888 results match your criteria prevention pts

First- and second-line treatment strategies for hormone-receptor (HR)-positive HER2-negative metastatic breast cancer: A real-world study.

Breast 2021 Mar 12;57:104-112. Epub 2021 Mar 12.

Department of Medicine, University of Udine, 33100, Udine, Italy; Department of Medical Oncology, Unit of Medical Oncology and Cancer Prevention, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081, Aviano, Italy.

Background: Endocrine therapy (ET) plus cyclin-dependent-kinases 4/6 inhibitors (CDK4/6i) represents the standard treatment for luminal-metastatic breast cancer (MBC). However, prospective head-to-head comparisons are still lacking for 1st line (L) options, and it is still crucial to define the best strategy between 1st and 2nd L.

Materials And Methods: 717 consecutive luminal-MBC pts treated between 2008 and 2020 were analyzed at the Oncology Department of Aviano and Udine, Italy. Read More

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Functional Genetic Variants in Are Associated with Acute Myeloid Leukemia.

Cancers (Basel) 2021 Mar 16;13(6). Epub 2021 Mar 16.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.

Acute myeloid leukemia (AML) is the most common acute leukemia, characterized by a heterogeneous genetic landscape contributing, among others, to the occurrence of metabolic reprogramming. Autophagy, a key player on metabolism, plays an essential role in AML. Here, we examined the association of three potentially functional genetic polymorphisms in the gene, central for the autophagosome formation. Read More

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Compression treatment in acute symptomatic proximal deep venous thrombosis - Results of a worldwide survey.

Phlebology 2021 Mar 21:2683555211003801. Epub 2021 Mar 21.

Private Practice Phlebology & Dermatology, Bonn, Germany and Department of Dermatology, University of Cologne, Köln, Germany.

Objectives: The aim of this study was to illustrate how compression is performed worldwide in proximal DVT and if compression management has changed recently.

Methods: A global online survey, consisting of 36 questions, was used. The survey was solicited from membership lists of Union Internationale de Phlébologie (UIP) membership societies. Read More

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Identification of Contamination in a Ready-to-Eat Meat Processing Plant in China.

Front Microbiol 2021 25;12:628204. Epub 2021 Feb 25.

Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.

is the etiologic agent of listeriosis, which remains a significant public health concern in many countries due to its high case-fatality rate. The constant risk of transmission to consumers remains a central challenge in the food production industry. At present, there is very little known about contamination in ready-to-eat (RTE) processing plants in China. Read More

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February 2021

Pentacyclic Triterpene Profile and Its Biosynthetic Pathway in as a Prospective Dietary Supplement.

Molecules 2021 Feb 18;26(4). Epub 2021 Feb 18.

Department of Pharmaceutical Sciences, School of Natural Sciences, Universidad Icesi, Cali 760031, Colombia.

Promising research over the past decades has shown that some types of pentacyclic triterpenes (PTs) are associated with the prevention of type 2 diabetes (T2D), especially those found in foods. The most abundant edible sources of PTs are those belonging to the ursane and oleanane scaffold. The principal finding is that contains abundant oleanane and ursane PT types with similar oxygenation patterns to those found in food matrices. Read More

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February 2021

Perceptions of Signs of Addiction Among Opioid Naive Patients Prescribed Opioids in the Emergency Department.

J Addict Med 2021 Feb 5. Epub 2021 Feb 5.

Department of Emergency Medicine, Northwestern University, Chicago, IL (PTS, PML, HSK, DMM); Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University, Chicago, IL (KAC, LAO, LMC, MSW); Department of Emergency Medicine, University of Texas Southwestern, Dallas, TX (DMC).

Objectives: Patient knowledge deficits related to opioid risks, including lack of knowledge regarding addiction, are well documented. Our objective was to characterize patients' perceptions of signs of addiction.

Methods: This study utilized data obtained as part of a larger interventional trial. Read More

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February 2021

ICD therapy in the elderly: a retrospective single-center analysis of mortality.

Herzschrittmacherther Elektrophysiol 2021 Jan 29. Epub 2021 Jan 29.

Department of Electrophysiology, Cologne, University Heart Center Cologne, Kerpener Str. 62, 50937, Köln, Germany.

Background: Current implantable cardioverter-defibrillator (ICD) guidelines do not impose age limitations for ICD implantation (IMPL) and generator exchange (GE); however, patients (pts) should be expected to survive for 1 year. With higher age, comorbidity and mortality due to non-sudden cardiac death increase. Thus, the benefit of ICD therapy in elderly pts remains unclear. Read More

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January 2021

Beliefs toward mental illness in Turkish physiotherapists.

Physiother Theory Pract 2021 Jan 21:1-7. Epub 2021 Jan 21.

School of Physical Therapy and Rehabilitation, Dokuz Eylul University , Izmir, Turkey.

Physiotherapists (PTs) are responsible for the prevention and promotion of physical and mental health. Their beliefs toward mental illness (MI) are important to disclose stigmatization. To investigate the beliefs of PTs toward MI. Read More

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January 2021

Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb.

Cochrane Database Syst Rev 2021 01 19;1:CD002783. Epub 2021 Jan 19.

Department of General Surgery, Norfolk and Norwich University Hospital, Norwich, UK.

Background: Standard treatment for deep vein thrombosis (DVT) aims to reduce immediate complications. Use of thrombolytic clot removal strategies (i.e. Read More

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January 2021

Surgical and non-surgical approaches in the management of lower limb post-thrombotic syndrome.

Expert Rev Cardiovasc Ther 2021 Jan 26:1-10. Epub 2021 Jan 26.

Academic Section of Vascular Surgery, Department of Surgery & Cancer, Imperial College London , London, UK.

: Post-thrombotic syndrome (PTS) is a common lifelong condition affecting up to 50% of those suffering from deep vein thrombosis (DVT). PTS compromises function and quality of life with subsequent venous ulceration in up to 29% of those affected. : A literature review of surgical and non-surgical approaches in the prevention and treatment of PTS was undertaken. Read More

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January 2021

Can we predict and prevent the postthrombotic syndrome?

Vasa 2021 Jan;50(1):11-21

Department of Surgery, Stony Brook University School of Medicine, Stony Brook University Hospital, Stony Brook, NY, USA.

Postthrombotic syndrome (PTS) remains one of the major late complications of deep vein thrombosis (DVT) with a reported prevalence from 10 to 50%. Many factors were found to be related with the development and severity of PTS such as ipsilateral recurrent DVT, advanced age, obesity, ilio-femoral DVT and primary chronic venous disease presence. Some PTS prediction models have been proposed based on risk factor weight. Read More

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January 2021

Compression stockings to prevent postthrombotic syndrome: Literature overview and presentation of the CELEST trial.

Res Pract Thromb Haemost 2020 Nov 30;4(8):1239-1250. Epub 2020 Oct 30.

Department of Public Health University Grenoble Alpes CNRS Grenoble-Alpes University Hospital TIMC-IMAG F38000 Grenoble France.

Postthrombotic syndrome (PTS) is a burdensome and costly complication of deep vein thrombosis (DVT) that develops in 20%-40% of patients within 2 years after proximal DVT. In the absence of effective curative treatment, management of PTS relies on its prevention after DVT. The effectiveness of elastic compression stockings (ECS) to prevent PTS is uncertain. Read More

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November 2020

Nature-Based Interventions and Mind-Body Interventions: Saving Public Health Costs Whilst Increasing Life Satisfaction and Happiness.

Int J Environ Res Public Health 2020 10 23;17(21). Epub 2020 Oct 23.

School of Sport, Rehabilitation and Exercise Sciences, University of Essex, Colchester CO4 3SQ, UK.

A number of countries have begun to adopt prevention pays policies and practices to reduce pressure on health and social care systems. Most affluent countries have seen substantial increases in the incidence and costs of non-communicable diseases. The interest in social models for health has led to the growth in use of social prescribing and psychological therapies. Read More

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October 2020

Feasibility and Efficacy of a Resiliency Intervention for the Prevention of Chronic Emotional Distress Among Survivor-Caregiver Dyads Admitted to the Neuroscience Intensive Care Unit: A Randomized Clinical Trial.

JAMA Netw Open 2020 10 1;3(10):e2020807. Epub 2020 Oct 1.

Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston.

Importance: To our knowledge, there are no evidence-based interventions to prevent chronic emotional distress (ie, depression, anxiety, and posttraumatic stress [PTS]) in critical care survivors and their informal caregivers.

Objective: To determine the feasibility and preliminary effect of the novel dyadic resiliency intervention Recovering Together (RT) on reducing symptoms of depression, anxiety, and PTS among hospitalized patients and their informal caregivers.

Design, Setting, And Participants: This single-blind, pilot randomized clinical trial of RT vs an educational control was conducted among 58 dyads in which either the survivor or caregiver endorsed clinically significant symptoms of depression, anxiety, or PTS. Read More

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October 2020

Do myeloproliferative neoplasms and multiple myeloma share the same genetic susceptibility loci?

Int J Cancer 2021 Apr 27;148(7):1616-1624. Epub 2020 Oct 27.

Department of Biology, University of Pisa, Pisa, Italy.

Myeloproliferative neoplasms (MPNs) are a group of diseases that cause myeloid hematopoietic cells to overproliferate. Epidemiological and familial studies suggest that genetic factors contribute to the risk of developing MPN, but the genetic susceptibility of MPN is still not well known. Indeed, only few loci are known to have a clear role in the predisposition to this disease. Read More

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Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy.

Cancer Discov 2020 Nov 9;10(11):1635-1644. Epub 2020 Oct 9.

Clinical and Translational Oncology Group, Clínica del Country, Bogotá, Colombia.

Despite major therapeutic progress, most advanced solid tumors are still incurable. Cancer interception is the active way to combat cancer onset, and development of this approach within high-risk populations seems a logical first step. Until now, strategies for the identification of high-risk subjects have been based on low-sensitivity and low-specificity assays. Read More

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November 2020

Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy.

J Neurol 2020 Oct 7. Epub 2020 Oct 7.

Department of Neurology, Papa Giovanni XXIII Hospital, Piazza OMS 1, 24127, Bergamo, Italy.

Objectives: Evidences from either small series or spontaneous reporting are accumulating that SARS-CoV-2 involves the Nervous Systems. The aim of this study is to provide an extensive overview on the major neurological complications in a large cohort of COVID-19 patients.

Methods: Retrospective, observational analysis on all COVID-19 patients admitted from February 23rd to April 30th, 2020 to ASST Papa Giovanni XXIII, Bergamo, Italy for whom a neurological consultation/neurophysiological assessment/neuroradiologic investigation was requested. Read More

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October 2020

Midwifery continuity of care versus standard maternity care for women at increased risk of preterm birth: A hybrid implementation-effectiveness, randomised controlled pilot trial in the UK.

PLoS Med 2020 10 6;17(10):e1003350. Epub 2020 Oct 6.

Department of Women and Children's Health, Faculty of Life Science and Medicine, King's College London, London, United Kingdom.

Background: Midwifery continuity of care is the only health system intervention shown to reduce preterm birth (PTB) and improve perinatal survival, but no trial evidence exists for women with identified risk factors for PTB. We aimed to assess feasibility, fidelity, and clinical outcomes of a model of midwifery continuity of care linked with a specialist obstetric clinic for women considered at increased risk for PTB.

Methods And Findings: We conducted a hybrid implementation-effectiveness, randomised, controlled, unblinded, parallel-group pilot trial at an inner-city maternity service in London (UK), in which pregnant women identified at increased risk of PTB were randomly assigned (1:1) to either midwifery continuity of antenatal, intrapartum, and postnatal care (Pilot study Of midwifery Practice in Preterm birth Including women's Experiences [POPPIE] group) or standard care group (maternity care by different midwives working in designated clinical areas). Read More

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October 2020

No Association Between T-peak to T-end Interval on the Resting ECG and Long-Term Incidence of Ventricular Arrhythmias Triggering ICD Interventions.

Front Physiol 2020 31;11:1115. Epub 2020 Aug 31.

Faculty of Medicine, Slovak Medical University in Bratislava, Bratislava, Slovakia.

Background And Objectives: Potential of using the T-peak to T-end (TpTe) interval as an electrocardiographic parameter reflecting the transmural dispersion of ventricular repolarization (TDR) to identify patients (pts.) with higher risk of malignant ventricular arrhythmias (MVA) for better selection of candidates for implantable cardioverter-defibrillator (ICD) in primary prevention (PP) of sudden cardiac death (SCD) remains controversial. The primary objective of this study was to investigate the relationship between the TpTe interval in patient's preimplantation resting 12-lead electrocardiogram (ECG) and the incidence of MVA resulting in appropriate ICD intervention (AI). Read More

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Incidence of hyponatremia in patients given levetiracetam vs. phenytoin for early posttraumatic seizure prophylaxis.

Am J Surg 2020 12 9;220(6):1503-1505. Epub 2020 Sep 9.

UCSF Fresno Department of Surgery, 2823 Fresno St., 1st Floor Surgery, Fresno, CA, USA, 93721. Electronic address:

Background: Levetiracetam and phenytoin are comparable for acute posttraumatic seizure(PTS) prophylaxis. Levetiracetam-induced hyponatremia has been reported in non-trauma patients. We studied hyponatremia in posttraumatic intracranial hemorrhage(ICH) patients receiving either drug. Read More

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December 2020

Transitions into and out of post-traumatic stress among children involved in the child welfare system.

Child Youth Serv Rev 2020 Nov 25;118. Epub 2020 Aug 25.

Department of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA.

Purpose: To describe the transition patterns into and out of post-traumatic stress (PTS) for youth and identify social supports preceding these transitions.

Methods: We used inhomogeneous, continuous-time, Markov Chain models to model transitions in and out of PTS using data from Waves 1, 3, 4, and 5 of the National Survey of Child and Adolescent Wellbeing (NSCAW I)-a longitudinal study of children who first had contact with the child welfare system between 1999 and 2000. Our analytic sample contained 915 individuals aged 11-17 years. Read More

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November 2020

Genetic polymorphisms associated with telomere length and risk of developing myeloproliferative neoplasms.

Blood Cancer J 2020 09 1;10(8):89. Epub 2020 Sep 1.

Department of Biology, University of Pisa, Pisa, Italy.

Telomere length measured in leukocyte (LTL) has been found to be associated with the risk of developing several cancer types, including myeloproliferative neoplasms (MPNs). LTL is genetically determined by, at least, 11 SNPs previously shown to influence LTL. Their combination in a score has been used as a genetic instrument to measure LTL and evaluate the causative association between LTL and the risk of several cancer types. Read More

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September 2020

Psychological impact of COVID-19 on medical care workers in China.

Infect Dis Poverty 2020 Aug 12;9(1):113. Epub 2020 Aug 12.

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 South Panjiayuan, Chaoyang District, Beijing, China.

Background: Medical care workers experienced unprecedented levels of workload and pressure since the outbreak of coronavirus disease 2019 (COVID-19). Little is known about its exact impact on medical care workers and related factors in China. This study aims to identify the psychological impact of COVID-19 on medical care workers in China. Read More

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Computational causal discovery for post-traumatic stress in police officers.

Transl Psychiatry 2020 08 11;10(1):233. Epub 2020 Aug 11.

Department of Psychiatry, New York University School of Medicine, New York, NY, USA.

This article reports on a study aimed to elucidate the complex etiology of post-traumatic stress (PTS) in a longitudinal cohort of police officers, by applying rigorous computational causal discovery (CCD) methods with observational data. An existing observational data set was used, which comprised a sample of 207 police officers who were recruited upon entry to police academy training. Participants were evaluated on a comprehensive set of clinical, self-report, genetic, neuroendocrine and physiological measures at baseline during academy training and then were re-evaluated at 12 months after training was completed. Read More

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A Network Analysis of Peritraumatic Distress Reactions and Their Relation to Posttraumatic Stress Symptoms in People Exposed to Community Fires.

Psychiatry 2020 3;83(4):375-389. Epub 2020 Aug 3.

: Research indicates that people who experience more intense peritraumatic reactions are at higher risk of subsequently developing PTSD. The study used network analysis to: 1) explore the network structure of peritraumatic distress reactions; 2) identify clusters of peritraumatic distress reactions; and 3) assess whether central items in the peritraumatic network have stronger network associations with subsequent posttraumatic stress symptoms (PTS). : A convenience sample of adults living in communities affected by large-scale community fires in Israel (November 2016) were recruited. Read More

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Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis.

PLoS One 2020 28;15(7):e0228429. Epub 2020 Jul 28.

Department of Otorhinolaryngology-Head and Neck Surgery, Health Science University Adana City Hospital, Adana, Turkey.

Diabetes mellitus (DM) causes ototoxicity by inducing oxidative stress, microangiopathy, and apoptosis in the cochlear sensory hair cells. The natural anti-oxidant pterostilbene (PTS) (trans-3,5-dimethoxy-4-hydroxystylbene) has been reported to relieve oxidative stress and apoptosis in DM, but its role in diabetic-induced ototoxicity is unclear. This study aimed to investigate the effects of dose-dependent PTS on the cochlear cells of streptozotocin (STZ)-induced diabetic rats. Read More

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September 2020

Children and young adults treated with transvenous and subcutaneous implantable cardioverter-defibrillators: a 22-year single-center experience and new perspectives.

Kardiol Pol 2020 09 2;78(9):869-874. Epub 2020 Jul 2.

National Institute of Cardiology, Warsaw, Poland

Background: Over the last several years the evolution of transvenous implantable cardioverter‑defibrillator (T‑ICD) system and the introduction of subcutaneous ICD (S‑ICD) have contributed to the development of the sudden cardiac death (SCD) prevention in clinical practice.

Aims: To report our clinical experience with ICD therapy in children and young adults during the twenty‑ ‑two years of the follow‑up.

Methods: We reviewed the database of ICD recipients choosing 80 consecutive patients (pts) implanted at the age of 6-21 in 1996-2018. Read More

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September 2020

Association of Successful Ultrasound-Accelerated Catheter-Directed Thrombolysis with Postthrombotic Syndrome: A Post Hoc Analysis of the CAVA Trial.

Thromb Haemost 2020 Aug 30;120(8):1188-1199. Epub 2020 Jun 30.

Cardiovascular Research Institute Maastricht (CARIM), School for Cardiovascular Diseases, Maastricht University Medical Centre, Maastricht, The Netherlands.

Background:  The CAVA trial did not show the anticipated risk reduction for postthrombotic syndrome (PTS) after thrombus removal via additional ultrasound-accelerated catheter-directed thrombolysis (UACDT) in patients with acute iliofemoral deep vein thrombosis (IFDVT). Difficulties in achieving an effective degree of recanalization through thrombolysis may have influenced outcomes. We therefore assessed whether successful UACDT (restored patency ≥ 90%) did reduce the development of PTS. Read More

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The SENECA study: Prognostic role of serum biomarkers in older patients with metastatic colorectal cancer.

J Geriatr Oncol 2020 11 21;11(8):1268-1273. Epub 2020 Jun 21.

Department of Medicine (DAME), University of Udine, Udine, IT, Italy; Department of Medical Oncology, Unit of medical oncology and cancer prevention, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, IT, Italy.

Background: Aging induces meaningful changes in the immune system and inflammation response with increase in monocyte-lymphocyte ratio (MLR) and serum lactate dehydrogenase (LDH) levels. Aim of this study was to explore the prognostic role of MLR and LDH levels in older patients (pts) with metastatic colorectal cancer (mCRC).

Methods: We conducted a retrospective analysis of a consecutive cohort of 168 older (>70 years) patients with mCRC. Read More

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November 2020

A decreased ratio of height of lateral femoral condyle to anteroposterior diameter is a risk factor for anterior cruciate ligament rupture.

BMC Musculoskelet Disord 2020 Jun 23;21(1):402. Epub 2020 Jun 23.

Department of Orthopaedics, People's Hospital of Deyang City, No. 173, section 3, North Taishan Road, Deyang, 618000, Sichuan Province, China.

Background: Studies have shown that the spherical shape of the lateral femoral condyle has a clear relationship with the relative axial movement of tibiofemoral joint and the anterior cruciate ligament (ACL) rupture. The purpose of this study was to describe the distal curvature of the lateral femoral condyle by ratio of height of lateral femoral condyle to anteroposterior diameter (HAPR), and evaluate its correlation with ACL rupture.

Methods: A retrospective case-control study of 64 patients was conducted. Read More

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