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December Is Coming: A Time Trend Analysis of Monthly Variation in Adult Elective Anesthesia Caseload across Florida and Texas Locations of a Large Multistate Practice.

Anesthesiology 2021 Sep 15. Epub 2021 Sep 15.

Background: Anesthesia staffing models rely on predictable surgical case volumes. Previous studies have found no relationship between month of the year and surgical volume. However, seasonal events and greater use of high-deductible health insurance plans may cause U. Read More

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September 2021

Developing a Psychological Intervention for Decreasing Bedtime Procrastination: The BED-PRO Study.

Behav Sleep Med 2021 Sep 15:1-15. Epub 2021 Sep 15.

Department of Psychology, Sungshin University, Seoul, Republic of Korea.

Introduction: Bedtime Procrastination (BP) is defined as the behavior of going to bed later than intended, without having external reasons for doing so. Previous studies have shown that BP has a negative effect on sleep and health, emphasizing the need to develop interventions to decrease BP. This intervention development study is a proof-of-concept study for a psychological intervention designed for decreasing bedtime procrastination, namely BED-PRO. Read More

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September 2021

Arthroscopic Versus Mini-open Rotator Cuff Repair: A Randomized Trial and Meta-analysis.

Am J Sports Med 2021 Sep 15:3635465211038233. Epub 2021 Sep 15.

Department of Surgery, University of Western Ontario, London, Ontario, Canada; Roth McFarlane Hand and Upper Limb Centre, St. Joseph's Health Care, London, Ontario, Canada.

Background: Patients with complete rotator cuff tears who fail a course of nonoperative therapy can benefit from surgical repair.

Purpose: This randomized trial compared mini-open (MO) versus all-arthroscopic (AA) rotator cuff repair.

Study Design: Randomized controlled trial; Level of evidence, 1. Read More

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September 2021

Comparison of Vestibular Depth Relapse and Wound Healing After Reconstructive Preprosthetic Surgery Using Cryopreserved Amniotic Membrane and Acellular Dermal Matrix - A Comparative Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):12-16. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: The significance of membranes as wound dressing in oral surgeries has been reported by previous studies. The aim of the present split-mouth randomized clinical study was to assess and compare the wound dressing properties of acellular dermal matrix (ADM) and cryopreserved human amniotic membrane (AM) after reconstructive preprosthetic oral surgery.

Materials And Methods: Twenty-eight patients with complete mandibular edentulism and resorbed alveolar bone were included. Read More

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A randomized controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website (EFAR Spain).

Internet Interv 2021 Dec 20;26:100446. Epub 2021 Aug 20.

GRAC, Addictions Unit, Department of Psychiatry, Clinical Institute of Neuroscience, Hospital Clínic, RETICS, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: Brief interventions (BI) for risky drinkers in primary healthcare have been demonstrated to be cost-effective but they are still poorly implemented. Digital BI seems to be a complementary strategy to overcome some barriers to implementation but there is a scarcity of studies in clinical environments. We present the results of a randomized controlled non-inferiority trial which tests the non-inferiority of facilitated access to a digital intervention (experimental condition) for risky drinkers against a face-to-face BI (control condition) provided by primary healthcare professionals. Read More

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December 2021

Status epilepticus management and mortality risk factors: a retrospective study.

Neurologia (Engl Ed) 2021 Sep 11. Epub 2021 Sep 11.

Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Introduction: Status epilepticus (SE) is a neurological emergency with relatively high mortality rates. In this study, we analysed the management of SE and identified mortality risk factors that may be addressed with educational interventions or modifications to hospital protocols.

Methods: In this retrospective study, we analysed demographic, treatment, and outcome data from 65 patients (mean age, 59 years [range, 44. Read More

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September 2021

Association between pericoronary adipose tissue attenuation and outcome after second-generation cryoballoon ablation for atrial fibrillation.

Br J Radiol 2021 Sep 14:20210361. Epub 2021 Sep 14.

Department of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.

Objectives: Previous studies reported the association between inflammation and atrial fibrillation (AF). Pericoronary adipose tissue (PCAT) attenuation, PCATA, on cardiac CT angiography (CTA) reflects pericoronary inflammation. We hypothesized that the PCATA predicts AF recurrence after cryoballoon ablation (CBA) for paroxysmal and persistent AF. Read More

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September 2021

Educational strategy based on the NutrIMSS program in patients with prediabetes.

Rev Med Inst Mex Seguro Soc 2020 09 1;58(5):566-573. Epub 2020 Sep 1.

Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar No. 80, Coordinación de Educación e Investigación en Salud.

Background: Prediabetes is an altered metabolic state of glucose; it does not present symptoms, it is considered an intermediate stage in the progression to diabetes; it is possible to detect it early to avoid or delay the disease. NutrIMSS strategy was implemented so that these patients achieve a healthy lifestyle.

Objective: To evaluate the impact of an educational intervention based on the NutrIMSS strategy on somatometric and biochemical parameters in patients with prediabetes. Read More

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September 2020

Prevalence and prognostic impact of cachexia among older patients with cancer: a nationwide cross-sectional survey (NutriAgeCancer).

J Cachexia Sarcopenia Muscle 2021 Sep 14. Epub 2021 Sep 14.

Assistance Publique - Hôpitaux de Paris (AP-HP), Paris Cancer Institute CARPEM, Geriatric Oncology Unit, Georges Pompidou European Hospital, Paris, France.

Background: Nutritional impairment is common in cancer patients and is associated with poor outcomes. Only few studies focused on cachexia. We assessed the prevalence of cachexia in older cancer patients, identified associated risk factors, and evaluated its impact on 6 month overall mortality. Read More

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September 2021

Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis.

J Child Psychol Psychiatry 2021 Sep 13. Epub 2021 Sep 13.

Development and Neurodiversity Lab, Department of Psychology, Uppsala University, Uppsala, Sweden.

Background: Studies of infants with an elevated likelihood of autism spectrum disorder can identify basic developmental processes that are associated with subsequently emerging clinical symptoms. Atypical responsiveness to sounds in infancy is such a potential early marker of autism. Here, we used pupillometry to quantify reactivity to social and nonsocial sounds in infants with a subsequent diagnosis. Read More

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September 2021

Injecting frequency trajectories and hepatitis C virus acquisition: Findings from a cohort of people who inject drugs in Montréal, Canada.

Int J Drug Policy 2021 Sep 10:103439. Epub 2021 Sep 10.

CHUM Research Centre, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada; Department of Family and Emergency Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. Electronic address:

Background: Frequent injecting increases hepatitis C (HCV) acquisition risk among people who inject drugs (PWID). However, few studies have examined how temporal fluctuations in injecting frequency may effect HCV infection risk. Thus, this study examined HCV incidence according to injecting frequency trajectories followed by PWID over one year in Montréal, Canada. Read More

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September 2021

Alveolar Nitric Oxide and Peripheral Oxygen Saturation in Frequent Exacerbators with Asthma: A Pilot Study.

Int Arch Allergy Immunol 2021 Aug 26:1-11. Epub 2021 Aug 26.

Department of Clinical and Biological Sciences, University of Turin, Rare Lung Disease Unit and Severe Asthma Centre, San Luigi Gonzaga University Hospital, Turin, Italy.

Introduction: Asthmatics can experience recurrent exacerbations (AEs), irrespectively of asthma severity. Airway inflammatory monitoring could be fundamental to optimize the asthma management. The present study evaluated whether exhaled NO concentrations in proximal and distal respiratory compartments are different in AE-prone patients in combination with T2 blood biomarkers and resting oxygen saturation (SpO2). Read More

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Switching the Basal Insulin to Insulin Glargine 300 U/mL in People with Type 2 Diabetes under Basal Insulin Supported Oral Therapy - Observational Trial on Effectiveness and Safety.

Diabetes Obes Metab 2021 Sep 13. Epub 2021 Sep 13.

Medical Clinic I, Evang. Bethesda-Hospital Duisburg, Duisburg, Germany.

Aims: This study evaluated effectiveness and safety of switching the basal insulin (BI) in a BI supported oral therapy (BOT) to insulin glargine 300 U/mL (Gla-300) in adult people with inadequately controlled type 2 diabetes (T2D).

Materials And Methods: This non-interventional, multicentre, prospective 12-month study, conducted in Germany, Austria and Switzerland, documented people with T2D with an HbA between 7.5-10. Read More

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September 2021

Impact of the COVID-19 pandemic on incidence, time of diagnosis and delivery of healthcare among paediatric oncology patients in Germany in 2020: Evidence from the German Childhood Cancer Registry and a qualitative survey.

Lancet Reg Health Eur 2021 Aug 18:100188. Epub 2021 Aug 18.

Division of Pediatric Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Straße 69, 55131 Mainz, Germany.

Background: The indirect impact of the COVID-19 pandemic on cancer care and timely diagnosis is of increasing concern. We investigated the impact of the COVID-19 pandemic on incidence, time of diagnosis and delivery of healthcare among paediatric oncology patients in Germany in 2020.

Methods: We analysed incident paediatric cancer cases diagnosed in 0- to 17-year olds in Germany in 2020 using data of the German Childhood Cancer Registry. Read More

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Clinical Characteristics, Management, and Outcomes of Cancer Patients With Coronavirus Disease 2019 Admitted to the ICU.

Crit Care Explor 2021 Sep 7;3(9):e0535. Epub 2021 Sep 7.

All authors: Critical Care Center, Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Adult patients with cancer have a greater likelihood of developing severe illness and death from coronavirus disease 2019 compared with patients without cancer. We sought to characterize the clinical characteristics and outcomes of cancer patients who tested positive for severe acute respiratory syndrome coronavirus 2 and were admitted to the ICU at the peak of the first wave of the pandemic in the United States.

Design: A single-center retrospective cohort study. Read More

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September 2021

Analysis of Predictive Risk Factors in Aquaporin-4-IgG Positive Highly Active Neuromyelitis Optica Spectrum Disorders.

Front Neurol 2021 26;12:731835. Epub 2021 Aug 26.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Neuromyelitis optica spectrum disorders (NMOSDs) are inflammatory diseases with a high risk of recurrence and progressive disability, and it is crucial to find sensitive and reliable biomarkers for prognosis and the early prediction of relapse. Highly active NMOSD is defined as two or more clinical relapses within a 12-month period. In this study, we analyzed independent risk factors among patients with aquaporin-4 (AQP4)-IgG positive highly active NMOSD. Read More

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Functional Disability After Ischemic Stroke: A Community-Based Cross-Sectional Study in Shanghai, China.

Front Neurol 2021 26;12:649088. Epub 2021 Aug 26.

Clinical Research Center, Shanghai Skin Diseases Hospital, Tongji University, Shanghai, China.

This study aimed to understand the demographics, functional disabilities, cognitive impairment, and depressive mood among stroke patients and to explore the correlation between functional disability and the other health conditions so as to provide some data for community rehabilitation among stroke patients. A cross-sectional study was conducted to investigate the functional status of ischemic stroke patients with stroke history between 1 month and 2 years by applying the modified Rankin Scale (mRS). Data were collected during October 2016 and January 2017 from 11 communities in two districts of Shanghai, China. Read More

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Agreement Between Self-Reported Information and Administrative Data on Comorbidities, Imaging and Treatment in Denmark - A Validation Study of 38,745 Patients with Knee or Hip Osteoarthritis.

Clin Epidemiol 2021 30;13:779-790. Epub 2021 Aug 30.

Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

Purpose: To validate self-reported information obtained from patients with knee or hip osteoarthritis (OA) in primary care against administrative data from the three national Danish registries.

Patients And Methods: We compared the baseline and 12-month follow-up data from 38,745 patients with knee or hip OA participating in the Good Life with osteoArthritis in Denmark (GLA:D) program with registry-based data on joint surgeries, pain medication dispensing, radiographs, and hospital diagnoses. Agreement was calculated using Cohen's Kappa (k) and percentage agreement, both with 95% CI. Read More

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Health service utilization and experiences of stigma amongst people who inject drugs in Melbourne, Australia.

J Viral Hepat 2021 Sep 12. Epub 2021 Sep 12.

Disease Elimination Program, Burnet Institute, Melbourne, Vic., Australia.

Whilst the testing and treatment of people who inject drugs (PWID) in Australia is a priority for local hepatitis C (HCV) elimination efforts, perceived stigma related to injecting drug use (IDU) has been identified as a major barrier for PWID engaging in health services. We used data from the EC Experience cohort study to explore associations between IDU-related perceived stigma and the number of different health services accessed by PWID in Melbourne, Australia. Data from the baseline questionnaire were used. Read More

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September 2021

Durability of treatment response to zolpidem using a partial reinforcement regimen: does this strategy require priming?

Sleep Med 2021 Aug 21;87:56-61. Epub 2021 Aug 21.

In memoriam.

Background: Previous research has shown that after one month of full dose nightly treatment with zolpidem (priming), subjects with chronic insomnia (CI) switched to intermittent dosing with medication and placebos were able to maintain their treatment responses. This approach to maintenance therapy is referred to as partial reinforcement. The present study sought to assess whether priming is required for partial reinforcement or whether intermittent dosing with placebos (50% placebos and 50% active medication) can, by itself, be used for both acute and extended treatment. Read More

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Brain-specific PAPP-A knock-out mice?

Exp Gerontol 2021 Sep 9;154:111548. Epub 2021 Sep 9.

Division of Endocrinology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States of America. Electronic address:

PAPP-A knock-out (KO) mice are a valuable model for investigating the effects of down-regulating localized insulin-like growth factor (IGF) action, which has been shown to extend lifespan and healthspan when the PAPP-A gene is globally deleted. Based on previous mouse models of brain-specific reduction in IGF signaling associated with longevity, we sought to generate brain-specific PAPP-A KO mice and determine effects on metabolism and lifespan. Mice with the PAPP-A gene floxed (fPAPP-A) were crossed with Nestin promoter-driven Cre recombinase transgenic mice. Read More

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September 2021

Ageing enhances cellular immunity to myeloperoxidase and experimental anti-myeloperoxidase glomerulonephritis.

Rheumatology (Oxford) 2021 Sep 11. Epub 2021 Sep 11.

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria, Australia.

Objectives: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disease characterised by small blood vessel inflammation, commonly affecting the kidneys and respiratory tract. It is unclear why the incidence of this condition increases with age. Previous studies in a passive antibody transfer system in aged mice have implicated innate effectors. Read More

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September 2021

Hospital Stay of Orthopedic Cases in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

Pramod Joshi

JNMA J Nepal Med Assoc 2021 Apr 30;59(236):310-312. Epub 2021 Apr 30.

Department of Orthopedics, Seti Provincial Hospital, Dhangadhi, Nepal.

Introduction: Orthopedic conditions includes a range of condition varying from traumatic injuries, congenital anomalies, chronic back pain, arthritis, rheumatologic conditions, and other. Length of hospital stay is determined by a number of factors such as symptom severity, patient co morbidity and hospital availability. Our study aims to study the length of hospital stay of the patients admitted in a provincial hospital. Read More

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Characteristics of severe malaria in hospitalized children in Ho Chi Minh City from 2012 to 2019.

Trop Biomed 2021 Sep;38(3):371-376

Molecular Biomedical Center, University Medical Center - Campus 2, 700000 Ho Chi Minh City, Vietnam.

In Vietnam, severe malaria is currently rare but is a life-threatening disease. It may be misdiagnosed with other common diseases. This descriptive study aimed to characterize severe malaria and its clinical aspects, as well as outcomes of infected pediatric patients to improve case management. Read More

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September 2021

Risk factors for poor health-related quality of life in patients with colon cancer include stoma and smoking habits.

Health Qual Life Outcomes 2021 Sep 10;19(1):216. Epub 2021 Sep 10.

Department of Surgery, Västmanland Hospital Västerås, Västerås, Sweden.

Background: Previous studies have shown that health-related quality of life (HRQoL) is associated with the prognosis of cancer patients. The aim of this study was to investigate risk factors for poor HRQoL in patients with colon cancer.

Methods: This was a prospective population-based study of patients with colon cancer included between 2012 and 2016. Read More

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September 2021

Meckel's Masquerade: Penetrating the Disguise.

Pediatr Emerg Care 2021 Sep 9. Epub 2021 Sep 9.

From the Division of Emergency Medicine, Children's Hospital of San Antonio, Baylor College of Medicine, San Antonio, TX.

Abstract: Children with abdominal pain are frequently seen in emergency departments. Physicians and parents worry about appendicitis; physicians are also concerned about intussusception and bowel obstruction in patients with previous surgical procedures. Sometimes the patient is ill, and the diagnosis is elusive. Read More

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September 2021

Dissociated profiles of sleep timing and sleep quality changes across the first and second wave of the COVID-19 pandemic.

J Psychiatr Res 2021 Sep 3;143:222-229. Epub 2021 Sep 3.

Department of Psychology, University of Campania L. Vanvitelli, Viale Ellittico 31, 81100 Caserta, Italy. Electronic address:

Previous work showed a significant impact of the COVID-19 pandemic on Italians' sleep both during the first wave, when a total lockdown (TL) was imposed, and during the second wave, when a partial lockdown (PL) was mandated (autumn 2020). Here we complement these data by describing the profile of sleep across four time-points: the first and second lockdown (TL, PL) and the months preceding them (pre-TL, pre-PL). An online survey was completed by 214 participants (M = 36. Read More

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September 2021

Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV?

J Acquir Immune Defic Syndr 2021 Oct;88(2):192-196

VA Connecticut Healthcare System, West Haven, CT.

Background: The extensive research on falls and fragility fractures among persons living with HIV (PWH) has not explored the association between serious falls and subsequent fragility fracture. We explored this association.

Setting: Veterans Aging Cohort Study. Read More

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October 2021

Primary central nervous system lymphoma in a patient with neuropsychiatric systemic lupus erythematosus receiving mycophenolate mofetil: A case report and literature review.

Mod Rheumatol Case Rep 2021 Sep 10. Epub 2021 Sep 10.

Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Gunma, Japan.

A 41-year-old woman with a 14-month history of systemic lupus erythematosus (SLE) presented with headache, aphasia, and agraphia. A laboratory examination revealed mild proteinuria, hypocomplementemia, and elevated anti-double-stranded DNA antibody levels. A cerebrospinal fluid analysis demonstrated elevated protein and interleukin-6 levels. Read More

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September 2021