.

Nutr Rev 2021 Jun;79(7):758-776

Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.

Context: Apart from ruminant fat, trans-fatty acids are produced during the partial hydrogenation of vegetable oils, (eg, in the production of ultraprocessed foods). Harmful cardiovascular effects of trans-fatty acids are already proven, but the link with cancer risk has not yet been summarized.

Objective: A systematic review (following PRISMA guidelines) - including observational studies on the association of trans-fatty acid intake with any cancer risk - was conducted, with no limitations on population types. Read More

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