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Development of Integrated Neural Network Model for Identification of Fake Reviews in E-Commerce Using Multidomain Datasets.

Appl Bionics Biomech 2021 14;2021:5522574. Epub 2021 Apr 14.

Community College of Abqaiq, King Faisal University, P.O. Box 400, Al-Ahsa, Saudi Arabia.

Online product reviews play a major role in the success or failure of an E-commerce business. Before procuring products or services, the shoppers usually go through the online reviews posted by previous customers to get recommendations of the details of products and make purchasing decisions. Nevertheless, it is possible to enhance or hamper specific E-business products by posting fake reviews, which can be written by persons called fraudsters. Read More

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Single-cell analysis reveals urothelial cell heterogeneity and regenerative cues following cyclophosphamide-induced bladder injury.

Cell Death Dis 2021 May 5;12(5):446. Epub 2021 May 5.

State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Cyclophosphamide is a commonly used chemotherapeutic drug to treat cancer with side effects that trigger bladder injury and hemorrhagic cystitis. Although previous studies have demonstrated that certain cell subsets and communications are activated to drive the repair and regeneration of bladder, it is not well understood how distinct bladder cell subsets function synergistically in this process. Here, we used droplet-based single-cell RNA sequencing (scRNA-seq) to profile the cell types within the murine bladder mucous layer under normal and injured conditions. Read More

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Design and Evaluation of Hybrid Composite Plates for Ballistic Protection: Experimental and Numerical Investigations.

Polymers (Basel) 2021 Apr 30;13(9). Epub 2021 Apr 30.

School of Civil Engineering, College of Engineering, Sudan University of Science and Technology, Khartoum P.O. Box 72, Sudan.

In this paper, hybrid composite plates for ballistic protection were investigated experimentally and numerically, with a target to reduce the weight of currently used body armor inserts and, at the same time, satisfy the requirements of the National Institute of Justice's (NIJ) ballistic protection standards. The current study has three phases to improve the ballistic plate's energy absorption capability. The first phase is devoted to studying the effect of the material types, including three different fibers: carbon fiber, date palm fiber, and Kevlar fiber. Read More

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Aquaporin 4 expression in the hippocampus in sudden infant death syndrome and sudden unexplained death in childhood.

J Chem Neuroanat 2021 May 1;115:101962. Epub 2021 May 1.

Oslo University Hospital, Division of Laboratory Medicine, Department of Forensic Sciences, Oslo, Norway. Electronic address:

Aquaporin 4 (AQP4) is the main membrane water channel in the brain involved in regulating water homeostasis. The water distribution in neural tissue is often dysregulated after hypoxic neural injury. Previous research has indicated that victims of sudden infant death syndrome (SIDS) and sudden unexplained death in childhood (SUDC) have an underlying brain dysfunction that impairs their critical arousal response to hypoxic stress during sleep. Read More

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Diagnostic layering: Patient accounts of breast cancer classification in the molecular era.

Soc Sci Med 2021 Apr 28;278:113965. Epub 2021 Apr 28.

Centre for Biomedicine, Self and Society, Usher Institute, Old Medical School, University of Edinburgh, Edinburgh, Scotland, EH8 9AG, UK.

Social scientific work has considered the promise of genomic medicine to transform healthcare by personalising treatment. However, little qualitative research attends to already well-established molecular techniques in routine care. In this article we consider women's experiences of routine breast cancer diagnosis in the UK NHS. Read More

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Cytotoxicity of filtering respiratory protective devices from the waste sorting industry: A comparative study between interior layer and exhalation valve.

Environ Int 2021 Apr 30;155:106603. Epub 2021 Apr 30.

H&TRC- Health & Technology Research Center, ESTeSL- Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.

Filtering respiratory protection devices (FRPD) are mandatory for workers to wear in the Portuguese waste-sorting industry. Previous results regarding microbial contamination found on FRPD interior layer raised the question of whether microbial contamination from the exhalation valve would also have cytotoxicity effects. Since the FRPD exhalation valves are very close to workers' nose and mouth, they represent a source of exposure to bioburden by inhalation. Read More

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Dynamics of Mud Blister Worm Infestation and Shell Repair by Oysters.

Biol Bull 2021 Apr 8;240(2):118-131. Epub 2021 Apr 8.

AbstractMud blister worms bore into oyster shells; and oysters respond to shell penetration by secreting new layers of shell, resulting in mud blisters on inner surfaces of oyster shells. We conducted two experiments in off-bottom oyster farms along Alabama's coast in summer 2017 to explore the dynamics of worm infestation, blister formation, and shell repair. Results support our hypothesis that only a small proportion of worms that bore into oysters cause blisters. Read More

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Autologous retina transplantation for treatment of refractory double full-thickness macular hole in Alport syndrome.

Retin Cases Brief Rep 2021 Jan 13. Epub 2021 Jan 13.

1Department of Ophthalmology, Centro de Oftalmología Barraquer, Barcelona, Spain; 2Instituto Barraquer, Universitat Autònoma de Barcelona, Barcelona, Spain.

Purpose: To report the structural and functional outcomes of autologous neurosensory retinal transplantation for closure of refractory double full-thickness macular hole in a patient diagnosed with Alport syndrome.

Methods: Patient with previous pars plana vitrectomy (PPV) and a failed macular hole surgery (ILM removal) underwent PPV and autologous neurosensory retinal flap transplantation with silicone oil tamponade. Follow-up was performed after one year. Read More

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January 2021

Naturalistic Spike Trains Drive State-Dependent Homeostatic Plasticity in Superficial Layers of Visual Cortex.

Front Synaptic Neurosci 2021 15;13:663282. Epub 2021 Apr 15.

The Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.

The history of neural activity determines the synaptic plasticity mechanisms employed in the brain. Previous studies report a rapid reduction in the strength of excitatory synapses onto layer 2/3 (L2/3) pyramidal neurons of the primary visual cortex (V1) following two days of dark exposure and subsequent re-exposure to light. The abrupt increase in visually driven activity is predicted to drive homeostatic plasticity, however, the parameters of neural activity that trigger these changes are unknown. Read More

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Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic vs. regulatory immune cell subsets.

J Allergy Clin Immunol 2021 Apr 28. Epub 2021 Apr 28.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA. Electronic address:

Background: Inflammatory cells in previous human skin single-cell data constituted only a small fraction of the overall cell population, such that functional subsets were difficult to ascertain.

Objective: Our aims were to overcome the limitation by applying single-cell transcriptomics to emigrating cells from skin and elucidate ex vivo gene expression profiles of pathogenic vs. regulatory immune cell subsets in psoriasis skin. Read More

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Nonlinearity of intracochlear motion and local cochlear microphonic: Comparison between guinea pig and gerbil.

Hear Res 2021 Apr 15;405:108234. Epub 2021 Apr 15.

Department of Biomedical Engineering, Columbia University, New York City, NY, United States; Department of Otolaryngology-Head and Neck Surgery, Columbia University, New York City, NY, United States. Electronic address:

Studying the in-vivo mechanical and electrophysiological cochlear responses in several species helps us to have a comprehensive view of the sensitivity and frequency selectivity of the cochlea. Different species might use different mechanisms to achieve the sharp frequency-place map. The outer hair cells (OHC) play an important role in mediating frequency tuning. Read More

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Enabling Lithium Metal Anode in Nonflammable Phosphate Electrolyte with Electrochemically Induced Chemical Reactions.

Angew Chem Int Ed Engl 2021 Apr 29. Epub 2021 Apr 29.

Boston College, Department of Chemistry, 2609 Beacon St., 2467, Chestnut Hill, UNITED STATES.

Lithium metal anode holds great promises for next-generation battery technologies but is notoriously difficult to work with. The key to solving this challenge is believed to lie in the ability of forming stable solid-electrolyte interphase (SEI) layers. To further address potential safety issues, it is critical to achieve this goal in nonflammable electrolytes. Read More

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Responses to Mineral Supplementation and Salmon Lice () Infestation in Skin Layers of Atlantic Salmon ( L.).

Genes (Basel) 2021 Apr 19;12(4). Epub 2021 Apr 19.

Nofima AS, Muninbakken 9, 9019 Tromsø, Norway.

The crustacean ectoparasite salmon louse (), which severely affects Atlantic salmon health and welfare is one of the main problems of commercial aquaculture. In the present study, fish were fed a diet supplemented with extra minerals through the inclusion of a commercial additive (Biofeed Forte Salmon), substituting wheat in the control diet, before experimental infestation with salmon lice. Lice counts reduced with time but with no apparent effect of the diets. Read More

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Pressure Orientation-Dependent Recovery of 3D-Printed PLA Objects with Varying Infill Degree.

Polymers (Basel) 2021 Apr 14;13(8). Epub 2021 Apr 14.

Virtual Institute of Applied Research on Advanced Materials (VIARAM).

Poly(lactic acid) is not only one of the most often used materials for 3D printing via fused deposition modeling (FDM), but also a shape-memory polymer. This means that objects printed from PLA can, to a certain extent, be deformed and regenerate their original shape automatically when they are heated to a moderate temperature of about 60-100 °C. It is important to note that pure PLA cannot restore broken bonds, so that it is necessary to find structures which can take up large forces by deformation without full breaks. Read More

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Comparison of the Benzanthrone Luminophores: They Are Not Equal for Rapid Examination of (Trematoda: Digenea).

Biomolecules 2021 Apr 18;11(4). Epub 2021 Apr 18.

Institute of Life Sciences and Technology, Daugavpils University, Parades Street 1A, LV-5401 Daugavpils, Latvia.

Luminescent derivatives of benzanthrone are becoming more useful based on their light-absorbing and fluorescent-emitting properties. Our previous studies showed that luminescent staining properties of the same benzanthrone dye differ for variable parasite samples. Therefore, two types of benzanthrone dyes were prepared. Read More

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Selective Extraction of Nonfullerene Acceptors from Bulk-Heterojunction Layer in Organic Solar Cells for Detailed Analysis of Microstructure.

Materials (Basel) 2021 Apr 21;14(9). Epub 2021 Apr 21.

Graduate School of Natural Science and Technology, Kanazawa University, Ishikawa 920-1192, Japan.

Detailed analyses of the microstructures of bulk-heterojunction (BHJ) layers are important for the development of high-performance photovoltaic organic solar cells (OSCs). However, analytical methods for BHJ layer microstructures are limited because BHJ films are composed of a complex mixture of donor and acceptor materials. In our previous study on the microstructure of a BHJ film composed of donor polymers and fullerene-based acceptors, we analyzed donor polymer-only films after selectively extracting fullerene-based acceptors from the film by atomic force microscopy (AFM). Read More

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Role of Rho GTPase Interacting Proteins in Subcellular Compartments of Podocytes.

Int J Mol Sci 2021 Apr 1;22(7). Epub 2021 Apr 1.

Division of Nephrology, McGill University Health Centre, 1001 Decarie, Montreal, QC H4A 3J1, Canada.

The first step of urine formation is the selective filtration of the plasma into the urinary space at the kidney structure called the glomerulus. The filtration barrier of the glomerulus allows blood cells and large proteins such as albumin to be retained while eliminating the waste products of the body. The filtration barrier consists of three layers: fenestrated endothelial cells, glomerular basement membrane, and podocytes. Read More

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The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies.

Neurology 2021 Apr 28. Epub 2021 Apr 28.

Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.

Objective: To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations.

Methods: To identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative" and "optical coherence tomography" from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial APOSTEL recommendations via online surveys following the principle of a modified Delphi method. Read More

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Quantitative relations between BOLD responses, cortical energetics and impulse firing across cortical depth.

Eur J Neurosci 2021 Apr 26. Epub 2021 Apr 26.

Center for Mathematical Biology, University of Sydney, Sydney, NSW, 2006, Australia.

The blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal arises as a consequence of changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMR ) that in turn are modulated by changes in neural activity. Recent advances in imaging have achieved sub-millimeter resolution and allowed investigation of the BOLD response as a function of cortical depth. Here, we adapt our previous theory relating the BOLD signal to neural activity to produce a quantitative model that incorporates venous blood draining between cortical layers. Read More

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Class-Imbalanced Deep Learning via a Class-Balanced Ensemble.

IEEE Trans Neural Netw Learn Syst 2021 Apr 26;PP. Epub 2021 Apr 26.

Class imbalance is a prevalent phenomenon in various real-world applications and it presents significant challenges to model learning, including deep learning. In this work, we embed ensemble learning into the deep convolutional neural networks (CNNs) to tackle the class-imbalanced learning problem. An ensemble of auxiliary classifiers branching out from various hidden layers of a CNN is trained together with the CNN in an end-to-end manner. Read More

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Parametric Cortical Representations of Complexity and Preference for Artistic and Computer-Generated Fractal Patterns Revealed by Single-Trial EEG Power Spectral Analysis.

Neuroimage 2021 Apr 22:118092. Epub 2021 Apr 22.

Department of Psychological Sciences, University of Arkansas.

Fractals are self-similar patterns that repeat at different scales, the complexity of which are expressed as a fractional Euclidean dimension D between 0 (a point) and 2 (a filled plane). The drip paintings of American painter Jackson Pollock (JP) are fractal in nature, and Pollock's most illustrious works are of the high-D (∼1.7) category. Read More

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Automatic glaucoma detection based on transfer induced attention network.

Biomed Eng Online 2021 Apr 23;20(1):39. Epub 2021 Apr 23.

Beijing Children's Hospital, Capital Medical University, Beijing, China.

Background: Glaucoma is one of the causes that leads to irreversible vision loss. Automatic glaucoma detection based on fundus images has been widely studied in recent years. However, existing methods mainly depend on a considerable amount of labeled data to train the model, which is a serious constraint for real-world glaucoma detection. Read More

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Unraveling the mechanisms of surround suppression in early visual processing.

PLoS Comput Biol 2021 Apr 22;17(4):e1008916. Epub 2021 Apr 22.

Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America.

This paper uses mathematical modeling to study the mechanisms of surround suppression in the primate visual cortex. We present a large-scale neural circuit model consisting of three interconnected components: LGN and two input layers (Layer 4Ca and Layer 6) of the primary visual cortex V1, covering several hundred hypercolumns. Anatomical structures are incorporated and physiological parameters from realistic modeling work are used. Read More

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Politicisation, depoliticisation, and repoliticisation of health care controversies: Vaccination and mental health care reform in the Czech Republic.

Soc Sci Med 2021 Apr 18;277:113916. Epub 2021 Apr 18.

Department of Sociology, Faculty of Social Sciences, Charles University Prague, Czech Republic. Electronic address:

This article analyses the politicisation of public health debates by focusing on vaccination and mental health care in the Czech Republic. The mainstream understanding of politicisation commonly refers to politics-as-sphere, linked with the political instrumentalisation of health care controversies as part of electoral campaigning and power struggles. In our analysis, we conceive politicisation more broadly, as politics-as-activity, which encompasses the role of civic engagement and the involvement of patients in these processes. Read More

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Photocurrent-Detected 2D Electronic Spectroscopy Reveals Ultrafast Hole Transfer in Operating PM6/Y6 Organic Solar Cells.

J Phys Chem Lett 2021 Apr 20;12(16):3983-3988. Epub 2021 Apr 20.

ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona 08860, Spain.

The performance of nonfullerene-acceptor-(NFA)-based organic solar cells is rapidly approaching the efficiency of inorganic cells. The chemical versatility of NFAs extends the light-harvesting range to the infrared, while preserving a considerably high open-circuit-voltage, crucial to achieve power-conversion efficiencies >17%. Such low voltage losses in the charge separation process have been attributed to a low-driving-force and efficient exciton dissociation. Read More

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Risk of Uterine Rupture with Vaginal Birth after Cesarean in Twin Gestations.

Kimya Baradaran

Obstet Gynecol Int 2021 31;2021:6693142. Epub 2021 Mar 31.

Master of Science in Physician Assistant Studies, Dominican University of California, San Rafael, CA 94901, USA.

Background: Women with a previous cesarean delivery may attempt a subsequent vaginal birth or repeat cesarean. Vaginal birth after cesarean carries a greater risk of uterine rupture, defined as the disruption of all uterine layers, resulting in maternal-fetal morbidity or mortality. It is unclear how the risk of uterine rupture compares in patients with twin gestations who undergo different delivery methods. Read More

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Decoding molecular markers and transcriptional circuitry of naive and primed states of human pluripotency.

Stem Cell Res 2021 Apr 8;53:102334. Epub 2021 Apr 8.

Centre of Bioinformatics, Institute of Interdisciplinary Studies, University of Allahabad, Prayagraj 211002, India. Electronic address:

Pluripotent stem cells (PSCs) have been observed to occur in two distinct states - naive and primed. Both naive and primed state PSCs can give rise to tissues of all the three germ layers in vitro but differ in their potential to generate germline chimera in vivo. Understanding the molecular mechanisms that govern these two states of pluripotency in human can open a plethora of opportunities for studying early embryonic development and in biomedical applications. Read More

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Sciatic hernia: repair after recurrence.

BMJ Case Rep 2021 Apr 14;14(4). Epub 2021 Apr 14.

General Surgery, Maxima Medical Center, Veldhoven, The Netherlands.

Sciatic hernia is a rare pelvic floor hernia. A variety of treatment modalities were proposed, but a guideline is lacking although a mesh-based tension-free repair may be preferred. A 67-year-old woman with an uncomplicated sciatic hernia received primarily closing of the hernia orifice that was covered with a preperitoneal mesh in March 2019. Read More

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MoS2/WSe2 Nanohybrids for flexible paper-based photodetectors.

Nanotechnology 2021 Apr 13. Epub 2021 Apr 13.

Department of Physics, Charotar University of Science and Technology, Changa, Anand, 388 421, changa, INDIA.

Flexible photodetectors functionalised by transition metal dichalcogenides have captivated intensive attention due their excellent photo-harvesting efficiency. However, field of opto-electronics still needs advancement in production of large area, broad band and flexible photodetectors. Herein, we reported the flexible, stable, broad band and fast photodetector based on MoS2/WSe2 heterostructure on ordinary photocopy paper with pencil drawn graphite electrodes. Read More

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ePCL Electrospun Microfibrous Layers for Immune Assays: Sensitive ELISA for the Detection of Serum Antibodies Against HPV16 E7 Oncoprotein.

ACS Omega 2021 Apr 26;6(13):8778-8783. Epub 2021 Mar 26.

HPV-Unit UOSD Tumor Immunology and Immunotherapy-IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.

Human papillomavirus (HPV) type 16 is the etiologic agent of more than 50% anal/cervical cancers and about 20% oropharyngeal cancers. HPV16 E6 and E7 oncogenes favor the transformation and are essential for maintaining the transformed status. Serum anti-E6 and anti-E7 antibodies appear to have prognostic significance for HPV-associated cancers. Read More

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